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Article ; Online: Current status of the evaluation and management of antibody-mediated rejection in kidney transplantation.

Haririan, Abdolreza

Current opinion in nephrology and hypertension

2015 Volume 24, Issue 6, Page(s) 576–581

Abstract: Purpose of review: Antibody-mediated rejection (AMR) has come to the forefront of clinical and research challenges in clinical transplantation. Despite the major progress made over the past two decades, there remains a large number of unanswered ... ...

Abstract	Purpose of review: Antibody-mediated rejection (AMR) has come to the forefront of clinical and research challenges in clinical transplantation. Despite the major progress made over the past two decades, there remains a large number of unanswered diagnostic, prognostic, and therapeutic questions. Here we review the recent studies that have helped improve our understanding of AMR. Recent findings: Complement binding capacity of the HLA antibodies using modified single antigen bead Luminex assays to detect C1q, C4d, or C3d binding, has been associated with risk of AMR and graft failure. However, this property correlates with the antibody mean fluorescent intensity, and, in many cases, may not add additional insight. The use of molecular methods to examine expression profiles in the kidney biopsy specimens, in peripheral mononuclear cells, or urinary chemokine signature, has improved our understanding of the mechanisms of AMR-induced injury and refined our current diagnostic tools. On the treatment front, monoclonal antiinterleukin 6 receptor antibody, and C1 esterase inhibitor have shown promising results in the pilot studies but further larger trials are needed to evaluate their safety and efficacy. Summary: We are making constant progress in the pursuit of a better understanding the AMR process and finding new diagnostic and therapeutic options.
MeSH term(s)	Antibodies/immunology ; Antibodies/therapeutic use ; Complement System Proteins/immunology ; Graft Rejection/diagnosis ; Graft Rejection/drug therapy ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Kidney Transplantation ; Tissue Donors ; Treatment Outcome
Chemical Substances	Antibodies ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	2015-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1151092-4
ISSN	1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
ISSN (online)	1473-6543 ; 1535-3842
ISSN	1062-4813 ; 1062-4821
DOI	10.1097/MNH.0000000000000167
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Article ; Online: Impact of Renal Replacement Therapy on Rejection among Liver Transplant Recipients.

Farghaly, Sara / Sparkes, Tracy / Masters, Brian / Haririan, Abdolreza / Jakhete, Neha / Maluf, Daniel / Barth, Rolf N / Freedman, Sari

Progress in transplantation (Aliso Viejo, Calif.)

2023 Volume 33, Issue 4, Page(s) 348–355

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation ; Cohort Studies ; Retrospective Studies ; Living Donors ; Tacrolimus/therapeutic use ; Renal Replacement Therapy ; Kidney Diseases ; Graft Rejection ; Graft Survival
Chemical Substances	Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2023-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2864264-8
ISSN	2164-6708 ; 1526-9248
ISSN (online)	2164-6708
ISSN	1526-9248
DOI	10.1177/15269248231212915
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Article ; Online: Antibody-mediated Rejection of Kidney Allografts Following COVID-19: A Report of Two Cases.

Fazeli, Seyed Amirhossein / Takyar, Miralireza / Parvin, Mahmoud / Haririan, Abdolreza / Alirezaei, Amirhesam

Iranian journal of kidney diseases

2022 Volume 16, Issue 6, Page(s) 330–336

Abstract: Increased risk of graft rejection could be the consequence of COVID-19 in kidney transplant recipients (KTRs). We report two cases of kidney transplant (KT) with stable graft function who experienced antibody-mediated rejection (ABMR) following recovery ... ...

