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Article ; Online: Response to Jia and Wang.

Liu, Xu / Liu, Qi / Yao, Xueting / Zhang, Miao / Cui, Cheng / Li, Haiyan / Liu, Dongyang

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 73, Issue 2, Page(s) 352–353

MeSH term(s)	Humans ; Methotrexate
Chemical Substances	Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2020-11-09
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa1390
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article ; Online: Correction: Jia et al. Exposure to Polypropylene Microplastics via Oral Ingestion Induces Colonic Apoptosis and Intestinal Barrier Damage through Oxidative Stress and Inflammation in Mice.

Jia, Rui / Han, Jie / Liu, Xiaohua / Li, Kang / Lai, Wenqing / Bian, Liping / Yan, Jun / Xi, Zhuge

Toxics

2023 Volume 11, Issue 9

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11090733
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The pharmacological mechanism of chaihu-jia-longgu-muli-tang for treating depression: integrated meta-analysis and network pharmacology analysis.

Zhao, Yang / Xu, Dan / Wang, Jing / Zhou, Dandan / Liu, Anlan / Sun, Yingying / Yuan, Yuan / Li, Jianxiang / Guo, Weifeng

Frontiers in pharmacology

2023 Volume 14, Page(s) 1257617

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1257617
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Article: [Clinical application of Chaihu Jia Longgu Muli Decoction based on modern pathophysiology mechanism].

Liu, Heng-Liang / Jin, Zi-Xuan / Su, Ke-Lei / Wang, Peng-Qian / Xiong, Xing-Jiang

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2023 Volume 48, Issue 10, Page(s) 2620–2624

Abstract: Chaihu Jia Longgu Muli Decoction was firstly recorded in Treatise on Cold Damage(ZHANG Zhong-jing ... the classic provisions of Chaihu Jia Longgu Muli Decoction. Original records of "chest fullness" "annoyance ...

Abstract	Chaihu Jia Longgu Muli Decoction was firstly recorded in Treatise on Cold Damage(ZHANG Zhong-jing, Eastern Han dynasty). According to this medical classic, it is originally used in the treatment of the Shaoyang and Yangming syndrome. Based on the modern pathophysiological mechanism, this study interpreted the classic provisions of Chaihu Jia Longgu Muli Decoction. Original records of "chest fullness" "annoyance" "shock" "difficult urination" "delirium" "heavy body and failing to turn over" all have profound pathophysiological basis, involving disorders in cardiovascular, respiratory, nervous, and mental systems. This formula is widely used, which can be applied to treat epilepsy, cerebral arteriosclerosis, cerebral infarction, and other cerebrovascular diseases, hypertension, arrhythmia, and other cardiovascular diseases, insomnia, constipation, anxiety, depression, cardiac neurosis and other acute and chronic diseases as well as diseases in psychosomatic medicine. The clinical indications include Bupleuri Radix-targeted syndrome such as fullness and discomfort in chest and hypochondrium, bitter taste mouth, dry throat, and dizziness, the insomnia, anxiety, depression, susceptibility to fright, upset, dreamfulness and other psychiatric symptoms, red tongue, thick and yellow tongue coating, and wiry hard and powerful pulse. This formula was found to be used in combination with other formulas, such as Gualou Xiebai Decoction, Wendan Decoction, Zhizhu Pills, Juzhijiang Decoction, Suanzaoren Decoction, and Banxia Baizhu Tianma Decoction.
MeSH term(s)	Humans ; Sleep Initiation and Maintenance Disorders/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Hypertension/drug therapy ; Syndrome ; Arrhythmias, Cardiac/drug therapy ; Medicine, Chinese Traditional
Chemical Substances	Baizhu ; Drugs, Chinese Herbal
Language	Chinese
Publishing date	2023-06-01
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230206.501
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Zs.A 3056: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Thoracic Jia-Ji electro-acupuncture mitigates low skeletal muscle atrophy and improves motor function recovery following thoracic spinal cord injury in rats.

