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  1. Article ; Online: Hb Andrew-Minneapolis Variant in a Turkish Family

    Sümter, Hamza / Mızrak, Soycan / Ceylaner, Serdar / Canatan, Duran

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2023  Volume 40, Issue 3, Page(s) 234–235

    MeSH term(s) Humans ; Hemoglobins, Abnormal/genetics ; Hemoglobins, Abnormal/analysis ; Chromatography, High Pressure Liquid
    Chemical Substances hemoglobin Andrew-Minneapolis (53986-72-4) ; Hemoglobins, Abnormal
    Language English
    Publishing date 2023-07-31
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2023.2023-0239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The medical concerns of patients with thalassemias at the time of COVID-19 outbreak: The personal experience and the international recommendations.

    Canatan, Duran / De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 2, Page(s) 218–221

    Abstract: ...

    Abstract .
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Hemoglobinopathies ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Thalassemia ; Turkey
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i2.9533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The impact of MicroRNAs (miRNAs) on the genotype of coronaviruses.

    Canatan, Duran / De Sanctis, Vincenzo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 2, Page(s) 195–198

    Abstract: Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is ... ...

    Abstract Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is arranged as 5p-replicase (orf1/ab)-structural proteins [Spike (S) -Envelope (E) - Membrane (M) -Nucleocapsid (N)] -3. Viruses are obligate intracellular infectious agents that use the host cellular machinery to ensure their own fitness and survival. MicroRNAs (miRNA9) systems are potent post-transcriptional gene expression regulators that are important modulators of viral infections, and could play an important role in the treatment of viral infections. This review focuses to the genomic structure of coronaviruses, the functions of genomic proteins, the effects of micro RNA (miRNA) on virus replication and its pathogenesis.
    MeSH term(s) Animals ; Betacoronavirus/genetics ; Coronavirus/genetics ; Genome, Viral ; Genotype ; Humans ; MicroRNAs/genetics ; SARS-CoV-2 ; Virus Replication
    Chemical Substances MicroRNAs
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i2.9534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Thalassemias and hemoglobinopathies in Turkey.

    Canatan, Duran

    Hemoglobin

    2014  Volume 38, Issue 5, Page(s) 305–307

    Abstract: Thalassemias and hemoglobinopathies are a serious health problem in Turkey. There is a 70-year history of thalassemia in Turkey. The first patient with β-thalassemia major (β-TM) was reported in 1941. The first clinical and hematological studies were ... ...

    Abstract Thalassemias and hemoglobinopathies are a serious health problem in Turkey. There is a 70-year history of thalassemia in Turkey. The first patient with β-thalassemia major (β-TM) was reported in 1941. The first clinical and hematological studies were published by Aksoy in 1958. The overall incidence of β-thalassemia (β-thal) was reported by Çavdar and Arcasoy to be 2.1% in 1971. Important steps such as written regulations, education and prevention campaigns, have been taken to prevent thalassemia in Turkey by the Ministry of Health (MOH), the Turkish National Hemoglobinopathy Council (TNHC) and the Thalassemia Federation of Turkey (TFT) since 2000. A national hemoglobinopathy prevention program was started in provinces with a high prevalence by the MOH in 2003. While the percentage of premarital screening test was 30.0% of all couples in 2003, it reached 86.0% in 2013. While the number of newborn with thalassemias and hemoglobinopathies was 272 in 2002, it had dropped to 25 in 2010. There has been a 90.0% reduction of affected births in the last 10 years.
    MeSH term(s) Consumer Health Information ; Genetic Counseling ; Genetic Testing ; Health Education ; Health Promotion ; Hemoglobinopathies/epidemiology ; Hemoglobinopathies/genetics ; Hemoglobinopathies/prevention & control ; Hemoglobinopathies/therapy ; Humans ; Incidence ; Mutation ; Premarital Examinations ; Prevalence ; Thalassemia/epidemiology ; Thalassemia/genetics ; Thalassemia/prevention & control ; Thalassemia/therapy ; Turkey/epidemiology
    Language English
    Publishing date 2014-07-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 750615-6
    ISSN 1532-432X ; 0363-0269
    ISSN (online) 1532-432X
    ISSN 0363-0269
    DOI 10.3109/03630269.2014.938163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Protective Effects of Pyridoxine on Linezolid-Induced Hematological Toxicity, Hepatotoxicity, and Oxidative Stress in Rats.

    Kendir-Demirkol, Yasemin / Jenny, Laura A / Demirkol, Aykut / Özen, Metahan / Ayata, Ali / Canatan, Duran

    Turkish archives of pediatrics

    2023  Volume 58, Issue 3, Page(s) 298–301

    Abstract: Objective: Linezolid is often used to treat antibacterial-resistant infections. Linezolid can cause side effects. To date, the effectiveness of the simultaneous administration of pyridoxine and linezolid is unclear. Here we investigate the protective ... ...

