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Article ; Online: Understanding the clinical significance of cytomegalovirus viremia after chimeric antigen receptor T-cell therapy: Should we be treating a value?

Kampouri, Eleftheria / Boeckh, Michael J / Hill, Joshua A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae030
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Book: Allgemeine Pharmakologie und Toxikologie

Boeckh, Michael

[über 1210 Original-Prüfungsfragen ...; 160 Lerntexte ...; 117 Seiten tabellarische Lernhilfen]

(Original-Prüfungsfragen mit Kommentar GK 2 ; <10,15> ; Schwarze Reihe)

2002

Author's details	bearb. von M. Boeckh
Series title	Original-Prüfungsfragen mit Kommentar GK 2 ; <10,15> Schwarze Reihe Original-Prüfungsfragen mit Kommentar GK 2 Original-Prüfungsfragen mit Kommentar GK 2
Collection	Original-Prüfungsfragen mit Kommentar GK 2 Original-Prüfungsfragen mit Kommentar GK 2
Keywords	Pharmacology ; Toxicology
Language	German
Size	XIV, 601 S.
Edition	15. Aufl., Stand: Frühjahr 2002
Publisher	Thieme
Publishing place	Stuttgart u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT013447665
ISBN	3-13-112535-7 ; 978-3-13-112535-4
Database	Catalogue ZB MED Medicine, Health

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2002 A 4267	order for loan	Magazin

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Article: New insights into cytomegalovirus infection after allogeneic hematopoietic stem cell transplant.

Boeckh, Michael

Clinical advances in hematology & oncology : H&O

2017 Volume 15, Issue 7, Page(s) 515–517

MeSH term(s)	Allografts ; Cytomegalovirus ; Cytomegalovirus Infections/blood ; Cytomegalovirus Infections/etiology ; Cytomegalovirus Infections/mortality ; Cytomegalovirus Infections/prevention & control ; Hematopoietic Stem Cell Transplantation ; Humans
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2271951-9
ISSN	1543-0790
ISSN	1543-0790
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Zs.A 6505: Show issues

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Article ; Online: How I prevent viral reactivation in high-risk patients.

Dadwal, Sanjeet S / Papanicolaou, Genovefa A / Boeckh, Michael

Blood

2023 Volume 141, Issue 17, Page(s) 2062–2074

Abstract: Preventing viral infections at an early stage is a key strategy for successfully improving transplant outcomes. Preemptive therapy and prophylaxis with antiviral agents have been successfully used to prevent clinically significant viral infections in ... ...

Abstract	Preventing viral infections at an early stage is a key strategy for successfully improving transplant outcomes. Preemptive therapy and prophylaxis with antiviral agents have been successfully used to prevent clinically significant viral infections in hematopoietic cell transplant recipients. Major progress has been made over the past decades in preventing viral infections through a better understanding of the biology and risk factors, as well as the introduction of novel antiviral agents and advances in immunotherapy. High-quality evidence exists for the effective prevention of herpes simplex virus, varicella-zoster virus, and cytomegalovirus infection and disease. Few data are available on the effective prevention of human herpesvirus 6, Epstein-Barr virus, adenovirus, and BK virus infections. To highlight the spectrum of clinical practice, here we review high-risk situations that we handle with a high degree of uniformity and cases that feature differences in approaches, reflecting distinct hematopoietic cell transplant practices, such as ex vivo T-cell depletion.
MeSH term(s)	Humans ; Hematopoietic Stem Cell Transplantation/adverse effects ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/prevention & control ; Herpesvirus 4, Human ; Virus Diseases/prevention & control ; Virus Diseases/etiology ; Antiviral Agents/therapeutic use
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-02-08
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2021014676
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

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Book: Allgemeine Pharmakologie und Toxikologie

Boeckh, Michael

[mit 160 Lerntexten und 117 Seiten Tabellen]

(Original-Prüfungsfragen mit Kommentar GK 2 ; <10,14> ; Schwarze Reihe)