Abstract	Increased risk of graft rejection could be the consequence of COVID-19 in kidney transplant recipients (KTRs). We report two cases of kidney transplant (KT) with stable graft function who experienced antibody-mediated rejection (ABMR) following recovery from COVID-19. It seems that reduced immunosuppression during the acute illness, is the main explanation for post-COVID-19 ABMR. However, the inflammatory state associated with COVID-19, as well as direct cytopathic effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can predispose the kidney allograft to rejection. There is no definite guideline for the modification of immunosuppressives during COVID-19 in kidney transplant recipients. However, re-institution of full-dose immunosuppressives soon after recovery from COVID-19 and frequent outpatient follow-up visits are recommended. DOI: 10.52547/ijkd.7176.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Antibodies ; Kidney ; Immunosuppressive Agents/adverse effects ; Allografts
Chemical Substances	Antibodies ; Immunosuppressive Agents
Language	English
Publishing date	2022-12-01
Publishing country	Iran
Document type	Case Reports ; Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of a continuously active disinfectant wipe on the environmental bioburden in the intensive care unit: A randomized controlled study.

Nadimpalli, Gita / Johnson, J Kristie / Magder, Laurence S / Haririan, Abdolreza / Stevens, Deborah / Harris, Anthony D / O'Hara, Lyndsay M

Infection control and hospital epidemiology

2023 Volume 44, Issue 12, Page(s) 2036–2043

Abstract: Objective: To evaluate the efficacy of a new continuously active disinfectant (CAD) to decrease bioburden on high-touch environmental surfaces compared to a standard disinfectant in the intensive care unit.: Design: A single-blind randomized ... ...

Abstract	Objective: To evaluate the efficacy of a new continuously active disinfectant (CAD) to decrease bioburden on high-touch environmental surfaces compared to a standard disinfectant in the intensive care unit. Design: A single-blind randomized controlled trial with 1:1 allocation. Setting: Medical intensive care unit (MICU) at an urban tertiary-care hospital. Participants: Adult patients admitted to the MICU and on contact precautions. Intervention: A new CAD wipe used for daily cleaning. Methods: Samples were collected from 5 high-touch environmental surfaces before cleaning and at 1, 4, and 24 hours after cleaning. The primary outcome was the mean bioburden 24 hours after cleaning. The secondary outcome was the detection of any epidemiologically important pathogen (EIP) 24 hours after cleaning. Results: In total, 843 environmental samples were collected from 43 unique patient rooms. At 24 hours, the mean bioburden recovered from the patient rooms cleaned with the new CAD wipe (intervention) was 52 CFU/mL, and the mean bioburden was 92 CFU/mL in the rooms cleaned the standard disinfectant (control). After log transformation for multivariable analysis, the mean difference in bioburden between the intervention and control arm was -0.59 (95% CI, -1.45 to 0.27). The odds of EIP detection were 14% lower in the rooms cleaned with the CAD wipe (OR, 0.86; 95% CI, 0.31-2.32). Conclusions: The bacterial bioburden and odds of detection of EIPs were not statistically different in rooms cleaned with the CAD compared to the standard disinfectant after 24 hours. Although CAD technology appears promising in vitro, larger studies may be warranted to evaluate efficacy in clinical settings.
MeSH term(s)	Adult ; Humans ; Disinfectants/pharmacology ; Disinfection ; Cross Infection/prevention & control ; Cross Infection/microbiology ; Single-Blind Method ; Intensive Care Units
Chemical Substances	Disinfectants
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2023.111
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Article ; Online: Tubular Epithelial and Peritubular Capillary Endothelial Injury in COVID-19 AKI.

Papadimitriou, John C / Drachenberg, Cinthia B / Kleiner, David / Choudhri, Nadia / Haririan, Abdolreza / Cebotaru, Valeriu

Kidney international reports

2020 Volume 6, Issue 2, Page(s) 518–525

Keywords	covid19
Language	English
Publishing date	2020-11-05
Publishing country	United States
Document type	Case Reports
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2020.10.029
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Article: Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression.

Yakubu, Idris / Haririan, Abdolreza / Bartlett, Stephen / Sparkes, Tracy

Case reports in transplantation

2018 Volume 2018, Page(s) 9842893

Abstract: Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. Despite monozygosity, there is a ...

