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Article ; Online: Dual-responsive 3D DNA nanomachines cascaded hybridization chain reactions for novel self-powered flexible microRNA-detecting platform.

Wang, Futing / Zhang, Chunxiao / Deng, Suping / Jiang, Yifei / Zhang, Penghui / Yang, Hongfen / Xiang, Li / Lyu, Yifan / Cai, Ren / Tan, Weihong

Biosensors & bioelectronics

2024 Volume 252, Page(s) 116149

Abstract: The microRNA-21 is closely related to chromatin remodeling and epigenetic regulation. In this work, an efficient double-response 3D DNA nanomachine (DRDN) was assembled by co-immobilizing two different lengths of hairpin DNA on the surface of gold ... ...

Abstract	The microRNA-21 is closely related to chromatin remodeling and epigenetic regulation. In this work, an efficient double-response 3D DNA nanomachine (DRDN) was assembled by co-immobilizing two different lengths of hairpin DNA on the surface of gold nanoparticles (AuNPs) to capture microRNA-21 (miRNA-21), recycle miRNA-21, and trigger hybridization chain reactions (HCR). This work reports the fabrication of a laser-scribed graphene (LSG) electrode with excellent flexibility and electrical conductivity by laser-scribing commercial polyimide films (PI). The as-proposed self-powered biosensing platform presents significantly increased instantaneous current to in real-time monitor miRNA-21 by a capacitor. The biosensing platform exhibited highly sensitive detection of miRNA-21 with a detection limit of 0.142 fM in the range of 0.5 fM to 1 × 10
MeSH term(s)	MicroRNAs/genetics ; MicroRNAs/analysis ; Gold ; Epigenesis, Genetic ; Metal Nanoparticles ; Biosensing Techniques ; Electrochemical Techniques ; DNA/genetics ; Limit of Detection
Chemical Substances	MicroRNAs ; Gold (7440-57-5) ; DNA (9007-49-2)
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2024.116149
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Article ; Online: Corrigendum to "Protracted rosiglitazone treatment exacerbates inflammation in white adipose tissues of adipocyte-specific Nfe2l1 knockout mice" [Food Chem. Toxicol. 146 (2020) 111836].

Ren, Suping / Hou, Yongyong / Zuo, Zhuo / Liu, Zhiyuan / Wang, Huihui / Xu, Yuanyuan / Yamamoto, Masayuki / Zhang, Qiang / Fu, Jingqi / Pi, Jingbo

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 164, Page(s) 113063

Language	English
Publishing date	2022-05-05
Publishing country	England
Document type	Published Erratum
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113063
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Article ; Online: Tumor-Targeted Delivery of IL-2 by Fusing with a pH Low Insertion Peptide for Antitumor Immunotherapy.

Chu, Tianjiao / Cao, Bowei / Wang, Peina / Li, Bozhao / Ren, Jinna / Nie, Guangjun / Wei, Jingyan / Li, Suping

Bioconjugate chemistry

2023 Volume 34, Issue 10, Page(s) 1894–1901

Abstract: As a pleiotropic cytokine, interleukin-2 (IL-2) can effectively regulate lymphocyte proliferation, survival, and active antitumor immune responses in tumor microenvironments. Although the ability of IL-2 to boost immune responses was reported in cancer ... ...

Abstract	As a pleiotropic cytokine, interleukin-2 (IL-2) can effectively regulate lymphocyte proliferation, survival, and active antitumor immune responses in tumor microenvironments. Although the ability of IL-2 to boost immune responses was reported in cancer patients, its short circulating half-life and high toxicity hinder its broad and continual clinical application. Herein, we developed a novel tumor target agent by fusing pH low insertion peptides (pHLIP) with IL-2, forming the fusion protein pHLIP-IL2. Based on the low pH insertion property of pHLIP, the pHLIP-IL2 fusion protein could be selectively delivered to the acidic tumor microenvironments and then promote the proliferation of killer immune cells to elicit tumor regression. We found that pHLIP-IL2 fusion proteins can be significantly enriched in tumor tissues and can effectively reduce tumor size in diverse tumor models, including breast cancer and melanoma, without apparent adverse effects. These data suggest that the pHLIP-IL2 fusion protein may be a promising solution for the continual and extensive application of IL-2, and pHLIP-IL2 is a potential and valuable therapeutic drug for cancer patients with antitumor immunotherapy.
MeSH term(s)	Humans ; Cell Line, Tumor ; Hydrogen-Ion Concentration ; Immunotherapy ; Interleukin-2/administration & dosage ; Melanoma/drug therapy ; Tumor Microenvironment ; Drug Delivery Systems
Chemical Substances	Interleukin-2
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.3c00401
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Article ; Online: The presence of busulfan metabolites and pharmacometabolomics in plasma drawn immediately before allograft infusion in hematopoietic cell transplant recipients.

