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Article ; Online: Investigation of oncolytic effect of recombinant Newcastle disease virus in primary and metastatic oral melanoma.

Numpadit, Supaporn / Ito, Chiaki / Nakaya, Takaaki / Hagiwara, Katsuro

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 5, Page(s) 138

Abstract: Malignant melanoma is aggressive cancer with a high rate of local invasiveness and metastasis. Currently, the treatment options for patients with advanced-stage and metastatic oral melanoma are limited. A promising treatment option is oncolytic viral ... ...

Abstract	Malignant melanoma is aggressive cancer with a high rate of local invasiveness and metastasis. Currently, the treatment options for patients with advanced-stage and metastatic oral melanoma are limited. A promising treatment option is oncolytic viral therapy. This study aimed to evaluate novel therapies for malignant melanoma using a canine model. Oral melanoma, which frequently occurs in dogs is used as a model for human melanoma, was isolated and cultured and used for the evaluation of the tumor lytic effect induced by viral infection. We constructed a recombinant Newcastle disease virus (rNDV) that promotes the extracellular release of IFNγ from the virus-infected melanoma. The expression of oncolytic and apoptosis-related genes, the immune response by lymphocytes, and IFNγ expression were evaluated in virus-infected melanoma cells. The results showed that the rate of rNDV infection varied according to the isolated melanoma cells and the oncolytic effect differed between melanoma cells owing to the infectivity of the virus. The oncolytic effect tended to be greater for the IFNγ-expressing virus than for the GFP-expressing prototype virus. Additionally, lymphocytes co-cultured with the virus showed induced expression of Th1 cytokines. Therefore, recombinant NDV expressing IFNγ is expected to induce cellular immunity and oncolytic activity. This oncolytic treatment shows promise as a therapeutic approach for melanoma treatment once evaluated using clinical samples from humans.
MeSH term(s)	Humans ; Animals ; Dogs ; Newcastle disease virus/genetics ; Melanoma/therapy ; Oncolytic Viruses/genetics ; Mouth Neoplasms/therapy ; Oncolytic Virotherapy/methods ; Melanoma, Cutaneous Malignant
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-023-02002-z
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Article: Hepatitis E Virus (HEV) Spreads from Pigs and Sheep in Mongolia.

Batmagnai, Enkhbaatar / Boldbaatar, Bazartseren / Sodbayasgalan, Amarbayasgalan / Kato-Mori, Yuko / Hagiwara, Katsuro

Animals : an open access journal from MDPI

2023 Volume 13, Issue 5

Abstract: Hepatitis E is a viral infectious disease in pigs, wild boars, cows, deer, rabbits, camels, and humans as hosts caused ... ...

Abstract	Hepatitis E is a viral infectious disease in pigs, wild boars, cows, deer, rabbits, camels, and humans as hosts caused by
Language	English
Publishing date	2023-03-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13050891
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Article ; Online: Hepatitis E Virus (HEV) Spreads from Pigs and Sheep in Mongolia

Enkhbaatar Batmagnai / Bazartseren Boldbaatar / Amarbayasgalan Sodbayasgalan / Yuko Kato-Mori / Katsuro Hagiwara

Animals, Vol 13, Iss 891, p

2023 Volume 891

Abstract: Hepatitis E is a viral infectious disease in pigs, wild boars, cows, deer, rabbits, camels, and humans as hosts caused by Paslahepevirus . Recently, it has been detected in a wide variety of animals including domestic small ruminants. Mongolia is a land ... ...