    Abstract Objective: Linezolid is often used to treat antibacterial-resistant infections. Linezolid can cause side effects. To date, the effectiveness of the simultaneous administration of pyridoxine and linezolid is unclear. Here we investigate the protective effect of pyridoxine on linezolid-induced hematological toxicity, hepatotoxicity, and oxidative stress in rats.
    Material and methods: The 40 male pediatric Spraque-Dawley rats were separated into 4 groups: control, linezolid, pyridoxine, and linezolid-pyridoxine. A complete blood count, liver function test, and measurements of antioxidant enzyme activities for superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation were performed in blood before treatment and 2 weeks after administration of the treatment.
    Results: White blood cell and hemoglobin counts for the linezolid group decreased, and the alanine aminotransferase level in the linezolid group increased compared to their respective baseline values. Post-treatment white blood cell decreased in the linezolid and linezolid- pyridoxine groups compared to those in the control group (P < .001). Alanine aminotransferase levels increased in the linezolid and linezolid-pyridoxine groups compared to those in the control group (P < .001 and P < .05, respectively). The activity of superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde levels increased in the linezolid group compared to the control group (P < .001, P < .05, P < .001, and P < .001, respectively). Linezolid plus pyridoxine treatment caused a significant decrease in malondialdehyde levels and superoxide dismutase, catalase, and glutathione peroxidase enzyme activities compared to the linezolid group (P < .001, P < .01, P < .001, and P < .01, respectively).
    Conclusion: Pyridoxine may be an effective adjuvant agent for the prevention of linezolid toxicity in rat models.
    Language English
    Publishing date 2023-04-18
    Publishing country Turkey
    Document type Journal Article
    ISSN 2757-6256
    ISSN 2757-6256
    DOI 10.5152/TurkArchPediatr.2023.21363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Thalassemia center of Antalya State Hospital: 15 years of experience (1994 to 2008).

    Canatan, Duran

    Journal of pediatric hematology/oncology

    2013  Volume 35, Issue 1, Page(s) 24–27

    Abstract: The Thalassemia center of Antalya State Hospital was established in 1994 in Antalya, Turkey. The number of newborns with thalassemia decreased statistically because of actions taken as a result of prevention studies. A total of 388 patients, including ... ...

    Abstract The Thalassemia center of Antalya State Hospital was established in 1994 in Antalya, Turkey. The number of newborns with thalassemia decreased statistically because of actions taken as a result of prevention studies. A total of 388 patients, including 246 with thalassemia major (63.4%), 86 with thalassemia intermediate (22.1%), 23 with sickle cell+β-thalassemia (5.9%), 20 with sickle cell disease (5.1%), and 13 with other hemoglobin abnormalities (3.3%), were studied. Complications were found to be as follows: cardiomyopathy in 45 of them (11.5%), diabetes mellitus in 10 (2.5%), hypothyroidism in 17 (4.3%), hypoparathyroidism in 2 (0.5%), osteoporosis in 53 (13.6%), growth retardation in 110 (28.3%), and hypogonadism in 75 patients (19.3%). The incidence of autoantibody and alloantibody in patients with thalassemia major was 5.6% and 10.5%, respectively. Transfusion-transmission diseases evaluated in patients found the incidence of hepatit A virus IgG to be 97.5%, that of HBs Ab to be 99.5%, HBs Ag to be 0.5%, HCV Ab to be 18%, CMV IgG to be 72.3%, CMV IgM to be 2%, and HIV-Ab to be 0%. Therefore, for the first time in our country the thalassemia center was established as a model and included subunits and a team. It served all patients for 15 years until the team was dispersed; thereafter, most of the patients were not followed up on a regular basis.
    MeSH term(s) Adolescent ; Adult ; Anemia, Sickle Cell/complications ; Child ; Child, Preschool ; Diabetes Mellitus/etiology ; Endocrine System Diseases/etiology ; Female ; HIV ; HIV Infections/etiology ; Hospitals, State ; Humans ; Hypothyroidism/etiology ; Male ; Prognosis ; Thalassemia/complications ; Thalassemia/therapy ; Time Factors ; Transfusion Reaction ; Turkey ; Young Adult
    Language English
    Publishing date 2013-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0b013e3182755f1e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The incidence of alpha-thalassemia in iraqi turks.

    Canatan, Duran

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2012  Volume 29, Issue 1, Page(s) 96

    Language English
    Publishing date 2012-03-05
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.5505/tjh.2012.48751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The medical concerns of patients with thalassemias at the time of COVID-19 outbreak: The personal experience and the international recommendations

    Canatan, Duran / De Sanctis, Vincenzo

    Acta Biomed

    Abstract: ...

    Abstract .
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #314911
    Database COVID19

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  9. Article: The impact of MicroRNAs (miRNAs) on the genotype of coronaviruses

    Canatan, Duran / De Sanctis, Vincenzo

    Acta Biomed

    Abstract: Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is ... ...

    Abstract Summar y. The beginning of 2020 has seen the emergence of COVID-19, an outbreak caused by a novel coronavirus, SARS-CoV-2, an important pathogen for humans. SARS-CoV-2 is an RNA virus containing 29891 nucleotides encoding 9889 amino acids. The genome is arranged as 5p-replicase (orf1/ab)-structural proteins [Spike (S) -Envelope (E) - Membrane (M) -Nucleocapsid (N)] -3. Viruses are obligate intracellular infectious agents that use the host cellular machinery to ensure their own fitness and survival. MicroRNAs (miRNA9) systems are potent post-transcriptional gene expression regulators that are important modulators of viral infections, and could play an important role in the treatment of viral infections. This review focuses to the genomic structure of coronaviruses, the functions of genomic proteins, the effects of micro RNA (miRNA) on virus replication and its pathogenesis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32420944
    Database COVID19

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  10. Article ; Online: The incidence of alpha-thalassemia in Iraqi Turks

    Duran Canatan

    Turkish Journal of Hematology, Vol 29, Iss 1, Pp 96-

    2012  Volume 96

    Keywords Internal medicine ; RC31-1245 ; Diseases of the blood and blood-forming organs ; RC633-647.5
    Language English
    Publishing date 2012-03-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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