Abstract	Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. Despite monozygosity, there is a possibility of discordant protein presentation in identical twins that could trigger alloimmune response and lead to graft injury. Therefore, the optimal immunosuppression regimen in this patient population is unknown, and the safety of immunosuppression withdrawal remains controversial. Herein, we describe two patients who underwent successful renal transplantation from monozygotic identical twin donors. Monozygosity was determined using short tandem repeat (STR) analysis. All immunosuppression was successfully discontinued at 2 days and 3 weeks, respectively, after transplantation. Both patients are alive with functioning renal grafts at 1 year and 5 years after transplant, respectively. These two cases suggest that immunosuppression can be withdrawn safely and rapidly in select monozygous identical twin renal transplant recipients.
Language	English
Publishing date	2018-06-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627657-4
ISSN	2090-6951 ; 2090-6943
ISSN (online)	2090-6951
ISSN	2090-6943
DOI	10.1155/2018/9842893
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Article ; Online: The Impact of Treatment Delay on Hepatitis C Liver Transplant Outcomes.

Booth, Ian A / Clark, Jacqueline E / LaMattina, John C / Barth, Rolf N / Haririan, Abdolreza / Ravichandran, Bharath R

Journal of pharmacy practice

2021 Volume 36, Issue 2, Page(s) 264–270

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Liver Transplantation ; Hepacivirus ; Time-to-Treatment ; Antiviral Agents/therapeutic use ; Retrospective Studies ; Hepatitis C, Chronic/drug therapy ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Graft Rejection
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1027474-1
ISSN	1531-1937 ; 0897-1900
ISSN (online)	1531-1937
ISSN	0897-1900
DOI	10.1177/08971900211034261
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Zs.A 2893: Show issues

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Article: An Initial Analysis of the Baseline Levels of Dd-cfDNA After Pancreas Transplantation: A Prospective Study From High-volume Centers in the United States.

Yoo, Ashley / Riedel, Alexandria / Qian, Ian / Bartosic, Amanda / Soltani, Rudi / Kibria, Gulam / Haririan, Abdolreza / Drachenberg, Cinthia B / Abrams, Peter L / Odorico, Jon S / Cooper, Matthew / Bromberg, Jonathan S / Scalea, Joseph R

Transplantation direct

2023 Volume 9, Issue 4, Page(s) e1459

Abstract: Pancreas transplantation offers patients with diabetes an opportunity for glucose homeostasis. Current blood tests to surveil for rejection have poor sensitivity and specificity for identifying rejection, and pancreas biopsies are challenging and ... ...

Abstract	Pancreas transplantation offers patients with diabetes an opportunity for glucose homeostasis. Current blood tests to surveil for rejection have poor sensitivity and specificity for identifying rejection, and pancreas biopsies are challenging and associated with morbidity and graft loss. Donor-derived cell-free DNA (dd-cfDNA) is shed from transplanted organs and detectable in peripheral blood. Thus, a potential dd-cfDNA blood test assessing rejection would be clinically advantageous. Methods: One hundred eighty-one dd-cfDNA samples (n) were collected from 77 patients (N) up to 132 mo posttransplant. Results: The median dd-cfDNA level among all subjects was 0.28% (0.13%, 0.71%). In simultaneous pancreas-kidney (SPK) transplant recipients, the median dd-cfDNA level was 0.29% (0.13%, 0.71%), and it was 0.23% (0.08%, 0.71%) in pancreas transplant alone (PTA) recipients. When isolating for when without infection or rejection, the median dd-cfDNA level was 0.28% (0.13%, 0.64%) for SPK and 0.20% (0.00%, 0.32%) for PTA. Both transplant types approached 1.0% ≤1 mo posttransplant followed by a decrease in median dd-cfDNA. During episodes of rejection or infection, median dd-cfDNA levels were greater among all transplant types. Conclusions: The mean dd-cfDNA level for all pancreas transplant recipients is <1.0%, consistent with the published kidney transplant rejection threshold (>1.0%), regardless of SPK or PTA. Early posttransplant dd-cfDNA levels are transiently higher than later measurements. Dd-cfDNA elevation also correlates with rejection and infection and thus is a promising biomarker for surveilling pancreas transplant dysfunction.
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001459
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Article ; Online: Acute glomerulonephritis in a hematopoietic blood stem cell donor.

