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  1. Book ; Online: Cellulose-Based Biosensing Platforms

    Morales-Narváez, Eden / Morales-Narváez, Eden / de la Escosura-Muñiz, Alfredo / Golmohammadi, Hamed / Zor, Erhan

    2021  

    Keywords Research & information: general ; biosensing ; point-of-care ; photoluminescence ; portable devices ; miniaturization ; biosensors ; C-reactive protein ; carbon nanotubes ; electrospinning ; electrochemical impedance ; superparamagnetic iron oxide nanoflowers ; lateral flow immunoassays ; biosensor ; extracellular vesicles ; exosomes ; paper device ; signal enhancement ; mercury ion ; colorimetric detection ; paper-based origami sensor ; three-dimensional microfluidic ; potentiometric ; carbon paste electrode ; biomarker ; carbon nanofiber ; cellulose ; diagnostics ; immunoassay ; lateral flow assays ; paper ; point-of-care testing ; troponin I ; nanobioengineering ; matrix design ; cytosensing ; human health ; SPIONs ; encapsulation ; PLGA ; lipid ; lipid-polymer hybrid nanoparticles ; lateral flow immunoassays (LFIA) ; wearables ; paper microfluidics ; fabric microfluidics ; solid-state sensors ; electrochemical (bio)sensor ; clinical analysis ; paper sensors ; toxic substances ; biological receptors ; optical detection ; electrochemical methods ; rapid tests ; DNA ; enzyme ; antibody ; cell ; molecularly imprinted polymers ; lateral flow immunoassay ; carcinoembryonic antigen ; cancer diagnosis ; smartphone-based sensors
    Size 1 electronic resource (228 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021290331
    ISBN 9783036524016 ; 3036524010
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Editorial: Integrated biosensors towards clinical and point-of-care diagnostics.

    Dincer, Can / Chandra, Pranjal / Morales-Narváez, Eden

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 1008603

    Language English
    Publishing date 2022-09-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1008603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Nanobiophotonics and Related Novel Materials Aimed at Biosciences and Biomedicine.

    Altucci, Carlo / Kurapati, Rajendra / Morales-Narváez, Eden

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 898752

    Language English
    Publishing date 2022-04-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.898752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Next-generation of smart dressings: Integrating multiplexed sensors and theranostic functions.

    Horta-Velázquez, Amauri / Mota-Morales, Josué D / Morales-Narváez, Eden

    International journal of biological macromolecules

    2023  Volume 254, Issue Pt 1, Page(s) 127737

    Abstract: Non-healing wounds represent a significant burden for healthcare systems and society, giving rise to severe economic and human issues. Currently, the use of dressings and visual assessment represent the primary and standard care for wounds. Conventional ... ...

    Abstract Non-healing wounds represent a significant burden for healthcare systems and society, giving rise to severe economic and human issues. Currently, the use of dressings and visual assessment represent the primary and standard care for wounds. Conventional dressings, like cotton gauze, provide only passive physical protection. Besides, they end up paradoxically hampering the wound-healing process by producing tissue damage and pain when removed during routine check-ups. In response to these limitations, researchers, engineers, and technologists are developing innovative dressings that incorporate advanced diagnostic and therapeutic functionalities, coined as "smart dressings". Now, the maturation of smart dressing is bringing them closer to real-life applications, leading to an exciting new generation of these devices. The next generation of smart dressings is capable of monitoring in real-time multiple biomarkers while including pro-healing capabilities in a single platform. Such multiplexed and theranostic smart dressings are expected to offer a timely biomarker-directed diagnosis of non-healing wounds while enabling rapid, automated, and personalized treatments of infection and chronicity. Herein, we provide an insightful overview of these advantageous devices, delving into the diverse spectrum of possible engineering strategies. This encompasses the use of electrochemical and optical platforms with diverse multiplexing architectures, such as multi-zone sensing arrays and multi-layered devices. Open or closed-loop theranostic mechanisms using various stimuli-responsive materials that could be internally or externally controlled are also included. Finally, a critical discussion on the main challenges and future directions of smart dressings is also offered.
    MeSH term(s) Humans ; Bandages ; Precision Medicine ; Wound Healing
    Language English
    Publishing date 2023-10-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Flexible 3D Plasmonic Web Enables Remote Surface Enhanced Raman Spectroscopy.

