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  1. Article ; Online: CHRONIC MEDICAL CONDITIONS IN CROATIAN WAR VETERANS COMPARED TO THE GENERAL POPULATION: 25 YEARS AFTER THE WAR.

    Nakić, Dario / Stipčević, Mira / Morić Perić, Martina / Bakotić, Zoran / Lončar, Jelena Vučak / Bačkov, Kristina / Vojković, Marina / Jakab, Jelena / Včev, Aleksandar

    Acta clinica Croatica

    2024  Volume 62, Issue 1, Page(s) 3–10

    Abstract: ... veterans and the general population. This study included two groups of subjects, i.e. 1453 participants ...

    Abstract Many published reports have documented an increased prevalence of chronic medical conditions among veterans, but there were only a few studies that compared these increases with the general population. The aim of this study was to determine differences in chronic medical conditions between Croatian war veterans and the general population. This study included two groups of subjects, i.e. 1453 participants who are Croatian war veterans and 1429 participants from the general population. Medical history, physical examination, laboratory tests and specific diagnostic procedures were taken during systematic physical examination in both groups. The prevalence of hypertension, diabetes, hyperlipidemia, hypothyroidism and hyperthyroidism, chronic obstructive pulmonary disease, coronary heart disease, malignancy, psychiatric diseases, cholelithiasis, nephrolithiasis, smoking and alcohol consumption was analyzed. Croatian war veterans were found to be more likely to develop hypertension than individuals in the general population (29.5% vs. 24.3%), as well as diabetes (7.3% vs. 3.8%), hyperlipidemia (56.4% vs. 27.3%), hyperthyroidism (3.1% vs. 0.8%), coronary heart disease (4.3% vs. 1%), malignancy (4.1% vs. 2.2%), psychiatric diseases (15.4% vs. 1.1%), and alcohol consumption (53% vs. 29%). Significant difference was found in favor of the general population for hypothyroidism (14.3% vs. 8%). There were no differences in the prevalence of chronic obstructive pulmonary disease, cholelithiasis, nephrolithiasis, and smoking. Our findings confirmed the hypothesis of a higher prevalence of cardiovascular diseases, malignancy and psychiatric diseases among Croatian war veterans and emphasized the need of better control of their medical conditions.
    MeSH term(s) Humans ; Veterans/psychology ; Croatia/epidemiology ; Chronic Disease ; Diabetes Mellitus ; Cholelithiasis ; Pulmonary Disease, Chronic Obstructive ; Hypertension ; Hypothyroidism ; Hyperlipidemias/epidemiology ; Hyperthyroidism ; Coronary Disease ; Neoplasms ; Nephrolithiasis ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology
    Language English
    Publishing date 2024-01-25
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1478635-7
    ISSN 1333-9451 ; 0353-9466
    ISSN (online) 1333-9451
    ISSN 0353-9466
    DOI 10.20471/acc.2023.62.01.01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Associations between Selected

    Moric-Janiszewska, Ewa / Smolik, Sławomir / Szydłowski, Lesław / Kapral, Małgorzata

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 12

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Child ; Female ; Humans ; Adrenergic beta-Antagonists/therapeutic use ; Arrhythmias, Cardiac/genetics ; Cytochrome P-450 CYP2D6/genetics ; DNA ; Polymorphism, Genetic/genetics ; Receptors, Adrenergic, beta-1/genetics
    Chemical Substances ADRB1 protein, human ; Adrenergic beta-Antagonists ; Cytochrome P-450 CYP2D6 (EC 1.14.14.1) ; DNA (9007-49-2) ; Receptors, Adrenergic, beta-1 ; CYP2D6 protein, human
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59122057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prolonged Proton Pump Inhibitor Use and Thrombohemorrhagic Risk in Essential Thrombocythemia and Polycythemia Vera Patients Treated with Long-Term Aspirin: A Pilot Study.

    Krečak, Ivan / Pivac, Ljerka / Holik, Hrvoje / Perić, Martina Morić / Zekanović, Ivan / Čubrić, Eva / Skelin, Marko / Lucijanić, Marko

    Pharmacology

    2024  Volume 109, Issue 2, Page(s) 110–114

    Abstract: Introduction: Proton pump inhibitors (PPIs) are known to decrease the risk of gastrointestinal (GI) bleeding. However, concerns have been raised regarding the potential pharmacodynamic interactions of PPIs and antiplatelet drugs with respect to ... ...