Zhang, Xinyi / Xu, Hailiang / Zhu, Lei / Huang, Dageng / Kong, Lingbo / Wang, Zhiyuan / Tian, Fang / Lu, Botao / Wu, Weidong / Jiang, Chao / Liu, Youjun / Wang, Chengwen / Jia, Shuaijun / Li, Yongliang / Yang, Minyi / Liu, Xifang / Hao, Dingjun

American journal of translational research

2022 Volume 14, Issue 11, Page(s) 8103–8116

Abstract: Objectives: The goal of this study was to determine whether electro-acupuncture (EA) stimulation might protect the motor endplate, minimize muscle atrophy in the hind limbs, and enhance functional recovery of rats with spinal cord injury (SCI).: ... ...

Abstract	Objectives: The goal of this study was to determine whether electro-acupuncture (EA) stimulation might protect the motor endplate, minimize muscle atrophy in the hind limbs, and enhance functional recovery of rats with spinal cord injury (SCI). Methods: Sprague-Dawley adult female rats (n = 30) were randomly assigned into Sham, SCI, and EA + SCI groups (n = 10 each). Rats in the Sham and SCI groups were bound in prone position only for 30 min, and rats in the EA + SCI group were treated with electro-acupuncture. The EA was conducted from the first day after surgery, lasted for 30 mins, once every day for 28 consecutive days. Results: EA significantly prevented motor endplate degeneration, improved electrophysiological function, and ameliorated hindlimb muscle atrophy after SCI. Meanwhile, EA upregulated Tuj-1 expression, downregulated GFAP expression, and reduced glial scar formation. Additionally, after 4 weeks of EA treatment, the serum of SCI rats exhibited a reduced inflammatory response. Conclusion: These findings suggest that EA can preserve the motor endplate and reduce muscular atrophy. In addition, EA has been shown to improve the function of upper and lower neurons, reduce glial scar formation, suppress systemic inflammation, and improve axon regeneration.
Language	English
Publishing date	2022-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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Article ; Online: Inhibition Ras/MEK/ERK pathway: An important mechanism of Baihu Jia Guizhi Decoction ameliorated rheumatoid arthritis.

Chen, Qi / Yang, Jinming / Chen, Huan / Pan, Ting / Liu, Panwang / Xu, Shi-Jun

Journal of ethnopharmacology

2022 Volume 304, Page(s) 116072

Abstract: ... treatment for rheumatoid arthritis (RA). Baihu Jia Guizhi Decoction (BHJGZ) is a classic prescription and ...

Abstract	Ethnopharmacological relevance: Alleviating rheumatism by inhibiting synovitis is a routine treatment for rheumatoid arthritis (RA). Baihu Jia Guizhi Decoction (BHJGZ) is a classic prescription and has a long history of application for treating RA with a good anti-inflammatory action. However, the underlying molecular mechanisms have not been fully elucidated. Aim of the study: This work aimed to decipher the potential mechanism of BHJGZ against RA focusing on Ras/MEK/ERK pathway. Materials and methods: Based on the prediction of network pharmacology, the inhibition action of BHJGZ on Ras/MEK/ERK pathway was firstly validated in vivo and in vitro. Moreover, the affinity with the ingredients of BHJGZ in serum and the targets of Ras/MEK/ERK pathway were evaluated. Finally, the efficacy of BHJGZ for relieving RA was assessed in AA rats. Results: The Ras/MEK/ERK pathway was predicted by network pharmacology as one of important mechanisms of BHJGZ to treat RA. The high expression of Ras protein in synovitis of AA rats was significantly reduced by the treatment with BHJGZ, and the activation of Ras/MEK/ERK pathway in vivo and in vitro was also markedly inhibited (p < 0.05 or p < 0.01). Moreover, the level of p-ERK/ERK, IL-6 and TNF-α in vitro were further suppressed after Ras or MEK was inhibited by mirdametinib or lonafarnib respectively (p < 0.01). Furthermore, the results of molecular docking showed a good affinity and stable binding with the ingredients of BHJGZ in serum and multiple key proteins of the Ras/MEK/ERK pathway. Finally, paw swelling, paw circumference and pathological changes of joint synovitis were significantly reduced by BHJGZ in AA rats (p < 0.05). Conclusion: The inhibition of Ras/MEK/ERK pathway is one of crucial mechanisms of BHJGZ for ameliorating synovitis of RA.
MeSH term(s)	Rats ; Animals ; MAP Kinase Signaling System ; Molecular Docking Simulation ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/pathology ; Synovitis/drug therapy ; Mitogen-Activated Protein Kinase Kinases
Chemical Substances	guizhi decoction ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
Language	English
Publishing date	2022-12-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.116072
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Zs.A 1494: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Jia-Ji Electro-Acupuncture Improves Locomotor Function With Spinal Cord Injury by Regulation of Autophagy Flux and Inhibition of Necroptosis.

