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Article ; Online: Measurement of e^{+}e^{-} Momentum and Angular Distributions from Linearly Polarized Photon Collisions.

Adam, J / Adamczyk, L / Adams, J R / Adkins, J K / Agakishiev, G / Aggarwal, M M / Ahammed, Z / Alekseev, I / Anderson, D M / Aparin, A / Aschenauer, E C / Ashraf, M U / Atetalla, F G / Attri, A / Averichev, G S / Bairathi, V / Barish, K / Behera, A / Bellwied, R /

Bhasin, A / Bielcik, J / Bielcikova, J / Bland, L C / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Butterworth, J / Caines, H / Calderón de la Barca Sánchez, M / Cebra, D / Chakaberia, I / Chaloupka, P / Chan, B K / Chang, F-H / Chang, Z / Chankova-Bunzarova, N / Chatterjee, A / Chen, D / Chen, J H / Chen, X / Chen, Z / Cheng, J / Cherney, M / Chevalier, M / Choudhury, S / Christie, W / Crawford, H J / Csanád, M / Daugherity, M / Dedovich, T G / Deppner, I M / Derevschikov, A A / Didenko, L / Dong, X / Drachenberg, J L / Dunlop, J C / Edmonds, T / Elsey, N / Engelage, J / Eppley, G / Esha, R / Esumi, S / Evdokimov, O / Ewigleben, A / Eyser, O / Fatemi, R / Fazio, S / Federic, P / Fedorisin, J / Feng, C J / Feng, Y / Filip, P / Finch, E / Fisyak, Y / Francisco, A / Fulek, L / Gagliardi, C A / Galatyuk, T / Geurts, F / Gibson, A / Gopal, K / Grosnick, D / Hamad, A I / Hamed, A / Harris, J W / He, S / He, W / He, X / Heppelmann, S / Herrmann, N / Hoffman, E / Holub, L / Hong, Y / Horvat, S / Hu, Y / Huang, H Z / Huang, S L / Huang, T / Huang, X / Humanic, T J / Huo, P / Igo, G / Isenhower, D / Jacobs, W W / Jena, C / Jentsch, A / Ji, Y / Jia, J / Jiang, K / Jowzaee, S / Ju, X / Judd, E G / Kabana, S / Kabir, M L / Kagamaster, S / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kelsey, M / Khyzhniak, Y V / Kikoła, D P / Kim, C / Kimelman, B / Kincses, D / Kinghorn, T A / Kisel, I / Kiselev, A / Kisiel, A / Klein, S R / Kocan, M / Kochenda, L / Kosarzewski, L K / Kramarik, L / Kravtsov, P / Krueger, K / Kulathunga Mudiyanselage, N / Kumar, L / Kunnawalkam Elayavalli, R / Kwasizur, J H / Lacey, R / Lan, S / Landgraf, J M / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Leung, Y H / Li, C / Li, W / Li, X / Li, Y / Liang, Y / Licenik, R / Lin, T / Lin, Y / Lisa, M A / Liu, F / Liu, H / Liu, P / Liu, T / Liu, X / Liu, Y / Liu, Z / Ljubicic, T / Llope, W J / Longacre, R S / Lukow, N S / Luo, S / Luo, X / Ma, G L / Ma, L / Ma, R / Ma, Y G / Magdy, N / Majka, R / Mallick, D / Margetis, S / Markert, C / Matis, H S / Mazer, J A / Minaev, N G / Mioduszewski, S / Mohanty, B / Mooney, I / Moravcova, Z / Morozov, D A / Nagy, M / Nam, J D / Nasim, Md / Nayak, K / Neff, D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nogach, L V / Nonaka, T / Odyniec, G / Ogawa, A / Oh, S / Okorokov, V A / Page, B S / Pak, R / Pandav, A / Panebratsev, Y / Pawlik, B / Pawlowska, D / Pei, H / Perkins, C / Pinsky, L / Pintér, R L / Pluta, J / Porter, J / Posik, M / Pruthi, N K / Przybycien, M / Putschke, J / Qiu, H / Quintero, A / Radhakrishnan, S K / Ramachandran, S / Ray, R L / Reed, R / Ritter, H G / Roberts, J B / Rogachevskiy, O V / Romero, J L / Ruan, L / Rusnak, J / Sahoo, N R / Sako, H / Salur, S / Sandweiss, J / Sato, S / Schmidke, W B / Schmitz, N / Schweid, B R / Seck, F / Seger, J / Sergeeva, M / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Shen, F / Shen, W Q / Shi, S S / Shou, Q Y / Sichtermann, E P / Sikora, R / Simko, M / Singh, J / Singha, S / Smirnov, N / Solyst, W / Sorensen, P / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stefaniak, M / Stewart, D J / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sumbera, M / Summa, B / Sun, X M / Sun, Y / Surrow, B / Svirida, D N / Szymanski, P / Tang, A H / Tang, Z / Taranenko, A / Tarnowsky, T / Thomas, J H / Timmins, A R / Tlusty, D / Tokarev, M / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tripathy, S K / Tsai, O D / Tu, Z / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vanek, J / Vasiliev, A N / Vassiliev, I / Videbæk, F / Vokal, S / Voloshin, S A / Wang, F / Wang, G / Wang, J S / Wang, P / Wang, Y / Wang, Z / Webb, J C / Weidenkaff, P C / Wen, L / Westfall, G D / Wieman, H / Wissink, S W / Witt, R / Wu, Y / Xiao, Z G / Xie, G / Xie, W / Xu, H / Xu, N / Xu, Q H / Xu, Y F / Xu, Y / Xu, Z / Yang, C / Yang, Q / Yang, S / Yang, Y / Yang, Z / Ye, Z / Yi, L / Yip, K / Zbroszczyk, H / Zha, W / Zhang, D / Zhang, S / Zhang, X P / Zhang, Y / Zhang, Z J / Zhang, Z / Zhao, J / Zhong, C / Zhou, C / Zhu, X / Zhu, Z / Zurek, M / Zyzak, M

