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Article ; Online: Letter to the Editor: Five Hundred Fifty-five Retrieved Metal-on-metal Hip Replacements of a Single Design Show a Wide Range of Wear, Surface Features, and Histopathologic Reactions.

Langton, David J

Clinical orthopaedics and related research

2018 Volume 476, Issue 11, Page(s) 2278–2279

MeSH term(s)	Arthroplasty, Replacement, Hip ; Hip Prosthesis ; Metal-on-Metal Joint Prostheses
Language	English
Publishing date	2018-10-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80301-7
ISSN	1528-1132 ; 0009-921X
ISSN (online)	1528-1132
ISSN	0009-921X
DOI	10.1097/CORR.0000000000000517
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Article ; Online: The impact of femoral head size on the wear evolution at contacting surfaces of total hip prostheses: A finite element analysis.

Ashkanfar, Ariyan / Toh, Shawn Ming Song / English, Russell / Langton, David J / Joyce, Thomas J

Journal of the mechanical behavior of biomedical materials

2024 Volume 153, Page(s) 106474

Abstract: Total Hip Arthroplasty has been a revolutionary technique in restoring mobility to patients with damaged hip joints. The introduction of modular components of the hip prosthesis allowed for bespoke solutions based on the requirements of the patient. The ... ...

Abstract	Total Hip Arthroplasty has been a revolutionary technique in restoring mobility to patients with damaged hip joints. The introduction of modular components of the hip prosthesis allowed for bespoke solutions based on the requirements of the patient. The femoral stem is designed with a conical trunnion to allow for assembly of different femoral head sizes based on surgical requirements. The femoral head diameters for a metal-on-polyethylene hip prosthesis have typically ranged between 22 mm and 36 mm and are typically manufactured using Cobalt-Chromium alloy. A smaller femoral head diameter is associated with lower wear of the polyethylene, however, there is a higher risk of dislocation. In this study, a finite element model of a standard commercial hip arthroplasty prosthesis was modelled with femoral head diameters ranging from 22 mm to 36 mm to investigate the wear evolution and material loss at both contacting surfaces (acetabular cup and femoral stem trunnion). The finite element model, coupled with a validated in-house wear algorithm modelled a human walking for 10 million steps. The results have shown that as the femoral head size increased, the amount of wear on all contacting surfaces increased. As the femoral head diameter increased from 22 mm to 36 mm, the highly cross-linked polyethylene (XLPE) volumetric wear increased by 61% from 98.6 mm
MeSH term(s)	Humans ; Arthroplasty, Replacement, Hip ; Hip Prosthesis ; Femur Head ; Finite Element Analysis ; Prosthesis Design ; Prosthesis Failure ; Polyethylene ; Chromium Alloys
Chemical Substances	Polyethylene (9002-88-4) ; Chromium Alloys
Language	English
Publishing date	2024-02-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2024.106474
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Article ; Online: Letter to the Editor on "Factors Associated With Trunnionosis in the Metal-on-Metal Pinnacle Hip".

Langton, David J

The Journal of arthroplasty

2017 Volume 32, Issue 3, Page(s) 1044

Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Letter
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2016.09.030
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Article ; Online: Response to Letter to the Editor on "Factors Associated With Trunnionosis in the Metal-on-Metal Pinnacle Hip".

Langton, David J

The Journal of arthroplasty

2017 Volume 32, Issue 3, Page(s) 1045–1046

Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Letter
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2016.10.025
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Article ; Online: How does bicycling affect the longevity of Total Hip Arthroplasty? A finite element wear analysis.

Toh, Shawn Ming Song / Ashkanfar, Ariyan / English, Russell / Rothwell, Glynn / Langton, David J / Joyce, Thomas J

Journal of the mechanical behavior of biomedical materials

2023 Volume 139, Page(s) 105673

Abstract: As the number of young and active individuals undergoing Total Hip Arthroplasty (THA) are increasing yearly, there is a need for hip prostheses to have increased longevity. Current investigations into the longevity of these prostheses only include ... ...

Abstract	As the number of young and active individuals undergoing Total Hip Arthroplasty (THA) are increasing yearly, there is a need for hip prostheses to have increased longevity. Current investigations into the longevity of these prostheses only include walking as the patient's activity as there is limited data on the amount and intensity of other activity performed by the patient. To further understand the evolution of wear and increase the longevity of these implants, the impact of different activities on the hip prosthesis needs to be investigated. In this study, a finite element model and wear algorithm was developed to simulate both walking and bicycling over a 5-year period. The XLPE acetabular cup volumetric wear rate was found to be 33 mm
MeSH term(s)	Humans ; Arthroplasty, Replacement, Hip ; Finite Element Analysis ; Bicycling ; Prosthesis Failure ; Prosthesis Design ; Hip Prosthesis ; Polyethylene
Chemical Substances	Polyethylene (9002-88-4)
Language	English
Publishing date	2023-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2023.105673
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Article: The establishment of winter wheat root system architecture in field soils: The effect of soil type on root development in a temperate climate.

