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  1. Article ; Online: The impact of coronavirus (COVID-19) in the diagnosis and treatment of obsessive-compulsive disorder.

    Fontenelle, Leonardo F / Miguel, Euripedes C

    Depression and anxiety

    2020  Volume 37, Issue 6, Page(s) 510–511

    MeSH term(s) Betacoronavirus ; COVID-19 ; Compulsive Personality Disorder ; Coronavirus ; Coronavirus Infections ; Humans ; Obsessive-Compulsive Disorder ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1378635-0
    ISSN 1520-6394 ; 1091-4269
    ISSN (online) 1520-6394
    ISSN 1091-4269
    DOI 10.1002/da.23037
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    Zs.A 3823: Show issues Location:
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  2. Article ; Online: Early intervention in obsessive-compulsive disorder: From theory to practice.

    Fontenelle, Leonardo F / Nicolini, Humberto / Brakoulias, Vlasios

    Comprehensive psychiatry

    2022  Volume 119, Page(s) 152353

    Abstract: Obsessive-compulsive disorder (OCD) is frequent and often disabling. Yet, correct diagnosis and appropriate treatment implementation are usually delayed, with undesirable consequences. In this paper we review the rationale for early intervention in OCD ... ...

    Abstract Obsessive-compulsive disorder (OCD) is frequent and often disabling. Yet, correct diagnosis and appropriate treatment implementation are usually delayed, with undesirable consequences. In this paper we review the rationale for early intervention in OCD and provide recommendations for early intervention services. Two scenarios are discussed, i.e., subclinical (prodromal) obsessive-compulsive symptoms (OCS) and full-blown OCD. Although the typical patient with OCD reports a long history of subclinical OCS, longitudinal studies suggest most individuals with OCS in the community do not convert to full-blown OCD. Thus, research on "at risk" phenotypes for OCD and how they should incorporate different risk factors (e.g., polygenic risk scores) are badly needed. For this specific scenario, preventative treatments that are cheap, well tolerated and highly scalable (e.g., lifestyle interventions) are of major interest. On the other hand, increasing evidence suggests OCD to be a progressive disorder and the severity and duration of illness to be associated with both biological changes and increased clinical complexity, including greater number of physical and psychiatric comorbidities, increased family accommodation and worse treatment response. Therefore, prompt identification and early treatment implementation for full-blown OCD are also critical for ethical, clinical and therapeutic reasons. Based on the existing findings, we argue that, regardless of focusing on subclinical OCS or clinical OCD, early intervention services need to target a childhood age group. In addition to delivering well established treatments to people with full-blown OCD early on their illness, early intervention services also need to provide psychoeducation for patients, families and teachers.
    MeSH term(s) Humans ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/therapy ; Obsessive-Compulsive Disorder/epidemiology ; Comorbidity
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127556-2
    ISSN 1532-8384 ; 0010-440X
    ISSN (online) 1532-8384
    ISSN 0010-440X
    DOI 10.1016/j.comppsych.2022.152353
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  3. Article ; Online: A New Consensus Framework for Phenotyping and Treatment Selecting in Addiction and Obsessive-Compulsive-Related Disorders.

    Yücel, Murat / Lee, Rico S C / Fontenelle, Leonardo F

    JAMA psychiatry

    2021  Volume 78, Issue 7, Page(s) 699–700

    MeSH term(s) Behavior, Addictive/diagnosis ; Behavior, Addictive/physiopathology ; Behavior, Addictive/therapy ; Consensus ; Delphi Technique ; Humans ; Obsessive-Compulsive Disorder/diagnosis ; Obsessive-Compulsive Disorder/physiopathology ; Obsessive-Compulsive Disorder/therapy ; Phenotype ; Practice Guidelines as Topic ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/physiopathology ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2021.0243
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  4. Article ; Online: Vallejo-Nágera (1926-1990) and the concept of 'soteric neurosis': a forgotten sketch of hoarding disorder in the obsessive-compulsive spectrum literature.

    Fontenelle, Leonardo F

    Journal of medical biography

    2016  Volume 24, Issue 1, Page(s) 85–89

    Abstract: Juan Antonio Vallejo-Nágera, psychiatrist, painter and writer, wrote a widely adopted textbook of psychiatry in Spanish- and Portuguese-speaking countries, particularly during the 1970s, the famous Introducción a la psiquiatría. There, he advanced the ... ...

