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Article: Editorial: Specific macroscopic brain changes in psychotic disorders.

Brandl, Felix / Knolle, Franziska / Meng, Chun / Borgwardt, Stefan

2023 Volume 17, Page(s) 1141866

Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2023.1141866
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of spectral basis set composition on estimated levels of cingulate glutamate and its associations with different personality traits.

Demler, Verena F / Sterner, Elisabeth F / Wilson, Martin / Zimmer, Claus / Knolle, Franziska

BMC psychiatry

2024 Volume 24, Issue 1, Page(s) 320

Abstract: Background: 1: Methods: To ensure comparability, we utilized five different exemplar basis sets, used in research, and two different analysis tools, r-based spant applying the ABfit method and Osprey using the LCModel.: Results: Our findings ... ...

Abstract	Background: 1 Methods: To ensure comparability, we utilized five different exemplar basis sets, used in research, and two different analysis tools, r-based spant applying the ABfit method and Osprey using the LCModel. Results: Our findings revealed that the types of metabolites included in the basis set significantly affected the glutamate concentration. We observed that three basis sets led to more consistent results across different concentration types (i.e., absolute Glu in mol/kg, Glx (glutamate + glutamine), Glu/tCr), spectral fit and quality measurements. Interestingly, all three basis sets included phosphocreatine. Importantly, our findings also revealed that glutamate levels were differently associated with both schizotypal and autistic traits depending on basis set configuration and analysis tool, with the same three basis sets showing more consistent results. Conclusions: Our study highlights that scientific results may be significantly altered depending on the choices of metabolites included in the basis set, and with that emphasizes the importance of carefully selecting the configuration of the basis set to ensure accurate and consistent results, when using MR spectroscopy. Overall, our study points out the need for standardized analysis pipelines and reporting.
MeSH term(s)	Humans ; Gyrus Cinguli/metabolism ; Glutamic Acid/metabolism ; Male ; Adult ; Female ; Proton Magnetic Resonance Spectroscopy/methods ; Young Adult ; Personality/physiology ; Psychotic Disorders/metabolism ; Magnetic Resonance Spectroscopy/methods ; Glutamine/metabolism
Chemical Substances	Glutamic Acid (3KX376GY7L) ; Glutamine (0RH81L854J)
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-024-05646-x
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Article ; Online: Association between increased anterior cingulate glutamate and psychotic-like experiences, but not autistic traits in healthy volunteers.

Demler, Verena F / Sterner, Elisabeth F / Wilson, Martin / Zimmer, Claus / Knolle, Franziska

Scientific reports

2023 Volume 13, Issue 1, Page(s) 12792

Abstract: Despite many differences, autism spectrum disorder and schizophrenia spectrum disorder share environmental risk factors, genetic predispositions as well as neuronal abnormalities, and show similar cognitive deficits in working memory, perspective taking, ...

Abstract	Despite many differences, autism spectrum disorder and schizophrenia spectrum disorder share environmental risk factors, genetic predispositions as well as neuronal abnormalities, and show similar cognitive deficits in working memory, perspective taking, or response inhibition. These shared abnormalities are already present in subclinical traits of these disorders. The literature proposes that changes in the inhibitory GABAergic and the excitatory glutamatergic system could explain underlying neuronal commonalities and differences. Using magnetic resonance spectroscopy (
MeSH term(s)	Humans ; Female ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/metabolism ; Glutamic Acid/metabolism ; Autism Spectrum Disorder/metabolism ; Healthy Volunteers ; Magnetic Resonance Spectroscopy
Chemical Substances	Glutamic Acid (3KX376GY7L)
Language	English
Publishing date	2023-08-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-39881-1
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Article ; Online: Neural Circuitry of Salience and Reward Processing in Psychosis.

Kesby, James P / Murray, Graham K / Knolle, Franziska

Biological psychiatry global open science

2021 Volume 3, Issue 1, Page(s) 33–46

Abstract: The processing of salient and rewarding stimuli is integral to engaging our attention, stimulating anticipation for future events, and driving goal-directed behaviors. Widespread impairments in these processes are observed in psychosis, which may be ... ...

