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  1. Article ; Online: Premature Cardiovascular Misdiagnosis of Senior Endurance-Trained Athletes

    John K. Jackson

    Hearts, Vol 4, Iss 4, Pp 28-

    2023  Volume 37

    Abstract: A mature Caucasian patient, an endurance-trained triathlete (age group), had a routine ECG. The patient was immediately referred to Emergency based on supposed ECG abnormalities indicating a heart attack. This diagnosis was quickly dismissed based on no ... ...

    Abstract A mature Caucasian patient, an endurance-trained triathlete (age group), had a routine ECG. The patient was immediately referred to Emergency based on supposed ECG abnormalities indicating a heart attack. This diagnosis was quickly dismissed based on no symptoms, heart rate of 50 BPM, athletic status, excellent health, and no prior cardiovascular problems. The patient had a history of severe white coat hypertension and underwent a further stress test and echocardiogram. The stress test showed exaggerated systolic blood pressures (over 225 mmHg) and high in-clinic basal blood pressures (160/90 mmHg), and the patient was diagnosed as hypertensive with exercise blood pressure close to stroke territory. He was told to stop racing, reduce training, and was prescribed antihypertensive drugs (which he did not take). Subsequent at-home 24 h (values close to 120/80 mmHg) and stress blood pressure measurements reversed that decision when considered in combination with an excellent echocardiogram result. The literature clearly describes endurance-trained athletes with systolic pressures over 225 mmHg Hg as being conditioned with no pathological aspects. Endurance-trained athletes should be examined as special cases in the field of cardiovascular medicine as trained physiological responses often present as cardiac abnormalities, and misdiagnosis can inappropriately change the athlete’s life.
    Keywords ECG misdiagnosis ; senior athlete ; stress test ; Medicine ; R
    Subject code 796
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Pyrroloiminoquinone Alkaloids: Total Synthesis of Makaluvamines A and K.

    An, Jason / Jackson, Richard K / Tuccinardi, Joseph P / Wood, John L

    Organic letters

    2023  Volume 25, Issue 11, Page(s) 1868–1871

    Abstract: Herein, an efficient, scalable, and concise approach to an advanced pyrroloiminoquinone synthetic intermediate ( ...

    Abstract Herein, an efficient, scalable, and concise approach to an advanced pyrroloiminoquinone synthetic intermediate (
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c00350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Tepsin binds LC3B to promote ATG9A trafficking and delivery.

    Wallace, Natalie S / Gadbery, John E / Cohen, Cameron I / Kendall, Amy K / Jackson, Lauren P

    Molecular biology of the cell

    2024  Volume 35, Issue 4, Page(s) ar56

    Abstract: Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at ... ...

    Abstract Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at the
    MeSH term(s) Animals ; Humans ; Autophagosomes/metabolism ; Autophagy/genetics ; trans-Golgi Network/metabolism ; HeLa Cells ; Autophagy-Related Proteins/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Mammals/metabolism
    Chemical Substances Autophagy-Related Proteins ; Adaptor Proteins, Signal Transducing
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E23-09-0359-T
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Total Synthesis of

    Jackson, Richard K / Wood, John L

    Organic letters

    2021  Volume 23, Issue 4, Page(s) 1243–1246

    Abstract: An enantioselective total synthesis of plagiochianin B is described that employs (+)-3-carene as its point of departure and delivers the enantiomer of the natural product. Key features of the synthesis include a palladium-mediated regioselective ... ...

    Abstract An enantioselective total synthesis of plagiochianin B is described that employs (+)-3-carene as its point of departure and delivers the enantiomer of the natural product. Key features of the synthesis include a palladium-mediated regioselective oxidative cleavage of an olefin residing on a pyridine derived from a 6π-azatriene electrocyclization.
    MeSH term(s) Alkenes/chemistry ; Biological Products ; Cyclization ; Molecular Structure ; Palladium/chemistry ; Stereoisomerism
    Chemical Substances Alkenes ; Biological Products ; Palladium (5TWQ1V240M)
    Language English
    Publishing date 2021-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c04219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: An evaluation of the Australian Community Pharmacy Agreement from a public policy perspective: industry policy cloaked as health policy?

    Jackson, John K / Scahill, Shane L / Mintrom, Michael / Kirkpatrick, Carl M

    Journal of pharmaceutical policy and practice

    2023  Volume 16, Issue 1, Page(s) 71

    Abstract: Background: A series of Community Pharmacy Agreements (Agreements) between the Federal government and a pharmacy-owners' body, the Pharmacy Guild of Australia (PGA) have been influential policy in Australian community pharmacy (CP) since 1990. While ... ...

