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  1. Article ; Online: John Peever.

    Peever, John

    Current biology : CB

    2020  Volume 30, Issue 18, Page(s) R1024–R1025

    Abstract: Interview with John Peever, who studies the brain mechanisms that control REM sleep and how ...

    Abstract Interview with John Peever, who studies the brain mechanisms that control REM sleep and how their dysfunction underlies sleep disorders at the University of Toronto.
    MeSH term(s) Brain/physiopathology ; History, 21st Century ; Humans ; Interviews as Topic ; Sleep Wake Disorders/history ; Sleep Wake Disorders/physiopathology ; Sleep, REM/physiology
    Language English
    Publishing date 2020-09-21
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.08.057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3208: Show issues Location:
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  2. Article ; Online: Sleep: How stress keeps you up at night.

    Luke, Russell / Fraigne, Jimmy J / Peever, John

    Current biology : CB

    2024  Volume 34, Issue 1, Page(s) R23–R25

    Abstract: Stress disrupts sleep, but the neural mechanisms underlying this relationship remain unclear. Novel findings in mice reveal a hypothalamic circuit that fragments sleep and promotes arousal after stress. ...

    Abstract Stress disrupts sleep, but the neural mechanisms underlying this relationship remain unclear. Novel findings in mice reveal a hypothalamic circuit that fragments sleep and promotes arousal after stress.
    MeSH term(s) Animals ; Mice ; Sleep ; Arousal
    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.11.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Neuroscience: A 'Skin Warming' Circuit that Promotes Sleep and Body Cooling.

    Peever, John

    Current biology : CB

    2018  Volume 28, Issue 14, Page(s) R800–R802

    Abstract: Skin and body warming help initiate sleep, but the underlying neural mechanisms remain unclear. New research in mice shows that skin warming recruits a previously unidentified hypothalamic circuit that functions to promote sleep and body cooling. ...

    Abstract Skin and body warming help initiate sleep, but the underlying neural mechanisms remain unclear. New research in mice shows that skin warming recruits a previously unidentified hypothalamic circuit that functions to promote sleep and body cooling.
    MeSH term(s) Animals ; Hypothalamus ; Mice ; Neurons ; Neurosciences ; Skin ; Sleep
    Language English
    Publishing date 2018-07-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2018.06.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Glutamate neurons in the pedunculopontine tegmental nucleus control arousal state and motor behavior in mice.

    Dugan, Brittany J / Lee, Hanhee / Peever, John

    Sleep

    2023  Volume 46, Issue 4

    MeSH term(s) Mice ; Animals ; Pedunculopontine Tegmental Nucleus/physiology ; Glutamic Acid ; Neurons/physiology ; Arousal
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2023-01-08
    Publishing country United States
    Document type Letter
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsac322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Brain Circuits Underlying Narcolepsy.

    Pintwala, Sara Katherine / Peever, John

    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

    2021  Volume 29, Issue 6, Page(s) 751–766

    Abstract: Narcolepsy is a sleep disorder manifesting symptoms such as excessive daytime sleepiness and often cataplexy, a sudden and involuntary loss of muscle activity during wakefulness. The underlying neuropathological basis of narcolepsy is the loss of orexin ... ...

    Abstract Narcolepsy is a sleep disorder manifesting symptoms such as excessive daytime sleepiness and often cataplexy, a sudden and involuntary loss of muscle activity during wakefulness. The underlying neuropathological basis of narcolepsy is the loss of orexin neurons from the lateral hypothalamus. To date numerous animal models of narcolepsy have been produced in the laboratory, being invaluable tools for delineating the brain circuits of narcolepsy. This review will examine the evidence regarding the function of the orexin system, and how loss of this wake-promoting system manifests in excessive daytime sleepiness. This review will also outline the brain circuits controlling cataplexy, focusing on the contribution of orexin signaling loss in narcolepsy. Although our understanding of the brain circuits of narcolepsy has made great progress in recent years, much remains to be understood.
    MeSH term(s) Animals ; Orexins ; Cataplexy ; Narcolepsy ; Disorders of Excessive Somnolence ; Brain
    Chemical Substances Orexins
    Language English
    Publishing date 2021-10-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1233753-5
    ISSN 1089-4098 ; 1073-8584
    ISSN (online) 1089-4098
    ISSN 1073-8584
    DOI 10.1177/10738584211052263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4315: Show issues Location:
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  6. Article ; Online: Immortal orexin cell transplants restore motor-arousal synchrony during cataplexy.

    Pintwala, Sara K / Fraigne, Jimmy J / Belsham, Denise D / Peever, John H

    Current biology : CB

    2023  Volume 33, Issue 8, Page(s) 1550–1564.e5

    Abstract: Waking behaviors such as sitting or standing require suitable levels of muscle tone. But it is unclear how arousal and motor circuits communicate with one another so that appropriate motor tone occurs during wakefulness. Cataplexy is a peculiar condition ...