Abstract	The processing of salient and rewarding stimuli is integral to engaging our attention, stimulating anticipation for future events, and driving goal-directed behaviors. Widespread impairments in these processes are observed in psychosis, which may be associated with worse functional outcomes or mechanistically linked to the development of symptoms. Here, we summarize the current knowledge of behavioral and functional neuroimaging in salience, prediction error, and reward. Although each is a specific process, they are situated in multiple feedback and feedforward systems integral to decision making and cognition more generally. We argue that the origin of salience and reward processing dysfunctions may be centered in the subcortex during the earliest stages of psychosis, with cortical abnormalities being initially more spared but becoming more prominent in established psychotic illness/schizophrenia. The neural circuits underpinning salience and reward processing may provide targets for delaying or preventing progressive behavioral and neurobiological decline.
Language	English
Publishing date	2021-12-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2667-1743
ISSN (online)	2667-1743
DOI	10.1016/j.bpsgos.2021.12.003
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Article ; Online: The impact of the COVID-19 pandemic on mental health in the general population: a comparison between Germany and the UK.

Knolle, Franziska / Ronan, Lisa / Murray, Graham K

BMC psychology

2021 Volume 9, Issue 1, Page(s) 60

Abstract: Background: The COVID-19 pandemic has led to dramatic social and economic changes in daily life. First studies report an impact on mental health of the general population showing increased levels of anxiety, stress and depression. In this study, we ... ...

Abstract	Background: The COVID-19 pandemic has led to dramatic social and economic changes in daily life. First studies report an impact on mental health of the general population showing increased levels of anxiety, stress and depression. In this study, we compared the impact of the pandemic on two culturally and economically similar European countries: the UK and Germany. Methods: Participants (UK = 241, German = 541) completed an online-survey assessing COVID-19 exposure, impact on financial situation and work, substance and media consumption, mental health using the Symptom-Check-List-27 (SCL-27) and the Schizotypal Personality Questionnaire. Results: We found distinct differences between the two countries. UK responders reported a stronger direct impact on health, financial situation and families. UK responders had higher clinical scores on the SCL-27, and higher prevalence. Interestingly, German responders were less hopeful for an end of the pandemic and more concerned about their life-stability. Conclusion: As 25% of both German and UK responders reported a subjective worsening of the general psychological symptoms and 20-50% of German and UK responders reached the clinical cut-off for depressive and dysthymic symptoms as well as anxieties, it specifically shows the need for tailored intervention systems to support large proportions of the general public.
MeSH term(s)	Anxiety/epidemiology ; COVID-19 ; Depression/epidemiology ; Germany/epidemiology ; Humans ; Mental Health ; Pandemics ; SARS-CoV-2 ; United Kingdom/epidemiology
Language	English
Publishing date	2021-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-021-00565-y
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Article ; Online: Investigating the relationship of COVID-19 related stress and media consumption with schizotypy, depression, and anxiety in cross-sectional surveys repeated throughout the pandemic in Germany and the UK.

Daimer, Sarah / Mihatsch, Lorenz L / Neufeld, Sharon A S / Murray, Graham K / Knolle, Franziska

eLife

2022 Volume 11

Abstract: Background: Studies report a strong impact of the COVID-19 pandemic and related stressors on the mental well-being of the general population. In this paper, we investigated whether COVID-19 related concerns and social adversity affected schizotypal ... ...

