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  1. Article ; Online: Retraction: AKAP12 mediates PKA-induced phosphorylation of ATR to enhance nucleotide excision repair.

    Jarrett, Stuart G / Wolf Horrell, Erin M / D'Orazio, John A

    Nucleic acids research

    2020  Volume 48, Issue 20, Page(s) 11814

    Language English
    Publishing date 2020-10-22
    Publishing country England
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkaa984
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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  2. Article ; Online: Retraction Note: The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage.

    Jarrett, Stuart G / Carter, Katharine M / Shelton, Brent J / D'Orazio, John A

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 847

    Language English
    Publishing date 2021-01-07
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-80467-y
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  3. Article ; Online: Retraction Notice to: PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage.

    Jarrett, Stuart G / Wolf Horrell, Erin M / Christian, Perry A / Vanover, Jillian C / Boulanger, Mary C / Zou, Yue / D'Orazio, John A

    Molecular cell

    2022  Volume 82, Issue 22, Page(s) 4400

    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.10.023
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    Zs.A 5055: Show issues Location:
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  4. Article ; Online: The combination of Raman spectroscopy and mass spectrometry to investigate cutaneous metallosis.

    Chung, Jenny G / Holtkamp, Hannah / Nieuwoudt, Michel / Matthews, Hannah / Aguergaray, Claude / Morrow, Stuart / Caughey, Michael / Poppito, Natalie / Jarrett, Paul

    The British journal of dermatology

    2022  Volume 187, Issue 3, Page(s) 447–448

    MeSH term(s) Humans ; Mass Spectrometry/methods ; Skin ; Spectrum Analysis, Raman/methods
    Language English
    Publishing date 2022-04-07
    Publishing country England
    Document type Letter
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.20902
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  5. Article ; Online: Retraction Note

    Stuart G. Jarrett / Katharine M. Carter / Brent J. Shelton / John A. D’Orazio

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage

    2021  Volume 1

    Abstract: Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-020-80467-y . ...

    Abstract Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-020-80467-y .
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Withdrawal: Sirtuin 1-mediated deacetylation of XPA DNA repair protein enhances its interaction with ATR protein and promotes cAMP-induced DNA repair of UV damage.

    Jarrett, Stuart G / Carter, Katharine M / Bautista, Robert-Marlo / He, Daheng / Wang, Chi / D'Orazio, John A

    The Journal of biological chemistry

    2021  Volume 296, Page(s) 100185

    Language English
    Publishing date 2021-03-27
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2020.100185
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    Uc I Zs.108: Show issues Location:
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  7. Article ; Online: Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2.

    Tao, Yongfeng / Felber, Jan G / Zou, Zhongyu / Njomen, Evert / Remsberg, Jarrett R / Ogasawara, Daisuke / Ye, Chang / Melillo, Bruno / Schreiber, Stuart L / He, Chuan / Remillard, David / Cravatt, Benjamin F

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 51, Page(s) e202311924

    Abstract: 5-Methylcytosine ( ... ...

    Abstract 5-Methylcytosine (m
    MeSH term(s) Humans ; Acrylamides ; Azetidines ; Cysteine/metabolism ; Methylation ; Methyltransferases/antagonists & inhibitors ; Proteomics ; RNA, Transfer/chemistry ; tRNA Methyltransferases/antagonists & inhibitors ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology
    Chemical Substances Acrylamides ; Azetidines ; Cysteine (K848JZ4886) ; Methyltransferases (EC 2.1.1.-) ; NSUN2 protein, human (EC 2.1.1.-) ; RNA, Transfer (9014-25-9) ; tRNA Methyltransferases (EC 2.1.1.-) ; Enzyme Inhibitors
    Language English
    Publishing date 2023-11-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202311924
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  8. Article ; Online: Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis.

    Jarrett, Stuart G / D'Orazio, John A

    Photochemistry and photobiology

    2016  Volume 93, Issue 1, Page(s) 245–258

    Abstract: Melanoma is the deadliest form of skin cancer because of its propensity to spread beyond the primary site of disease and because it resists many forms of treatment. Incidence of melanoma has been increasing for decades. Although ultraviolet radiation (UV) ...

