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  1. Article ; Online: The impact of COVID-19 on patients of Italian mental health supported accommodation services.

    Martinelli, Alessandra / Ruggeri, Mirella

    Social psychiatry and psychiatric epidemiology

    2020  Volume 55, Issue 10, Page(s) 1395–1396

    Keywords covid19
    Language English
    Publishing date 2020-07-25
    Publishing country Germany
    Document type Letter
    ZDB-ID 623071-4
    ISSN 1433-9285 ; 0037-7813 ; 0933-7954
    ISSN (online) 1433-9285
    ISSN 0037-7813 ; 0933-7954
    DOI 10.1007/s00127-020-01897-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 327: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: A practical algorithm for acute myeloid leukaemia diagnosis following the updated 2022 classifications.

    Della Porta, Matteo Giovanni / Martinelli, Giovanni / Rambaldi, Alessandro / Santoro, Alessandra / Voso, Maria Teresa

    Critical reviews in oncology/hematology

    2024  Volume 198, Page(s) 104358

    Abstract: Disease classification of complex and heterogenous diseases, such as acute myeloid leukaemia (AML), is continuously updated to define diagnoses, appropriate treatments, and assist research and education. Recent availability of molecular profiling ... ...

    Abstract Disease classification of complex and heterogenous diseases, such as acute myeloid leukaemia (AML), is continuously updated to define diagnoses, appropriate treatments, and assist research and education. Recent availability of molecular profiling techniques further benefits the classification of AML. The World Health Organization (WHO) classification of haematolymphoid tumours and the International Consensus Classification of myeloid neoplasms and acute leukaemia from 2022 are two updated versions of the WHO 2016 classification. As a consequence, the European LeukemiaNet 2022 recommendations on the diagnosis and management of AML in adults have been also updated. The current review provides a practical interpretation of these guidelines to facilitate the diagnosis of AML and discusses genetic testing, disease genetic heterogeneity, and FLT3 mutations. We propose a practical algorithm for the speedy diagnosis of AML. Future classifications may need to incorporate gene mutation combinations to enable personalised treatment regimens in the management of patients with AML.
    Language English
    Publishing date 2024-04-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2024.104358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: How I Manage Chronic Lymphocytic Leukemia.

    Nasnas, Patrice / Cerchione, Claudio / Musuraca, Gerardo / Martinelli, Giovanni / Ferrajoli, Alessandra

    Hematology reports

    2023  Volume 15, Issue 3, Page(s) 454–464

    Abstract: Chronic lymphocytic leukemia (CLL), is a hematologic malignancy characterized by the uncontrolled proliferation of mature B lymphocytes. CLL is the most prevalent leukemia in Western countries. Its presentation can range from asymptomatic with the ... ...

    Abstract Chronic lymphocytic leukemia (CLL), is a hematologic malignancy characterized by the uncontrolled proliferation of mature B lymphocytes. CLL is the most prevalent leukemia in Western countries. Its presentation can range from asymptomatic with the incidental finding of absolute lymphocytosis on a routine blood test, to symptomatic disease requiring immediate intervention. Prognosis of the disease is defined by the presence or absence of specific mutations such as TP53, chromosomal abnormalities such as del(17p), a type of IGHV mutational status, and elevation of B2M and LDH. Treatment of CLL in the United States and Europe has evolved over the recent years thanks to the development of targeted therapies. The standard of care has shifted from traditional chemoimmunotherapy approaches to targeted therapies including Bruton tyrosine kinase inhibitors (BTKis) and BCL2 inhibitors, administered either as monotherapy or in combination with CD20 monoclonal antibodies. Several clinical trials have also recently evaluated combinations of BTKi and venetoclax and showed the combination to be well tolerated and able to induce deep remissions. Targeted therapies have a good safety profile overall; however, they also have unique toxicities that are important to recognize. Diarrhea, fatigue, arthralgia, infections, cytopenias, bleeding, and cardiovascular toxicities (including atrial fibrillation, ventricular arrhythmias, and hypertension) are the adverse events (AEs) commonly associated with BTKis. Initiation of therapy with venetoclax requires close monitoring because of the risk for tumor lysis syndrome associated with this agent, particularly in patients with a high disease burden. Development of newer target therapies is ongoing and the therapeutic landscape in CLL is expanding rapidly.
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2586645-X
    ISSN 2038-8330 ; 2038-8322
    ISSN (online) 2038-8330
    ISSN 2038-8322
    DOI 10.3390/hematolrep15030047
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  4. Article: Pegfilgrastim in Supportive Care of Hodgkin Lymphoma.

