LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 3222

Search options

  1. Article ; Online: A Semi-Automatic Environmental Monitoring Device for Mercury and Cobalt Ion Detection.

    Chiou, Yi-Ru / Pang, Hao-Ming / Huang, Yu-Fen / Chen, Chien-Fu

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 8, Page(s) e2303871

    Abstract: A syringe-based, semi-automatic environmental monitoring device is developed for on-site detection of harmful heavy metal ions in water. This portable device consists of a spring-embedded syringe and a polydimethylsiloxane (PDMS) membrane-based flow ... ...

    Abstract A syringe-based, semi-automatic environmental monitoring device is developed for on-site detection of harmful heavy metal ions in water. This portable device consists of a spring-embedded syringe and a polydimethylsiloxane (PDMS) membrane-based flow regulator for semi-automatic fix-and-release fluidic valve actuation, and a paper-based analytical device (PAD) with two kinds of gold nanoclusters (AuNCs) for sensitive Hg
    Language English
    Publishing date 2023-10-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202303871
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Murine model of eosinophilic chronic rhinosinusitis with nasal polyposis inducing neuroinflammation and olfactory dysfunction.

    Huang, Wei-Hao / Hung, Yu-Wen / Hung, Wei / Lan, Ming-Ying / Yeh, Chien-Fu

    The Journal of allergy and clinical immunology

    2024  

    Abstract: Background: Chronic rhinosinusitis (CRS) is a common inflammatory condition affecting the nasal and paranasal sinus mucosa, often accompanied by olfactory dysfunction. Eosinophilic CRS with nasal polyps (ECRSwNP) is a subtype of CRS characterized by ... ...

    Abstract Background: Chronic rhinosinusitis (CRS) is a common inflammatory condition affecting the nasal and paranasal sinus mucosa, often accompanied by olfactory dysfunction. Eosinophilic CRS with nasal polyps (ECRSwNP) is a subtype of CRS characterized by eosinophilic infiltration. Animal models for ECRSwNP with olfactory dysfunction are necessary for exploring potential therapeutic strategies.
    Objective: The aim of this study was to establish a mouse model of ECRSwNP combined with olfactory dysfunction in a shorter time frame using intranasal ovalbumin and Aspergillus protease (AP) administration. The efficacy of the model was validated by evaluating sinonasal inflammation, cytokine levels, olfactory function, and neuroinflammation in the olfactory bulb.
    Methods: Male BALB/c mice were intranasally administered ovalbumin and AP for 6 and 12 weeks to induce ECRSwNP. The resultant ECRSwNP mouse model underwent histologic assessment, cytokine analysis of nasal lavage fluid, olfactory behavioral tests, and gene expression profiling to identify neuroinflammatory markers within the olfactory bulb.
    Results: The developed mouse model exhibited substantial eosinophil infiltration, increased levels of inflammatory cytokines in nasal lavage fluid, and confirmed olfactory dysfunction through behavioral assays. Furthermore, olfactory bulb inflammation and reduced mature olfactory sensory neurons were observed in the model.
    Conclusion: This study successfully established a validated mouse model of ECRSwNP with olfactory dysfunction within a remarkably short span of 6 weeks, providing a valuable tool for investigating the pathogenesis and potential therapies for this condition. The model offers an efficient approach for future research in CRS with nasal polyps and olfactory dysfunction.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2024.02.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Correction to: Vertebral artery stenosis predicts cerebrovascular diseases following radiotherapy for nasopharyngeal carcinoma.

    Yeh, Chien-Fu / Chin, Yu-Ching / Hung, Wei / Huang, Pin-I / Lan, Ming-Ying

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 8, Page(s) 456

    Language English
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07924-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Clinicopathological Features and Prognostic Factors of Sinonasal Rhabdomyosarcoma.