McCune, Jeannine S / Navarro, Sandi L / Risler, Linda J / Phillips, Brian R / Ren, Suping / Schoch, H Gary / Baker, K Scott

Clinical and translational science

2023 Volume 16, Issue 12, Page(s) 2577–2590

Abstract: Busulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ-glutamyldehydroalanylglycine, which is too unstable to be quantitated in vivo. We ... ...

Abstract	Busulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ-glutamyldehydroalanylglycine, which is too unstable to be quantitated in vivo. We sought to evaluate if pre-graft (i.e., immediately before allograft infusion) concentrations of busulfan metabolites' and of endogenous metabolomic compounds (EMCs) representing the glutathione pathway were associated with clinical outcomes in hematopoietic cell transplant (HCT) recipients receiving busulfan. The clinical outcomes evaluated were relapse, acute graft versus host disease (GVHD), chronic GVHD, non-relapse mortality, and neutrophil nadir. In pre-graft samples obtained from patients immediately before allograft infusion, our objectives were to evaluate for: (1) the presence of busulfan and its metabolites tetrahydrothiophenium ion (THT+), tetrahydrothiophene 1-oxide, sulfolane, and 3-hydroxysulfolane (N = 124); (2) EMCs using a global metabolomics assay (N = 77); and (3) the association of the busulfan metabolites and the EMCs with clinical outcomes. In the pre-graft samples, busulfan and THT+ could not be detected. THT 1-oxide, sulfolane, and 3-hydroxysulfolane were quantitated in 9.6%, 26%, and 58% of pre-graft samples; their concentrations were not associated with clinical outcomes. Four pre-graft EMCs were statistically significantly associated with the neutrophil nadir. The pre-graft EMCs were not associated with the other clinical outcomes. In conclusion, busulfan's metabolites are present in patients' plasma immediately before allograft infusion; the neutrophil nadir is associated with pre-graft EMCs. Future research should investigate the association of clinical outcomes with the concentrations of busulfan's metabolites and EMCs in the pre-graft plasma from allogeneic HCT recipients.
MeSH term(s)	Humans ; Busulfan ; Transplant Recipients ; Hematopoietic Stem Cell Transplantation ; Graft vs Host Disease/etiology ; Glutathione/metabolism ; Allografts
Chemical Substances	Busulfan (G1LN9045DK) ; sulfolane (Y5L06AH4G5) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2433157-0
ISSN	1752-8062 ; 1752-8054
ISSN (online)	1752-8062
ISSN	1752-8054
DOI	10.1111/cts.13651
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Article: Effects of ATP on the Physicochemical Properties and Cytocompatibility of Calcium Sulfate/Calcium Citrate Composite Cement.

Liu, Xiangyue / Chen, Hong / Ren, Haohao / Wang, Bo / Li, Xiaodan / Peng, Suping / Zhang, Qiyi / Yan, Yonggang

Materials (Basel, Switzerland)

2023 Volume 16, Issue 11

Abstract: Adenosine triphosphate (ATP), acting as a source of energy, has effects on cellular activities, such as adhesion, proliferation, and differentiation. In this study, ATP-loaded calcium sulfate hemihydrate/calcium citrate tetrahydrate cement (ATP/CSH/CCT) ... ...