Abstract	Hepatitis E is a viral infectious disease in pigs, wild boars, cows, deer, rabbits, camels, and humans as hosts caused by Paslahepevirus . Recently, it has been detected in a wide variety of animals including domestic small ruminants. Mongolia is a land of nomadic people living with livestock such as sheep, goats, and cattle. Due to how Mongolian lifestyles have changed, pork has become popular and swine diseases have emerged. Among them, Hepatitis E disease has become a zoonotic infectious disease that needs to be addressed. The HEV problem in pigs is that infected pigs excrete the virus without showing clinical symptoms and it spreads into the environment. We attempted to detect HEV RNA in sheep which had been raised in Mongolia for a long time, and those animals living together with pigs in the same region currently. We also conducted a longitudinal analysis of HEV infection in pigs in the same area and found that they were infected with HEV of the same genotype and cluster. In this study, we examined 400 feces and 120 livers (pigs and sheep) by RT-PCR in Töv Province, Mongolia. HEV detection in fecal samples was 2% (4/200) in sheep and 15% (30/200) in pigs. The results of ORF2 sequence analysis of the HEV RT-PCR-positive pigs and sheep confirmed genotype 4 in both animals. The results suggest that HEV infection is widespread in both pigs and sheep and that urgent measures to prevent infection are needed. This case study points to the changing nature of infectious diseases associated with livestock farming. It will be necessary to reconsider livestock husbandry and public health issues based on these cases.
Keywords	hepatitis E ; pig ; sheep ; prevalence ; Mongolia ; phylogenetic analysis ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Anti-inflammatory effect a specific Lactiplantibacillus plantarum in an ovalbumin-induced asthma model.

Kishida, Shigefumi / Kato-Mori, Yuko / Okamoto, Minoru / Hagiwara, Katsuro

Microbiology and immunology

2022 Volume 66, Issue 9, Page(s) 442–452

Abstract: Autoimmune, allergic, and respiratory inflammatory diseases are some of the most important health issues worldwide. Disorders of the gut microbiota have been associated with the induction of allergic and inflammatory diseases, and probiotics are being ... ...

Abstract	Autoimmune, allergic, and respiratory inflammatory diseases are some of the most important health issues worldwide. Disorders of the gut microbiota have been associated with the induction of allergic and inflammatory diseases, and probiotics are being tested for disease prevention. We examined functional Lactiplantibacillus plantarum RGU (Lp-1) to mice with ovalbumin (OVA)-induced asthma model to elucidate the inhibitory effect on pathological progression in asthma model. Prior to the experiments, the intestinal lactic acid bacteria were reduced by administering multiple antibiotics (MAB) to evaluate the administration effect of lactic acid bacteria. Mice were administered with Lp-1 or comparative control lactic acid bacteria in each group. After that, OVA-induced asthma was induced, and cytokine gene expression and histological findings were compared. Exacerbation of lung lesions was confirmed in the MAB group. The Lp-1 group mice had alleviated lung lesions with a decrease in IL-1β, IL-13, IL-17 and an increase in IL-10 of the splenocytes and bronchial lymph nodes compared with the MAB group, but not in the other groups. In OVA-induced asthma, administration of specific Lactiplantibacillus was confirmed to induce anti-inflammatory cytokines.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Asthma/chemically induced ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Disease Models, Animal ; Lung/pathology ; Mice ; Mice, Inbred BALB C ; Ovalbumin
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2022-07-07
Publishing country	Australia
Document type	Journal Article
ZDB-ID	224792-6
ISSN	1348-0421 ; 0385-5600
ISSN (online)	1348-0421
ISSN	0385-5600
DOI	10.1111/1348-0421.13014
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Article ; Online: Genetic stability of the open reading frame 2 (ORF2) of borna disease virus 1 (BoDV-1) distributed in cattle in Hokkaido.

Sukmak, Manakorn / Okamoto, Minoru / Ando, Tatsuya / Hagiwara, Katsuro

The Journal of veterinary medical science

2021 Volume 83, Issue 10, Page(s) 1526–1533

Abstract: Borna disease virus (BoDV) is a neurotropic virus that causes several infections in humans and neurological diseases in a wide range of animals worldwide. BoDV-1 has been molecularly and serologically detected in many domestic and wild animals in Japan; ... ...