    Abstract Juan Antonio Vallejo-Nágera, psychiatrist, painter and writer, wrote a widely adopted textbook of psychiatry in Spanish- and Portuguese-speaking countries, particularly during the 1970s, the famous Introducción a la psiquiatría. There, he advanced the concept of soteric neurosis, a condition regarded as a 'mirror image' of phobias and similar to the diagnostic entity described in DSM-5 under the heading of hoarding disorder. Indeed, much earlier than the recent nosological discussions on hoarding, Vallejo-Nágera already reported soteric neurosis to be distinct from obsessive-compulsive disorder and to be associated with excessive attachment to objects and positive affect (pleasure), leading to accumulation, decreased treatment seeking, increasing interference in daily activities and blurred boundaries with normality. Vallejo-Nágera also made several predictions, including the propensity soteric neurosis patients may have towards the development of separation anxiety, obesity and other 'masked' symptoms. In the light of his original and insightful contributions to the concept of hoarding disorder, it would be interesting to assess his hypotheses in future studies.
    MeSH term(s) Diagnosis, Differential ; History, 20th Century ; Hoarding Disorder/diagnosis ; Hoarding Disorder/history ; Humans ; Obsessive-Compulsive Disorder/history ; Spain
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 1159267-9
    ISSN 1758-1087 ; 0967-7720
    ISSN (online) 1758-1087
    ISSN 0967-7720
    DOI 10.1177/0967772014525106
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    Zs.A 3995: Show issues Location:
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  5. Article ; Online: Prevalence and psychopathology features of mental rituals in patients with obsessive-compulsive disorder: A descriptive exploratory study of 1001 patients.

    Ferrão, João Vítor Bueno / do Rosário, Maria Conceição / Fontenelle, Leonardo F / Ferrão, Ygor Arzeno

    Clinical psychology & psychotherapy

    2023  Volume 30, Issue 6, Page(s) 1520–1533

    Abstract: Introduction: Mental rituals (MR) are compulsions with no overt behavioural or motoric signs. It is presently unclear whether MR found in obsessive-compulsive disorder are associated with a distinctive clinical profile.: Objectives: The main ... ...

    Abstract Introduction: Mental rituals (MR) are compulsions with no overt behavioural or motoric signs. It is presently unclear whether MR found in obsessive-compulsive disorder are associated with a distinctive clinical profile.
    Objectives: The main objectives of this paper were to assess the prevalence and psychopathological correlates of mental rituals in a large sample of OCD patients.
    Methods: This exploratory case-control study compared 519 patients with versus 447 without MR in terms of sociodemographics, presence and severity of obsessive-compulsive symptoms, psychiatric comorbidities, sensory phenomena, suicidality, and insight.
    Results: Current MR were found in 51.8%, while lifetime MR were found in 55.4% of the sample. The multiple logistic regression model determined that the most relevant clinical factors independently associated with current MR in OCD patients were the absence of any sensory phenomena and the presence of lifetime suicide ideation.
    Conclusion: Due to its relation to OCD clinical aspects, MR are a frequent feature among OCD patients. It also seems to be associated with a range of features that are probably relevant for treatment, especially sensory phenomena and suicidality.
    MeSH term(s) Humans ; Prevalence ; Ceremonial Behavior ; Case-Control Studies ; Obsessive-Compulsive Disorder/psychology ; Compulsive Behavior/epidemiology ; Compulsive Behavior/psychology
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1169313-7
    ISSN 1099-0879 ; 1063-3995
    ISSN (online) 1099-0879
    ISSN 1063-3995
    DOI 10.1002/cpp.2890
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    Zs.A 3950: Show issues Location:
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  6. Article ; Online: A Clinical Staging Model for Obsessive-Compulsive Disorder: Is It Ready for Prime Time?

    Fontenelle, Leonardo F / Yücel, Murat

    EClinicalMedicine

    2019  Volume 7, Page(s) 65–72

    Abstract: Recent changes to the diagnostic classification of obsessive-compulsive disorder (OCD), including its removal from the anxiety/neurotic, stress-related and somatoform disorders chapters of the Diagnostic and Statistical Manual of Mental Disorders, Fifth ... ...