Abstract	Background: Studies report a strong impact of the COVID-19 pandemic and related stressors on the mental well-being of the general population. In this paper, we investigated whether COVID-19 related concerns and social adversity affected schizotypal traits, anxiety, and depression using structural equational modelling. In mediation analyses, we furthermore explored whether these associations were mediated by healthy (sleep and physical exercise) or unhealthy behaviours (drug and alcohol consumption, excessive media use). Methods: We assessed schizotypy, depression, and anxiety as well as healthy and unhealthy behaviours and a wide range of sociodemographic scores using online surveys from residents of Germany and the United Kingdom over 1 year during the COVID-19 pandemic. Four independent samples were collected (April/May 2020: N=781, September/October 2020: N=498, January/February 2021: N=544, May 2021: N=486). The degree of schizotypy was measured using the Schizotypal Personality Questionnaire (SPQ), anxiety, and depression symptoms were surveyed with the Symptom Checklist (SCL-27), and healthy and unhealthy behaviours were assessed with the Coronavirus Health Impact Survey (CRISIS). Structural equation models were used to consider the influence of COVID-19 related concerns and social adversity on depressive and anxiety-related symptoms and schizotypal traits in relation to certain healthy (sleep and exercise) and unhealthy behaviours (alcohol and drug consumption, excessive media use). Results: The results revealed that COVID-19 related life concerns were significantly associated with schizotypy in the September/October 2020 and May 2021 surveys, with anxiety in the September/October 2020, January/February 2021, and May 2021 surveys, and with depressive symptoms in all surveys. Social adversity significantly affected the expression of schizotypal traits and depressive and anxiety symptoms in all four surveys. Importantly, we found that excessive media consumption (>4 hr per day) fully mediated the relationship between COVID-19 related life concerns and schizotypal traits in the January/February 2021 survey. Furthermore, several of the surveys showed that excessive media consumption was associated with increased depressive and anxiety-related symptoms in people burdened by COVID-19 related life. Conclusions: The ongoing uncertainties of the pandemic and the restrictions on social life have a strong impact on mental well-being and especially the expression of schizotypal traits. The negative impact is further boosted by excessive media consumption, which is especially critical for people with high schizotypal traits. Funding: FK received funding from the European Union's Horizon 2020 (Grant number 754,462). SN received funding from the Cundill Centre for Child and Youth Depression at the Centre for Addiction and Mental Health, Toronto, Canada and the Wellcome Trust Institutional Strategic Support Fund from the University of Cambridge.
MeSH term(s)	Adolescent ; Anxiety/psychology ; COVID-19/epidemiology ; Child ; Cross-Sectional Studies ; Depression/epidemiology ; Germany/epidemiology ; Humans ; Pandemics ; Schizotypal Personality Disorder
Language	English
Publishing date	2022-07-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.75893
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Book ; Online ; Thesis: Der Einfluss von Hepatitis-B-Virus auf den E-Cadherin-beta-Catenin-Komplex und seine Folgen für die hepatozelluläre Karzinogenese

Olshausen, Gesa von / Protzer-Knolle, Ulrike / Goeser, Tobias

2010

Institution	Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
Author's details	vorgelegt von Gesa Franziska von Olshausen ; 1. Berichterstatterin: Frau Universitätsprofessor Dr. med. U. Protzer, 2. Berichterstatter: Universitätsprofessor Dr. med. T. Goeser ; aus dem Institut für medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln
Subject code	610
Language	German
Publishing country	Germany
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 2010
Note	Open Access
HBZ-ID	HT016290673
DOI	10.4126/38m-000000210
Database	Repository for Life Sciences

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Book ; Thesis: Der Einfluss von Hepatitis-B-Virus auf den E-Cadherin-beta-Catenin-Komplex und seine Folgen für die hepatozelluläre Karzinogenese

Olshausen, Gesa von / Protzer-Knolle, Ulrike / Goeser, Tobias

2010

Institution	Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
Author's details	vorgelegt von Gesa Franziska von Olshausen ; 1. Berichterstatterin: Frau Universitätsprofessor Dr. med. U. Protzer, 2. Berichterstatter: Universitätsprofessor Dr. med. T. Goeser ; aus dem Institut für medizinische Mikrobiologie, Immunologie und Hygiene der Universität zu Köln
Language	German
Size	82 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 2010
HBZ-ID	HT016382371
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2010 D 1274	order for loan	Magazin

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Article ; Online: Survey of German medical students during the COVID-19 pandemic: attitudes toward volunteering versus compulsory service and associated factors.