Abstract	Borna disease virus (BoDV) is a neurotropic virus that causes several infections in humans and neurological diseases in a wide range of animals worldwide. BoDV-1 has been molecularly and serologically detected in many domestic and wild animals in Japan; however, the genetic diversity of this virus and the origin of its infection are not fully understood. In this study, we investigated BoDV-1 infection and genetic diversity in samples collected from animals in Hokkaido between 2006 and 2020. The analysis was performed by focusing on the P region of BoDV-1 for virus detection. The presence of BoDV-1 RNA was observed in samples of brain tissue and various organs derived from persistently infected cattle. Moreover, after inoculation, BoDV-positive brains were isolated from neonatal rats. The gene sequences of the P region of BoDV obtained from the rat brain were in the same cluster as the P region of the virus isolated from the original bovine. Thus, genetic variation in BoDV-1 was extremely low. The phylogenetic analysis revealed that BoDV-1 isolates obtained in this study were part of the same cluster, which suggested that BoDV-1 of the same cluster was widespread among animals in Hokkaido.
MeSH term(s)	Animals ; Borna Disease/epidemiology ; Borna disease virus/genetics ; Brain ; Cattle ; Cattle Diseases/epidemiology ; Open Reading Frames ; Phylogeny ; Rats
Language	English
Publishing date	2021-08-13
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.21-0155
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Article ; Online: Hepatitis E Virus (HEV) Spreads from Pigs and Sheep in Mongolia

Batmagnai, Enkhbaatar / Boldbaatar, Bazartseren / Sodbayasgalan, Amarbayasgalan / Kato-Mori, Yuko / Hagiwara, Katsuro

Animals. 2023 Mar. 01, v. 13, no. 5

2023

Abstract: Hepatitis E is a viral infectious disease in pigs, wild boars, cows, deer, rabbits, camels, and humans as hosts caused by Paslahepevirus. Recently, it has been detected in a wide variety of animals including domestic small ruminants. Mongolia is a land ... ...

Abstract	Hepatitis E is a viral infectious disease in pigs, wild boars, cows, deer, rabbits, camels, and humans as hosts caused by Paslahepevirus. Recently, it has been detected in a wide variety of animals including domestic small ruminants. Mongolia is a land of nomadic people living with livestock such as sheep, goats, and cattle. Due to how Mongolian lifestyles have changed, pork has become popular and swine diseases have emerged. Among them, Hepatitis E disease has become a zoonotic infectious disease that needs to be addressed. The HEV problem in pigs is that infected pigs excrete the virus without showing clinical symptoms and it spreads into the environment. We attempted to detect HEV RNA in sheep which had been raised in Mongolia for a long time, and those animals living together with pigs in the same region currently. We also conducted a longitudinal analysis of HEV infection in pigs in the same area and found that they were infected with HEV of the same genotype and cluster. In this study, we examined 400 feces and 120 livers (pigs and sheep) by RT-PCR in Töv Province, Mongolia. HEV detection in fecal samples was 2% (4/200) in sheep and 15% (30/200) in pigs. The results of ORF2 sequence analysis of the HEV RT-PCR-positive pigs and sheep confirmed genotype 4 in both animals. The results suggest that HEV infection is widespread in both pigs and sheep and that urgent measures to prevent infection are needed. This case study points to the changing nature of infectious diseases associated with livestock farming. It will be necessary to reconsider livestock husbandry and public health issues based on these cases.
Keywords	Orthohepevirus A ; RNA ; case studies ; cattle ; deer ; feces ; genotype ; hepatitis E ; livestock husbandry ; longitudinal studies ; nomadic people ; pork ; public health ; sequence analysis ; sheep ; swine ; viruses ; Mongolia
Language	English
Dates of publication	2023-0301
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13050891
Database	NAL-Catalogue (AGRICOLA)

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Article: Zika Virus Potential Vectors among

Uchida, Leo / Shibuya, Miki / Morales-Vargas, Ronald Enrique / Hagiwara, Katsuro / Muramatsu, Yasukazu

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 8

Abstract: The Zika virus (ZIKV) is a rapidly expanding mosquito-borne virus that causes febrile illness in humans. ...