    Abstract Background: A series of Community Pharmacy Agreements (Agreements) between the Federal government and a pharmacy-owners' body, the Pharmacy Guild of Australia (PGA) have been influential policy in Australian community pharmacy (CP) since 1990. While ostensibly to support the public's access and use of medicines, the core elements of the Agreements have been remuneration for dispensing and rules that limit the establishment of new pharmacies. Criticism has focused on the self-interest of pharmacy owners, the exclusion of other pharmacy stakeholders from the Agreement negotiations, the lack of transparency, and the impact on competition. The objective of this paper is to determine the true nature of the policy by examining the evolution of the CPA from a policy theory perspective.
    Methods: A qualitative evaluation of all seven Agreement documents and their impact was undertaken using policy theories including a linear policy development model, Multiple Streams Framework, Incremental Theory, the Advocacy Coalition Framework, the Theory of Economic Regulation, the Punctuated Equilibrium Framework, and Elite Theory. The Agreements were evaluated using four lenses: their objectives, evidentiary base, stakeholders and beneficiaries.
    Results: The PGA has acted as an elite organisation with long-standing influence on the policy's development and implementation. Notable has been the failure of other pharmacy stakeholders to establish broad-based advocacy coalitions in order to influence the Agreements. The incremental changes negotiated every 5 years to the core elements of the Agreements have supported the publics' access to medication, provided stability for the government, and security for existing pharmacy owners. Their impact on the evolution of pharmacists' scope of practice and through that, on the public's safe and appropriate use of medication, has been less clear.
    Conclusions: The Agreements can be characterised predominantly as industry policy benefiting pharmacy owners, rather than health policy. An emerging issue is whether incremental change will continue to be an adequate policy response to the social, political, and technological changes that are affecting health care, or whether policy disruption is likely to arise.
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2734772-2
    ISSN 2052-3211
    ISSN 2052-3211
    DOI 10.1186/s40545-023-00571-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pituitary Adenomas as a Barometer for Health Care Access.

    Wallace, Nathan John / Palmer, William Jackson / Devaiah, Anand K

    Journal of neurological surgery. Part B, Skull base

    2022  Volume 84, Issue 3, Page(s) 248–254

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-05-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/a-1808-1445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Tepsin binds LC3B to promote ATG9A export and delivery at the cell periphery.

    Wallace, Natalie S / Gadbery, John E / Cohen, Cameron I / Kendall, Amy K / Jackson, Lauren P

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at ... ...

    Abstract Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at the
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.18.549521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Association between Covid-19 Vaccination and Influenza Vaccination Rates.

    Leuchter, Richard K / Jackson, Nicholas J / Mafi, John N / Sarkisian, Catherine A

    The New England journal of medicine

    2022  Volume 386, Issue 26, Page(s) 2531–2532

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Humans ; Influenza Vaccines/therapeutic use ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Patient Acceptance of Health Care ; Vaccination/statistics & numerical data
    Chemical Substances COVID-19 Vaccines ; Influenza Vaccines
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2204560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Stimulus-dependent differences in cortical versus subcortical contributions to visual detection in mice.

    Cone, Jackson J / Mitchell, Autumn O / Parker, Rachel K / Maunsell, John H R

    Current biology : CB

    2024  

    Abstract: The primary visual cortex (V1) and the superior colliculus (SC) both occupy stations early in the processing of visual information. They have long been thought to perform distinct functions, with the V1 supporting the perception of visual features and ... ...

    Abstract The primary visual cortex (V1) and the superior colliculus (SC) both occupy stations early in the processing of visual information. They have long been thought to perform distinct functions, with the V1 supporting the perception of visual features and the SC regulating orienting to visual inputs. However, growing evidence suggests that the SC supports the perception of many of the same visual features traditionally associated with the V1. To distinguish V1 and SC contributions to visual processing, it is critical to determine whether both areas causally contribute to the detection of specific visual stimuli. Here, mice reported changes in visual contrast or luminance near their perceptual threshold while white noise patterns of optogenetic stimulation were delivered to V1 or SC inhibitory neurons. We then performed a reverse correlation analysis on the optogenetic stimuli to estimate a neuronal-behavioral kernel (NBK), a moment-to-moment estimate of the impact of V1 or SC inhibition on stimulus detection. We show that the earliest moments of stimulus-evoked activity in the SC are critical for the detection of both luminance and contrast changes. Strikingly, there was a robust stimulus-aligned modulation in the V1 contrast-detection NBK but no sign of a comparable modulation for luminance detection. The data suggest that behavioral detection of visual contrast depends on both V1 and SC spiking, whereas mice preferentially use SC activity to detect changes in luminance. Electrophysiological recordings showed that neurons in both the SC and V1 responded strongly to both visual stimulus types, while the reverse correlation analysis reveals when these neuronal signals actually contribute to visually guided behaviors.
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2024.03.061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Oxygen limitation fails to explain upper chronic thermal limits and the temperature size rule in mayflies.

    Funk, David H / Sweeney, Bernard W / Jackson, John K

    The Journal of experimental biology

    2021  Volume 224, Issue Pt 1

    Abstract: An inability to adequately meet tissue oxygen demands has been proposed as an important factor setting upper thermal limits in ectothermic invertebrates (especially aquatic species) as well as explaining the observed decline in adult size with increased ... ...

    Abstract An inability to adequately meet tissue oxygen demands has been proposed as an important factor setting upper thermal limits in ectothermic invertebrates (especially aquatic species) as well as explaining the observed decline in adult size with increased rearing temperature during the immature stages (a phenomenon known as the temperature size rule, or TSR). We tested this by rearing three aquatic insects (the mayflies
    MeSH term(s) Animals ; Ephemeroptera ; Insecta ; Oxygen ; Oxygen Consumption ; Temperature
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.233338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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