2001

Author's details	bearb. von M. Boeckh
Series title	Original-Prüfungsfragen mit Kommentar GK 2 ; <10,14> Schwarze Reihe Original-Prüfungsfragen mit Kommentar GK 2 Original-Prüfungsfragen mit Kommentar GK 2
Collection	Original-Prüfungsfragen mit Kommentar GK 2 Original-Prüfungsfragen mit Kommentar GK 2
Keywords	Pharmakologie ; Toxikologie
Subject	Giftkunde ; Klinische Toxikologie ; Arzneimittellehre ; Arzneimittelwirkung ; Arzneiwirkung ; Experimentelle Pharmakologie
Language	German
Size	XIV, 529 S.
Edition	14. Aufl., Stand: Herbst 2000
Publisher	Thieme
Publishing place	Stuttgart u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT012957410
ISBN	3-13-112534-9 ; 978-3-13-112534-7
Database	Catalogue ZB MED Medicine, Health

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2001 A 1685	order for loan	Magazin

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Article ; Online: Cytomegalovirus Viral Load Threshold to Guide Preemptive Therapy in Hematopoietic Cell Transplant Recipients: Correlation with CMV Disease.

Sadowska-Klasa, Alicja / Leisenring, Wendy M / Limaye, Ajit P / Boeckh, Michael

The Journal of infectious diseases

2023

Abstract: A systematic review of recent randomized and observational studies demonstrated that antiviral preemptive therapy started at cytomegalovirus (CMV) viral load thresholds between 2 and 3 log10 IU/mL were associated with similar CMV disease rates. Thus, ... ...

Abstract	A systematic review of recent randomized and observational studies demonstrated that antiviral preemptive therapy started at cytomegalovirus (CMV) viral load thresholds between 2 and 3 log10 IU/mL were associated with similar CMV disease rates. Thus, viral thresholds in this range appear to effectively protect patients not receiving prophylaxis.
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad386
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Zs.MO 445: Show issues

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Article ; Online: Monoclonal antibodies for prophylaxis and treatment of respiratory viral infections.

Boonyaratanakornkit, Jim / Boeckh, Michael / Waghmare, Alpana

Current opinion in infectious diseases

2022 Volume 35, Issue 4, Page(s) 280–287

Abstract: Purpose of review: Monoclonal antibody (mAb) administration represents an important strategy for preventing and treating respiratory viral infections in vulnerable populations, including immunocompromised individuals. The purpose of this review is to ... ...

Abstract	Purpose of review: Monoclonal antibody (mAb) administration represents an important strategy for preventing and treating respiratory viral infections in vulnerable populations, including immunocompromised individuals. The purpose of this review is to provide an overview of mAbs in clinical use against respiratory viruses, highlight factors that modulate mAb clinical efficacy, and provide a perspective on future innovations in the field. This review focuses on publications from the last year. Recent findings: Historically, clinical development of a single mAb has taken over a decade. The COVID-19 pandemic has demonstrated that this timeframe can be reduced to less than a year and has catalyzed rapid innovations in the field. Several novel mAbs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have received emergency use authorization by the Food and Drug Administration (FDA) for the early treatment of mild to moderate COVID-19. However, the majority of these mAbs have ultimately failed due to the emergence of variants, highlighting an important lesson about predicting and countering resistance. Novel mAbs are also in clinical use or in late-stage development for the prevention of infection by SARS-CoV-2 and respiratory syncytial virus (RSV) in vulnerable populations. Several factors can be modulated to improve the clinical efficacy of mAbs. For example, Fc modifications can extend mAb half-life and increase respiratory tract bioavailability, both of which are attractive properties for achieving protection against respiratory viruses. Summary: The mAb landscape is rapidly evolving with numerous examples of success and failure. The armamentarium of clinically-available mAbs to protect vulnerable populations is expected to undergo continued growth.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral ; COVID-19/prevention & control ; Humans ; Pandemics ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Virus Infections/prevention & control ; SARS-CoV-2 ; Viruses
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Viral
Language	English
Publishing date	2022-07-05
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000000846
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2462: Show issues

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Article ; Online: Within-Host Rhinovirus Evolution in Upper and Lower Respiratory Tract Highlights Capsid Variability and Mutation-Independent Compartmentalization.