    Cerchione, Claudio / Nappi, Davide / Romano, Alessandra / Martinelli, Giovanni

    Cancers

    2022  Volume 14, Issue 17

    Abstract: Neutropenia and febrile neutropenia are common and potentially life-threating events associated with chemotherapy treatment in Hodgkin lymphoma (HL). Neutropenia-related infectious events could be an issue both for direct clinical consequences and for ... ...

    Abstract Neutropenia and febrile neutropenia are common and potentially life-threating events associated with chemotherapy treatment in Hodgkin lymphoma (HL). Neutropenia-related infectious events could be an issue both for direct clinical consequences and for delay in treatment delivery, affecting final outcomes in a potentially highly curable disease. Pegfilgrastim is the pegylated form of filgrastim, the recombinant form of human G-CSF, capable of prevent and mitigate neutropenic effects of chemotherapy, when adopted as primary prophylaxis in several hematological malignancies. No updated version of major international guidelines provides clear indication on prophylaxis use of pegfilgrastim in HL to prevent febrile neutropenia episodes in HL. Moreover, to date, scarce and non-uniform clinical experiences evaluating pegfilgrastim as prophylaxis in HL are present in the literature. Herein, we propose a brief summary of the literature data about efficacy and safety of the use of pegfilgrastim as primary prophylaxis in HL during chemotherapy treatment.
    Language English
    Publishing date 2022-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14174063
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  5. Article ; Online: Addressing Challenges in Residential Facilities: Promoting Human Rights and Recovery While Pursuing Functional Autonomy.

    Martinelli, Alessandra / Dal Corso, Elisa / Pozzan, Tecla / Cristofalo, Doriana / Bonetto, Chiara / Ruggeri, Mirella

    Psychiatric research and clinical practice

    2023  Volume 6, Issue 1, Page(s) 12–22

    Abstract: Objective: Italian residential facilities (RFs) aim to promote human rights and recovery for individuals with severe mental disorders. Italian RFs can be distinguished into five main types: high-intensity rehabilitation (RF1), medium-intensity ... ...

    Abstract Objective: Italian residential facilities (RFs) aim to promote human rights and recovery for individuals with severe mental disorders. Italian RFs can be distinguished into five main types: high-intensity rehabilitation (RF1), medium-intensity rehabilitation (RF2), medium-level support (RF3.1), high-level support (RF3.2), low-level support (RF3.3). This study aimed to assess the effectiveness of Italian RFs in achieving functional autonomy while upholding human rights and recovery.
    Methods: Data on socio-demographics, clinical information, patient and staff assessments of functional autonomy, types of interventions, and RF performance in various domains were collected in a pilot study with a cross-sectional design. Descriptive and inferential analyses were conducted.
    Results: Twelve RFs and 113 patients participated, with varying proportions in each RF type. RF1 patients were the oldest (
    Conclusions: This pilot study suggests that Italian RFs generally aligne with their mission and human rights principles, but personalizing interventions and implementing recovery-oriented practices face challenges.
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 2575-5609
    ISSN (online) 2575-5609
    DOI 10.1176/appi.prcp.20230034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The impact of COVID‑19 on patients of Italian mental health supported accommodation services

    Martinelli Alessandra / Ruggeri Mirella

    Social Psychiatry and Psychiatric Epidemiology

    2020  

    Abstract: Abstract At this pandemic time, each person is experimenting with the feeling of being at risk of a sudden and invincible attack of an invisible enemy. Users with Severe Mental Illness (SMI) of mental health supported accommodation services in Verona ... ...

    Abstract Abstract At this pandemic time, each person is experimenting with the feeling of being at risk of a sudden and invincible attack of an invisible enemy. Users with Severe Mental Illness (SMI) of mental health supported accommodation services in Verona have reacted differently to the pandemic lockdown, depending on the specific mental health disorder they suffer. Severe psychotic patients after the first two weeks of relaxation had relapsed, people with DOC was helpful for services cleaning common spaces, patients with psychotic personality disorders felt released of not being obliged to have external relationships, persons with borderline disorders self-contained or 'dare' the virus, manic users had difficulties in respecting rules and patients with depression and anxiety worsen. Overall, the staff adapted interventions according to each user-specific reaction to the lockdown, the level of solidarity grew up among users who have shown a higher than the expected capacity of resilience. The overall impact of the pandemic state arose consciousness on the importance of the well-know and developed daily rehabilitation interventions for SMI. Probably this experience might be a model for the general population.
    Keywords covid-19 ; mental health supported accommodation services ; psychopathology ; covid19
    Language English
    Publishing date 2020-07-25
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Exploring gender impact on collaborative care planning: insights from a community mental health service study in Italy.