    Rodríguez-Sevilla, Erika / Álvarez-Martínez, Jonathan Ulises / Castro-Beltrán, Rigoberto / Morales-Narváez, Eden

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2402192

    Abstract: Nanoplasmonic materials concentrate light in specific regions of dramatic electromagnetic enhancement: hot spots. Such regions can be employed to perform single molecule detection via surface-enhanced Raman spectroscopy. However, this phenomenon is ... ...

    Abstract Nanoplasmonic materials concentrate light in specific regions of dramatic electromagnetic enhancement: hot spots. Such regions can be employed to perform single molecule detection via surface-enhanced Raman spectroscopy. However, this phenomenon is challenging since hot spots are expected to be highly intense/abundant and positioning of molecules within such hot spots is crucial to manage with ultrasensitive SERS. Herein, it is discovered that a 3D plasmonic web embedded within a biohybrid (3D-POWER) exhibits plasmonic transmission, spontaneously absorbs the analyte, and meets these so much needed criteria in ultrasensitive SERS. 3D-POWER is built with nanopaper and self-assembled layers of graphene oxide and gold nanorods. According to in silico experiments, 3D-POWER captures light in a small region and performs plasmonic field transmission in a surrounding volume, thereby activating a plasmonic web throughout the simulated volume. The study also provides experimental evidence supporting the plasmonic field transport ability of 3D power, which operates as a SERS signal carrier (even beyond the apparatus field of view), and the ultrasensitive behavior of this ecofriendly and flexible material facilitating yoctomolar limit of detection. Besides, 3D-POWER is proven useful in food and biofluids analysis. It is foreseen that 3D-POWER can be employed as a valuable platform in (bio)analytical applications.
    Language English
    Publishing date 2024-04-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202402192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bioactive Luminescent Silver Clusters Confined in Zeolites Enable Quick and Wash-Free Biosensing.

    García-Guzmán, Cecilia / Morales-Narváez, Eden / Coutino-Gonzalez, Eduardo

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 51, Page(s) e202307718

    Abstract: The simultaneous capture and detection of biomolecules is crucial for revolutionizing bioanalytical platforms in terms of portability, response time and cost-efficiency. Herein, we demonstrate how the sensitivity to external stimuli and changes in the ... ...

    Abstract The simultaneous capture and detection of biomolecules is crucial for revolutionizing bioanalytical platforms in terms of portability, response time and cost-efficiency. Herein, we demonstrate how the sensitivity to external stimuli and changes in the local electronic environment of silver clusters lead to an advantageous biosensing platform based on the fluorometric response of bioactive luminescent silver clusters (BioLuSiC) confined in faujasite X zeolites functionalized with antibodies. The photoluminescence response of BioLuSiC was enhanced upon immunocomplex formation, empowering a wash-free and quick biodetection system offering optimal results from 5 min. Proteins and pathogens (immunoglobulin G and Escherichia coli) were targeted to demonstrate the biosensing performance of BioLuSiC, and a human serum titration assay was also established. BioLuSiC will pave the way for innovative bioanalytical platforms, including real-time monitoring systems, point-of-care devices and bioimaging techniques.
    MeSH term(s) Humans ; Silver ; Zeolites ; Escherichia coli ; Luminescence ; Immunoglobulin G ; Biosensing Techniques/methods
    Chemical Substances Silver (3M4G523W1G) ; Zeolites (1318-02-1) ; Immunoglobulin G
    Language English
    Publishing date 2023-10-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202307718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The impact of biosensing in a pandemic outbreak: COVID-19.

    Morales-Narváez, Eden / Dincer, Can

    Biosensors & bioelectronics

    2020  Volume 163, Page(s) 112274

    Abstract: COVID-19 pandemic outbreak is the most astounding scene ever experienced in the XXI century. In this opinionated review, we underscore the crucial role of biosensing to handle with such situations. As a matter of fact, testing accelerates life-saving ... ...

