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  1. Article: Peer review: Pearls and pitfalls.

    Datta, Rakesh

    Journal of Ayurveda and integrative medicine

    2021  Volume 12, Issue 1, Page(s) 4–6

    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 0975-9476
    ISSN 0975-9476
    DOI 10.1016/j.jaim.2020.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Medical Journal Armed Forces India: 75 years young!

    Datta, Rakesh

    Medical journal, Armed Forces India

    2019  Volume 75, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2019-01-18
    Publishing country India
    Document type Editorial
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/j.mjafi.2018.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Increased heterogeneity in expression of genes associated with cancer progression and drug resistance.

    Bose, Anwesha / Datta, Subhasis / Mandal, Rakesh / Ray, Upasana / Dhar, Riddhiman

    Translational oncology

    2024  Volume 41, Page(s) 101879

    Abstract: Fluctuations in the number of regulatory molecules and differences in timings of molecular events can generate variation in gene expression among genetically identical cells in the same environmental condition. This variation, termed as expression noise, ...

    Abstract Fluctuations in the number of regulatory molecules and differences in timings of molecular events can generate variation in gene expression among genetically identical cells in the same environmental condition. This variation, termed as expression noise, can create differences in metabolic state and cellular functions, leading to phenotypic heterogeneity. Expression noise and phenotypic heterogeneity have been recognized as important contributors to intra-tumor heterogeneity, and have been associated with cancer growth, progression, and therapy resistance. However, how expression noise changes with cancer progression in actual cancer patients has remained poorly explored. Such an analysis, through identification of genes with increasing expression noise, can provide valuable insights into generation of intra-tumor heterogeneity, and could have important implications for understanding immune-suppression, drug tolerance and therapy resistance. In this work, we performed a genome-wide identification of changes in gene expression noise with cancer progression using single-cell RNA-seq data of lung adenocarcinoma patients at different stages of cancer. We identified 37 genes in epithelial cells that showed an increasing noise trend with cancer progression, many of which were also associated with cancer growth, EMT and therapy resistance. We found that expression of several of these genes was positively associated with expression of mitochondrial genes, suggesting an important role of mitochondria in generation of heterogeneity. In addition, we uncovered substantial differences in sample-specific noise profiles which could have implications for personalized prognosis and treatment.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2024.101879
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  4. Article: Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence.

    Ahuja, Kriti / Batra, Vipul / Kumar, Rakesh / Datta, Tirtha Kumar

    Frontiers in veterinary science

    2024  Volume 10, Page(s) 1324647

    Abstract: Introduction: One of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes. The ... ...

    Abstract Introduction: One of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes. The present study was undertaken to modulate the canonical Wnt (Wingless/integration) signaling pathway in the poor-quality (colorless cytoplasm after Brilliant Cresyl Blue staining, BCB-) buffalo cumulus-oocyte complexes (COCs) to improve their
    Methods: The expression of key Wnt pathway genes was initially assessed in the good (blue cytoplasm after Brilliant Cresyl Blue staining, BCB+) and poor quality (BCB-) buffalo COCs to establish a differential activity of the Wnt pathway. The BCB- COCs were supplemented with the Wnt pathway inhibitor, Dickkopf-related protein 1 (DKK1) and later subjected to IVM and IVEP along with the BCB+ and BCB- controls. The cumulus expansion index (CEI), rate of nuclear maturation (mean percentage of oocytes in the MII stage) and embryo production, and the expression of developmentally important genes were evaluated to assess the effect of Wnt pathway inhibition on the development competence of these poor-quality oocytes.
    Results: The Wnt pathway genes exhibited a significantly higher expression (
    Conclusion: These data indicate that inhibition of the Wnt pathway during the initial course of oocyte maturation can improve the development competence of poor-quality buffalo oocytes.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1324647
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  5. Article: COVID-19: Shades of Grey.

    Naithani, Nardeep / Datta, Rakesh

    Medical journal, Armed Forces India

    2020  Volume 76, Issue 2, Page(s) 123–124

    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country India
    Document type Editorial
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/j.mjafi.2020.04.010
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  6. Article ; Online: Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence

    Kriti Ahuja / Vipul Batra / Rakesh Kumar / Tirtha Kumar Datta

    Frontiers in Veterinary Science, Vol

    2024  Volume 10

    Abstract: IntroductionOne of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes. The present ... ...

