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  1. Article ; Online: Kidney stones: KI at the crossroads of nephrology and urology.

    Wyatt, Christina M

    Kidney international

    2020  Volume 97, Issue 6, Page(s) 1070–1073

    MeSH term(s) Humans ; Kidney Calculi/therapy ; Nephrology ; Urology
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.03.019
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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Article ; Online: Real-world safety of pre-exposure prophylaxis for HIV.

    Burns, Charles M / Wyatt, Christina

    The lancet. HIV

    2022  Volume 9, Issue 4, Page(s) e225–e226

    MeSH term(s) Anti-HIV Agents/adverse effects ; HIV Infections/drug therapy ; HIV Infections/prevention & control ; Humans ; Pre-Exposure Prophylaxis ; Tenofovir/adverse effects
    Chemical Substances Anti-HIV Agents ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2022-03-07
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(22)00058-3
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  3. Article ; Online: HIV at 40: kidney disease in HIV treatment, prevention, and cure.

    Lucas, Anika / Wyatt, Christina M

    Kidney international

    2022  Volume 102, Issue 4, Page(s) 740–749

    Abstract: Four decades after the first cases of HIV were reported, kidney disease remains an important comorbidity in people with HIV (PWH). Both HIV-associated nephropathy and immune complex kidney disease were recognized as complications of HIV infection in the ... ...

    Abstract Four decades after the first cases of HIV were reported, kidney disease remains an important comorbidity in people with HIV (PWH). Both HIV-associated nephropathy and immune complex kidney disease were recognized as complications of HIV infection in the early years before treatment was available. Although the introduction of effective antiretroviral therapy in the late 1990s resulted in dramatic improvements in survival and health in PWH, several commonly used antiretroviral agents have been associated with kidney injury. HIV infection and treatment may also promote the progression of comorbid chronic kidney disease due to traditional risk factors such as diabetes, and HIV is one of the strongest "second hits" for the high-risk APOL1 genotype. Unique considerations in the management of chronic kidney disease in PWH are largely related to the need for lifelong antiretroviral therapy, with potential for toxicity, drug-drug interactions, and polypharmacy. PWH who develop progressive chronic kidney disease are candidates for all modalities of kidney replacement therapy, including kidney transplantation, and at some centers, PWH may be candidates to serve as donors for recipients with HIV. Transplantation of kidney allografts from donors with HIV also offers a unique opportunity to study viral dynamics in the kidney, with implications for kidney health and for research toward HIV cure. In addition, HIV-transgenic animal models have provided important insights into kidney disease pathogenesis beyond HIV, and experience with HIV and HIV-related kidney disease has provided important lessons for future pandemics.
    MeSH term(s) AIDS-Associated Nephropathy/epidemiology ; AIDS-Associated Nephropathy/therapy ; Animals ; Anti-Retroviral Agents/therapeutic use ; Antigen-Antibody Complex ; Apolipoprotein L1/genetics ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy
    Chemical Substances APOL1 protein, human ; Anti-Retroviral Agents ; Antigen-Antibody Complex ; Apolipoprotein L1
    Language English
    Publishing date 2022-07-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.06.021
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  4. Article ; Online: Regional and Racial Disparities in HIV-Related Kidney Disease.

    Sinclair, Matthew / Wyatt, Christina M

    Contributions to nephrology

    2021  Volume 199, Page(s) 106–113

    Abstract: Clinical Background and Epidemiology: Worldwide, an estimated 38 million people are living with HIV infection. The classic kidney disease of HIV infection, commonly known as HIV-associated nephropathy, is a collapsing form of focal segmental ... ...

