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  1. Article ; Online: RANK Ligand Helps Immunity to

    Rigoni, Thaís S / Vellozo, Natália S / Cabral-Piccin, Mariela / Fabiano-Coelho, Laryssa / Lopes, Ulisses G / Filardy, Alessandra A / DosReis, George A / Lopes, Marcela F

    Frontiers in immunology

    2020  Volume 11, Page(s) 886

    Abstract: Macrophages ... ...

    Abstract Macrophages host
    MeSH term(s) Animals ; Cell Differentiation/immunology ; Leishmania major ; Macrophage Activation ; Macrophages/immunology ; Macrophages/parasitology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; RANK Ligand/immunology ; Signal Transduction
    Chemical Substances RANK Ligand ; Tnfsf11 protein, mouse
    Language English
    Publishing date 2020-05-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Trypanosoma cruzi

    Guimarães-Pinto, Kamila / Nascimento, Danielle Oliveira / Corrêa-Ferreira, Antonia / Morrot, Alexandre / Freire-de-Lima, Celio G / Lopes, Marcela F / DosReis, George A / Filardy, Alessandra A

    Frontiers in immunology

    2018  Volume 9, Page(s) 1569

    Abstract: Trypanosoma ... ...

    Abstract Trypanosoma cruzi
    Language English
    Publishing date 2018
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.01569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Macrophages and neutrophils cooperate in immune responses to Leishmania infection.

    Filardy, Alessandra A / Pires, Dayana R / DosReis, George A

    Cellular and molecular life sciences : CMLS

    2011  Volume 68, Issue 11, Page(s) 1863–1870

    Abstract: Neutrophils and macrophages are phagocytic cells that cooperate during inflammation and tissue repair. Neutrophils undergo apoptosis and are engulfed by macrophages. Engulfment modulates macrophage activation and microbicidal activity. Infection by ... ...

    Abstract Neutrophils and macrophages are phagocytic cells that cooperate during inflammation and tissue repair. Neutrophils undergo apoptosis and are engulfed by macrophages. Engulfment modulates macrophage activation and microbicidal activity. Infection by Leishmania takes place in the context of tissue repair. This article discusses cellular and molecular mechanisms involved in the intimate cooperation of neutrophils and macrophages in Leishmania infection.
    MeSH term(s) Animals ; Humans ; Immunity, Active ; Leishmaniasis/immunology ; Macrophage Activation ; Macrophages/immunology ; Neutrophils/immunology
    Language English
    Publishing date 2011-03-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-011-0653-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
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  4. Article ; Online: The importance of apoptosis for immune regulation in Chagas disease.

    DosReis, George A / Lopes, Marcela F

    Memorias do Instituto Oswaldo Cruz

    2009  Volume 104 Suppl 1, Page(s) 259–262

    Abstract: Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates ... ...

    Abstract Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression.
    MeSH term(s) Animals ; Apoptosis/immunology ; Chagas Disease/immunology ; Chagas Disease/parasitology ; Chagas Disease/pathology ; Disease Progression ; Host-Parasite Interactions/immunology ; Humans ; Immunity, Cellular ; Mice ; Phagocytosis/immunology ; Trypanosoma cruzi/immunology ; Trypanosoma cruzi/physiology
    Language English
    Publishing date 2009-09-10
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 953293-6
    ISSN 1678-8060 ; 0074-0276
    ISSN (online) 1678-8060
    ISSN 0074-0276
    DOI 10.1590/s0074-02762009000900033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.33: Show issues Location:
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  5. Article: All-

    Vellozo, Natália S / Pereira-Marques, Sâmara T / Cabral-Piccin, Mariela P / Filardy, Alessandra A / Ribeiro-Gomes, Flávia L / Rigoni, Thaís S / DosReis, George A / Lopes, Marcela F

    Frontiers in immunology

    2017  Volume 8, Page(s) 1560

    Abstract: As key cells, able to host and ... ...

    Abstract As key cells, able to host and kill
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2017.01560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Susceptible hosts

    DOSREIS GEORGE A.

    Anais da Academia Brasileira de Ciências, Vol 72, Iss 1, Pp 79-

    a resort for parasites right in the eye of the immune response

    2000  Volume 82

    Abstract: Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a ... ...

    Abstract Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed.
    Keywords Trypanosoma cruzi ; Leishmania chagasi ; T lymphocytes ; CTLA-4 ; apoptosis ; transforming growth factor ; Science ; Q
    Language English
    Publishing date 2000-01-01T00:00:00Z
    Publisher Academia Brasileira de Ciências
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Susceptible hosts

    GEORGE A. DOSREIS

    Anais da Academia Brasileira de Ciências, Vol 72, Iss 1, Pp 79-

    a resort for parasites right in the eye of the immune response

    2000  Volume 82

    Abstract: Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a ... ...

    Abstract Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed.
    Keywords Trypanosoma cruzi ; Leishmania chagasi ; T lymphocytes ; CTLA-4 ; apoptosis ; transforming growth factor ; Science ; Q
    Language English
    Publishing date 2000-03-01T00:00:00Z
    Publisher Academia Brasileira de Ciências
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The importance of apoptosis for immune regulation in Chagas disease

    George A DosReis / Marcela F Lopes

    Memórias do Instituto Oswaldo Cruz., Vol 104, Pp 259-

    2009  Volume 262

    Abstract: Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates ... ...