Physical review letters

2021 Volume 127, Issue 5, Page(s) 52302

Abstract: ... at the experimental limit of ≤0.2% of the observed yields. The differential cross section as a function of e^{+}e^ ...

Abstract	The Breit-Wheeler process which produces matter and antimatter from photon collisions is experimentally investigated through the observation of 6085 exclusive electron-positron pairs in ultraperipheral Au+Au collisions at sqrt[s_{NN}]=200 GeV. The measurements reveal a large fourth-order angular modulation of cos4Δϕ=(16.8±2.5)% and smooth invariant mass distribution absent of vector mesons (ϕ, ω, and ρ) at the experimental limit of ≤0.2% of the observed yields. The differential cross section as a function of e^{+}e^{-} pair transverse momentum P_{⊥} peaks at low value with sqrt[⟨P_{⊥}^{2}⟩]=38.1±0.9 MeV and displays a significant centrality dependence. These features are consistent with QED calculations for the collision of linearly polarized photons quantized from the extremely strong electromagnetic fields generated by the highly charged Au nuclei at ultrarelativistic speed. The experimental results have implications for vacuum birefringence and for mapping the magnetic field which is important for emergent QCD phenomena.
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.052302
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Article ; Online: Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor cells.

Slováková, Jana / Sikora, Mateusz / Arslan, Feyza Nur / Caballero-Mancebo, Silvia / Krens, S F Gabriel / Kaufmann, Walter A / Merrin, Jack / Heisenberg, Carl-Philipp

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 8

Abstract: Tension of the actomyosin cell cortex plays a key role in determining cell-cell contact growth and size. The level of cortical tension outside of the cell-cell contact, when pulling at the contact edge, scales with the total size to which a cell-cell ... ...

Abstract	Tension of the actomyosin cell cortex plays a key role in determining cell-cell contact growth and size. The level of cortical tension outside of the cell-cell contact, when pulling at the contact edge, scales with the total size to which a cell-cell contact can grow [J.-L. Maître
MeSH term(s)	Actin Cytoskeleton/physiology ; Actins/metabolism ; Actomyosin/metabolism ; Animals ; Cadherins/metabolism ; Cadherins/physiology ; Cell Adhesion/physiology ; Cell Communication/physiology ; Cell Proliferation/physiology ; Cytoskeleton/physiology ; Germ Cells/growth & development ; Germ Cells/metabolism ; Germ Cells/physiology ; Stem Cells/physiology ; Zebrafish/metabolism ; alpha Catenin/metabolism
Chemical Substances	Actins ; Cadherins ; alpha Catenin ; Actomyosin (9013-26-7)
Language	English
Publishing date	2022-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2122030119
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Article ; Online: Hepatitis E Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3.