    Abstract Introduction: Proton pump inhibitors (PPIs) are known to decrease the risk of gastrointestinal (GI) bleeding. However, concerns have been raised regarding the potential pharmacodynamic interactions of PPIs and antiplatelet drugs with respect to cardiovascular risk. Patients with BCR::ABL1-negative myeloproliferative neoplasms (MPNs), essential thrombocythemia (ET), and polycythemia vera (PV) often suffer from peptic ulcer disease (PUD) and frequently receive low-dose aspirin due to an intrinsically high thrombotic risk.
    Method: This retrospective multicenter study from a community setting investigated whether continuous PPI use may affect thrombohemorrhagic risk in ET and PV patients treated with long-term aspirin.
    Results: Ninety-four aspirin-treated MPN patients (ET = 36, PV = 58) were included; median age was 69.5 years (range 21-92) and 40 (42.6%) were males. Nineteen (20.2%) patients continuously received PPIs and pantoprazole (n = 15, 78.9%) was the most frequently received PPI. PV phenotype (p = 0.085), male sex (p = 0.011), and prior thrombosis (p = 0.005) were associated with PPI use, whereas no correlations were found with respect to age, disease risk, splenomegaly, mutational status, constitutional symptoms, cardiovascular risk factors, cytoreductive treatment, or any of the blood cell counts (p > 0.050 for all analyses). The median follow-up time was 55.5 months; 19 (20.2%) thrombotic and 13 (13.8%) bleeding events occurred during this time. The use of PPIs was not associated with an increased risk of thrombosis (p = 0.158) or overall bleeding (p = 0.229) and none of the patients treated with PPIs experienced GI bleeding.
    Conclusions: Considering that Helicobacter pylori infection and PUD are quite frequent in ET and PV patients, these preliminary results may provide some reassurance to physicians regarding the absence of thrombohemorrhagic risk associated with prolonged PPI use in MPN patients treated with long-term aspirin. Our observations may be even more important in the light of recent evidence suggesting suboptimal platelet inhibition in ET with once-daily when compared to twice- or triple-daily aspirin which may also cause more abdominal discomfort. Limitations of this study are its retrospective design, limited number of patients included, and the lack of pharmacodynamic and pharmacokinetic assessments.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Aspirin/adverse effects ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Helicobacter Infections ; Helicobacter pylori ; Hemorrhage/chemically induced ; Pilot Projects ; Polycythemia Vera/drug therapy ; Proton Pump Inhibitors/adverse effects ; Retrospective Studies ; Thrombocythemia, Essential/drug therapy ; Thrombosis/prevention & control
    Chemical Substances Aspirin (R16CO5Y76E) ; Proton Pump Inhibitors
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Multicenter Study ; News
    ZDB-ID 206671-3
    ISSN 1423-0313 ; 0031-7012
    ISSN (online) 1423-0313
    ISSN 0031-7012
    DOI 10.1159/000535078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Peter Klepec

    Anja Moric

    Ars & Humanitas, Vol 9, Iss 1, Pp 204-

    from a (Local) Hero to a (National) Allegory of Weakness

    2015  Volume 226

    Abstract: ... dilemmas that arose following the division of the Čabranka-Osilnica area, i.e., the originating area ...

    Abstract The narrative hero Peter Klepec is known (and laid claim to) by the inhabitants of the Čabranka-Osilnica valley, the border area on the Croatian and Slovenian side of the border. There circulate a number of quite similar stories about him, in which a frail illegitimate child Peter becomes a strong man, whose supernatural powers help the needy and drive the enemies from these regions. This paper shows the changing role and diversity of interpretations of myth in time and space using the example of folk and literary hero Peter Klepec. It focuses on the historical changes in the perception of Peter Klepec: namely, on his (local) function at the time of the Hapsburg imperial policy, the process of his nationalisation and dilemmas that arose following the division of the Čabranka-Osilnica area, i.e., the originating area of the creation of the legend of the two countries (Croatia and Slovenia). It shows that Klepec was due to different historical circumstances and (interpretive) discourse used for different purposes. First, he served as a symbol of strength and survival in the Čabranka-Osilnica valley, and then as the Hapsburg myth that justified the existence of the monarchy facing the hostile Ottomans, and lastly as an allegory of a servile Slovene, who is always just a faithful bondsman to other masters (first under the Austro-Hungarians and then the European Union).
    Keywords Peter Klepec ; hero ; myth ; border ; nationalism ; History of scholarship and learning. The humanities ; AZ20-999 ; Literature (General) ; PN1-6790
    Subject code 820
    Language German
    Publishing date 2015-04-01T00:00:00Z
    Publisher University of Ljubljana Press (Založba Univerze v Ljubljani)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Palpable spleen size is differently prognostic in primary and secondary myelofibrosis.