Hongna, Yin / Hongzhao, Tian / Quan, Li / Delin, Feng / Guijun, Liu / Xiaolin, Lv / Fulin, Guan / Zhongren, Sun

Frontiers in neuroscience

2021 Volume 14, Page(s) 616864

Abstract: Jia-Ji electro-acupuncture (EA) has been widely applied in clinic to exhibit curative effects ... Rats were randomly divided into four groups: Sham (only laminectomy), Model (SCI group), EA (SCI + Jia ... Ji EA treatment), EA + CQ (SCI + Jia-Ji EA treatment + inhibitor chloroquine). Basso-Beattie ...

Abstract	Jia-Ji electro-acupuncture (EA) has been widely applied in clinic to exhibit curative effects on spinal cord injury (SCI). However, its underlying mechanisms leading to improvement of motor function after SCI remain unclear. Allen's method was made by NYU Impactor M-III equipment to create the SCI rats model. Rats were randomly divided into four groups: Sham (only laminectomy), Model (SCI group), EA (SCI + Jia-Ji EA treatment), EA + CQ (SCI + Jia-Ji EA treatment + inhibitor chloroquine). Basso-Beattie-Bresnahan assessment showed improvement of hind limb motor function after Jia-Ji electro-acupuncture treatment. Histological change of injured spinal cord tissue was alleviated after treatment, observed by hematoxylin-eosin and Nissl staining. The mRNA and protein expression levels of RIPK1, RIPK3 and MLKL were decreased in EA group. Besides, the increased expression of LC3 and reduced expression of P62 after treatment compared with Model group, confirmed that Jia-Ji electro-acupuncture could enhance the autophagy flux. Electron microscopy imaging showed increasing the number of lysosomes, autophagosomes, and autolysosomes after Jia-Ji electro-acupuncture treatment. Furthermore, inhibition of lysosome function with CQ led to partly eliminate the effect of EA on reducing necroptosis. These data make the case that Jia-Ji electro-acupuncture treatment may improve locomotor function by promoting autophagy flux and inhibiting necroptosis.
Language	English
Publishing date	2021-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2020.616864
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Article: Bie-Jia-Ruan-Mai-Tang, a Chinese Medicine Formula, Inhibits Retinal Neovascularization in Diabetic Mice Through Inducing the Apoptosis of Retinal Vascular Endothelial Cells.

Liu, Qiu-Ping / Chen, Yu-Ying / Yu, Yuan-Yuan / An, Pei / Xing, Yi-Zhuo / Yang, Hong-Xuan / Zhang, Yin-Jian / Rahman, Khalid / Zhang, Lei / Luan, Xin / Zhang, Hong

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 959298

Abstract: ... Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically ...

Abstract	Proliferative diabetic retinopathy (PDR) is one of the main complications of diabetes, mainly caused by the aberrant proliferation of retinal vascular endothelial cells and the formation of new blood vessels. Traditional Chinese medicines possess great potential in the prevention and treatment of PDR. Bie-Jia-Ruan-Mai-Tang (BJ), a Chinese medicine formula, has a good therapeutic effect on PDR clinically; however, the mechanism of action involved remains unclear. Therefore, we investigated the effect of BJ on PDR through
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.959298
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Article ; Online: Effect of Chaihu-jia-Longgu-Muli decoction on withdrawal symptoms in rats with methamphetamine-induced conditioned place preference.

Li, Zifa / Qi, Yuchen / Liu, Kun / Cao, Yiming / Zhang, Hao / Song, Chunhong / Deng, Hualiang

Bioscience reports

2021 Volume 41, Issue 8

Abstract: Traditional Chinese medicine detoxification prescription Chaihu-jia-Longgu-Muli decoction (CLMD ...