    Lo, Wen-Ling / Huang, Wei-Hao / Yeh, Chien-Fu

    In vivo (Athens, Greece)

    2022  Volume 36, Issue 6, Page(s) 2965–2972

    Abstract: Background/aim: Sinonasal rhabdomyosarcoma (RMS) is a rare soft tissue malignancy. Due to the limited cases, the clinicopathological features and prognostic factors are still not well understood.: Patients and methods: This retrospective review ... ...

    Abstract Background/aim: Sinonasal rhabdomyosarcoma (RMS) is a rare soft tissue malignancy. Due to the limited cases, the clinicopathological features and prognostic factors are still not well understood.
    Patients and methods: This retrospective review included eight patients with sinonasal RMS at our institution between 2004 and 2020. Patient demographics, tumor features, Intergroup Rhabdomyosarcoma Study Group (IRSG) stage and clinical group, treatment strategy, and survival rates were evaluated. Kaplan-Meier analysis and log-rank tests were performed to analyze the possible prognostic factors.
    Results: We observed a predominance of male sex and alveolar-type tumor in sinonasal RMS. Nasal obstructions and neck masses were the most common symptoms. Patients with pretreatment lactate dehydrogenase (LDH) levels >400 U/l and negative immunohistochemical staining for desmin or MyoD1 had lower survival rates.
    Conclusion: In patients with sinonasal RMS, pretreatment LDH levels >400 U/l and negative immunohistochemical staining for desmin or MyoD1 may suggest a poor prognosis. These factors can not only contribute to the prediction of prognosis in patients with sinonasal RMS but also facilitate the design of more appropriate treatment strategies.
    MeSH term(s) Humans ; Male ; Female ; Prognosis ; Desmin ; Rhabdomyosarcoma/diagnosis ; Rhabdomyosarcoma/therapy ; Rhabdomyosarcoma/pathology ; Paranasal Sinus Neoplasms/diagnosis ; Paranasal Sinus Neoplasms/therapy ; Sarcoma/pathology
    Chemical Substances Desmin
    Language English
    Publishing date 2022-10-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13040
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Pantoea dispersa rhinosinusitis: clinical aspects of a rare sinonasal pathogen.

    Su, Yi-Wen / Huang, Wei-Hao / Yeh, Chien-Fu

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 9, Page(s) 4389–4395

    Abstract: Purpose: There is no report in the literature targeting the role of Pantoea dispersa in rhinosinusitis and P. dispersa has not been identified as a commensal bacterium in the sinonasal cavity. We aimed to investigate the role of P. dispersa in ... ...

    Abstract Purpose: There is no report in the literature targeting the role of Pantoea dispersa in rhinosinusitis and P. dispersa has not been identified as a commensal bacterium in the sinonasal cavity. We aimed to investigate the role of P. dispersa in rhinosinusitis.
    Methods: We retrospectively reviewed the data of patients diagnosed with rhinosinusitis at a medical center in Taiwan.
    Results: A total of 274 rhinosinusitis patients underwent sinus culture between July 2017 and July 2019. All 23 patients with acute P. dispersa rhinosinusitis experienced purulent rhinorrhea; three (13%) had nasal obstruction, but none had olfactory dysfunction, facial pressure/pain and nasal polyp. The patients with P. dispersa received a significantly shorter duration of antibiotic treatment (19.9 ± 2.6 vs. 28.9 ± 2.5 days, P = 0.015) and had lower surgery rate (0% vs. 16.7%, P = 0.043) than other patients. Patients with olfactory dysfunction were more likely to receive surgical treatment (P = 0.018).
    Conclusion: Acute rhinosinusitis caused by P. dispersa resulted in less surgical interventions and shorter treatment durations. Olfactory dysfunction may imply longer course and possibility for surgical intervention in chronic rhinosinusitis. The present study revealed that P. dispersa had the potential to colonize in human sinonasal cavities and cause rhinosinusitis.
    MeSH term(s) Acute Disease ; Chronic Disease ; Humans ; Nasal Polyps/surgery ; Olfaction Disorders/etiology ; Pantoea ; Retrospective Studies ; Rhinitis/surgery ; Sinusitis/surgery
    Language English
    Publishing date 2022-01-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07266-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Distinct Age-Specific Effects on Olfactory Associative Learning in C57BL/6 Substrains.