    Lucijanic, Marko / Krecak, Ivan / Soric, Ena / Galusic, Davor / Holik, Hrvoje / Perisa, Vlatka / Moric Peric, Martina / Zekanovic, Ivan / Kusec, Rajko

    Leukemia & lymphoma

    2023  Volume 64, Issue 4, Page(s) 893–896

    MeSH term(s) Humans ; Prognosis ; Spleen ; Primary Myelofibrosis/diagnosis ; Pyrazoles ; Nitriles
    Chemical Substances Pyrazoles ; Nitriles
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2179360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Priče o sjenama

    Morić Kinkel, Edin / Osmanbašić, Ibrahim

    2015  

    Abstract: Gedichte aus dem ... ...

    Author's details Edin Morić Kinkel. [Urednik: Ibrahim Osmanbašić]
    Abstract Gedichte aus dem Schatten
    Language Bosnian
    Size 100 S.
    Publisher Udruženje za kulturu Nova Svjetlost
    Publishing place Sarajevo
    Document type Book
    ISBN 9789958856259 ; 9958856255
    Database Former special subject collection: coastal and deep sea fishing

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  7. Article: Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis.

    Lucijanic, Marko / Krecak, Ivan / Soric, Ena / Sabljic, Anica / Galusic, Davor / Holik, Hrvoje / Perisa, Vlatka / Moric Peric, Martina / Zekanovic, Ivan / Budimir, Josipa / Kusec, Rajko

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Aim: To investigate the prognostic contribution of absolute neutrophil (ANC), lymphocyte (ALC), platelet count and their ratios, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), to thrombotic risk in patients with prefibrotic and ... ...

    Abstract Aim: To investigate the prognostic contribution of absolute neutrophil (ANC), lymphocyte (ALC), platelet count and their ratios, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), to thrombotic risk in patients with prefibrotic and overt fibrotic myelofibrosis (MF).
    Methods: We retrospectively analyzed a cohort of 256 patients with prefibrotic (85 patients) and overt fibrotic MF (171 patients) treated in six Croatian hematological centers.
    Results: Prefibrotic compared to overt fibrotic MF patients presented with significantly higher ALC, platelet count and PLR, and experienced longer time to thrombosis (TTT). Among prefibrotic patients, ANC > 8.33 × 10
    Conclusions: Prognostic properties of ANC, ALC and platelet count are mutually independent and exceed those of NLR and PLR regarding thrombotic risk stratification. ALC and platelet count associate in opposite directions with thrombotic risk in prefibrotic and overt fibrotic MF patients.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Expression levels of serum circulating microRNAs in pediatric patients with ventricular and supraventricular arrhythmias.

    Moric-Janiszewska, Ewa / Smolik, Sławomir / Morka, Aleksandra / Szydłowski, Lesław / Kapral, Małgorzata

    Advances in medical sciences

    2021  Volume 66, Issue 2, Page(s) 411–417

    Abstract: ... cardiac diseases, e.g., heart failure, hypertrophy, conduction disturbances, and arrhythmogenesis. The aim ...