Norder, Heléne / Galli, Cristina / Magnil, Ellen / Sikora, Per / Ekvärn, Elisabet / Nyström, Kristina / Magnius, Lars O

Intervirology

2018 Volume 61, Issue 2, Page(s) 96–103

Abstract: Hepatitis E virus (HEV) is a pathogen that causes hepatitis worldwide. Molecular studies have ...

Abstract	Hepatitis E virus (HEV) is a pathogen that causes hepatitis worldwide. Molecular studies have identified HEV RNA in blood products although its significance is not understood. This study was undertaken to characterize HEV genomes in asymptomatic plasma donors from Sweden and Germany lacking anti-HEV. Complete open reading frames (ORFs) were obtained from HEV strains in 5 out of 18 plasma donors who tested positive for HEV RNA. All strains had CUG as the start codon of ORF3, while 147 GenBank strains all had AUG as the start codon (p < 0.0001). This substitution was found in both interrelated and unrelated strains belonging to different phylogenetic clades. The HEV strains from the seronegative plasma donors had no other substitution in common, which may be why the CUG substitution seems to explain the seronegativity.
MeSH term(s)	Amino Acid Sequence ; Blood Donors ; Codon, Initiator ; Genome, Viral ; Genotype ; Hepatitis E/virology ; Hepatitis E virus/classification ; Hepatitis E virus/genetics ; Hepatitis E virus/immunology ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Open Reading Frames ; Phylogeny ; RNA, Viral ; Viral Proteins/chemistry ; Viral Proteins/genetics
Chemical Substances	Codon, Initiator ; Immunoglobulin G ; Immunoglobulin M ; ORF3 protein, Hepatitis E virus ; RNA, Viral ; Viral Proteins
Language	English
Publishing date	2018-10-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	184545-7
ISSN	1423-0100 ; 0300-5526
ISSN (online)	1423-0100
ISSN	0300-5526
DOI	10.1159/000491926
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Article ; Online: Low-p_{T} e^{+}e^{-} Pair Production in Au+Au Collisions at sqrt[s_{NN}]=200 GeV and U+U Collisions at sqrt[s_{NN}]=193 GeV at STAR.

Adam, J / Adamczyk, L / Adams, J R / Adkins, J K / Agakishiev, G / Aggarwal, M M / Ahammed, Z / Ajitanand, N N / Alekseev, I / Anderson, D M / Aoyama, R / Aparin, A / Arkhipkin, D / Aschenauer, E C / Ashraf, M U / Atetalla, F / Attri, A / Averichev, G S / Bai, X /