Hobson, David J / Harty, Mary A / Langton, David / McDonnell, Kevin / Tracy, Saoirse R

Soil use and management

2022 Volume 39, Issue 1, Page(s) 198–208

Abstract: Winter wheat ( ...

Abstract	Winter wheat (
Language	English
Publishing date	2022-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	742151-5
ISSN	1475-2743 ; 0266-0032
ISSN (online)	1475-2743
ISSN	0266-0032
DOI	10.1111/sum.12795
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Article ; Online: The establishment of winter wheat root system architecture in field soils: The effect of soil type on root development in a temperate climate

Hobson, David J. / Harty, Mary A. / Langton, David / McDonnell, Kevin / Tracy, Saoirse R.

Soil Use and Management. 2023 Jan., v. 39, no. 1 p.198-208

2023

Abstract: Winter wheat (Triticum aestivum L.) is an important cereal crop in the temperate climates of western Europe. Root system architecture is a significant contributor to resource capture and plant resilience. However, the impact of soil type on root system ... ...

Abstract	Winter wheat (Triticum aestivum L.) is an important cereal crop in the temperate climates of western Europe. Root system architecture is a significant contributor to resource capture and plant resilience. However, the impact of soil type on root system architecture (RSA) in field structured soils is yet to be fully assessed. This work studied the development of root growth using deep cultivation (250 mm) during the tillering phase stage (Zadock stage 25) of winter wheat across three soil types. The three sites of contrasting soil types covered a geographical area in the UK and Ireland in October 2018. Root samples were analysed using two methods: X‐ray computed tomography (CT) which provides 3D images of the undisturbed roots in the soil, and a WinRHIZO™ scanner used to generate 2D images of washed roots and to measure further root parameters. Important negative relationships existed between soil bulk density and root properties (root length density, root volume, surface area and length) across the three sites. The results revealed that despite reduced root growth, the clay (Southoe) site had a significantly higher crop yield irrespective of root depth. The loamy sand (Harper Adams) site had significantly higher root volume, surface area and root length density compared with the other sites. However, a reduction in grain yield of 2.42 Mt ha⁻¹ was incurred compared with the clay site and 1.6 Mt ha⁻¹ compared with the clay loam site. The significantly higher rooting characteristics found in the loamy sand site were a result of the significantly lower soil bulk density compared with the other two sites. The loamy sand site had a lower soil bulk density, but no significant difference in macroporosity between sites (p > 0.05). This suggests that soil type and structure directly influence crop yield to greater extent than root parameters, but the interactions between both need simultaneous assessment in field sites.
Keywords	Triticum aestivum ; X-radiation ; administrative management ; clay ; clay loam soils ; deep tillage ; grain yield ; loamy sand soils ; root growth ; root systems ; scanners ; soil density ; surface area ; temperate zones ; tillering ; tomography ; winter wheat ; Ireland ; Western European region
Language	English
Dates of publication	2023-01
Size	p. 198-208.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	742151-5
ISSN	1475-2743 ; 0266-0032
ISSN (online)	1475-2743
ISSN	0266-0032
DOI	10.1111/sum.12795
Database	NAL-Catalogue (AGRICOLA)

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Article: Periarticular metal hypersensitivity complications of hip bearings containing cobalt-chromium.

Wu, Dongmei / Bhalekar, Rohan M / Marsh, Jordan S / Langton, David J / Stewart, Alan J

EFORT open reviews

2022 Volume 7, Issue 11, Page(s) 758–771

Abstract: Hip joints with bearings composed of cobalt-chromium alloy (metal-on-metal bearings) have been one of the most widely used implants in joint replacement arthroplasty. Unfortunately, these implants can contribute to a complication called aseptic ... ...

