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Article: Aging Diminishes Mucociliary Clearance of the Lung.

Bailey, Kristina L

Advances in geriatric medicine and research

2022 Volume 4, Issue 2

Abstract: Healthy aging leads to a decrease in mucociliary clearance of the lung. Mucociliary clearance is an essential innate immune defense to protect against inhaled particles and microbes. Mucociliary clearance can be affected by changes in cilia function as ... ...

Abstract	Healthy aging leads to a decrease in mucociliary clearance of the lung. Mucociliary clearance is an essential innate immune defense to protect against inhaled particles and microbes. Mucociliary clearance can be affected by changes in cilia function as well as mucus quantity and qualities. With aging, cilia beat frequency slows and there are changes to the characteristics of mucus. These decreases in mucociliary clearance may lead to lung infection such as pneumonia or airway diseases such as bronchiectasis or Chronic Obstructive Pulmonary Diseases.
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article
DOI	10.20900/agmr20220005
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Article ; Online: Divergent Pathogenesis and Transmission of Highly Pathogenic Avian Influenza A(H5N1) in Swine.

Arruda, Bailey / Baker, Amy L Vincent / Buckley, Alexandra / Anderson, Tavis K / Torchetti, Mia / Bergeson, Nichole Hines / Killian, Mary Lea / Lantz, Kristina

Emerging infectious diseases

2024 Volume 30, Issue 4, Page(s) 738–751

Abstract: Highly pathogenic avian influenza (HPAI) viruses have potential to cross species barriers and cause pandemics. Since 2022, HPAI A(H5N1) belonging to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected poultry, wild birds, and ... ...

Abstract	Highly pathogenic avian influenza (HPAI) viruses have potential to cross species barriers and cause pandemics. Since 2022, HPAI A(H5N1) belonging to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected poultry, wild birds, and mammals across North America. Continued circulation in birds and infection of multiple mammalian species with strains possessing adaptation mutations increase the risk for infection and subsequent reassortment with influenza A viruses endemic in swine. We assessed the susceptibility of swine to avian and mammalian HPAI H5N1 clade 2.3.4.4b strains using a pathogenesis and transmission model. All strains replicated in the lung of pigs and caused lesions consistent with influenza A infection. However, viral replication in the nasal cavity and transmission was only observed with mammalian isolates. Mammalian adaptation and reassortment may increase the risk for incursion and transmission of HPAI viruses in feral, backyard, or commercial swine.
MeSH term(s)	Animals ; Birds ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza in Birds ; Mammals ; Phylogeny ; Poultry ; Swine ; Orthomyxoviridae Infections
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid3004.231141
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Article: The Effect of PGC-1alpha-SIRT3 Pathway Activation on

Maurice, Nicholas M / Bedi, Brahmchetna / Yuan, Zhihong / Lin, Kuo-Chuan / Goldberg, Joanna B / Hart, C Michael / Bailey, Kristina L / Sadikot, Ruxana T

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 2

Abstract: The innate immune response ... ...

Abstract	The innate immune response to
Language	English
Publishing date	2022-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11020116
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Article: Synergistic Detrimental Effects of Cigarette Smoke, Alcohol, and SARS-CoV-2 in COPD Bronchial Epithelial Cells.

Muralidharan, Abenaya / Bauer, Christopher D / Katafiasz, Dawn M / Strah, Heather M / Siddique, Aleem / Reid, St Patrick / Bailey, Kristina L / Wyatt, Todd A

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can have a significant impact on immunity against pathogens. Here, we ... ...