Abstract	Traditional Chinese medicine detoxification prescription Chaihu-jia-Longgu-Muli decoction (CLMD) relieves depressive symptoms in patients withdrawing from methamphetamine. In the present study, we assessed the effects of CLMD on methamphetamine withdrawal in rats. A methamphetamine-intoxicated rat model was established. Rats were randomly divided into the control, model, high-dosage, medium-dosage, and low-dosage groups, receiving high, medium, and low doses of CLMD, respectively. Weekly body weight measurements revealed that rats treated with methamphetamine had the lowest body weight. The conditioned place preference (CPP) experiment revealed that methamphetamine-intoxicated rats stayed significantly longer in the drug-paired chamber than the control rats. However, after administering high-dosage CLMD, the amount of time the rats spent in the drug-paired chamber was significantly less than that of the model rats. Our open-field test revealed that the model group had lower crossing and rearing scores than the control group. Additionally, rats that received CLMD treatment exhibited higher crossing and rearing scores than the model rats. Striatal dopamine (DA), 5-hydroxytryptamine (5-HT), and endorphins (β-EP) and serum interleukin (IL)-1α and IL-2 concentrations were estimated. Rats in the model group had lower striatal DA, 5-HT, and β-EP and higher serum IL-1α and IL-2 concentrations than those in the control group. High-dosage CLMD administration significantly changed the concentrations of these molecules, such that they approached normal concentrations. In general, CLMD could prevent the development of methamphetamine-induced withdrawal symptoms in rats by increasing the DA, 5-HT, and β-EP and lowering the IL-1α and IL-2 concentrations.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Central Nervous System Stimulants ; Conditioning, Psychological/drug effects ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Disease Models, Animal ; Dopamine/metabolism ; Drugs, Chinese Herbal/pharmacology ; Interleukin-1alpha/blood ; Interleukin-2/blood ; Male ; Methamphetamine ; Open Field Test/drug effects ; Rats, Sprague-Dawley ; Serotonin/metabolism ; Substance Withdrawal Syndrome/drug therapy ; Substance Withdrawal Syndrome/metabolism ; Substance Withdrawal Syndrome/psychology ; beta-Endorphin/metabolism ; Rats
Chemical Substances	Central Nervous System Stimulants ; Drugs, Chinese Herbal ; Interleukin-1alpha ; Interleukin-2 ; chaihu-longgu-muli decoction ; Serotonin (333DO1RDJY) ; Methamphetamine (44RAL3456C) ; beta-Endorphin (60617-12-1) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2021-08-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20211376
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Zs.A 1676: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo.

Yin, Ya-Ling / Zhu, Mo-Li / Wan, Jia / Zhang, Chong / Pan, Guo-Pin / Lu, Jun-Xiu / Ping, Song / Chen, Yuan / Zhao, Fan-Rong / Yu, Hai-Ya / Guo, Tao / Jian, Xu / Liu, Li-Ying / Zhang, Jia-Ning / Wan, Guang-Rui / Wang, Shuang-Xi / Li, Peng

Scientific reports

2017 Volume 7, Page(s) 43508

Abstract: ... an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia ...

Abstract	Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia (XMJ) recouples eNOS to exert anti-atherosclerotic effects. Pretreatment of XMJ (25, 50, 100 μg/ml) for 30 minutes concentration-dependently activated eNOS, improved cell viabilities, increased NO generations, and reduced ROS productions in human umbilical vein endothelial cells incubated with H
MeSH term(s)	Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/etiology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Biomarkers ; Cell Survival/drug effects ; Cytokines/metabolism ; Diet, High-Fat ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Gene Expression Profiling ; Human Umbilical Vein Endothelial Cells ; Humans ; Hydrogen Peroxide/pharmacology ; Male ; Medicine, Chinese Traditional ; Nitric Oxide/biosynthesis ; Nitric Oxide Synthase Type III/metabolism ; Oxidative Stress/drug effects ; Phosphorylation ; Plaque, Atherosclerotic/metabolism ; Plaque, Atherosclerotic/pathology ; Rats ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Transcriptome
Chemical Substances	Biomarkers ; Cytokines ; Drugs, Chinese Herbal ; Reactive Oxygen Species ; Nitric Oxide (31C4KY9ESH) ; Hydrogen Peroxide (BBX060AN9V) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
Language	English
Publishing date	2017-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep43508
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