Abstract	Hip joints with bearings composed of cobalt-chromium alloy (metal-on-metal bearings) have been one of the most widely used implants in joint replacement arthroplasty. Unfortunately, these implants can contribute to a complication called aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL), a type IV metal hypersensitivity response around the joint. Consistent with such bearings, increased metal debris can be found in the surrounding fluids and in remote tissues and organs, due to wear and corrosion. It is hypothesized that metal ions released from the prosthesis (including Co2+) can potentially form haptens with proteins such as serum albumin in synovial fluid that in turn elicit ALVAL. Generally, elevated cobalt and chromium levels in synovial fluids may indicate implant failure. However, such measurements cannot be used as a reliable tool to predict the onset of ALVAL. To detect ALVAL, some diagnostic tests, questionnaires and imaging techniques have been used clinically with some success, but a standardized approach is lacking. At present, guidelines for implant usage and patient management are ambiguous and inconsistent across health care authorities. To reduce and better manage the development of ALVAL, further research into the precise molecular mechanism(s) by which ALVAL develops is urgently needed. Identification of diagnostic and prognostic biomarkers for ALVAL is required, as are more standardized guidelines for surgery and patient management.
Language	English
Publishing date	2022-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2844421-8
ISSN	2058-5241 ; 2058-5241 ; 2396-7544
ISSN (online)	2058-5241
ISSN	2058-5241 ; 2396-7544
DOI	10.1530/EOR-22-0036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long-Term Dupilumab Efficacy on Severe Exacerbations and Lung Function in Patients with Type 2 Asthma.

Papi, Alberto / Castro, Mario / Busse, William W / Langton, David / Korn, Stephanie / Xia, Changming / Soler, Xavier / Pandit-Abid, Nami / Radwan, Amr / Jacob-Nara, Juby A / Rowe, Paul J / Deniz, Yamo

Annals of the American Thoracic Society

2024 Volume 21, Issue 4, Page(s) 675–679

MeSH term(s)	Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Lung ; Anti-Asthmatic Agents/therapeutic use ; Double-Blind Method
Chemical Substances	dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized ; Anti-Asthmatic Agents
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Letter
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202306-544RL
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Article ; Online: Safety of delivering bronchial thermoplasty in two treatment sessions.

Koshy, Kavya / Sha, Joy / Bennetts, Kim / Langton, David

Respiratory research

2021 Volume 22, Issue 1, Page(s) 307

Abstract: Background: Bronchial thermoplasty (BT) is a novel endoscopic therapy for severe asthma. Traditionally it is performed in three separate treatment sessions, targeting different portions of the lung, and each requires an anaesthetic and hospital ... ...

Abstract	Background: Bronchial thermoplasty (BT) is a novel endoscopic therapy for severe asthma. Traditionally it is performed in three separate treatment sessions, targeting different portions of the lung, and each requires an anaesthetic and hospital admission. Compression of treatment into 2 sessions would present a more convenient alternative for patients. In this prospective observational study, the safety of compressing BT into two treatment sessions was compared with the traditional 3 treatment approach. Methods: Sixteen patients meeting ERS/ATS criteria for severe asthma consented to participate in an accelerated treatment schedule (ABT), which treated the whole left lung followed by the right lung four weeks later. The short-term outcomes of these patients were compared with 37 patients treated with conventional BT scheduling (CBT). The outcome measures used to assess safety were (1) the requirement to remain in hospital beyond the electively planned 24-h admission and (2) the need for re-admission for any cause within of 30 days of treatment. Results: The total number of radiofrequency activations delivered in the ABT group was similar to CBT (187 ± 21 vs 176 ± 40, p = 0.326). With ABT, 11 in 31 admissions (37.9%) required prolonged admission due to wheezing, compared to 5.4% with CBT (p = 0.0025). The mean hospital length of stay with ABT was 1.8 ± 1.3 days, compared to 1.1 ± 0.4 days (p < 0.001). ICU monitoring was required on 5 occasions with ABT (16.1%), compared to 0.9% with CBT (p = 0.002). Subgroup analysis demonstrated that females were more likely to require prolonged admission (OR 11.6, p = 0.0025). The 30-day hospital readmission rate was similar for both groups (6.4% vs 5.4%, p = 0.67). All patients made a complete recovery after treatment with similar outcomes at the 6-month follow-up reassessment. Conclusion: This study demonstrates that ABT results in greater short-term deterioration in lung function associated with a greater risk of prolonged hospital and ICU stay, predominantly affecting females. Therefore, in females, these risks need to be balanced against the convenience of fewer treatment sessions. In males, it may be an advantage to compress treatment.
MeSH term(s)	Asthma/diagnosis ; Asthma/physiopathology ; Asthma/surgery ; Bronchial Thermoplasty/methods ; Bronchoscopy/methods ; Female ; Follow-Up Studies ; Forced Expiratory Flow Rates/physiology ; Humans ; Lung/physiopathology ; Male ; Middle Aged ; Prospective Studies ; Severity of Illness Index ; Treatment Outcome
Language	English
Publishing date	2021-11-29
Publishing country	England
Document type	Comparative Study ; Journal Article ; Observational Study
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-021-01901-x
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