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  1. Article ; Online: The influence of interval between doses on response to vaccines.

    Rodrigues, Charlene M C / Plotkin, Stanley A

    Vaccine

    2021  Volume 39, Issue 49, Page(s) 7123–7127

    MeSH term(s) COVID-19 ; Humans ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2021-11-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2021.10.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Challenges of Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Children.

    Rodrigues, Charlene M C

    Current therapeutic research, clinical and experimental

    2017  Volume 84, Page(s) e7–e11

    Abstract: Background: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality globally, responsible for more than 14% of deaths in children younger than 5 years of age. Due to difficulties with pathogen identification and diagnostics of ... ...

    Abstract Background: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality globally, responsible for more than 14% of deaths in children younger than 5 years of age. Due to difficulties with pathogen identification and diagnostics of CAP in children, targeted antimicrobial therapy is not possible, hence the widespread use of empirical antibiotics, in particular penicillins, cephalosporin, and macrolides.
    Objectives: This review aimed to address medical, societal, and political issues associated with the widespread use of empirical antibiotics for CAP in the United Kingdom, India, and Nigeria.
    Methods: A literature review was performed identifying the challenges pertaining to the use of widespread empirical antibiotics for CAP in children. A qualitative analysis of included studies identified relevant themes. Empirical guidance was based on guidelines from the World Health Organization, British Thoracic Society, and Infectious Diseases Society of America, used in both industrialized and resource-poor settings.
    Results: In the United Kingdom there was poor adherence to antibiotics guidelines. There was developing antibiotic resistance to penicillins and macrolides in both developing and industrialized regions. There were difficulties accessing the care and treatment when needed in Nigeria. Prevention strategies with vaccination against
    Conclusions: Effective and timely treatment is required for CAP and empirical antibiotics are evidence-based and appropriate in most settings. However, better diagnostics and education to target treatment may help to prevent antibiotic resistance. Ensuring the secure financing of clean food and water, sanitation, and public health infrastructure are also required to reduce the burden of disease in children in developing countries.
    Language English
    Publishing date 2017-01-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 205697-5
    ISSN 1879-0313 ; 0011-393X
    ISSN (online) 1879-0313
    ISSN 0011-393X
    DOI 10.1016/j.curtheres.2017.01.002
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  3. Article: Impact of Vaccines; Health, Economic and Social Perspectives.

    Rodrigues, Charlene M C / Plotkin, Stanley A

    Frontiers in microbiology

    2020  Volume 11, Page(s) 1526

    Abstract: In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent ...

    Abstract In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent life-threatening infectious diseases remains unequal to all infants, children and adults in the world. This is a problem that many individuals and agencies are working hard to address globally. As clinicians and biomedical scientists we often focus on the health benefits that vaccines provide, in the prevention of ill-health and death from infectious pathogens. Here we discuss the health, economic and social benefits of vaccines that have been identified and studied in recent years, impacting all regions and all age groups. After learning of the emergence of SARS-CoV-2 virus in December 2019, and its potential for global dissemination to cause COVID-19 disease was realized, there was an urgent need to develop vaccines at an unprecedented rate and scale. As we appreciate and quantify the health, economic and social benefits of vaccines and immunization programs to individuals and society, we should endeavor to communicate this to the public and policy makers, for the benefit of endemic, epidemic, and pandemic diseases.
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.01526
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  4. Article ; Online: Impact of Vaccines; Health, Economic and Social Perspectives

    Charlene M. C. Rodrigues / Stanley A. Plotkin

    Frontiers in Microbiology, Vol

    2020  Volume 11

    Abstract: In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent ...

    Abstract In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent life-threatening infectious diseases remains unequal to all infants, children and adults in the world. This is a problem that many individuals and agencies are working hard to address globally. As clinicians and biomedical scientists we often focus on the health benefits that vaccines provide, in the prevention of ill-health and death from infectious pathogens. Here we discuss the health, economic and social benefits of vaccines that have been identified and studied in recent years, impacting all regions and all age groups. After learning of the emergence of SARS-CoV-2 virus in December 2019, and its potential for global dissemination to cause COVID-19 disease was realized, there was an urgent need to develop vaccines at an unprecedented rate and scale. As we appreciate and quantify the health, economic and social benefits of vaccines and immunization programs to individuals and society, we should endeavor to communicate this to the public and policy makers, for the benefit of endemic, epidemic, and pandemic diseases.
    Keywords immunization ; vaccines ; infectious diseases ; infection ; children ; health economics ; Microbiology ; QR1-502 ; covid19
    Subject code 360
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Ribosomal MLST nucleotide identity (rMLST-NI), a rapid bacterial species identification method: application to

    Bray, James E / Correia, Annapaula / Varga, Margaret / Jolley, Keith A / Maiden, Martin C J / Rodrigues, Charlene M C

    Microbial genomics

    2022  Volume 8, Issue 9

    Abstract: Bacterial genomics is making an increasing contribution to the fields of medicine and public health microbiology. Consequently, accurate species identification of bacterial genomes is an important task, particularly as the number of genomes stored in ... ...

    Abstract Bacterial genomics is making an increasing contribution to the fields of medicine and public health microbiology. Consequently, accurate species identification of bacterial genomes is an important task, particularly as the number of genomes stored in online databases increases rapidly and new species are frequently discovered. Existing database entries require regular re-evaluation to ensure that species annotations are consistent with the latest species definitions. We have developed an automated method for bacterial species identification that is an extension of ribosomal multilocus sequence typing (rMLST). The method calculates an 'rMLST nucleotide identity' (rMLST-NI) based on the nucleotides present in the protein-encoding ribosomal genes derived from bacterial genomes. rMLST-NI was used to validate the species annotations of 11839 publicly available
    MeSH term(s) Genome, Bacterial/genetics ; Genomics/methods ; Klebsiella/genetics ; Multilocus Sequence Typing/methods ; Nucleotides
    Chemical Substances Nucleotides
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A world without bacterial meningitis: how genomic epidemiology can inform vaccination strategy.