    Abstract Waking behaviors such as sitting or standing require suitable levels of muscle tone. But it is unclear how arousal and motor circuits communicate with one another so that appropriate motor tone occurs during wakefulness. Cataplexy is a peculiar condition in which muscle tone is involuntarily lost during normal periods of wakefulness. Cataplexy therefore provides a unique opportunity for identifying the signaling mechanisms that synchronize motor and arousal behaviors. Cataplexy occurs when hypothalamic orexin neurons are lost in narcolepsy; however, it is unclear if motor-arousal decoupling in cataplexy is directly or indirectly caused by orexin cell loss. Here, we used genomic, proteomic, chemogenetic, electrophysiological, and behavioral assays to determine if grafting orexin cells into the brain of cataplectic (i.e., orexin
    MeSH term(s) Mice ; Animals ; Cataplexy/therapy ; Orexins/genetics ; Orexins/metabolism ; Proteomics ; Arousal/physiology ; Wakefulness/physiology ; Dorsal Raphe Nucleus ; Cell Transplantation
    Chemical Substances Orexins
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.03.077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Neuroscience: An Arousal Circuit that Senses Danger in Sleep.

    Lee, HanHee / Peever, John

    Current biology : CB

    2020  Volume 30, Issue 12, Page(s) R708–R709

    Abstract: Dangerous or alerting stimuli typically trigger arousal from sleep; however, the brain circuitry responsible for threat detection during sleep remains unclear. New research in mice identified a specific class of neuron in the basal forebrain that causes ... ...

    Abstract Dangerous or alerting stimuli typically trigger arousal from sleep; however, the brain circuitry responsible for threat detection during sleep remains unclear. New research in mice identified a specific class of neuron in the basal forebrain that causes arousal from sleep by responding to threatening stimuli.
    MeSH term(s) Animals ; Arousal ; Basal Forebrain ; Mice ; Neurons ; Parvalbumins ; Sleep
    Chemical Substances Parvalbumins
    Language English
    Publishing date 2020-06-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2020.04.082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Neuroscience: Glutamate neurons in the medial septum control wakefulness.

    Taksokhan, Anita / Fraigne, Jimmy / Peever, John

    Current biology : CB

    2021  Volume 31, Issue 7, Page(s) R340–R342

    Abstract: Despite intensive research efforts, biologists still do not have a clear picture of the brain circuitry that controls behavioural arousal. However, new research has identified a novel septo-hypothalamic circuit that functions to promote wakefulness. ...

    Abstract Despite intensive research efforts, biologists still do not have a clear picture of the brain circuitry that controls behavioural arousal. However, new research has identified a novel septo-hypothalamic circuit that functions to promote wakefulness.
    MeSH term(s) Arousal ; Brain ; Glutamic Acid ; Neurons ; Wakefulness
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2021-04-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2021.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A novel machine learning system for identifying sleep-wake states in mice.

    Fraigne, Jimmy J / Wang, Jeffrey / Lee, Hanhee / Luke, Russell / Pintwala, Sara K / Peever, John H

    Sleep

    2023  Volume 46, Issue 6

    Abstract: Research into sleep-wake behaviors relies on scoring sleep states, normally done by manual inspection of electroencephalogram (EEG) and electromyogram (EMG) recordings. This is a highly time-consuming process prone to inter-rater variability. When ... ...

    Abstract Research into sleep-wake behaviors relies on scoring sleep states, normally done by manual inspection of electroencephalogram (EEG) and electromyogram (EMG) recordings. This is a highly time-consuming process prone to inter-rater variability. When studying relationships between sleep and motor function, analyzing arousal states under a four-state system of active wake (AW), quiet wake (QW), nonrapid-eye-movement (NREM) sleep, and rapid-eye-movement (REM) sleep provides greater precision in behavioral analysis but is a more complex model for classification than the traditional three-state identification (wake, NREM, and REM sleep) usually used in rodent models. Characteristic features between sleep-wake states provide potential for the use of machine learning to automate classification. Here, we devised SleepEns, which uses a novel ensemble architecture, the time-series ensemble. SleepEns achieved 90% accuracy to the source expert, which was statistically similar to the performance of two other human experts. Considering the capacity for classification disagreements that are still physiologically reasonable, SleepEns had an acceptable performance of 99% accuracy, as determined blindly by the source expert. Classifications given by SleepEns also maintained similar sleep-wake characteristics compared to expert classifications, some of which were essential for sleep-wake identification. Hence, our approach achieves results comparable to human ability in a fraction of the time. This new machine-learning ensemble will significantly impact the ability of sleep researcher to detect and study sleep-wake behaviors in mice and potentially in humans.
    MeSH term(s) Mice ; Humans ; Animals ; Sleep Stages/physiology ; Wakefulness/physiology ; Sleep/physiology ; Sleep, REM/physiology ; Electroencephalography/methods ; Machine Learning
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dopamine neurons in the ventral tegmental area modulate rapid eye movement sleep.

    Fraigne, Jimmy J / Luppi, Pierre H / Mahoney, Carrie E / De Luca, Roberto / Shiromani, Priyattam J / Weber, Franz / Adamantidis, Antoine / Peever, John

    Sleep

    2023  Volume 46, Issue 8

    MeSH term(s) Ventral Tegmental Area/physiology ; Dopamine ; Sleep, REM/physiology ; Dopaminergic Neurons ; Eye Movements ; Amygdala
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsad024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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