Makhsous, Negar / Goya, Stephanie / Avendaño, Carlos C / Rupp, Jason / Kuypers, Jane / Jerome, Keith R / Boeckh, Michael / Waghmare, Alpana / Greninger, Alexander L

The Journal of infectious diseases

2024 Volume 229, Issue 2, Page(s) 403–412

Abstract: Background: Rhinovirus (RV) infections can progress from the upper (URT) to lower (LRT) respiratory tract in immunocompromised individuals, causing high rates of fatal pneumonia. Little is known about how RV evolves within hosts during infection.: ... ...

Abstract	Background: Rhinovirus (RV) infections can progress from the upper (URT) to lower (LRT) respiratory tract in immunocompromised individuals, causing high rates of fatal pneumonia. Little is known about how RV evolves within hosts during infection. Methods: We sequenced RV complete genomes from 12 hematopoietic cell transplant patients with infection for up to 190 days from both URT (nasal wash, NW) and LRT (bronchoalveolar lavage, BAL). Metagenomic and amplicon next-generation sequencing were used to track the emergence and evolution of intrahost single nucleotide variants (iSNVs). Results: Identical RV intrahost populations in matched NW and BAL specimens indicated no genetic adaptation is required for RV to progress from URT to LRT. Coding iSNVs were 2.3-fold more prevalent in capsid over nonstructural genes. iSNVs modeled were significantly more likely to be found in capsid surface residues, but were not preferentially located in known RV-neutralizing antibody epitopes. Newly emergent, genotype-matched iSNV haplotypes from immunocompromised individuals in 2008-2010 could be detected in Seattle-area community RV sequences in 2020-2021. Conclusions: RV infections in immunocompromised hosts can progress from URT to LRT with no specific evolutionary requirement. Capsid proteins carry the highest variability and emergent mutations can be detected in other, including future, RV sequences.
MeSH term(s)	Humans ; Capsid Proteins/genetics ; Capsid ; Rhinovirus/genetics ; Hematopoietic Stem Cell Transplantation ; Mutation ; Enterovirus Infections
Chemical Substances	Capsid Proteins
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiad284
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Zs.MO 445: Show issues

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Article: Evaluation of Three Cytomegalovirus IgG Lateral Flow Assays for Rapid Determination of CMV Serostatus.

Joncas-Schronce, Laurel / Ali, Fatima / Pepper, Gregory / Stapleton, Renee D / Rubenfeld, Gordon D / Boeckh, Michael / Limaye, Ajit P

Open forum infectious diseases

2024 Volume 11, Issue 3, Page(s) ofae084

Abstract: Background: Cytomegalovirus (CMV) serostatus is a major determinant of CMV infection, disease risk, and transplant outcomes. Current clinical serology assays are limited by relatively slow turnaround time, design for batched testing, need for trained ... ...