    Abstract Purpose: Aberrant expression of various miRNA species has been implicated in numerous cardiac diseases, e.g., heart failure, hypertrophy, conduction disturbances, and arrhythmogenesis. The aim of this study was to determine whether miR-1, miR-133a, and miR-133b can serve as biomarkers in the diagnosis of ventricular (Va) and supraventricular (SVa) arrhythmias in pediatric patients.
    Materials and methods: Molecular analysis included 30 patients with SVa or Va (13-17.5 years; 14 boys/16 girls) and 20 non-arrhythmic controls. Arrhythmia was confirmed by 24-h Holter ECG recording. miRNA was extracted from serum using the miRNeasy
    Results: The levels of miR-1 and miR-133a expression were significantly higher in the SVa group than in the controls (p ​= ​0.0327 and p<0.0001, respectively). Additionally, both groups of patients with arrhythmia presented significantly lower expression levels of miR-133b than the controls (p<0.01 for both comparisons). The level of miR-133a expression in the SVa group was significantly higher than in the Va group (p ​= ​0.0124). ROC analysis demonstrated that the expressions of miR-1 and miR-133a could differentiate between the SVa patients and arrhythmia-free controls (AUC ​= ​0.7091, p ​= ​0.07 and AUC ​= ​0.8021, p ​= ​0.007, respectively). Furthermore, the expression of miR-133b was shown to distinguish patients with SVa and Va from the arrhythmia-free controls (AUC ​= ​0.7273, p ​= ​0.07 and AUC ​= ​0.8030, p ​= ​0.04, respectively).
    Conclusions: miR-1, miR-133a, and miR-133b have the potential to become diagnostic biomarkers of arrhythmia in pediatric patients.
    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/genetics ; Biomarkers ; Child ; Circulating MicroRNA/genetics ; Female ; Humans ; Male ; MicroRNAs/genetics ; ROC Curve
    Chemical Substances Biomarkers ; Circulating MicroRNA ; MicroRNAs
    Language English
    Publishing date 2021-09-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273668-2
    ISSN 1898-4002 ; 1896-1126
    ISSN (online) 1898-4002
    ISSN 1896-1126
    DOI 10.1016/j.advms.2021.08.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Anti-Virulence Potential and In Vivo Toxicity of

    Jovanović, Marina / Morić, Ivana / Nikolić, Biljana / Pavić, Aleksandar / Svirčev, Emilija / Šenerović, Lidija / Mitić-Ćulafić, Dragana

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 8

    Abstract: Many traditional remedies represent potential candidates for integration with modern medical practice, but credible data on their activities are often scarce. For the first time, the anti-virulence potential and the safety for human use of the ethanol ... ...

    Abstract Many traditional remedies represent potential candidates for integration with modern medical practice, but credible data on their activities are often scarce. For the first time, the anti-virulence potential and the safety for human use of the ethanol extracts of two medicinal plants,
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Biofilms/drug effects ; Cell Line ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/physiology ; Humans ; Microbial Sensitivity Tests ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polygonaceae/chemistry ; Quorum Sensing/drug effects ; Signal Transduction ; Virulence/drug effects
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2020-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25081811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Effect of Single Mismatches on Primer Extension.

    Rejali, Nick A / Moric, Endi / Wittwer, Carl T

    Clinical chemistry

    2018  Volume 64, Issue 5, Page(s) 801–809

    Abstract: ... additional design direction and suggest when other methods (e.g., high-resolution melting analysis) may be ...

    Abstract Background: Allele-specific PCR is an important diagnostic tool that identifies single-nucleotide variants by preferential amplification of a particular allele, using primers that are mismatched to all but one allele variant.
    Methods: We applied a fluorescent stopped-flow polymerase assay to measure extension rates from oligonucleotide hairpins to simulate primer-template pairs. Under PCR-applicable conditions, reaction rates were recorded in nucleotides per second per polymerase (nt/s/poly). The effects of temperature, potassium chloride, mismatch type, and position were studied with primarily a deletion mutant of
    Results: Rates at 65 °C were between 205 ± 11 and 177 ± 8 nt/s/poly for matched templates and between 4.55 ± 0.21 and 0.008 ± 0.005 nt/s/poly for 3'-mismatched templates. Although extension rates progressively increased with mismatches further away from the 3' end, rates were still reduced by as much as 84% with a C · C mismatch 6 bases from the 3' end. The optimal extension temperature for matched sequences was 70 °C, shifting to 55-60 °C for 3' mismatches. KCl inhibited mismatch extension. The Michaelis constant (
    Conclusions: Although primer extension of mismatches depends on mismatch type and position, variation also depends on local sequence, KCl concentration, and the type of polymerase. Introduction of 3' mismatches reduces the optimal temperature for extension, suggesting higher annealing temperatures for better allele discrimination. Quantitative descriptions of expected specificity in allele-specific PCR provide additional design direction and suggest when other methods (e.g., high-resolution melting analysis) may be a better choice.
    MeSH term(s) Base Pair Mismatch ; DNA Primers/genetics ; Humans ; Kinetics ; Temperature
    Chemical Substances DNA Primers
    Language English
    Publishing date 2018-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2017.282285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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