    Abstract Melanoma is the deadliest form of skin cancer because of its propensity to spread beyond the primary site of disease and because it resists many forms of treatment. Incidence of melanoma has been increasing for decades. Although ultraviolet radiation (UV) has been identified as the most important environmental causative factor for melanoma development, UV-protective strategies have had limited efficacy in melanoma prevention. UV mutational burden correlates with melanoma development and tumor progression, underscoring the importance of UV in melanomagenesis. However, besides amount of UV exposure, melanocyte UV mutational load is influenced by the robustness of nucleotide excision repair, the genome maintenance pathway charged with removing UV photoproducts before they cause permanent mutations in the genome. In this review, we highlight the importance of the melanocortin hormonal signaling axis on regulating efficiency of nucleotide excision repair in melanocytes. By understanding the molecular mechanisms by which nucleotide excision repair can be increased, it may be possible to prevent many cases of melanoma by reducing UV mutational burden over time.
    MeSH term(s) Cyclic AMP/metabolism ; DNA Repair ; Humans ; Melanocortins/metabolism ; Melanocytes/metabolism ; Melanoma/epidemiology ; Pyrimidine Dimers/metabolism ; Receptor, Melanocortin, Type 1/agonists ; Receptor, Melanocortin, Type 1/antagonists & inhibitors ; Receptor, Melanocortin, Type 1/metabolism ; Signal Transduction ; Ultraviolet Rays/adverse effects ; United States/epidemiology ; Xeroderma Pigmentosum/etiology
    Chemical Substances Melanocortins ; Pyrimidine Dimers ; Receptor, Melanocortin, Type 1 ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2016-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.12640
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    Zs.B 1686: Show issues Location:
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  9. Article ; Online: Consequences of oxidative stress in age-related macular degeneration.

    Jarrett, Stuart G / Boulton, Michael E

    Molecular aspects of medicine

    2012  Volume 33, Issue 4, Page(s) 399–417

    Abstract: The retina resides in an environment that is primed for the generation of reactive oxygen species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen-consuming tissues in the human body. The highest oxygen levels are found in ... ...

    Abstract The retina resides in an environment that is primed for the generation of reactive oxygen species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen-consuming tissues in the human body. The highest oxygen levels are found in the choroid, but this falls dramatically across the outermost retina, creating a large gradient of oxygen towards the retina and inner segments of the photoreceptors which contain high levels of polyunsaturated fatty acids. This micro-environment together with abundant photosensitizers, visible light exposure and a high energy demand supports a highly oxidative milieu. However, oxidative damage is normally minimized by the presence of a range of antioxidant and efficient repair systems. Unfortunately, as we age oxidative damage increases, antioxidant capacity decreases and the efficiency of reparative systems become impaired. The result is retinal dysfunction and cell loss leading to visual impairment. It appears that these age-related oxidative changes are a hallmark of early age-related macular degeneration (AMD) which, in combination with hereditary susceptibility and other retinal modifiers, can progress to the pathology and visual morbidity associated with advanced AMD. This review reassesses the consequences of oxidative stress in AMD and strategies for preventing or reversing oxidative damage in retinal tissues.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Humans ; Macular Degeneration/etiology ; Macular Degeneration/metabolism ; Macular Degeneration/prevention & control ; Oxidative Stress/drug effects ; Reactive Nitrogen Species/metabolism ; Reactive Oxygen Species/metabolism ; Retina/drug effects ; Retina/metabolism ; Retina/pathology
    Chemical Substances Antioxidants ; Reactive Nitrogen Species ; Reactive Oxygen Species
    Language English
    Publishing date 2012-04-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2012.03.009
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    Zs.A 1189: Show issues Location:
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  10. Article ; Online: Ctr1-ing BRAF signaling with copper.

    Jarrett, Stuart G / D'Orazio, John A

    Pigment cell & melanoma research

    2014  Volume 27, Issue 5, Page(s) 689–691

    MeSH term(s) Animals ; Cell Transformation, Neoplastic ; Copper/metabolism ; Female ; Humans ; MAP Kinase Signaling System ; Proto-Oncogene Proteins B-raf/metabolism
    Chemical Substances Copper (789U1901C5) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Comment ; News
    ZDB-ID 2409570-9
    ISSN 1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
    ISSN (online) 1755-148X ; 1600-0749
    ISSN 0893-5785 ; 1755-1471
    DOI 10.1111/pcmr.12265
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