Abstract	Background: Cytomegalovirus (CMV) serostatus is a major determinant of CMV infection, disease risk, and transplant outcomes. Current clinical serology assays are limited by relatively slow turnaround time, design for batched testing, need for trained personnel, and/or specialized equipment. Rapid diagnostic assays in development have a role in emerging settings, such as critically ill patients, but have not been systematically evaluated. Methods: We assessed the performance of 3 rapid lateral flow assays (LFAs) for the detection of CMV immunoglobulin (Ig)G antibodies compared with a reference commercially available CMV IgG enzyme-linked immunosorbent assay in residual serum samples from 200 consecutive adults who underwent clinical CMV serology testing. Samples with discrepant results between the LFA and reference assay were tested by a second reference assay. A subset of serum samples was assessed for interoperator variability. Operating characteristics of the QooLabs LFA were separately assessed in plasma samples. Results: The sensitivity and specificity of the individual LFA assays using serum varied significantly: 86%/83%, 99/93%, and 57/97%, for Healgen, QNow automated reader, and nanoComposix, respectively, compared with the reference assay. Results for the QNow assay were comparable between automated and manual reads. Among a subset of 10 serum samples assessed by 5 individual operators, 44 of 50 (88%) results were concordant. Among 50 plasma samples assessed by the QooLabs LFA, the sensitivity and specificity were 72% and 96%. Conclusions: The ease of performance, rapid turnaround time, and good operating characteristics provide the rationale for further evaluation of the Qoolabs QNow LFA in specialized settings where rapid assessment of CMV serostatus would be advantageous.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofae084
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Article ; Online: Differential Association between Blood Glucose Levels and Nonrelapse Mortality after Allogeneic Hematopoietic Cell Transplantation Based on Presence or Absence of Preexisting Diabetes.

Rashid, Nahid / Gooley, Ted / Boeckh, Michael / Oshima, Masumi Ueda / Chao, Jing H / Hirsch, Irl B / Mielcarek, Marco

Transplantation and cellular therapy

2024 Volume 30, Issue 4, Page(s) 417.e1–417.e9

Abstract: Malglycemia, defined as hyperglycemia, hypoglycemia, or increased glycemic variability, has been associated with increased mortality after allogeneic hematopoietic cell transplantation (HCT). Among critically ill non-HCT recipients with diabetes and poor ...

Abstract	Malglycemia, defined as hyperglycemia, hypoglycemia, or increased glycemic variability, has been associated with increased mortality after allogeneic hematopoietic cell transplantation (HCT). Among critically ill non-HCT recipients with diabetes and poor glycemic control, compared to those without diabetes, stringent blood glucose control has been associated with increased mortality. This study investigated whether a pre-HCT diagnosis of diabetes and the type of pre-HCT diabetes treatment modulate the previously reported negative impact of malglycemia on post-HCT nonrelapse mortality (NRM). We performed a single-institution retrospective analysis of mortality outcomes after allogeneic HCT as a function of post-HCT blood glucose levels, pre-HCT diagnosis of diabetes, and type of pre-HCT diabetes treatment (insulin, no insulin). A total of 1062 patients who underwent allogeneic HCT between 2015 and 2020 were included in this study. Among these patients, 84 (8%) had a pre-HCT diagnosis of diabetes, of whom 38 (4%) used insulin and 46 (4%) used a noninsulin antiglycemic agent. Post-HCT blood glucose values measured within 100 days from HCT, modeled as a continuous nonlinear time-varying covariate, were associated with day-200 NRM, with both lower and higher glycemic values associated with higher NRM compared to normoglycemic values (adjusted P < .0001). The association between post-HCT blood glucose and NRM varied, however, depending on the presence or absence of a pre-HCT diagnosis of diabetes; that is, there was evidence of a statistical interaction between blood glucose levels and diabetes (adjusted P = .008). In particular, the detrimental impact of hyperglycemic values was more pronounced in patients without a pre-HCT diagnosis of diabetes compared to those with a pre-HCT diagnosis of diabetes. As reported previously, higher and lower blood glucose levels measured within 100 days after allogeneic HCT were associated with an increased risk of NRM; however, this association was more pronounced among patients without a pre-HCT diagnosis of diabetes compared to those with a pre-HCT diagnosis of diabetes, suggesting that patients with diabetes are relatively protected from the downstream effects of hyperglycemia. These data support the notion that patients with pre-HCT diabetes may need a different approach to blood glucose management after transplantation compared to those without diabetes. © 2024 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.
MeSH term(s)	Humans ; Blood Glucose ; Retrospective Studies ; Prognosis ; Hematopoietic Stem Cell Transplantation/adverse effects ; Diabetes Mellitus/etiology ; Hyperglycemia/etiology ; Insulins
Chemical Substances	Blood Glucose ; Insulins
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2024.01.065
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