Abstract	Lung conditions such as COPD, as well as risk factors such as alcohol misuse and cigarette smoking, can exacerbate COVID-19 disease severity. Synergistically, these risk factors can have a significant impact on immunity against pathogens. Here, we studied the effect of a short exposure to alcohol and/or cigarette smoke extract (CSE) in vitro on acute SARS-CoV-2 infection of ciliated human bronchial epithelial cells (HBECs) collected from healthy and COPD donors. We observed an increase in viral titer in CSE- or alcohol-treated COPD HBECs compared to untreated COPD HBECs. Furthermore, we treated healthy HBECs accompanied by enhanced lactate dehydrogenase activity, indicating exacerbated injury. Finally, IL-8 secretion was elevated due to the synergistic damage mediated by alcohol, CSE, and SARS-CoV-2 in COPD HBECs. Together, our data suggest that, with pre-existing COPD, short exposure to alcohol or CSE is sufficient to exacerbate SARS-CoV-2 infection and associated injury, impairing lung defences.
Language	English
Publishing date	2023-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12030498
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Article ; Online: Alcohol use disorder: A pre-existing condition for COVID-19?

Bailey, Kristina L / Samuelson, Derrick R / Wyatt, Todd A

Alcohol (Fayetteville, N.Y.)

2020 Volume 90, Page(s) 11–17

Abstract: Alcohol misuse is long established as a contributor to the pathophysiology of the lung. The intersection of multi-organ responses to alcohol-mediated tissue injury likely contributes to the modulation of lung in response to injury. Indeed, the negative ... ...

Abstract	Alcohol misuse is long established as a contributor to the pathophysiology of the lung. The intersection of multi-organ responses to alcohol-mediated tissue injury likely contributes to the modulation of lung in response to injury. Indeed, the negative impact of alcohol on susceptibility to infection and on lung barrier function is now well documented. Thus, the alcohol lung represents a very likely comorbidity for the negative consequences of both COVID-19 susceptibility and severity. In this review, we present the known alcohol misuse ramifications on the lung in the context of the current coronavirus pandemic.
MeSH term(s)	Alcoholism/epidemiology ; Alcoholism/immunology ; Alcoholism/metabolism ; Animals ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/metabolism ; Cytokines/immunology ; Cytokines/metabolism ; Ethanol/administration & dosage ; Ethanol/adverse effects ; Humans ; Lung/drug effects ; Lung/immunology ; Lung/metabolism ; Risk Factors
Chemical Substances	Cytokines ; Ethanol (3K9958V90M)
Keywords	covid19
Language	English
Publishing date	2020-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605912-0
ISSN	1873-6823 ; 0741-8329
ISSN (online)	1873-6823
ISSN	0741-8329
DOI	10.1016/j.alcohol.2020.10.003
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Article: mTOR signaling regulates aberrant epithelial cell proliferative and migratory behaviors characteristic of airway mucous metaplasia in asthma.

Kudrna, Katrina / Staab, Elizabeth B / Eilers, Evan / Thomes, Paul / Maurya, Shailendra / Brody, Steven L / Wyatt, Todd A / Bailey, Kristina L / Dickinson, John D

bioRxiv : the preprint server for biology

2024

Abstract: In asthma, the airway epithelium is hyperplastic, hypertrophied, and lined with numerous large MUC5AC-containing goblet cells (GC). Furthermore, the normal epithelial architecture is disorganized with numerous, what we here describe as, ectopic goblet ... ...