Abstract	Adenosine triphosphate (ATP), acting as a source of energy, has effects on cellular activities, such as adhesion, proliferation, and differentiation. In this study, ATP-loaded calcium sulfate hemihydrate/calcium citrate tetrahydrate cement (ATP/CSH/CCT) was successfully prepared for the first time. The effect of different contents of ATP on the structure and physicochemical properties of ATP/CSH/CCT was also studied in detail. The results indicated that incorporating ATP into the cement did not significantly alter their structures. However, the addition ratio of ATP directly impacted the mechanical properties and in vitro degradation properties of the composite bone cement. The compressive strength of ATP/CSH/CCT gradually decreased with an increasing ATP content. The degradation rate of ATP/CSH/CCT did not significantly change at low concentrations of ATP, but it increased with a higher ATP content. The composite cement induced the deposition of a Ca-P layer in a phosphate buffer solution (PBS, pH = 7.4). Additionally, the release of ATP from the composite cement was controlled. The ATP was controlled releasing at the 0.5% and 1% ATP in cement by the diffusion of ATP and the degradation of the cement, whereas it was controlled by the diffusion process merely at the 0.1% ATP in cement. Furthermore, ATP/CSH/CCT demonstrated good cytoactivity with the addition of ATP and is expected to be used for the repair and regeneration of bone tissue.
Language	English
Publishing date	2023-05-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16113947
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Article ; Online: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice.

Shen, Wei / Ren, Suping / Hou, Yongyong / Zuo, Zhuo / Liu, Shengnan / Liu, Zhiyuan / Fu, Jingqi / Wang, Huihui / Yang, Bei / Zhao, Rui / Chen, Yanyan / Yamamoto, Masayuki / Xu, Yuanyuan / Zhang, Qiang / Pi, Jingbo

Redox biology

2023 Volume 67, Page(s) 102879

Abstract: Brown adipose tissue (BAT) is a major site of non-shivering thermogenesis in mammals and plays an important role in energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a master regulator of cellular metabolic ... ...

Abstract	Brown adipose tissue (BAT) is a major site of non-shivering thermogenesis in mammals and plays an important role in energy homeostasis. Nuclear factor-erythroid 2-related factor 1 (NFE2L1, also known as Nrf1), a master regulator of cellular metabolic homeostasis and numerous stress responses, has been found to function as a critical driver in BAT thermogenic adaption to cold or obesity by providing proteometabolic quality control. Our recent studies using adipocyte-specific Nfe2l1 knockout [Nfe2l1(f)-KO] mice demonstrated that NFE2L1-dependent transcription of lipolytic genes is crucial for white adipose tissue (WAT) homeostasis and plasticity. In the present study, we found that Nfe2l1(f)-KO mice develop an age-dependent whitening and shrinking of BAT, with signatures of down-regulation of proteasome, impaired mitochondrial function, reduced thermogenesis, pro-inflammation, and elevated regulatory cell death (RCD). Mechanistic studies revealed that deficiency of Nfe2l1 in brown adipocytes (BAC) primarily results in down-regulation of lipolytic genes, which decelerates lipolysis, making BAC unable to fuel thermogenesis. These changes lead to BAC hypertrophy, inflammation-associated RCD, and consequently cold intolerance. Single-nucleus RNA-sequencing of BAT reveals that deficiency of Nfe2l1 induces significant transcriptomic changes leading to aberrant expression of a variety of genes involved in lipid metabolism, proteasome, mitochondrial stress, inflammatory responses, and inflammation-related RCD in distinct subpopulations of BAC. Taken together, our study demonstrated that NFE2L1 serves as a vital transcriptional regulator that controls the lipid metabolic homeostasis in BAC, which in turn determines the metabolic dynamics, cellular heterogeneity and subsequently cell fates in BAT.
MeSH term(s)	Animals ; Mice ; Adipocytes, Brown/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Inflammation/metabolism ; Mammals/genetics ; Mice, Knockout ; Proteasome Endopeptidase Complex/metabolism ; RNA ; Thermogenesis/genetics
Chemical Substances	Proteasome Endopeptidase Complex (EC 3.4.25.1) ; RNA (63231-63-0) ; Nfe2L1 protein, mouse ; Nrf1 protein, mouse
Language	English
Publishing date	2023-09-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2023.102879
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Article: Quantitative whole-body MR imaging for assessment of tumor burden in patients with multiple myeloma: correlation with prognostic biomarkers.

Sun, Mengtian / Cheng, Jingliang / Ren, Cuiping / Zhang, Yong / Li, Yinhua / Li, Ying / Zhang, Suping

Quantitative imaging in medicine and surgery

2021 Volume 11, Issue 8, Page(s) 3767–3780

Abstract: Background: To assess the quantification of tumor burden in multiple myeloma (MM) patients using whole-body magnetic resonance imaging (MRI) and to identify the correlation between MRI parameters and prognostic biomarkers.: Methods: We ... ...