Bairathi, V / Barish, K / Bassill, A J / Behera, A / Bellwied, R / Bhasin, A / Bhati, A K / Bielcik, J / Bielcikova, J / Bland, L C / Bordyuzhin, I G / Brandenburg, J D / Brandin, A V / Brown, D / Bryslawskyj, J / Bunzarov, I / Butterworth, J / Caines, H / Calderón de la Barca Sánchez, M / Campbell, J M / Cebra, D / Chakaberia, I / Chaloupka, P / Chang, F-H / Chang, Z / Chankova-Bunzarova, N / Chatterjee, A / Chattopadhyay, S / Chen, J H / Chen, X / Cheng, J / Cherney, M / Christie, W / Contin, G / Crawford, H J / Das, S / Dedovich, T G / Deppner, I M / Derevschikov, A A / Didenko, L / Dilks, C / Dong, X / Drachenberg, J L / Dunlop, J C / Efimov, L G / Elsey, N / Engelage, J / Eppley, G / Esha, R / Esumi, S / Evdokimov, O / Ewigleben, J / Eyser, O / Fatemi, R / Fazio, S / Federic, P / Federicova, P / Fedorisin, J / Filip, P / Finch, E / Fisyak, Y / Flores, C E / Fulek, L / Gagliardi, C A / Galatyuk, T / Geurts, F / Gibson, A / Grosnick, D / Gunarathne, D S / Guo, Y / Gupta, A / Guryn, W / Hamad, A I / Hamed, A / Harlenderova, A / Harris, J W / He, L / Heppelmann, S / Herrmann, N / Hirsch, A / Holub, L / Horvat, S / Huang, X / Huang, B / Huang, S L / Huang, H Z / Huang, T / Humanic, T J / Huo, P / Igo, G / Jacobs, W W / Jentsch, A / Jia, J / Jiang, K / Jowzaee, S / Judd, E G / Kabana, S / Kalinkin, D / Kang, K / Kapukchyan, D / Kauder, K / Ke, H W / Keane, D / Kechechyan, A / Kikoła, D P / Kim, C / Kinghorn, T A / Kisel, I / Kisiel, A / Klein, S R / Kochenda, L / Kosarzewski, L K / Kraishan, A F / Kramarik, L / Krauth, L / Kravtsov, P / Krueger, K / Kulathunga, N / Kumar, S / Kumar, L / Kvapil, J / Kwasizur, J H / Lacey, R / Landgraf, J M / Lauret, J / Lebedev, A / Lednicky, R / Lee, J H / Li, X / Li, C / Li, W / Li, Y / Liang, Y / Lidrych, J / Lin, T / Lipiec, A / Lisa, M A / Liu, F / Liu, P / Liu, H / Liu, Y / Ljubicic, T / Llope, W J / Lomnitz, M / Longacre, R S / Luo, X / Luo, S / Ma, G L / Ma, Y G / Ma, L / Ma, R / Magdy, N / Majka, R / Mallick, D / Margetis, S / Markert, C / Matis, H S / Matonoha, O / Mayes, D / Mazer, J A / Meehan, K / Mei, J C / Minaev, N G / Mioduszewski, S / Mishra, D / Mohanty, B / Mondal, M M / Mooney, I / Morozov, D A / Nasim, Md / Negrete, J D / Nelson, J M / Nemes, D B / Nie, M / Nigmatkulov, G / Niida, T / Nogach, L V / Nonaka, T / Nurushev, S B / Odyniec, G / Ogawa, A / Oh, K / Oh, S / Okorokov, V A / Olvitt, D / Page, B S / Pak, R / Panebratsev, Y / Pawlik, B / Pei, H / Perkins, C / Pluta, J / Porter, J / Posik, M / Pruthi, N K / Przybycien, M / Putschke, J / Quintero, A / Radhakrishnan, S K / Ramachandran, S / Ray, R L / Reed, R / Ritter, H G / Roberts, J B / Rogachevskiy, O V / Romero, J L / Ruan, L / Rusnak, J / Rusnakova, O / Sahoo, N R / Sahu, P K / Salur, S / Sandweiss, J / Schambach, J / Schmah, A M / Schmidke, W B / Schmitz, N / Schweid, B R / Seck, F / Seger, J / Sergeeva, M / Seto, R / Seyboth, P / Shah, N / Shahaliev, E / Shanmuganathan, P V / Shao, M / Shen, W Q / Shen, F / Shi, S S / Shou, Q Y / Sichtermann, E P / Siejka, S / Sikora, R / Simko, M / Singha, S / Smirnov, N / Smirnov, D / Solyst, W / Sorensen, P / Spinka, H M / Srivastava, B / Stanislaus, T D S / Stewart, D J / Strikhanov, M / Stringfellow, B / Suaide, A A P / Sugiura, T / Sumbera, M / Summa, B / Sun, Y / Sun, X / Sun, X M / Surrow, B / Svirida, D N / Szymanski, P / Tang, Z / Tang, A H / Taranenko, A / Tarnowsky, T / Thomas, J H / Timmins, A R / Tlusty, D / Todoroki, T / Tokarev, M / Tomkiel, C A / Trentalange, S / Tribble, R E / Tribedy, P / Tripathy, S K / Tsai, O D / Tu, B / Ullrich, T / Underwood, D G / Upsal, I / Van Buren, G / Vanek, J / Vasiliev, A N / Vassiliev, I / Videbæk, F / Vokal, S / Voloshin, S A / Vossen, A / Wang, G / Wang, Y / Wang, F / Webb, J C / Wen, L / Westfall, G D / Wieman, H / Wissink, S W / Witt, R / Wu, Y / Xiao, Z G / Xie, G / Xie, W / Xu, Q H / Xu, Z / Xu, J / Xu, Y F / Xu, N / Yang, S / Yang, C / Yang, Q / Yang, Y / Ye, Z / Yi, L / Yip, K / Yoo, I-K / Yu, N / Zbroszczyk, H / Zha, W / Zhang, Z / Zhang, L / Zhang, Y / Zhang, X P / Zhang, J / Zhang, S / Zhao, J / Zhong, C / Zhou, C / Zhou, L / Zhu, Z / Zhu, X / Zyzak, M