    Abstract Clinical Background and Epidemiology: Worldwide, an estimated 38 million people are living with HIV infection. The classic kidney disease of HIV infection, commonly known as HIV-associated nephropathy, is a collapsing form of focal segmental glomerulosclerosis that almost exclusively affects individuals of African descent with advanced HIV disease. People living with HIV are also at risk for immune-complex kidney diseases, antiretroviral nephrotoxicity, and kidney disease due to co-infections and comorbidities. Challenges: The burden of HIV-related kidney disease is greatest in traditionally disadvantaged populations in resource-limited settings in sub-Saharan Africa and the Caribbean and among minority populations in the United States and Europe. Factors contributing to these disparities include a higher prevalence of HIV infection, limited access to optimal antiretroviral therapy, and genetic susceptibility to kidney disease. Treatment and Prevention: Current treatment guidelines recommend the initiation of life-long antiretroviral therapy in all people living with HIV to prevent AIDS and non-AIDS complications, including kidney disease. People living with HIV who progress to end-stage kidney disease despite treatment are candidates for dialysis and kidney transplant, including the possibility of accepting organs from HIV-positive donors in some settings. Although HIV prevention is currently the only definitive solution, expanding access to antiretroviral therapy, dialysis, and kidney transplantation in people living with HIV are important intermediate steps to address the global burden of HIV-related kidney disease.
    MeSH term(s) AIDS-Associated Nephropathy/epidemiology ; AIDS-Associated Nephropathy/etiology ; AIDS-Associated Nephropathy/therapy ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Kidney ; Renal Dialysis/adverse effects ; Renal Insufficiency/complications ; United States
    Language English
    Publishing date 2021-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2782 ; 0302-5144
    ISSN (online) 1662-2782
    ISSN 0302-5144
    DOI 10.1159/000517702
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  5. Article: Mechanisms of Proteinuria in HIV.

    Hall, Gentzon / Wyatt, Christina M

    Frontiers in medicine

    2021  Volume 8, Page(s) 749061

    Abstract: Proteinuria is common in the setting of HIV infection, and may reflect comorbid kidney disease, treatment-related nephrotoxicity, and HIV-related glomerular diseases. The mechanisms of podocyte and tubulointerstial injury in HIV-associated nephropathy ( ... ...

    Abstract Proteinuria is common in the setting of HIV infection, and may reflect comorbid kidney disease, treatment-related nephrotoxicity, and HIV-related glomerular diseases. The mechanisms of podocyte and tubulointerstial injury in HIV-associated nephropathy (HIVAN) have been the subject of intense investigation over the past four decades. The pathologic contributions of viral gene expression, dysregulated innate immune signaling, and ancestry-driven genetic risk modifiers have been explored in sophisticated cellular and whole animal models of disease. These studies provide evidence that injury-induced podocyte dedifferentiation, hyperplasia, cytoskeletal dysregulation, and apoptosis may cause the loss of glomerular filtration barrier integrity and slit diaphragm performance that facilitates proteinuria and tuft collapse in HIVAN. Although the incidence of HIVAN has declined with the introduction of antiretroviral therapy, the collapsing FSGS lesion has been observed in the context of other viral infections and chronic autoimmune disorders, and with the use of interferon-based therapies in genetically susceptible populations. This highlights the fact that the lesion is not specific to HIVAN and that the role of the immune system in aggravating podocyte injury warrants further exploration. This review will summarize our progress in characterizing the molecular mechanisms of podocyte dysfunction in HIVAN and other forms of HIV-associated kidney disease.
    Language English
    Publishing date 2021-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.749061
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  6. Article ; Online: Kidney Disease and HIV Infection.

    Wyatt, Christina M

    Topics in antiviral medicine

    2017  Volume 25, Issue 1, Page(s) 13–16

    Abstract: ... summarizes a presentation by Christina M. Wyatt, MD, at the Ryan White HIV/AIDS Program Clinical Care ...

    Abstract The risk of acute and chronic kidney disease remains higher in HIV-infected persons than in the general population, and kidney disease in HIV-infected persons is associated with poor outcomes, including increased mortality. HIV-associated nephropathy occurs less frequently in the era of antiretroviral therapy. HIV immune complex kidney disease is being diagnosed more frequently, but the term is currently used to refer to a heterogeneous group of kidney diseases. Comorbid chronic kidney disease poses a growing burden in HIV-infected persons due to an overrepresentation of risk factors such as black race, diabetes, hypertension, and coinfection with hepatitis C virus. Drug-induced kidney toxicity also remains a concern. This article summarizes a presentation by Christina M. Wyatt, MD, at the Ryan White HIV/AIDS Program Clinical Care Conference held in New Orleans, Louisiana, in December 2015.
    MeSH term(s) Comorbidity ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Kidney Diseases/complications ; Kidney Diseases/epidemiology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Prevalence
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5861
    ISSN (online) 2161-5853
    ISSN 2161-5861
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  7. Article ; Online: Inhibition of HIF prolyl-hydroxylase domain to correct anemia in patients with chronic kidney disease.