    Abstract Recent changes to the diagnostic classification of obsessive-compulsive disorder (OCD), including its removal from the anxiety/neurotic, stress-related and somatoform disorders chapters of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and International Classification of Diseases 11th Revision (ICD-11), are based on growing evidence of unique pathogenic signatures and linked diagnostic and treatment approaches. In this review, we build on these recent developments and propose a 'clinical staging model' of OCD that integrates the severity of symptoms and phase of illness for personalised case management. A clinical staging model is especially relevant for the early identification and management of subthreshold OCD - a substantial and largely neglected portion of the population who, despite having milder symptoms, experience harms that may impact personal relationships, work-related functioning and productivity. Research on the pathogenesis, classification and management of such cases is needed, including the development of new outcomes measures that prove sensitive to changes in future clinical trials. Early intervention strategies in OCD are likely to yield better long-term outcomes.
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2019.01.014
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  8. Article ; Online: The impact of coronavirus (COVID‐19) in the diagnosis and treatment of obsessive‐compulsive disorder

    Fontenelle, Leonardo F. / Miguel, Euripedes C.

    Depression and Anxiety

    2020  Volume 37, Issue 6, Page(s) 510–511

    Keywords Clinical Psychology ; Psychiatry and Mental health ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1378635-0
    ISSN 1520-6394 ; 1091-4269
    ISSN (online) 1520-6394
    ISSN 1091-4269
    DOI 10.1002/da.23037
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Clarifying and extending our understanding of problematic pornography use through descriptions of the lived experience.

    Ince, Campbell / Fontenelle, Leonardo F / Carter, Adrian / Albertella, Lucy / Tiego, Jeggan / Chamberlain, Samuel R / Rotaru, Kristian

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 18193

    Abstract: Problematic pornography use (PPU) is a complex and growing area of research. However, knowledge of the PPU lived experience is limited. To address this gap, we conducted an online qualitative study with 67 individuals who self-identified as having ... ...

    Abstract Problematic pornography use (PPU) is a complex and growing area of research. However, knowledge of the PPU lived experience is limited. To address this gap, we conducted an online qualitative study with 67 individuals who self-identified as having problematic pornography use (76% male; M
    MeSH term(s) Humans ; Male ; Young Adult ; Adult ; Female ; Erotica ; Sexual Behavior ; Behavior, Addictive ; Physical Examination
    Language English
    Publishing date 2023-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-45459-8
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  10. Article ; Online: A Clinical Staging Model for Obsessive–Compulsive Disorder

    Leonardo F. Fontenelle / Murat Yücel

    EClinicalMedicine, Vol 7, Iss , Pp 65-

    Is It Ready for Prime Time?

    2019  Volume 72

    Abstract: Recent changes to the diagnostic classification of obsessive–compulsive disorder (OCD), including its removal from the anxiety/neurotic, stress-related and somatoform disorders chapters of the Diagnostic and Statistical Manual of Mental Disorders, Fifth ... ...

    Abstract Recent changes to the diagnostic classification of obsessive–compulsive disorder (OCD), including its removal from the anxiety/neurotic, stress-related and somatoform disorders chapters of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and International Classification of Diseases 11th Revision (ICD-11), are based on growing evidence of unique pathogenic signatures and linked diagnostic and treatment approaches. In this review, we build on these recent developments and propose a ‘clinical staging model’ of OCD that integrates the severity of symptoms and phase of illness for personalised case management. A clinical staging model is especially relevant for the early identification and management of subthreshold OCD - a substantial and largely neglected portion of the population who, despite having milder symptoms, experience harms that may impact personal relationships, work-related functioning and productivity. Research on the pathogenesis, classification and management of such cases is needed, including the development of new outcomes measures that prove sensitive to changes in future clinical trials. Early intervention strategies in OCD are likely to yield better long-term outcomes. Keywords: Obsessive–compulsive disorder, Clinical staging, Early intervention, Neuroprogression, Cognitive functioning, Biological markers, Treatment outcome, Transdiagnostic framework
    Keywords Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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