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  1. Book: Metabolic acidosis

    Wesson, Donald E.

    a guide to clinical assessment and management

    2016  

    Author's details Donald E. Wesson ed
    Keywords Acidosis ; Acidosis/Treatment
    Subject code 616.3992
    Language English
    Size x, 159 Seiten, Illustrationen, Diagramme, 24 cm
    Publisher Springer
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018950493
    ISBN 978-1-4939-3461-4 ; 978-1-4939-3463-8 ; 1-4939-3461-9 ; 1-4939-3463-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1002 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Does Acid Stress Cause Vascular Dysfunction?

    Wesson, Donald E

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 8, Page(s) 1299–1301

    MeSH term(s) Humans ; Oxidative Stress ; Endothelium, Vascular ; Vascular Diseases/etiology ; Vascular Diseases/metabolism
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Racial and Ethnic Diversity is a Tool for Eliminating Unequal Racial and Ethnic Kidney Health.

    Wesson, Donald E

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 12, Page(s) 1938–1940

    MeSH term(s) United States ; Delivery of Health Care ; Minority Groups ; Kidney
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Kidney Health Disparities: The Goal is Elimination.

    Wesson, Donald E

    Journal of the American Society of Nephrology : JASN

    2022  Volume 33, Issue 7, Page(s) 1237–1239

    MeSH term(s) Ethnicity ; Goals ; Health Services Accessibility ; Health Status Disparities ; Healthcare Disparities ; Humans ; Kidney ; Minority Groups ; United States
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2022040509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pathophysiology of Diet-Induced Acid Stress.

    Goraya, Nimrit / Wesson, Donald E

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: ... an ongoing acid challenge. Acid accumulation severe enough to reduce serum bicarbonate concentration, i.e ...

    Abstract Diets can influence the body's acid-base status because specific food components yield acids, bases, or neither when metabolized. Animal-sourced foods yield acids and plant-sourced food, particularly fruits and vegetables, generally yield bases when metabolized. Modern diets proportionately contain more animal-sourced than plant-sourced foods, are, thereby, generally net acid-producing, and so constitute an ongoing acid challenge. Acid accumulation severe enough to reduce serum bicarbonate concentration, i.e., manifesting as chronic metabolic acidosis, the most extreme end of the continuum of "acid stress", harms bones and muscles and appears to enhance the progression of chronic kidney disease (CKD). Progressive acid accumulation that does not achieve the threshold amount necessary to cause chronic metabolic acidosis also appears to have deleterious effects. Specifically, identifiable acid retention without reduced serum bicarbonate concentration, which, in this review, we will call "covert acidosis", appears to cause kidney injury and exacerbate CKD progression. Furthermore, the chronic engagement of mechanisms to mitigate the ongoing acid challenge of modern diets also appears to threaten health, including kidney health. This review describes the full continuum of "acid stress" to which modern diets contribute and the mechanisms by which acid stress challenges health. Ongoing research will develop clinically useful tools to identify stages of acid stress earlier than metabolic acidosis and determine if dietary acid reduction lowers or eliminates the threats to health that these diets appear to cause.
    MeSH term(s) Animals ; Bicarbonates/pharmacology ; Acid-Base Equilibrium ; Diet ; Acidosis/metabolism ; Renal Insufficiency, Chronic/complications
    Chemical Substances Bicarbonates
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Importance of Recognizing and Addressing the Spectrum of Acid Stress.

    Wesson, Donald E

    Advances in chronic kidney disease

    2022  Volume 29, Issue 4, Page(s) 364–372

    Abstract: Acid accumulation sufficient to reduce plasma bicarbonate concentration, thereby recognized as chronic metabolic acidosis, harms bones and muscles and appears to enhance progression of CKD. Evolving evidence supports that progressive acid accumulation ... ...