Abstract	The Zika virus (ZIKV) is a rapidly expanding mosquito-borne virus that causes febrile illness in humans.
Language	English
Publishing date	2021-07-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10080938
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Article ; Online: Stability of enveloped and nonenveloped viruses in hydrolyzed gelatin liquid formulation.

Kadji, Francois Marie Ngako / Kotani, Kazuki / Tsukamoto, Hiroshi / Hiraoka, Yosuke / Hagiwara, Katsuro

Virology journal

2022 Volume 19, Issue 1, Page(s) 94

Abstract: Background: The thermal stability of viruses in gelatin liquid formulations for medical research and application is poorly understood and this study aimed to examine the thermal stability of 4 enveloped and nonenveloped DNA and RNA viruses in hydrolyzed ...

Abstract	Background: The thermal stability of viruses in gelatin liquid formulations for medical research and application is poorly understood and this study aimed to examine the thermal stability of 4 enveloped and nonenveloped DNA and RNA viruses in hydrolyzed gelatin liquid formulations. Methods: Bovine herpesvirus (BHV) was used as a model virus to examine the molecular weight (MW), concentration and gelatin type and to optimize virus stability in liquid formulations at 25 °C and 4 °C. Using the model virus liquid formulation, the stability of multiple enveloped and nonenveloped RNA and DNA viruses, including parainfluenza virus, reovirus (RV), BHV, and adenovirus (AdV), was monitored over up to a 30-week storage period. Results: The BHV model virus was considered stable after 3 weeks in hydrolyzed gelatin (MW: 4000) with a 0.8 LRV (log10 reduction value) at 25 °C or a 0.2 LRV at 4 °C, compared to the stabilities observed in higher MW gelatin (60,000 and 160,000) with an LRV above 1. Based on the gelatin type, BHV in alkaline-treated hydrolyzed gelatin samples were unexpectantly more stable than in acid-treated hydrolyzed gelatin sample. All four viruses exhibited stability at 4 °C for at least 8 weeks, BHV or AdV remained stable for over 30 weeks of storage, and at 25 °C, AdV and RV remained stable for 8 weeks. Conclusion: The results demonstrated that 5% of 4000 MW hydrolyzed gelatin formulation can act as a relevant stabilizer for the thermal stability of viruses in medical research and application.
MeSH term(s)	Adenoviridae ; DNA Viruses ; Gelatin ; RNA Viruses ; Viruses
Chemical Substances	Gelatin (9000-70-8)
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-022-01819-w
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Article ; Online: Identification of Three Novel Genes in Phenuiviridae Detected from Aedes Mosquitoes in Hokkaido, Japan.

Uchida, Leo / Sakurai, Yoshimi / Shimooka, Makoto / Morales-Vargas, Ronald Enrique / Hagiwara, Katsuro / Muramatsu, Yasukazu

Japanese journal of infectious diseases

2022 Volume 76, Issue 1, Page(s) 55–63

Abstract: Mosquitoes are important arthropod vectors of arboviruses. The family Phenuiviridae includes several medically important arboviruses, such as the Rift Valley fever phlebovirus and Toscana phlebovirus. Recent comprehensive genetic analyses have identified ...