    Chen, Hung-Lun / Chen, Chien-Fu F / Huang, Han-Bin

    Frontiers in behavioral neuroscience

    2022  Volume 16, Page(s) 808978

    Abstract: C57BL/6 is the most widely used mouse strain in the laboratories. Two substrains of C57BL/6, C57BL/6J (B6J), and C57BL/6N (B6N) are well-known backgrounds for genetic modification and have been shown difference in quite a few tests, including open field ... ...

    Abstract C57BL/6 is the most widely used mouse strain in the laboratories. Two substrains of C57BL/6, C57BL/6J (B6J), and C57BL/6N (B6N) are well-known backgrounds for genetic modification and have been shown difference in quite a few tests, including open field test, rotarod test, and Morris water maze. However, difference between these two substrains in olfaction-dependent behaviors remains unknown. Here, we used olfactory two-alternative choice task, which is modified to have two training stages, to evaluate animals' ability in instrumental learning and olfactory association. In the first (rule learning) stage, the mice were trained to use the operant chamber to collect water rewards. An odor cue was provided in the procedure, with no indication about reward locations. In the following (discrimination learning) stage, two odor cues were provided, with each indicating a specific water port. The animals were rewarded upon correct port choices following cue deliveries. We found that during young adulthood (7-10 weeks old), proportionally more B6J than B6N mice were able to pass rule learning (58.3% vs. 29.2%) and ultimately acquire this task (54.2% vs. 25%), with the two substrains showing similar pass rates in discrimination learning (92.9% vs. 85.7%). Surprisingly, at a more mature age (17 weeks old), this substrain difference disappeared. Mature B6N mice had a significant improvement in pass percentages of rule learning and overall task, whereas similar improvement was not observed in the B6J counterparts. Instead, mature B6J mice had an improved speed in rule learning and overall task. We further examined behavioral patterns of 8-week-old B6J and B6N mice in the olfactory habituation or dishabituation test. We observed normal olfactory habituation from subjects of both substrains, with the B6J mice exhibiting stronger investigative responses to newly presented odorants. These results reveal for the first time that B6J and B6N mice are different in acquisition processes of a behavioral task that requires instrumental learning and olfactory association, and that maturation appears to employ different effects on these two substrains during these processes. Furthermore, young adult B6J and B6N mice might be similar in olfactory habituation but different in the olfactory aspects of novelty seeking.
    Language English
    Publishing date 2022-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2022.808978
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Book: Shou fu t'o la chi ch'ang chien ku chang 100 li

    Huang, Chieh-chang / Lü, Yün-lung

    (Nung ts'un wen k'u)

    1983  

    Title translation One hundred cases on commonly seen breakdown problems of manual tractors.
    Author's details Huang Chieh-chang, Lü Yün-lung pien hsieh
    Series title Nung ts'un wen k'u
    Keywords Farm tractors. ; Farm tractors
    Language Chinese
    Size 5, 85 p. :, ill. ;, 19 cm.
    Edition Ti 1 pan.
    Publisher Che-chiang k'o hsüeh chi shu ch'u pan she
    Publishing place Hang-chou shih
    Document type Book
    Note Cover title also in pinyin: Shoufu tuolaji changjian guzhang 100li.
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  8. Article: Congenital Heart Diseases Impair Female Fertility.

    Chien, Shao-Ju / Lin, Ying-Jui / Lo, Mao-Hung / Huang, Chien-Fu / Yang, Yao-Hsu

    Frontiers in pediatrics

    2021  Volume 9, Page(s) 687276

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-07-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2021.687276
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Prior cancer history predicts the worse survival of patients with nasopharyngeal carcinoma.

    Yeh, Chien-Fu / Chin, Yu-Ching / Huang, Wei-Hao / Lan, Ming-Ying

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2022  Volume 279, Issue 11, Page(s) 5381–5387

    Abstract: Purpose: Previous cancers can be observed in patients with nasopharyngeal carcinoma (NPC). However, whether prior cancer diagnosis affects survival outcomes remains unknown. This study aimed to explore the impact of prior cancer on the survival of ... ...