Abstract	In asthma, the airway epithelium is hyperplastic, hypertrophied, and lined with numerous large MUC5AC-containing goblet cells (GC). Furthermore, the normal epithelial architecture is disorganized with numerous, what we here describe as, ectopic goblet cells (eGC) deep within the thickened epithelial layer disconnected from the lumenal surface. mTOR is a highly conserved pathway that regulates cell size and proliferation. We hypothesized that the balance between mTOR and autophagy signaling regulates key features of the asthma epithelial layer. Airway histological sections from subjects with asthma had increased frequency of eGC and increased levels of mTOR phosphorylation target-Ribosomal S6. Using human airway epithelial cells (hAECs) with IL-13 stimulation and timed withdrawal to stimulate resolution, we found that multiple key downstream phosphorylation targets downstream from the mTOR complex were increased during early IL-13-mediated mucous metaplasia, and then significantly declined during resolution. The IL-13-mediated changes in mTOR signaling were paralleled by morphologic changes with airway epithelial hypertrophy, hyperplasia, and frequency of eGC. We then examined the relationship between mTOR and autophagy using mice deficient in autophagy protein Atg16L1. Despite having increased cytoplasmic mucins, mouse AECs from Atg16L1 deficient mice had no significant difference in mTOR downstream signaling. mTOR inhibition with rapamycin led to a loss of IL-13-mediated epithelial hypertrophy, hyperplasia, ectopic GC distribution, and reduction in cytoplasmic MUC5AC levels. mTOR inhibition was also associated with a reduction in aberrant IL-13-mediated hAEC proliferation and migration. Our findings demonstrate that mTOR signaling is associated with mucous metaplasia and is crucial to the disorganized airway epithelial structure and function characteristic of muco-obstructive airway diseases such as asthma. Graphical abstract key concepts: The airway epithelium in asthma is disorganized and characterized by cellular proliferation, aberrant migration, and goblet cell mucous metaplasia.mTOR signaling is a dynamic process during IL-13-mediated mucous metaplasia, increasing with IL-13 stimulation and declining during resolution.mTOR signaling is strongly increased in the asthmatic airway epithelium.mTOR signaling is associated with the development of key features of the metaplastic airway epithelium including cell proliferation and ectopic distribution of goblet cells and aberrant cellular migration.Inhibition of mTOR leads to decreased epithelial hypertrophy, reduced ectopic goblet cells, and cellular migration.
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.12.579905
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Article ; Online: Personal Financial Wellness Curricula for Medical Trainees: A Systematic Review.

Wesslund, Hannah M / Payne, Jeremy S / Baxter, Jared D / Westmark, Danielle M / Bartels, Karsten / Bailey, Kristina L / Krutsinger, Dustin C

Academic medicine : journal of the Association of American Medical Colleges

2023 Volume 98, Issue 5, Page(s) 636–643

Abstract: Purpose: Education debt, poor financial literacy, and a late start to retirement savings can cause financial stress among physicians. This systematic review identifies methods for curriculum development, methods for curriculum delivery, and outcome ... ...

Abstract	Purpose: Education debt, poor financial literacy, and a late start to retirement savings can cause financial stress among physicians. This systematic review identifies methods for curriculum development, methods for curriculum delivery, and outcome measures to evaluate the effectiveness of personal financial wellness curricula for medical students, residents, and fellows. Method: The authors searched the Embase, MEDLINE (via EBSCO), Scopus, Education Resources Information Center (via EBSCO), and Cochrane Library databases and MedEdPORTAL (via PubMed) on July 28, 2022. Studies must have reported the outcome of at least 1 postcourse assessment to be included. Results: Of the 1,996 unique citations identified, 13 studies met the inclusion criteria. Three curricula (23.1%) were designed for medical students, 8 (61.5%) for residents, 1 (7.7%) for internal medicine fellows, and 1 (7.7%) for obstetrics-gynecology residents and fellows. The most frequently discussed personal finance topics included student loans, investment options, disability insurance, life insurance, retirement savings, budgeting, debt management, and general personal finance. A median (interquartile range) of 3.5 (1.4-7.0) hours was spent on personal finance topics. Eleven curricula (85.6%) relied on physicians to deliver the content. Four studies (30.8%) reported precourse and postcourse financial literacy evaluations, each showing improved financial literacy after the course. Four studies (30.8%) assessed actual or planned financial behavior changes, each credited with encouraging or assisting with financial behavioral changes. One study (7.7%) assessed participants' well-being using the Expanded Well-Being Index, which showed an improvement after the course. Conclusions: Given the impact educational debt and other financial stressors can have on the wellness of medical trainees, institutions should consider investments in teaching financial literacy. Future studies should report more concrete outcome measures, including financial behavior change and validated measures of wellness.
MeSH term(s)	Humans ; Internship and Residency ; Education, Medical/methods ; Gynecology/education ; Curriculum ; Internal Medicine/education
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000005136
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Zs.A 112: Show issues

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Article ; Online: Malondialdehyde Acetaldehyde-Adduction Changes Surfactant Protein D Structure and Function.