Abstract	Background: To assess the quantification of tumor burden in multiple myeloma (MM) patients using whole-body magnetic resonance imaging (MRI) and to identify the correlation between MRI parameters and prognostic biomarkers. Methods: We retrospectively analyzed 95 newly diagnosed MM patients treated at our hospital from June 2018 to March 2020. All patients underwent whole-body MRI examination, including diffusion-weighted whole-body imaging with background body signal suppression (DWIBS), modified Dixon chemical-shift imaging (mDIXON), and short TI inversion recovery (STIR) sequences. The MRI presentation was used to determine MM infiltration patterns and calculate apparent diffusion coefficient (ADC) and a fat fraction (FF). The one-way ANOVA and Kruskal-Wallis test were used to compare the differences of these values between DS, ISS, and R-ISS stages in different MM infiltration patterns. Spearman correlation test was used for correlation analysis of ADC and FF against prognostic biomarkers, and two independent sample Results: The MRI presentation was classified into normal pattern (36 patients; 37.9%), diffuse (27 patients; 28.4%), and focal (32 patients; 33.7%) infiltration patterns. Statistically significant ADC and FF differences between different DS, ISS, and R-ISS stages were observed in normal/diffuse infiltration patterns but not in focal infiltration patterns. The ADC and FF of the normal/diffuse infiltration pattern showed correlations with hemoglobin, β2-microglobulin, bone marrow plasma cells, flow cytometry of bone marrow cells, and serum monoclonal protein. In contrast, ADC in focal infiltration patterns was negatively correlated with β2-microglobulin and C-reactive protein. The FF of patients with a normal/diffuse infiltration pattern was higher in the low free light-chain ratio group than that in the high free light-chain ratio group (P=0.023). Conclusions: Our observations indicate that quantitative whole-body functional MRI examination may serve as an effective complement to imaging diagnosis based on morphology and provide further information on the tumor burden of patients with MM.
Language	English
Publishing date	2021-07-28
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-20-1361
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Article ; Online: Precipitation-Use Efficiency and Its Conversion with Climate Types in Mainland China

Suping Wang / Qiang Zhang / Ping Yue / Jianshun Wang / Jinhu Yang / Wei Wang / Hongli Zhang / Xueyuan Ren

Remote Sensing, Vol 14, Iss 2467, p

2022 Volume 2467

Abstract: The impacts of climate change on ecosystem productivity and water resources over a long term in China are not well quantified. Precipitation-use efficiency (PUE) is a key parameter that describes carbon and water exchange in terrestrial ecosystems. ... ...

Abstract	The impacts of climate change on ecosystem productivity and water resources over a long term in China are not well quantified. Precipitation-use efficiency (PUE) is a key parameter that describes carbon and water exchange in terrestrial ecosystems. Research on the response of regional PUE to climate change and its driving forces is of great significance to climate-change mitigation and the sustainable development of regional ecology. Based on an improved actual evapotranspiration (ET a ) model, the responses of ET a , net primary productivity (NPP), and PUE to climate change in different climatic regions of China were analyzed; the contributions of various environmental factors to PUE changes were quantified; and the conversion characteristics and regulatory mechanisms of the PUE regime in different climatic regions were identified. The results indicate that the improved ET a model, after considering the limiting effect of energy on ET a in humid regions, can simulate the ET a distribution in China well. Over the past 58 years (1960–2017), ET a and NPP have increased in the western regions and decreased in the eastern regions, with the boundary at 103° E. PUE presents a “low-high-low” spatial distribution from northwest to southeast in China. It is noteworthy that there was a zonal distribution for a high value area of PUE, which coincided with the summer monsoon transition zone. The soil moisture (SM) increase in arid regions is the main driving force of the PUE increase, whereas the annual net radiation (Rn) change in humid regions is the main driving force of the PUE change. The transition zone is the conversion zone, where the prevailing factor limiting vegetation growth transitions from water to energy.
Keywords	typical climatic zones ; precipitation-use efficiency ; net primary productivity ; contribution of environmental factors ; transformation characteristics ; Science ; Q
Subject code	550
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The presence of busulfan metabolites and pharmacometabolomics in plasma drawn immediately before allograft infusion in hematopoietic cell transplant recipients

Jeannine S. McCune / Sandi L. Navarro / Linda J. Risler / Brian R. Phillips / Suping Ren / H. Gary Schoch / K. Scott Baker

Clinical and Translational Science, Vol 16, Iss 12, Pp 2577-

2023 Volume 2590

Abstract: Abstract Busulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ‐glutamyldehydroalanylglycine, which is too unstable to be quantitated in ... ...

