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  1. Article ; Online: Tracking malaria transmission at the antenatal clinic.

    Walker, Patrick G T

    The Lancet. Global health

    2015  Volume 3, Issue 10, Page(s) e581–2

    MeSH term(s) Female ; Humans ; Malaria/epidemiology ; Male ; Pregnancy ; Pregnancy Complications, Parasitic/epidemiology
    Language English
    Publishing date 2015-08-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(15)00090-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Seasonal dynamics of

    Whittaker, Charles / Hamlet, Arran / Sherrard-Smith, Ellie / Winskill, Peter / Cuomo-Dannenburg, Gina / Walker, Patrick G T / Sinka, Marianne / Pironon, Samuel / Kumar, Ashwani / Ghani, Azra / Bhatt, Samir / Churcher, Thomas S

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 8, Page(s) e2216142120

    Abstract: Invasion of the malaria ... ...

    Abstract Invasion of the malaria vector
    MeSH term(s) Animals ; Humans ; Malaria/epidemiology ; Malaria/prevention & control ; Anopheles ; Seasons ; Mosquito Vectors ; Africa/epidemiology ; Mosquito Control
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2216142120
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  3. Article ; Online: Targeting Pregnant Women for Malaria Surveillance.

    Mayor, Alfredo / Menéndez, Clara / Walker, Patrick G T

    Trends in parasitology

    2019  Volume 35, Issue 9, Page(s) 677–686

    Abstract: Women attending antenatal care (ANC) are a generally healthy, easy-access population, contributing valuable data for infectious disease surveillance at the community level. ANC-based malaria surveillance would provide a routine measure of the malaria ... ...

    Abstract Women attending antenatal care (ANC) are a generally healthy, easy-access population, contributing valuable data for infectious disease surveillance at the community level. ANC-based malaria surveillance would provide a routine measure of the malaria burden in pregnancy, which countries lack, whilst potentially improving pregnancy outcomes. It could also offer contemporary information on temporal trends and the geographic distribution of malaria burden as well as intervention coverage in the population to guide resource allocation and to assess progress towards elimination. Here, we review the factors underlying the relationship between Plasmodium falciparum in pregnancy and in the community, and outline strengths and limitations of an ANC-based surveillance in sub-Saharan Africa, its potential role within wider malaria surveillance systems, and subsequent programmatic applications.
    MeSH term(s) Africa South of the Sahara ; Female ; Humans ; Malaria/epidemiology ; Malaria/prevention & control ; Plasmodium falciparum/physiology ; Population Surveillance ; Pregnancy ; Prenatal Care
    Language English
    Publishing date 2019-08-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2019.07.005
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  4. Article ; Online: Author Correction: Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context.

    Sheppard, Richard J / Watson, Oliver J / Pieciak, Rachel / Lungu, James / Kwenda, Geoffrey / Moyo, Crispin / Chanda, Stephen Longa / Barnsley, Gregory / Brazeau, Nicholas F / Gerard-Ursin, Ines C G / Olivera Mesa, Daniela / Whittaker, Charles / Gregson, Simon / Okell, Lucy C / Ghani, Azra C / MacLeod, William B / Del Fava, Emanuele / Melegaro, Alessia / Hines, Jonas Z /
    Mulenga, Lloyd B / Walker, Patrick G T / Mwananyanda, Lawrence / Gill, Christopher J

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2213

    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44940-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Monthly malaria chemoprevention shows potential in an area of very high, perennial malaria transmission.

    Cairns, Matthew / Walker, Patrick G T

    Evidence-based medicine

    2015  Volume 20, Issue 3, Page(s) 110

    MeSH term(s) Antimalarials/therapeutic use ; Female ; Humans ; Malaria/drug therapy ; Male
    Chemical Substances Antimalarials
    Language English
    Publishing date 2015-04-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1324346-9
    ISSN 1473-6810 ; 1356-5524
    ISSN (online) 1473-6810
    ISSN 1356-5524
    DOI 10.1136/ebmed-2015-110173
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    Zs.A 4793: Show issues Location:
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  6. Article ; Online: Health inequities and clustering of fever, acute respiratory infection, diarrhoea and wasting in children under five in low- and middle-income countries: a Demographic and Health Surveys analysis.