    Abstract COVID-19 pandemic outbreak is the most astounding scene ever experienced in the XXI century. In this opinionated review, we underscore the crucial role of biosensing to handle with such situations. As a matter of fact, testing accelerates life-saving decisions on treatment and isolation of COVID-19 patients in an early stage, and thereby, decelerating or even preventing the spread of such emerging infectious diseases. Meanwhile, it is also proven that a timely and broad application of testing leads to lower mortality rates in countries like Germany or South Korea. Besides, biosensors are also powerful tools for effective assessment of clinical progress and to provide alertness on severity or critical trends of infection. In view hereof, we critically discuss the state-of-the-art biosensing devices for COVID-19 testing. We spot the urgent needs and highlight innovative diagnostic approaches for targeting various COVID-19 related biomarkers. Finally, we outline our recommendations on biosensors and biosensing-related issues towards pandemic outbreaks.
    MeSH term(s) Betacoronavirus/isolation & purification ; Biomarkers/analysis ; Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/instrumentation ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Equipment Design ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2020.112274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Biointerfacing 2D Nanomaterials and Engineered Heterostructures.

    Gravagnuolo, Alfredo Maria / Morales-Narváez, Eden / Martucci, Alessandro

    Frontiers in bioengineering and biotechnology

    2021  Volume 8, Page(s) 639723

    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2020.639723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Toward smart diagnosis of pandemic infectious diseases using wastewater-based epidemiology.

    Mahmoudi, Tohid / Naghdi, Tina / Morales-Narváez, Eden / Golmohammadi, Hamed

    Trends in analytical chemistry : TRAC

    2022  Volume 153, Page(s) 116635

    Abstract: COVID-19 outbreak revealed fundamental weaknesses of current diagnostic systems, particularly in prediction and subsequently prevention of pandemic infectious diseases (PIDs). Among PIDs detection methods, wastewater-based epidemiology (WBE) has been ... ...

    Abstract COVID-19 outbreak revealed fundamental weaknesses of current diagnostic systems, particularly in prediction and subsequently prevention of pandemic infectious diseases (PIDs). Among PIDs detection methods, wastewater-based epidemiology (WBE) has been demonstrated to be a favorable mean for estimation of community-wide health. Besides, by going beyond purely sensing usages of WBE, it can be efficiently exploited in Healthcare 4.0/5.0 for surveillance, monitoring, control, and above all prediction and prevention, thereby, resulting in smart sensing and management of potential outbreaks/epidemics/pandemics. Herein, an overview of WBE sensors for PIDs is presented. The philosophy behind the smart diagnosis of PIDs using WBE with the help of digital technologies is then discussed, as well as their characteristics to be met. Analytical techniques that are pushing the frontiers of smart sensing and have a high potential to be used in the smart diagnosis of PIDs via WBE are surveyed. In this context, we underscore key challenges ahead and provide recommendations for implementing and moving faster toward smart diagnostics.
    Language English
    Publishing date 2022-04-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2022.116635
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Nanoplasmonics in Paper-Based Analytical Devices.

    Marquez, Salomón / Morales-Narváez, Eden

    Frontiers in bioengineering and biotechnology

    2019  Volume 7, Page(s) 69

    Abstract: Chemical and biological sensing are crucial tools in science and technology. Plasmonic nanoparticles offer a virtually limitless number of photons for sensing applications, which can be available for visual detection over long periods. Moreover, ... ...

    Abstract Chemical and biological sensing are crucial tools in science and technology. Plasmonic nanoparticles offer a virtually limitless number of photons for sensing applications, which can be available for visual detection over long periods. Moreover, cellulosic materials, such as paper, represent a versatile building block for implementation of simple, yet valuable, microfluidic analytical devices. This mini review outlines the basic theory of nanoplasmonics and the usability of paper as a nanoplasmonic substrate exploiting its features as a (bio)sensing platform based on different mechanisms depending on localized surface plasmon resonance response. Progress, current trends, challenges and opportunities are also underscored. It is intended for general researchers and technologists who are new to the topic as well as specialist/experts in the field.
    Language English
    Publishing date 2019-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2019.00069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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