Physical review letters

2018 Volume 121, Issue 13, Page(s) 132301

Abstract: We report first measurements of e^{+}e^{-} pair production in the mass region 0.4

Abstract	We report first measurements of e^{+}e^{-} pair production in the mass region 0.4<M_{ee}<2.6 GeV/c^{2} at low transverse momentum (p_{T}<0.15 GeV/c) in noncentral Au+Au collisions at sqrt[s_{NN}]=200 GeV and U+U collisions at sqrt[s_{NN}]=193 GeV. Significant enhancement factors, expressed as ratios of data over known hadronic contributions, are observed in the 40%-80% centrality of these collisions. The excess yields peak distinctly at low p_{T} with a width (sqrt[⟨p_{T}^{2}⟩]) between 40 and 60 MeV/c. The absolute cross section of the excess depends weakly on centrality, while those from a theoretical model calculation incorporating an in-medium broadened ρ spectral function and radiation from a quark gluon plasma or hadronic cocktail contributions increase dramatically with an increasing number of participant nucleons. Model calculations of photon-photon interactions generated by the initial projectile and target nuclei describe the observed excess yields but fail to reproduce the p_{T}^{2} distributions.<br />
Language	English
Publishing date	2018-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.121.132301
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Article ; Online: Hepatitis E virus genotype 3 strains and a plethora of other viruses detected in raw and still in tap water.

Wang, Hao / Kjellberg, Inger / Sikora, Per / Rydberg, Henrik / Lindh, Magnus / Bergstedt, Olof / Norder, Heléne

Water research

2019 Volume 168, Page(s) 115141

Abstract: ... However, for some viruses the reduction was 3.5-log10 after UF, as for hepatitis E virus (HEV), which was also detected ...

Abstract	In this study, next generation sequencing was used to explore the virome in 20L up to 10,000L water from different purification steps at two Swedish drinking water treatment plants (DWTPs), and in tap water. One DWTP used ultrafiltration (UF) with 20 nm pores, the other UV light treatment after conventional treatment of the water. Viruses belonging to 26 different families were detected in raw water, in which 6-9 times more sequence reads were found for phages than for known environmental, plant or vertebrate viruses. The total number of viral reads was reduced more than 4-log10 after UF and 3-log10 over UV treatment. However, for some viruses the reduction was 3.5-log10 after UF, as for hepatitis E virus (HEV), which was also detected in tap water, with sequences similar to those in raw water and after treatment. This indicates that HEV had passed through the treatment and entered into the supply network. However, the viability of the viruses is unknown. In tap water 10-130 International Units of HEV RNA/mL were identified, which is a comparable low amount of virus. The risk of getting infected through consumption of tap water is probably negligible, but needs to be investigated. The HEV strains in the waters belonged to subtypes HEV3a and HEV3c/i, which is associated with unknown source of infection in humans infected in Sweden. None of these subtypes are common among pigs or wild boar, the major reservoirs for HEV, indicating that water may play a role in transmitting this virus. The results indicate that monitoring small fecal/oral transmitted viruses in DWTPs may be considered, especially during community outbreaks, to prevent potential transmission by tap water.
MeSH term(s)	Animals ; Genotype ; Hepatitis E virus ; Humans ; Phylogeny ; RNA, Viral ; Sweden ; Swine ; Swine Diseases ; Viruses
Chemical Substances	RNA, Viral
Language	English
Publishing date	2019-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2019.115141
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Article ; Online: Distance Measurement on an Endogenous Membrane Transporter in E. coli Cells and Native Membranes Using EPR Spectroscopy.