    Abstract Host cell apoptosis plays an important immune regulatory role in parasitic infections. Infection of mice with Trypanosoma cruzi, the causative agent of Chagas disease, induces lymphocyte apoptosis. In addition, phagocytosis of apoptotic cells stimulates the growth of T. cruzi inside host macrophages. In spite of progress made in this area, the importance of apoptosis in the pathogenesis of Chagas disease remains unclear. Here we review the evidence of apoptosis in mice and humans infected with T. cruzi. We also discuss the mechanisms by which apoptosis can influence underlying host responses and tissue damage during Chagas disease progression.
    Keywords apoptosis ; lymphocytes ; phagocytosis ; cytokines ; Trypanosoma cruzi ; Arctic medicine. Tropical medicine ; RC955-962 ; Microbiology ; QR1-502
    Language English
    Publishing date 2009-07-01T00:00:00Z
    Publisher Instituto Oswaldo Cruz, Ministério da Saúde
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Antibody Repertoires Identify β-Tubulin as a Host Protective Parasite Antigen in Mice Infected With

    Montalvão, Fabricio / Nascimento, Danielle Oliveira / Nunes, Marise P / Koeller, Carolina M / Morrot, Alexandre / Lery, Leticia Miranda S / Bisch, Paulo M / Teixeira, Santuza M R / Vasconcellos, Rita / Freire-de-Lima, Leonardo / Lopes, Marcela F / Heise, Norton / DosReis, George A / Freire-de-Lima, Célio Geraldo

    Frontiers in immunology

    2018  Volume 9, Page(s) 671

    Abstract: Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice ... ...

    Abstract Few studies investigate the major protein antigens targeted by the antibody diversity of infected mice with
    MeSH term(s) Animals ; Antibodies, Protozoan/immunology ; Antigens, Protozoan/immunology ; Chagas Disease/immunology ; Disease Models, Animal ; Immunization ; Immunoglobulin G/immunology ; Male ; Mice, Inbred BALB C ; Mice, Mutant Strains ; Protozoan Proteins/immunology ; Trypanosoma cruzi/immunology ; Tubulin/immunology
    Chemical Substances Antibodies, Protozoan ; Antigens, Protozoan ; Immunoglobulin G ; Protozoan Proteins ; Tubulin
    Language English
    Publishing date 2018-04-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.00671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Degranulating Neutrophils Promote Leukotriene B4 Production by Infected Macrophages To Kill Leishmania amazonensis Parasites.

    Tavares, Natália / Afonso, Lilian / Suarez, Martha / Ampuero, Mariana / Prates, Deboraci Brito / Araújo-Santos, Théo / Barral-Netto, Manoel / DosReis, George A / Borges, Valéria Matos / Brodskyn, Cláudia

    Journal of immunology (Baltimore, Md. : 1950)

    2016  Volume 196, Issue 4, Page(s) 1865–1873

    Abstract: Neutrophils mediate early responses against pathogens, and they become activated during endothelial transmigration toward the inflammatory site. In the current study, human neutrophils were activated in vitro with immobilized extracellular matrix ... ...

    Abstract Neutrophils mediate early responses against pathogens, and they become activated during endothelial transmigration toward the inflammatory site. In the current study, human neutrophils were activated in vitro with immobilized extracellular matrix proteins, such as fibronectin (FN), collagen, and laminin. Neutrophil activation by FN, but not other extracellular matrix proteins, induces the release of the granules' contents, measured as matrix metalloproteinase 9 and neutrophil elastase activity in culture supernatant, as well as reactive oxygen species production. Upon contact with Leishmania amazonensis-infected macrophages, these FN-activated neutrophils reduce the parasite burden through a mechanism independent of cell contact. The release of granule proteases, such as myeloperoxidase, neutrophil elastase, and matrix metalloproteinase 9, activates macrophages through TLRs, leading to the production of inflammatory mediators, TNF-α and leukotriene B4 (LTB4), which are involved in parasite killing by infected macrophages. The pharmacological inhibition of degranulation reverted this effect, abolishing LTB4 and TNF production. Together, these results suggest that FN-driven degranulation of neutrophils induces the production of LTB4 and TNF by infected macrophages, leading to the control of Leishmania infection.
    MeSH term(s) Cell Degranulation/immunology ; Cell Line ; Coculture Techniques ; Fibronectins/immunology ; Humans ; Leishmania ; Leishmania mexicana ; Leishmaniasis, Cutaneous/immunology ; Leukotriene B4/biosynthesis ; Leukotriene B4/immunology ; Macrophages/immunology ; Macrophages/parasitology ; Microscopy, Electron, Transmission ; Neutrophil Activation/immunology ; Neutrophils/immunology
    Chemical Substances Fibronectins ; Leukotriene B4 (1HGW4DR56D)
    Language English
    Publishing date 2016-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1502224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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