    Abstract Acid accumulation sufficient to reduce plasma bicarbonate concentration, thereby recognized as chronic metabolic acidosis, harms bones and muscles and appears to enhance progression of CKD. Evolving evidence supports that progressive acid accumulation that is not enough to cause chronic metabolic acidosis nevertheless has deleterious effects. Measurable acid retention without reduced plasma bicarbonate concentration, called eubicarbonatemic acidosis, also appears to cause kidney injury and exacerbate CKD progression. Furthermore, chronic engagement of mechanisms to mitigate the ongoing acid challenge of net acid-producing diets of developed societies also appears to be deleterious, including for kidney health. This review challenges clinicians to consider the growing evidence for a spectrum of acid-accumulation disorders that include lesser degrees of acid accumulation than metabolic acidosis yet are harmful. Further research will develop clinically useful tools to identify individuals suffering from these earlier stages of acid stress and determine if the straightforward and comparatively inexpensive intervention of dietary acid reduction relieves or eliminates the harm they appear to cause.
    MeSH term(s) Bicarbonates ; Humans ; Kidney ; Renal Insufficiency, Chronic
    Chemical Substances Bicarbonates
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2022.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4627: Show issues Location:
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  7. Article ; Online: The Continuum of Acid Stress.

    Wesson, Donald E

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 8, Page(s) 1292–1299

    Abstract: Acid-related injury from chronic metabolic acidosis is recognized through growing evidence of its deleterious effects, including kidney and other organ injury. Progressive acid accumulation precedes the signature manifestation of chronic metabolic ... ...

    Abstract Acid-related injury from chronic metabolic acidosis is recognized through growing evidence of its deleterious effects, including kidney and other organ injury. Progressive acid accumulation precedes the signature manifestation of chronic metabolic acidosis, decreased plasma bicarbonate concentration. Acid accumulation that is not enough to manifest as metabolic acidosis, known as eubicarbonatemic acidosis, also appears to cause kidney injury, with exacerbated progression of CKD. Chronic engagement of mechanisms to mitigate the acid challenge from Western-type diets also appears to cause kidney injury. Rather than considering chronic metabolic acidosis as the only acid-related condition requiring intervention to reduce kidney injury, this review supports consideration of acid-related injury as a continuum. This "acid stress" continuum has chronic metabolic acidosis at its most extreme end, and high-acid-producing diets at its less extreme, yet detrimental, end.
    MeSH term(s) Acid-Base Equilibrium ; Acidosis/blood ; Acidosis/complications ; Acidosis/physiopathology ; Acids/metabolism ; Bicarbonates/blood ; Chronic Disease ; Diet ; Glomerular Filtration Rate ; Humans ; Kidney Diseases/etiology ; Stress, Physiological
    Chemical Substances Acids ; Bicarbonates
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.17541120
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  8. Article ; Online: Serum bicarbonate as a cardiovascular risk factor: evolving from 'non-traditional'?

    Wesson, Donald E

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  Volume 35, Issue 8, Page(s) 1282–1285

    MeSH term(s) Adult ; Bicarbonates ; Blood Pressure ; Cardiovascular Diseases/etiology ; Humans ; Hypertension ; Risk Factors
    Chemical Substances Bicarbonates
    Language English
    Publishing date 2020-01-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfz297
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  9. Article ; Online: Sodium zirconium cyclosilicate for hyperkalemia: a collateral acid-base benefit?

    Wesson, Donald E

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  Volume 36, Issue 5, Page(s) 756–760

    MeSH term(s) Humans ; Hyperkalemia/drug therapy ; Potassium ; Silicates
    Chemical Substances Silicates ; sodium zirconium cyclosilicate (D652ZWF066) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2020-11-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfaa241
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  10. Article ; Online: Does eGFR by Any Number Mean the Same?

    Wesson, Donald E

    Journal of the American Society of Nephrology : JASN

    2019  Volume 30, Issue 10, Page(s) 1806–1807

    MeSH term(s) Albuminuria ; ErbB Receptors ; Glomerular Filtration Rate ; Humans ; Renal Insufficiency, Chronic
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2019-09-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2019070749
    Database MEDical Literature Analysis and Retrieval System OnLINE

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