    Abstract Purpose: Previous cancers can be observed in patients with nasopharyngeal carcinoma (NPC). However, whether prior cancer diagnosis affects survival outcomes remains unknown. This study aimed to explore the impact of prior cancer on the survival of patients with NPC.
    Methods: We retrospectively collected data from 666 NPC patients between 2006 and 2018. The patients in this study were divided into those without prior cancer, with prior head and neck cancer, and prior non-head and neck cancer. The demographic data and survival of these groups were then analyzed. The independent prognostic factors for NPC were determined using multivariate Cox regression analysis.
    Results: We identified 25 NPC patients with prior cancer in our case series, most of whom had a history of colorectal cancer. Patients with a history of cancer were older than those without a history of cancer (p = 0.001). In the subgroup analysis stratified by the timing of prior cancer, NPC patients with prior non-head and neck cancer within 24, 36, 60, and 120 months showed worse survival than patients without prior cancer (all p < 0.05). When stratified by cancer stage, stage III NPC patients with prior non-head and neck cancer showed worse survival than patients without prior cancer (p < 0.001). Prior cancer and diabetes can predict worse survival in patients with stage III NPC.
    Conclusion: This study demonstrated that prior cancer and diabetes are independent prognostic factors in patients with stage III NPC.
    MeSH term(s) Humans ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Neoplasms/pathology ; Neoplasm Staging ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-06-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-022-07444-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Lipopolysaccharide-Initiated Rhinosinusitis Causes Neuroinflammation and Olfactory Dysfunction in Mice.

    Yeh, Chien-Fu / Huang, Wei-Hao / Lan, Ming-Ying / Hung, Wei

    American journal of rhinology & allergy

    2022  Volume 37, Issue 3, Page(s) 298–306

    Abstract: Background: Olfactory dysfunction is a common disease and it may be caused by sinonasal inflammation, toxin inhalation, or neurological disorders. After sinonasal inflammation, if both olfactory neuroinflammation and olfactory dysfunction occur still ... ...

    Abstract Background: Olfactory dysfunction is a common disease and it may be caused by sinonasal inflammation, toxin inhalation, or neurological disorders. After sinonasal inflammation, if both olfactory neuroinflammation and olfactory dysfunction occur still under investigation.
    Objective: This study aimed to investigate whether neuroinflammation and olfactory dysfunction occur after lipopolysaccharide (LPS)-initiated rhinosinusitis.
    Methods: Adult C57BL/6 mice were intranasally administered with LPS for 3 weeks. The olfactory function was evaluated with a buried food test. The inflammatory status of sinonasal cavity and olfactory bulb was evaluated with histology and biochemistry.
    Results: After 3-week LPS treatment, mice developed olfactory dysfunction, sinonasal cavity, and olfactory bulb inflammation. LPS-treated mice had greater sinonasal mucosal thickness. Besides, pro-inflammatory interleukin-6, the number of goblet cells and neutrophils in the sinonasal cavity was increased after LPS administration. The olfactory sensory neurons in the olfactory epithelium and the olfactory bulb were decreased, and the olfactory function was impaired by LPS administration. Inflammatory cytokines such as interferon-γ and tumor necrosis factor-α were increased in the olfactory bulb.
    Conclusion: This study showed that LPS-initiated rhinosinusitis caused olfactory neuroinflammation and olfactory dysfunction in mice.
    MeSH term(s) Mice ; Animals ; Lipopolysaccharides ; Neuroinflammatory Diseases ; Mice, Inbred C57BL ; Sinusitis/pathology ; Inflammation/pathology ; Olfactory Bulb/pathology ; Olfaction Disorders/chemically induced ; Olfaction Disorders/pathology
    Chemical Substances Lipopolysaccharides
    Language English
    Publishing date 2022-11-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.1177/19458924221140965
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top