    Rodrigues, Charlene M C / Maiden, Martin C J

    F1000Research

    2018  Volume 7, Page(s) 401

    Abstract: Bacterial meningitis remains an important cause of global morbidity and mortality. Although effective vaccinations exist and are being increasingly used worldwide, bacterial diversity threatens their impact and the ultimate goal of eliminating the ... ...

    Abstract Bacterial meningitis remains an important cause of global morbidity and mortality. Although effective vaccinations exist and are being increasingly used worldwide, bacterial diversity threatens their impact and the ultimate goal of eliminating the disease. Through genomic epidemiology, we can appreciate bacterial population structure and its consequences for transmission dynamics, virulence, antimicrobial resistance, and development of new vaccines. Here, we review what we have learned through genomic epidemiological studies, following the rapid implementation of whole genome sequencing that can help to optimise preventative strategies for bacterial meningitis.
    Language English
    Publishing date 2018-03-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.13793.1
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  7. Article ; Online: A world without bacterial meningitis

    Charlene M.C. Rodrigues / Martin C.J. Maiden

    F1000Research, Vol

    how genomic epidemiology can inform vaccination strategy [version 1; referees: 2 approved]

    2018  Volume 7

    Abstract: Bacterial meningitis remains an important cause of global morbidity and mortality. Although effective vaccinations exist and are being increasingly used worldwide, bacterial diversity threatens their impact and the ultimate goal of eliminating the ... ...

    Abstract Bacterial meningitis remains an important cause of global morbidity and mortality. Although effective vaccinations exist and are being increasingly used worldwide, bacterial diversity threatens their impact and the ultimate goal of eliminating the disease. Through genomic epidemiology, we can appreciate bacterial population structure and its consequences for transmission dynamics, virulence, antimicrobial resistance, and development of new vaccines. Here, we review what we have learned through genomic epidemiological studies, following the rapid implementation of whole genome sequencing that can help to optimise preventative strategies for bacterial meningitis.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: The independent and combined impact of moral injury and moral distress on post-traumatic stress disorder symptoms among healthcare workers during the COVID-19 pandemic.

    D'Alessandro-Lowe, Andrea M / Patel, Herry / Easterbrook, Bethany / Ritchie, Kim / Brown, Andrea / Xue, Yuanxin / Karram, Mauda / Millman, Heather / Sullo, Emily / Pichtikova, Mina / Nicholson, Andrew / Heber, Alex / Malain, Ann / O'Connor, Charlene / Schielke, Hygge / Rodrigues, Sarah / Hosseiny, Fardous / McCabe, Randi E / Lanius, Ruth A /
    McKinnon, Margaret C

    European journal of psychotraumatology

    2024  Volume 15, Issue 1, Page(s) 2299661

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Humans ; Stress Disorders, Post-Traumatic/epidemiology ; Pandemics ; COVID-19/epidemiology ; Canada ; Health Personnel ; Morals
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2586642-4
    ISSN 2000-8066 ; 2000-8066
    ISSN (online) 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008066.2023.2299661
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  9. Article: Impact of Vaccines; Health, Economic and Social Perspectives

    Rodrigues, Charlene M. C. / Plotkin, Stanley A.

    Front. Microbiol.

    Abstract: In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent ...

    Abstract In the 20th century, the development, licensing and implementation of vaccines as part of large, systematic immunization programs started to address health inequities that existed globally. However, at the time of writing, access to vaccines that prevent life-threatening infectious diseases remains unequal to all infants, children and adults in the world. This is a problem that many individuals and agencies are working hard to address globally. As clinicians and biomedical scientists we often focus on the health benefits that vaccines provide, in the prevention of ill-health and death from infectious pathogens. Here we discuss the health, economic and social benefits of vaccines that have been identified and studied in recent years, impacting all regions and all age groups. After learning of the emergence of SARS-CoV-2 virus in December 2019, and its potential for global dissemination to cause COVID-19 disease was realized, there was an urgent need to develop vaccines at an unprecedented rate and scale. As we appreciate and quantify the health, economic and social benefits of vaccines and immunization programs to individuals and society, we should endeavor to communicate this to the public and policy makers, for the benefit of endemic, epidemic, and pandemic diseases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #697903
    Database COVID19

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  10. Article ; Online: Evolution of Sequence Type 4821 Clonal Complex Hyperinvasive and Quinolone-Resistant Meningococci.

    Chen, Mingliang / Harrison, Odile B / Bratcher, Holly B / Bo, Zhiyan / Jolley, Keith A / Rodrigues, Charlene M C / Bray, James E / Guo, Qinglan / Zhang, Xi / Chen, Min / Maiden, Martin C J

    Emerging infectious diseases

    2021  Volume 27, Issue 4, Page(s) 1110–1122

    Abstract: Expansion of quinolone-resistant Neisseria meningitidis clone ... ...

    Abstract Expansion of quinolone-resistant Neisseria meningitidis clone China
    MeSH term(s) China ; Europe ; Humans ; Meningococcal Infections ; Meningococcal Vaccines ; Neisseria meningitidis ; Quinolones ; Serogroup
    Chemical Substances Meningococcal Vaccines ; Quinolones
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2704.203612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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