Joseph, Benesh / Sikora, Arthur / Bordignon, Enrica / Jeschke, Gunnar / Cafiso, David S / Prisner, Thomas F

Angewandte Chemie (International ed. in English)

2015 Volume 54, Issue 21, Page(s) 6196–6199

Abstract: Membrane proteins may be influenced by the environment, and they may be unstable in detergents or fail to crystallize. As a result, approaches to characterize structures in a native environment are highly desirable. Here, we report a novel general ... ...

Abstract	Membrane proteins may be influenced by the environment, and they may be unstable in detergents or fail to crystallize. As a result, approaches to characterize structures in a native environment are highly desirable. Here, we report a novel general strategy for precise distance measurements on outer membrane proteins in whole Escherichia coli cells and isolated outer membranes. The cobalamin transporter BtuB was overexpressed and spin-labeled in whole cells and outer membranes and interspin distances were measured to a spin-labeled cobalamin using pulse EPR spectroscopy. A comparative analysis of the data reveals a similar interspin distance between whole cells, outer membranes, and synthetic vesicles. This approach provides an elegant way to study conformational changes or protein-protein/ligand interactions at surface-exposed sites of membrane protein complexes in whole cells and native membranes, and provides a method to validate outer membrane protein structures in their native environment.
MeSH term(s)	Bacterial Outer Membrane Proteins/chemistry ; Electron Spin Resonance Spectroscopy/methods ; Escherichia coli/chemistry ; Escherichia coli Proteins/chemistry ; Membrane Transport Proteins/chemistry ; Models, Molecular
Chemical Substances	Bacterial Outer Membrane Proteins ; BtuB protein, E coli ; Escherichia coli Proteins ; Membrane Transport Proteins
Language	English
Publishing date	2015-05-18
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201501086
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Article: Comparative Seroprevalence of Hepatitis A And E Viruses in Blood Donors from Wielkopolska Region, West-Central Poland.

Bura, Maciej / Łagiedo-Żelazowska, Małgorzata / Michalak, Michał / Sikora, Jan / Mozer-Lisewska, Iwona

Polish journal of microbiology

2018 Volume 67, Issue 1, Page(s) 113–115

Abstract: The objective of the present study was to investigate the seroprevalence of HAV and HEV in Polish blood donors (BDs). One hundred and ten randomly selected healthy BDs, living in Wielkopolska Region were tested for anti-HAV IgG and anti-HEV IgG with ... ...

Abstract	The objective of the present study was to investigate the seroprevalence of HAV and HEV in Polish blood donors (BDs). One hundred and ten randomly selected healthy BDs, living in Wielkopolska Region were tested for anti-HAV IgG and anti-HEV IgG with commercial assays. The seroprevalence of anti-HAV was 11.8%; anti-HEV were detected in 60.9% of BDs (p < 0.0001). Consumption of risky food was more common in anti-HEV-positive BDs (59.1% vs. 33.3%; p = 0.01). Twelve out of 20 BDs (60%) with no history of travel abroad were exposed to HEV. Wielkopolska Region, Poland should be regarded as a new HEV infection-hyperendemic area in Europe.
MeSH term(s)	Adult ; Blood Donors ; Female ; Hepatitis A/epidemiology ; Hepatitis A virus/isolation & purification ; Hepatitis Antibodies/blood ; Hepatitis E/epidemiology ; Hepatitis E virus/isolation & purification ; Humans ; Male ; Middle Aged ; Poland/epidemiology ; Seroepidemiologic Studies ; Young Adult
Chemical Substances	Hepatitis Antibodies
Language	English
Publishing date	2018-07-17
Publishing country	Poland
Document type	Comparative Study ; Journal Article
ZDB-ID	2234080-4
ISSN	2544-4646 ; 1733-1331
ISSN (online)	2544-4646
ISSN	1733-1331
DOI	10.5604/01.3001.0011.6151
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Book: Vibrio cholerae