    Wyatt, Christina M / Drueke, Tilman B

    Kidney international

    2020  Volume 97, Issue 4, Page(s) 639–642

    MeSH term(s) Anemia ; Glycine/analogs & derivatives ; Humans ; Isoquinolines ; Prolyl Hydroxylases ; Renal Dialysis ; Renal Insufficiency, Chronic
    Chemical Substances Isoquinolines ; Prolyl Hydroxylases (EC 1.14.11.-) ; Glycine (TE7660XO1C) ; roxadustat (X3O30D9YMX)
    Language English
    Publishing date 2020-03-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.12.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Mechanisms of Proteinuria in HIV

    Gentzon Hall / Christina M. Wyatt

    Frontiers in Medicine, Vol

    2021  Volume 8

    Abstract: Proteinuria is common in the setting of HIV infection, and may reflect comorbid kidney disease, treatment-related nephrotoxicity, and HIV-related glomerular diseases. The mechanisms of podocyte and tubulointerstial injury in HIV-associated nephropathy ( ... ...

    Abstract Proteinuria is common in the setting of HIV infection, and may reflect comorbid kidney disease, treatment-related nephrotoxicity, and HIV-related glomerular diseases. The mechanisms of podocyte and tubulointerstial injury in HIV-associated nephropathy (HIVAN) have been the subject of intense investigation over the past four decades. The pathologic contributions of viral gene expression, dysregulated innate immune signaling, and ancestry-driven genetic risk modifiers have been explored in sophisticated cellular and whole animal models of disease. These studies provide evidence that injury-induced podocyte dedifferentiation, hyperplasia, cytoskeletal dysregulation, and apoptosis may cause the loss of glomerular filtration barrier integrity and slit diaphragm performance that facilitates proteinuria and tuft collapse in HIVAN. Although the incidence of HIVAN has declined with the introduction of antiretroviral therapy, the collapsing FSGS lesion has been observed in the context of other viral infections and chronic autoimmune disorders, and with the use of interferon-based therapies in genetically susceptible populations. This highlights the fact that the lesion is not specific to HIVAN and that the role of the immune system in aggravating podocyte injury warrants further exploration. This review will summarize our progress in characterizing the molecular mechanisms of podocyte dysfunction in HIVAN and other forms of HIV-associated kidney disease.
    Keywords podocyte ; glomerular disease ; HIVAN-associated nephropathy ; APOL1 ; collapsing FSGS ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Decreased incidence of end-stage renal disease in American Indians with diabetes: a model for other high-risk populations?

    Wyatt, Christina M

    Kidney international

    2017  Volume 91, Issue 4, Page(s) 766–768

    Abstract: Indigenous populations in North America have very high rates of diabetes and diabetic complications, including end-stage renal disease. A promising new report demonstrates a substantial decline in the incidence of diabetic end-stage renal disease among ... ...

    Abstract Indigenous populations in North America have very high rates of diabetes and diabetic complications, including end-stage renal disease. A promising new report demonstrates a substantial decline in the incidence of diabetic end-stage renal disease among American Indians and Alaska Natives, coinciding with a public health intervention targeting diabetes management in this population. This success may offer a model for interventions to improve kidney disease outcomes in other high-risk populations.
    MeSH term(s) Alaska Natives ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/ethnology ; Diabetes Mellitus/therapy ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/ethnology ; Diabetic Nephropathies/prevention & control ; Health Services, Indigenous ; Humans ; Incidence ; Indians, North American ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/ethnology ; Kidney Failure, Chronic/prevention & control ; Prognosis ; Public Health ; Risk Assessment ; Risk Factors ; Time Factors ; United States/epidemiology ; United States Indian Health Service
    Language English
    Publishing date 2017-03-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2017.01.027
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Removing race from GFR estimates: balancing potential benefits and unintended consequences.

    Lucas, Anika / Wyatt, Christina M / Inker, Lesley A

    Kidney international

    2021  Volume 100, Issue 1, Page(s) 11–13

    MeSH term(s) Creatinine ; Glomerular Filtration Rate ; Kidney
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2021-02-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.02.017
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