    Winskill, Peter / Hogan, Alexandra B / Thwing, Julie / Mwandigha, Lazaro / Walker, Patrick G T / Lambert, Ben

    BMC medicine

    2021  Volume 19, Issue 1, Page(s) 144

    Abstract: Background: Pneumonia, diarrhoea and malaria are responsible for over one third of all deaths in children under the age of 5 years in low and middle sociodemographic index countries; many of these deaths are also associated with malnutrition. We explore ...

    Abstract Background: Pneumonia, diarrhoea and malaria are responsible for over one third of all deaths in children under the age of 5 years in low and middle sociodemographic index countries; many of these deaths are also associated with malnutrition. We explore the co-occurrence and clustering of fever, acute respiratory infection, diarrhoea and wasting and their relationship with equity-relevant variables.
    Methods: Multilevel, multivariate Bayesian logistic regression models were fitted to Demographic and Health Survey data from over 380,000 children in 39 countries. The relationship between outcome indicators (fever, acute respiratory infection, diarrhoea and wasting) and equity-relevant variables (wealth, access to health care and rurality) was examined. We quantified the geographical clustering and co-occurrence of conditions and a child's risk of multiple illnesses.
    Results: The prevalence of outcomes was very heterogeneous within and between countries. There was marked spatial clustering of conditions and co-occurrence within children. For children in the poorest households and those reporting difficulties accessing healthcare, there were significant increases in the probability of at least one of the conditions in 18 of 21 countries, with estimated increases in the probability of up to 0.23 (95% CrI, 0.06-0.40).
    Conclusions: The prevalence of fever, acute respiratory infection, diarrhoea and wasting are associated with equity-relevant variables and cluster together. Via pathways of shared aetiology or risk, those children most disadvantaged disproportionately suffer from these conditions. This highlights the need for horizontal approaches, such as integrated community case management, with a focus on equity and targeted to those most at need.
    MeSH term(s) Bayes Theorem ; Child ; Child, Preschool ; Cluster Analysis ; Cross-Sectional Studies ; Developing Countries ; Diarrhea/epidemiology ; Family Characteristics ; Health Surveys ; Humans ; Infant ; Prevalence
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1741-7015
    ISSN (online) 1741-7015
    DOI 10.1186/s12916-021-02018-0
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  7. Article ; Online: Tracking malaria transmission at the antenatal clinic

    Patrick G T Walker

    The Lancet Global Health, Vol 3, Iss 10, Pp e581-e

    2015  Volume 582

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2015-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Assessing the utility of pregnant women as a sentinel surveillance population for malaria in Geita, Tanzania, 2019 - 2021.

    Munsey, Anna / Kinyina, Alen / Assenga, Melkior / Almeida, Annette / Kitojo, Chonge / Reaves, Erik / Simeo, Japhet / Aron, Sijenunu / Chacky, Frank / Nhiga, Samwel L / Drake, Mary / Lemwayi, Ruth / Lash, Ryan / Walker, Patrick G T / Gutman, Julie R

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 136, Page(s) 57–63

    Abstract: Objectives: Estimates of malaria burden and intervention uptake in Africa are primarily based on household surveys. However, their expense and infrequency limit their utility. We investigated whether data collected during antenatal care (ANC) can ... ...

    Abstract Objectives: Estimates of malaria burden and intervention uptake in Africa are primarily based on household surveys. However, their expense and infrequency limit their utility. We investigated whether data collected during antenatal care (ANC) can provide relevant information for decision-makers.
    Methods: Malaria test positivity rates and questionnaire data from ANC attendees at 39 health facilities were compared to questionnaire data and positivity rates among children from two cross-sectional surveys in the facilities' corresponding catchment areas.
    Results: Trends in parasitemia among ANC attendees were predictive of trends in parasitemia among children at the council level (mean absolute error 6.0%). Primigravid ANC attendees had the lowest rates of net ownership (modeled odds ratio [OR] 0.28, 95% CI 0.19-0.40) and use (OR 0.58, 95% CI 0.42-0.79). ANC attendees reported higher levels of care-seeking (OR 1.78, 95% CI 1.48-2.14), malaria testing (OR 4.16, 95% CI 3.44-5.04), and treatment for children with fever (OR 7.66, 95% CI 4.89-11.98) compared to women surveyed in households, raising concerns about social desirability bias disproportionately impacting ANC surveys.
    Conclusion: ANC surveillance is an effective strategy for tracking trends in malaria burden. More work is required to elucidate the value of administering questionnaires to ANC attendees.
    MeSH term(s) Child ; Female ; Pregnancy ; Humans ; Pregnant Women ; Sentinel Surveillance ; Tanzania/epidemiology ; Cross-Sectional Studies ; Parasitemia ; Malaria/diagnosis ; Malaria/epidemiology ; Prenatal Care
    Language English
    Publishing date 2023-08-10
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.08.007
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    Zs.A 4516: Show issues Location:
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  9. Article ; Online: 11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis.