Abstract	Abstract Busulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ‐glutamyldehydroalanylglycine, which is too unstable to be quantitated in vivo. We sought to evaluate if pre‐graft (i.e., immediately before allograft infusion) concentrations of busulfan metabolites' and of endogenous metabolomic compounds (EMCs) representing the glutathione pathway were associated with clinical outcomes in hematopoietic cell transplant (HCT) recipients receiving busulfan. The clinical outcomes evaluated were relapse, acute graft versus host disease (GVHD), chronic GVHD, non‐relapse mortality, and neutrophil nadir. In pre‐graft samples obtained from patients immediately before allograft infusion, our objectives were to evaluate for: (1) the presence of busulfan and its metabolites tetrahydrothiophenium ion (THT+), tetrahydrothiophene 1‐oxide, sulfolane, and 3‐hydroxysulfolane (N = 124); (2) EMCs using a global metabolomics assay (N = 77); and (3) the association of the busulfan metabolites and the EMCs with clinical outcomes. In the pre‐graft samples, busulfan and THT+ could not be detected. THT 1‐oxide, sulfolane, and 3‐hydroxysulfolane were quantitated in 9.6%, 26%, and 58% of pre‐graft samples; their concentrations were not associated with clinical outcomes. Four pre‐graft EMCs were statistically significantly associated with the neutrophil nadir. The pre‐graft EMCs were not associated with the other clinical outcomes. In conclusion, busulfan's metabolites are present in patients' plasma immediately before allograft infusion; the neutrophil nadir is associated with pre‐graft EMCs. Future research should investigate the association of clinical outcomes with the concentrations of busulfan's metabolites and EMCs in the pre‐graft plasma from allogeneic HCT recipients.
Keywords	Therapeutics. Pharmacology ; RM1-950 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Bacteroides vulgatus Ameliorates Lipid Metabolic Disorders and Modulates Gut Microbial Composition in Hyperlipidemic Rats.

Xu, Mingchao / Lan, Ruiting / Qiao, Lei / Lin, Xiaoying / Hu, Dalong / Zhang, Suping / Yang, Jing / Zhou, Juan / Ren, Zhihong / Li, Xianping / Liu, Guoxing / Liu, Liyun / Xu, Jianguo

Microbiology spectrum

2023 Volume 11, Issue 1, Page(s) e0251722

Abstract: Hyperlipidemia is a risk factor and key indicator for cardiovascular diseases, and the gut microbiota is highly associated with hyperlipidemia. Bacteroides vulgatus is a prevalent mutualist across human populations and confers multiple health benefits ... ...

Abstract	Hyperlipidemia is a risk factor and key indicator for cardiovascular diseases, and the gut microbiota is highly associated with hyperlipidemia. Bacteroides vulgatus is a prevalent mutualist across human populations and confers multiple health benefits such as immunoregulation, antiobesity, and coronary artery disease intervention. However, its role in antihyperlipidemia has not been systematically characterized. This study sought to identify the effect of B. vulgatus Bv46 on hyperlipidemia. Hyperlipidemic rats were modeled by feeding them a high-fat diet for 6 weeks. The effect of B. vulgatus Bv46 supplementation was evaluated by measuring anthropometric parameters, lipid and inflammation markers, and the liver pathology. Multi-omics was used to explore the underlying mechanisms. The ability of B. vulgatus Bv46 to produce bile salt hydrolase was confirmed by gene annotation and
MeSH term(s)	Rats ; Humans ; Animals ; Gastrointestinal Microbiome ; Ecosystem ; Bacteroides/metabolism ; Hyperlipidemias ; Fatty Acids, Volatile/metabolism ; Inflammation ; Lipid Metabolism ; Bile Acids and Salts
Chemical Substances	Fatty Acids, Volatile ; Bile Acids and Salts
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02517-22
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