Nissen, Claire G / Mosley, Deanna D / Kharbanda, Kusum K / Katafiasz, Dawn M / Bailey, Kristina L / Wyatt, Todd A

Frontiers in immunology

2022 Volume 13, Page(s) 866795

Abstract: Alcohol consumption with concurrent cigarette smoking produces malondialdehyde acetaldehyde (MAA)-adducted lung proteins. Lung surfactant protein D (SPD) supports innate ... ...

Abstract	Alcohol consumption with concurrent cigarette smoking produces malondialdehyde acetaldehyde (MAA)-adducted lung proteins. Lung surfactant protein D (SPD) supports innate immunity
MeSH term(s)	Acetaldehyde/chemistry ; Acetaldehyde/metabolism ; Alcoholism/metabolism ; Humans ; Lung/metabolism ; Malondialdehyde ; Pulmonary Surfactant-Associated Protein D/metabolism
Chemical Substances	Pulmonary Surfactant-Associated Protein D ; Malondialdehyde (4Y8F71G49Q) ; Acetaldehyde (GO1N1ZPR3B)
Language	English
Publishing date	2022-05-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.866795
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Article ; Online: Nrf2 Activation Protects Against Organic Dust and Hydrogen Sulfide Exposure Induced Epithelial Barrier Loss and

Shrestha, Denusha / Massey, Nyzil / Bhat, Sanjana Mahadev / Jelesijević, Tomislav / Sahin, Orhan / Zhang, Qijing / Bailey, Kristina L / Poole, Jill A / Charavaryamath, Chandrashekhar

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 848773

Abstract: Agriculture workers report various respiratory symptoms owing to occupational exposure to organic dust (OD) and various gases. Previously, we demonstrated that pre-exposure to hydrogen sulfide ( ... ...

Abstract	Agriculture workers report various respiratory symptoms owing to occupational exposure to organic dust (OD) and various gases. Previously, we demonstrated that pre-exposure to hydrogen sulfide (H
MeSH term(s)	Animals ; Cytokines/metabolism ; Dust ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Kelch-Like ECH-Associated Protein 1/metabolism ; Klebsiella pneumoniae/metabolism ; Mice ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Swine
Chemical Substances	Cytokines ; Dust ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2022-04-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.848773
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Article ; Online: The importance of the assessment of pulmonary function in COPD.

Bailey, Kristina L

The Medical clinics of North America

2012 Volume 96, Issue 4, Page(s) 745–752

Abstract: Spirometry is the gold standard for making the diagnosis of COPD. It should be performed in every case of suspected COPD. Other pulmonary functions, such as lung volumes, can give insight into physiologic consequences of COPD, such as hyperinflation. ... ...

Abstract	Spirometry is the gold standard for making the diagnosis of COPD. It should be performed in every case of suspected COPD. Other pulmonary functions, such as lung volumes, can give insight into physiologic consequences of COPD, such as hyperinflation. Pulmonary function testing can also aid in assessing the severity of disease and in managing the disease after diagnosis is made.
MeSH term(s)	Asthma/diagnosis ; Bronchodilator Agents ; Diagnosis, Differential ; Forced Expiratory Volume ; Humans ; Lung Volume Measurements ; Pulmonary Diffusing Capacity ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/therapy ; Severity of Illness Index ; Spirometry ; Vital Capacity
Chemical Substances	Bronchodilator Agents
Language	English
Publishing date	2012-05-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215710-x
ISSN	1557-9859 ; 0025-7125
ISSN (online)	1557-9859
ISSN	0025-7125
DOI	10.1016/j.mcna.2012.04.011
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