    Martinelli, Alessandra / Bonetto, Chiara / Pozzan, Tecla / Procura, Elena / Cristofalo, Doriana / Ruggeri, Mirella / Killaspy, Helen

    BMC psychiatry

    2023  Volume 23, Issue 1, Page(s) 834

    Abstract: Introduction: Personal recovery is associated with socio-demographic and clinical factors, and gender seems to influence the recovery process. This study aimed to investigate: i) differences in the recovery goals of men and women users of a community ... ...

    Abstract Introduction: Personal recovery is associated with socio-demographic and clinical factors, and gender seems to influence the recovery process. This study aimed to investigate: i) differences in the recovery goals of men and women users of a community mental health service in Italy; ii) any differences by gender in recovery over six months using the Mental Health Recovery Star (MHRS).
    Methods: Service users and staff completed the MHRS together at recruitment and six months later to agree the recovery goals they wished to focus on. Socio-demographic and clinical characteristics and ratings of symptoms (BPRS), needs (CAN), functioning (FPS), and functional autonomy (MPR) were collected at recruitment and six months follow-up. Comparisons between men and women were made using t-tests.
    Results: Ten women and 15 men completed the MHRS with 19 mental health professionals. Other than gender, men and women had similar socio-demographic, and clinical characteristics at recruitment. Women tended to choose recovery goals that focused on relationships whereas men tended to focus on work related goals. At follow-up, both men and women showed improvement in their recovery (MHRS) and women were less likely to focus on relationship related goals, perhaps because some had found romantic partners. There were also gains for both men and women in engagement with work related activities. Ratings of functional autonomy (MPR) improved for both men and women, and men also showed improvement in symptoms (BPRS) and functioning (FPS).
    Conclusions: Our findings suggest that collaborative care planning tools such as the MHRS can assist in identifying individualized recovery goals for men and women with severe mental health problems as part of their rehabilitation.
    MeSH term(s) Male ; Humans ; Female ; Community Mental Health Services ; Mental Disorders/psychology ; Health Personnel ; Mental Health Recovery ; Italy
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-023-05307-5
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  8. Article ; Online: Biological therapy in elderly patients with acute myeloid leukemia.

    Ciotti, Giulia / Marconi, Giovanni / Sperotto, Alessandra / Giannini, Maria B / Gottardi, Michele / Martinelli, Giovanni

    Expert opinion on biological therapy

    2023  Volume 23, Issue 2, Page(s) 175–194

    Abstract: Introduction: The introduction of target molecules and immunological therapies is changing the treatment landscape of acute myeloid leukemia (AML).: Areas covered: We recapitulate the biological therapies that can be employed in the treatment of ... ...

    Abstract Introduction: The introduction of target molecules and immunological therapies is changing the treatment landscape of acute myeloid leukemia (AML).
    Areas covered: We recapitulate the biological therapies that can be employed in the treatment of elderly patients with AML. Alongside small molecules inhibitors that target specific gene mutations, antibodies, tumor microenvironment modulators, and cellular therapies are being developed for the cure of the disease. Here, we report the biological activities, the efficacy and toxicities of humanized antibodies and antibody-drug conjugates that targets surface antigens as CD33 (gemtuzumab ozogamicine) or CD123 (pivekimab sunirine). We further explore mechanisms and effectiveness of medications that modify the microenvironment, such as glasdegib, or that harness the immune system against leukemia, such as CD47 antibody magrolimab, PD1/PDL1 inhibitors pembrolizumab and nivolumab, TIM3 inhibitor sabatolimab, T-cell and NK-cell engagers. Cellular therapies are considered, even if a large trial is still pending for the feasibility of the approach. In this scenario, a brief overview of the mechanism of action of target agents is provided, particularly with respect to their biological mechanisms.
    Expert opinion: Overall, this therapeutic armamentarium will constitute the basis for multimodal and personalized combinations that, in the idea of precision medicine, will enormously benefit elderly AML patients.
    MeSH term(s) Humans ; Aged ; Immunotherapy/methods ; Killer Cells, Natural ; T-Lymphocytes ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Tumor Microenvironment
    Chemical Substances sabatolimab
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2023.2174015
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  10. Article ; Online: The impact of COVID-19 on patients of Italian mental health supported accommodation services

    Martinelli, Alessandra / Ruggeri, Mirella

    2020  

    Abstract: no abstract available] ...

    Abstract [no abstract available]
    Keywords Italy ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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