Abstract	Mosquitoes are important arthropod vectors of arboviruses. The family Phenuiviridae includes several medically important arboviruses, such as the Rift Valley fever phlebovirus and Toscana phlebovirus. Recent comprehensive genetic analyses have identified many novel mosquito-specific viruses that are phylogenetically related to Phenuiviridae. We collected mosquitoes from Hokkaido in northern Japan, and conducted reverse transcription polymerase chain reactions (RT-PCRs) targeting the RNA-dependent RNA polymerase (RdRp) gene of Phenuiviridae. A total of 285 pools, comprising 3,082 mosquitoes from 2 genera and 8 species, were collected. Partial RdRp sequences were detected in 97 pools, which allowed us to classify the viruses into 3 clusters provisionally designated as Etutanne virus (ETTV) 1, 2, and 3. The virus most closely related to ETTVs is Narangue virus (family Phenuiviridae, genus Mobuvirus), which was detected in Mansonia mosquitoes; the nucleotide and amino acid sequences of the Narangue virus are 58.4-66.2% and 64.7-86.7% similar, respectively, to those of ETTVs. PCR and RT-PCR using DNA and RNase digestion methods showed that the ETTVs are RNA viruses that do not form non-retroviral integrated RNA virus sequences in the mosquito genome.
MeSH term(s)	Animals ; Aedes/genetics ; Japan ; Mosquito Vectors/genetics ; Arboviruses/genetics ; Viruses ; Phlebovirus/genetics ; RNA-Dependent RNA Polymerase
Chemical Substances	RNA-Dependent RNA Polymerase (EC 2.7.7.48)
Language	English
Publishing date	2022-09-30
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1478383-6
ISSN	1884-2836 ; 1344-6304
ISSN (online)	1884-2836
ISSN	1344-6304
DOI	10.7883/yoken.JJID.2022.179
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Article ; Online: Characterization of Myxovirus resistance protein in birds showing different susceptibilities to highly pathogenic influenza virus.

Hagiwara, Katsuro / Nakaya, Takaaki / Onuma, Manabu

The Journal of veterinary medical science

2020 Volume 82, Issue 5, Page(s) 619–625

Abstract: We compared the Mx expression and anti-viral function and the 3D structure of Mx protein in four species: chicken (Gallus gallus), whooper swan (Cygnus cygnus), jungle crow (Corvus macrorhynchos), and rock dove (Columba livia). We observed different ... ...

Abstract	We compared the Mx expression and anti-viral function and the 3D structure of Mx protein in four species: chicken (Gallus gallus), whooper swan (Cygnus cygnus), jungle crow (Corvus macrorhynchos), and rock dove (Columba livia). We observed different mortalities associated with highly pathogenic avian influenza virus (HPAIV) infection to understand the relationship between Mx function as an immune response factor and HPAIV proliferation in bird cells. Different levels of Mx were observed among the different bird species after virus infection. Strong Mx expression was confirmed in the rock dove and whooper swan 6 hr after viral infection. The lowest virus copy numbers were observed in rock dove. The virus infectivity was significantly reduced in the BALB/3T3 cells expressing rock dove and jungle crow Mx. These results suggested that high Mx expression and significant Mx-induced anti-viral effects might result in the rock dove primary cells having the lowest virus copy number. Comparison of the expected 3D structure of Mx protein in all four bird species demonstrated that the structure of loop L4 varied among the investigated species. It was reported that differences in amino acid sequence in loop L4 affect antiviral activity in human and mouse cells, and a significant anti-viral effect was observed in the rock dove Mx. Thus, the amino acid sequence of loop L4 in rock dove might represent relatively high anti-viral activity.
MeSH term(s)	3T3 Cells ; Amino Acid Sequence ; Animals ; Birds ; Cells, Cultured ; Influenza A Virus, H5N1 Subtype/growth & development ; Influenza A Virus, H5N1 Subtype/immunology ; Influenza in Birds/immunology ; Influenza in Birds/virology ; Mice ; Myxovirus Resistance Proteins/chemistry ; Myxovirus Resistance Proteins/genetics ; Myxovirus Resistance Proteins/metabolism ; Protein Conformation ; RNA, Viral ; Species Specificity
Chemical Substances	Myxovirus Resistance Proteins ; RNA, Viral
Language	English
Publishing date	2020-03-16
Publishing country	Japan
Document type	Comparative Study ; Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.19-0408
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