Mihatsch, Lorenz / von der Linde, Mira / Knolle, Franziska / Luchting, Benjamin / Dimitriadis, Konstantinos / Heyn, Jens

Journal of medical ethics

2021 Volume 48, Issue 9, Page(s) 630–636

Abstract: Due to the spread of COVID-19, a key challenge was to reduce potential staff shortages in the healthcare sector. Besides recruiting retired healthcare workers, medical students were considered to support this task. Commitment of medical students in ... ...

Abstract	Due to the spread of COVID-19, a key challenge was to reduce potential staff shortages in the healthcare sector. Besides recruiting retired healthcare workers, medical students were considered to support this task. Commitment of medical students in Germany during the COVID-19 pandemic was evaluated using an online survey, with particular focus on their burdens and anxieties. This survey was distributed to students within a 2-week period in April and May 2020. Ultimately, 1241 participants were included in the analysis. During the pandemic, 67.9% (65.3% to 70.5%) of the participants reported that they had volunteered. Furthermore, 88.9% (86.9% to 90.5%) stated that they were against compulsory recruitment in this context. Students who volunteered (committed students) had a significantly lower anxiety index than non-committed students. Additionally, students were more concerned about infecting other patients and relatives than themselves. Higher levels of anxiety were related to lower levels of commitment. A mandatory assignment during the pandemic was rejected by the students and does not seem to be necessary due to the large number of volunteers.
MeSH term(s)	COVID-19/epidemiology ; Humans ; Pandemics ; Students, Medical ; Surveys and Questionnaires ; Volunteers
Language	English
Publishing date	2021-05-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194927-5
ISSN	1473-4257 ; 0306-6800
ISSN (online)	1473-4257
ISSN	0306-6800
DOI	10.1136/medethics-2020-107202
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Article: Subjective Impact of the COVID-19 Pandemic on Schizotypy and General Mental Health in Germany and the United Kingdom, for Independent Samples in May and in October 2020.

Daimer, Sarah / Mihatsch, Lorenz / Ronan, Lisa / Murray, Graham K / Knolle, Franziska

Frontiers in psychology

2021 Volume 12, Page(s) 667848

Abstract: Studies reported a strong impact on mental health during the first wave of the COVID-19 pandemic in March-June, 2020. In this study, we assessed the impact of the pandemic on mental health in general and on schizotypal traits in two independent general ... ...

Abstract	Studies reported a strong impact on mental health during the first wave of the COVID-19 pandemic in March-June, 2020. In this study, we assessed the impact of the pandemic on mental health in general and on schizotypal traits in two independent general population samples of the United Kingdom (May sample N: 239, October sample N: 126; participation at both timepoints: 21) and in two independent general population samples of Germany (May sample N: 543, October sample N: 401; participation at both timepoints: 100) using online surveys. Whereas general psychological symptoms (global symptom index, GSI) and percentage of responders above clinical cut-off for further psychological investigation were higher in the May sample compared to the October sample, schizotypy scores (Schizotypal Personality Questionnaire) were higher in the October sample. We investigated potential associations, using general linear regression models (GLM). For schizotypy scores, we found that loneliness, use of drugs, and financial burden were more strongly corrected with schizotypy in the October compared to the May sample. We identified similar associations for GSI, as for schizotypy scores, in the May and October samples. We furthermore found that living in the United Kingdom was related to higher schizotypal scores or GSI. However, individual estimates of the GLM are highly comparable between the two countries. In conclusion, this study shows that while the general psychological impact is lower in the October than the May sample, potentially showing a normative response to an exceptional situation; schizotypy scores are higher at the second timepoint, which may be due to a stronger impact of estimates of loneliness, drug use, and financial burden. The ongoing, exceptional circumstances within this pandemic might increase the risk for developing psychosis in some individuals. The development of general psychological symptoms and schizotypy scores over time requires further attention and investigation.
Language	English
Publishing date	2021-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.667848
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