    Davidson, Callam T / Miller, Eileen / Muir, Morwenna / Dawson, John C / Lee, Martin / Aitken, Stuart / Serrels, Alan / Webster, Scott P / Homer, Natalie Z M / Andrew, Ruth / Brunton, Valerie G / Hadoke, Patrick W F / Walker, Brian R

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0255709

    Abstract: Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angiogenesis ... ...

    Abstract Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) reduces tissue-specific glucocorticoid action and promotes angiogenesis in murine models of myocardial infarction. Angiogenesis is important in the growth of some solid tumours. This study used murine models of squamous cell carcinoma (SCC) and pancreatic ductal adenocarcinoma (PDAC) to test the hypothesis that 11β-HSD1 inhibition promotes angiogenesis and subsequent tumour growth. SCC or PDAC cells were injected into female FVB/N or C57BL6/J mice fed either standard diet, or diet containing the 11β-HSD1 inhibitor UE2316. SCC tumours grew more rapidly in UE2316-treated mice, reaching a larger (P<0.01) final volume (0.158 ± 0.037 cm3) than in control mice (0.051 ± 0.007 cm3). However, PDAC tumour growth was unaffected. Immunofluorescent analysis of SCC tumours did not show differences in vessel density (CD31/alpha-smooth muscle actin) or cell proliferation (Ki67) after 11β-HSD1 inhibition, and immunohistochemistry of SCC tumours did not show changes in inflammatory cell (CD3- or F4/80-positive) infiltration. In culture, the growth/viability (assessed by live cell imaging) of SCC cells was not affected by UE2316 or corticosterone. Second Harmonic Generation microscopy showed that UE2316 reduced Type I collagen (P<0.001), whilst RNA-sequencing revealed that multiple factors involved in the innate immune/inflammatory response were reduced in UE2316-treated SCC tumours. 11β-HSD1 inhibition increases SCC tumour growth, likely via suppression of inflammatory/immune cell signalling and extracellular matrix deposition, but does not promote tumour angiogenesis or growth of all solid tumours.
    MeSH term(s) Mice ; Female ; Animals ; Glucocorticoids/metabolism ; 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism ; Inflammation ; Neovascularization, Pathologic ; Neoplasms ; Fibrosis
    Chemical Substances Glucocorticoids ; (4-(2-chlorophenyl-4-fluoro-1-piperidinyl)(5-(1H-pyrazol-4-yl)-3-thienyl)methanone ; 11-beta-Hydroxysteroid Dehydrogenase Type 1 (EC 1.1.1.146)
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0255709
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  10. Article: Targeting Pregnant Women for Malaria Surveillance

    Mayor, Alfredo / Menéndez, Clara / Walker, Patrick G.T

    Elsevier Ltd Trends in parasitology. 2019 Sept., v. 35, no. 9

    2019  

    Abstract: Women attending antenatal care (ANC) are a generally healthy, easy-access population, contributing valuable data for infectious disease surveillance at the community level. ANC-based malaria surveillance would provide a routine measure of the malaria ... ...

    Abstract Women attending antenatal care (ANC) are a generally healthy, easy-access population, contributing valuable data for infectious disease surveillance at the community level. ANC-based malaria surveillance would provide a routine measure of the malaria burden in pregnancy, which countries lack, whilst potentially improving pregnancy outcomes. It could also offer contemporary information on temporal trends and the geographic distribution of malaria burden as well as intervention coverage in the population to guide resource allocation and to assess progress towards elimination. Here, we review the factors underlying the relationship between Plasmodium falciparum in pregnancy and in the community, and outline strengths and limitations of an ANC-based surveillance in sub-Saharan Africa, its potential role within wider malaria surveillance systems, and subsequent programmatic applications.
    Keywords Plasmodium falciparum ; disease surveillance ; geographical distribution ; infectious diseases ; malaria ; monitoring ; pregnancy outcome ; pregnant women ; prenatal care ; resource allocation ; Sub-Saharan Africa
    Language English
    Dates of publication 2019-09
    Size p. 677-686.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2019.07.005
    Database NAL-Catalogue (AGRICOLA)

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