    Abstract IntroductionOne of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes. The present study was undertaken to modulate the canonical Wnt (Wingless/integration) signaling pathway in the poor-quality (colorless cytoplasm after Brilliant Cresyl Blue staining, BCB-) buffalo cumulus-oocyte complexes (COCs) to improve their in vitro maturation (IVM) and embryo production (IVEP) rates.MethodsThe expression of key Wnt pathway genes was initially assessed in the good (blue cytoplasm after Brilliant Cresyl Blue staining, BCB+) and poor quality (BCB-) buffalo COCs to establish a differential activity of the Wnt pathway. The BCB- COCs were supplemented with the Wnt pathway inhibitor, Dickkopf-related protein 1 (DKK1) and later subjected to IVM and IVEP along with the BCB+ and BCB- controls. The cumulus expansion index (CEI), rate of nuclear maturation (mean percentage of oocytes in the MII stage) and embryo production, and the expression of developmentally important genes were evaluated to assess the effect of Wnt pathway inhibition on the development competence of these poor-quality oocytes.ResultsThe Wnt pathway genes exhibited a significantly higher expression (p < 0.05) in the poor-quality BCB- oocytes compared to the good-quality BCB+ oocytes during the early maturation stages. The supplementation of BCB- COCs with 100 ng/mL DKK1 effectively inhibited the expression of the key mediators of the Wnt pathway (β-catenin and dishevelled homolog 1, DVL1). DKK1 supplemented BCB- COCs exhibited significantly improved cytoplasmic and nuclear maturation indices, development rates and significantly elevated expression (p < 0.05) of genes implicated in germinal vesicle breakdown (GVBD) and embryonic genome activation (EGA) vis-à-vis BCB- control COCs.ConclusionThese data indicate that inhibition of the Wnt pathway during the initial course of oocyte maturation ...
    Keywords Brilliant Cresyl Blue (BCB) screening ; oocyte quality and competence ; Wnt pathway ; in vitro embryo production (IVEP) ; buffalo ; Veterinary medicine ; SF600-1100
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Upcycling rust and plastic waste into an Fe MOF for effective energy storage applications: transformation of trash to treasure.

    Deka, Rakesh / Mal, Diptangshu Datta / Mobin, Shaikh M

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 24, Page(s) 8204–8210

    Abstract: The upcycling of waste into valuable chemicals has gained significant attention in recent years as a way to reduce waste and promote the circular economy. The transition to a circular economy that includes waste upcycling is crucial for addressing the ... ...

    Abstract The upcycling of waste into valuable chemicals has gained significant attention in recent years as a way to reduce waste and promote the circular economy. The transition to a circular economy that includes waste upcycling is crucial for addressing the global challenge of resource depletion and waste management. To that end, an Fe-based metal-organic framework material (
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt01436c
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  8. Article ; Online: Buffalo sperm membrane glycan-binding proteins reveal precise and preferential binding signatures with specific glycans targets on oviduct epithelium and zona pellucida-an implication in fertilization.

    Kashyap, Poonam / Solanki, Subhash / Datta, Tirtha Kumar / Kumar, Rakesh

    Theriogenology

    2023  Volume 207, Page(s) 96–109

    Abstract: Sperm membrane glycan-binding proteins (lectins) interact with the counterpart glycans in the oviduct, oocytes, and vice-versa. It has already been well known that specific glycans are present on oviductal epithelium and zona pellucida (ZP) in different ... ...