Chandra, Preeti / Dahiya, Saurabh / Sanchez-Petitto, Gabriela / Malik, Jawad / Bolanos, Jonathan / Haririan, Abdolreza / Weir, Matthew / Drachenberg, Cinthia / Rapoport, Aaron

Clinical nephrology. Case studies

2021 Volume 9, Page(s) 81–86

Abstract: Use of granulocyte colony-stimulating factor (G-CSF) has been associated with side effects including reports of acute glomerulonephritis (GN), almost all of which have been immune complex associated. There is one prior report of pauci-immune GN in a ... ...

Abstract	Use of granulocyte colony-stimulating factor (G-CSF) has been associated with side effects including reports of acute glomerulonephritis (GN), almost all of which have been immune complex associated. There is one prior report of pauci-immune GN in a child, but was negative for ANCA (anti-neutrophilic cytoplasmic antibodies). We describe the first case of ANCA-positive pauci-immune GN exacerbated by the use of G-CSF for peripheral blood stem cell (PBSC) donation in a patient with no prior history of vasculitis. Given the use of G-CSF in PBSC donation and neutropenias associated with various conditions, it is important that both the nephrologist and the hematologist are aware of the renal risks associated with its use.
Language	English
Publishing date	2021-07-01
Publishing country	Germany
Document type	Journal Article
ISSN	2196-5293
ISSN (online)	2196-5293
DOI	10.5414/CNCS110538
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Article ; Online: Comparison of Alemtuzumab Versus Basiliximab Induction Therapy in Elderly Kidney Transplant Recipients: A Single-Center Experience.

Yakubu, Idris / Ravichandran, Bharath / Sparkes, Tracy / Barth, Rolf N / Haririan, Abdolreza / Masters, Brian

Journal of pharmacy practice

2019 Volume 34, Issue 2, Page(s) 199–206

Abstract: Background: The optimal choice of induction immunosuppression for elderly kidney transplant recipients remains unclear. Although alemtuzumab has been associated with escalating risk of death and graft loss in this population, this risk has not been ... ...

Abstract	Background: The optimal choice of induction immunosuppression for elderly kidney transplant recipients remains unclear. Although alemtuzumab has been associated with escalating risk of death and graft loss in this population, this risk has not been adequately explored. The purpose of this study was to compare the safety and efficacy of alemtuzumab with basiliximab induction in this population. Methods: This is a retrospective matched cohort study of kidney transplant recipients aged ≥65 years. Patients who received alemtuzumab induction were matched (1:2) to a basiliximab control. The primary outcome was allograft survival. The incidence of acute rejection, infection, and all-cause mortality was measured. Results: Fifty-one and 102 patients were included in the alemtuzumab and basiliximab groups, respectively. Baseline demographics were similar between groups, except for more living donor transplant recipients in the alemtuzumab group (26/51 [51%] vs 31/102 [30.4%], Conclusions: Alemtuzumab induction is associated with similar outcomes to basiliximab in elderly kidney transplant recipients.
MeSH term(s)	Aged ; Alemtuzumab ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Basiliximab ; Cohort Studies ; Graft Rejection/epidemiology ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents ; Induction Chemotherapy ; Kidney Transplantation ; Retrospective Studies ; Transplant Recipients
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Immunosuppressive Agents ; Alemtuzumab (3A189DH42V) ; Basiliximab (9927MT646M)
Language	English
Publishing date	2019-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1027474-1
ISSN	1531-1937 ; 0897-1900
ISSN (online)	1531-1937
ISSN	0897-1900
DOI	10.1177/0897190019850934
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