Sikora, Aleksandra E.

methods and protocols

(Methods in molecular biology ; 1839 ; Springer protocols)

2018

Author's details	edited by Aleksandra E. Sikora
Series title	Methods in molecular biology ; 1839 Springer protocols
Collection
Keywords	Vibrio cholerae / Laboratory manuals ; Vibrio cholerae
Language	English
Size	x, 180 Seiten, Illustrationen
Publisher	Humana Press
Publishing place	New York
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT019861556
ISBN	978-1-4939-8684-2 ; 9781493986859 ; 1-4939-8684-8 ; 1493986856
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Article ; Online: Hepatitis E virus IgG seroprevalence in HIV patients and blood donors, west-central Poland.

Bura, Maciej / Łagiedo, Małgorzata / Michalak, Michał / Sikora, Jan / Mozer-Lisewska, Iwona

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2017 Volume 61, Page(s) 20–22

Abstract: Objective: To assess hepatitis E virus (HEV) seroprevalence in HIV patients and blood donors ...

Abstract	Objective: To assess hepatitis E virus (HEV) seroprevalence in HIV patients and blood donors from one region in Poland. Methods: A group of 490 persons (244 HIV patients and 246 blood donors) aged 18-55 years were examined using the anti-HEV IgG assay (Wantai Biological Pharmacy Enterprise, Beijing, China). An analysis of the association between certain factors and the presence of this HEV exposure marker was conducted in both groups. Results: An HEV seropositivity rate of 50.2% was found. There was no difference in HEV seroprevalence between blood donors (49.6%, 122/246) and HIV patients (50.8%, 124/244) (p=0.569). The anti-HEV IgG positivity rate increased with age as follows: 36.2% (59/163) in persons aged 18-30 years, 52.0% (92/177) in individuals aged 31-40 years and 63.3% (95/150) in those aged 41-55 years. HEV infection occurred in 56.4% (31/55) of people who had never travelled abroad. Conclusions: Wielkopolska Region in west-central Poland is an area hyperendemic for HEV infection. In this part of Poland, the exposure of HIV-positive persons to this virus is not greater than that of healthy blood donors.
Language	English
Publishing date	2017-08
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2017.05.014
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Article: Hepatitis E Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3

Norder, Heléne / Galli, Cristina / Magnil, Ellen / Sikora, Per / Ekvärn, Elisabet / Nyström, Kristina / Magnius, Lars O.

Intervirology

2018 Volume 61, Issue 2, Page(s) 96–103

Abstract: Hepatitis E virus (HEV) is a pathogen that causes hepatitis worldwide. Molecular studies have ...

Institution	Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Biomedical Sciences for Health, University of Milan, Milan, Italy Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Clinical Genomics Gothenburg, SciLife Labs, Gothenburg, Sweden Octapharma AB, Stockholm, Sweden Ulf Lundahls Foundation, Stockholm, Sweden
Abstract	Hepatitis E virus (HEV) is a pathogen that causes hepatitis worldwide. Molecular studies have identified HEV RNA in blood products although its significance is not understood. This study was undertaken to characterize HEV genomes in asymptomatic plasma donors from Sweden and Germany lacking anti-HEV. Complete open reading frames (ORFs) were obtained from HEV strains in 5 out of 18 plasma donors who tested positive for HEV RNA. All strains had CUG as the start codon of ORF3, while 147 GenBank strains all had AUG as the start codon (p < 0.0001). This substitution was found in both interrelated and unrelated strains belonging to different phylogenetic clades. The HEV strains from the seronegative plasma donors had no other substitution in common, which may be why the CUG substitution seems to explain the seronegativity.
Keywords	HEV3 ; Blood donors ; Mutation ; Nucleotide sequence
Language	English
Publishing date	2018-10-02
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Short Communication ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
ZDB-ID	184545-7
ISSN	1423-0100 ; 0300-5526
ISSN (online)	1423-0100
ISSN	0300-5526
DOI	10.1159/000491926
Database	Karger publisher's database

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