    Abstract Sperm membrane glycan-binding proteins (lectins) interact with the counterpart glycans in the oviduct, oocytes, and vice-versa. It has already been well known that specific glycans are present on oviductal epithelium and zona pellucida (ZP) in different mammalian species. Some of these glycans are necessary for oviductal sperm reservoir formation and gamete recognition. The specific binding phenomenon of lectin-glycans is one of the vital factors for successful fertilization in mammals. We hypothesized that buffalo sperm membrane glycan-binding proteins have specific glycan targets in the oviduct and ZP supporting the fertilization event. In the present investigation, sperm membrane proteins were extracted and assessed for their binding capacity with glycans using a high-throughput glycan microarray. The most promising glycan binding signals were evaluated to confirm the sperm putative receptors for glycan targets in the oviductal epithelial cells (OEC) and on ZP using an in-vitro competitive binding inhibition assay. Based on an array of 100 glycans, we found that N-acetyllactosamine (LacNAc), Lewis-a trisaccharide, 3'-sialyllactosamine and LacdiNAc were the most promising glycans and selected for further in-vitro validation. We established an inhibitory concentration of 12 mM Lewis-a trisaccharide and 10 μg/ml Lotus tetragonolobus (LTL) lectin for the sperm-OEC binding interaction, indicating its specificity and sensitivity. We observed that 3 mM 3'-sialyllactosamine, and LacdiNAc were the most competitive inhibitory concentration in sperm-ZP binding, suggesting a specific and abundance-dependent binding affinity. The competitive binding affinity of Maackia amurensis (MAA) lectin with Neu5Ac(α2-3)Gal(β1-4)GlcNAc further supports the abundance of 3'-sialyllactosamine on ZP responsible for sperm binding. Our findings develop the strong evidence on buffalo sperm putative receptors underlying their locking specificities with Lewis-a trisaccharide in oviduct and 3'-sialyllactosamine on ZP. The functional interaction of buffalo sperm lectins with the target glycans in OEC and ZP appears to be accomplished in an abundance-dependent manner, facilitating the fertilization event in buffaloes.
    MeSH term(s) Female ; Male ; Animals ; Zona Pellucida/metabolism ; Buffaloes/metabolism ; Semen/metabolism ; Spermatozoa/metabolism ; Fertilization/physiology ; Polysaccharides ; Zona Pellucida Glycoproteins ; Lectins/metabolism ; Oviducts/metabolism ; Trisaccharides/metabolism ; Trisaccharides/pharmacology ; Epithelium/metabolism ; Sperm-Ovum Interactions
    Chemical Substances Polysaccharides ; Zona Pellucida Glycoproteins ; Lectins ; Trisaccharides
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2023.05.005
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    Zs.A 3929: Show issues Location:
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  9. Article ; Online: F-18 FDG PET/CT in staging and response assessment of primary cutaneous diffuse large B-cell lymphoma (leg type).

    Datta, Deepanksha / Pandey, Rakesh Ramprakash / Kumar, Rajesh / Sharma, Rashim / Vedant, Deepak

    European journal of hybrid imaging

    2023  Volume 7, Issue 1, Page(s) 15

    Abstract: Primary cutaneous Diffuse Large B-Cell Lymphoma-leg type (PCDLBCL-LT) is a rare subtype of cutaneous lymphomas, with high frequency of extra-cutaneous relapse and poor prognosis. We report a case of 70-year-old lady who was diagnosed with PCDLBCL-LT on ... ...

    Abstract Primary cutaneous Diffuse Large B-Cell Lymphoma-leg type (PCDLBCL-LT) is a rare subtype of cutaneous lymphomas, with high frequency of extra-cutaneous relapse and poor prognosis. We report a case of 70-year-old lady who was diagnosed with PCDLBCL-LT on biopsy and underwent a baseline F-18 FDG PET/CT, followed by interim and post-treatment PET/CTs. With this case report, we highlight the findings of F-18 FDG PET/CT in the staging of this cutaneous lymphoma, and also emphasize on its role in the response assessment.
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2510-3636
    ISSN (online) 2510-3636
    DOI 10.1186/s41824-023-00174-5
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  10. Article: Identification of protein candidates in spermatozoa of water buffalo (

    Karanwal, Seema / Pal, Ankit / Chera, Jatinder Singh / Batra, Vipul / Kumaresan, Arumugam / Datta, Tirtha K / Kumar, Rakesh

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1119220

    Abstract: The water buffalo ( ...

    Abstract The water buffalo (
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1119220
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