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  1. Article ; Online: Safety of continuous intraoperative vagus nerve neuromonitoring during thyroid surgery.

    Mathieson, Timothy / Jimaja, Wedali / Triponez, Frédéric / Licker, Marc / Karenovics, Wolfram / Makovac, Petra / Muradbegovic, Mirza / Belfontali, Valentina / Bédat, Benoît / Demarchi, Marco Stefano

    BJS open

    2023  Volume 7, Issue 3

    Abstract: ... in measured proximo-distal amplitudes of -10.94 µV (95 per cent c.i. -17.06 to -4.82 µV) (P < 0.005 ... proximo-distal difference in amplitudes was -18.58 µV (95 per cent c.i. -28.31 to -8.86 µV) (P < 0.005 ...

    Abstract Background: Continuous intraoperative neuromonitoring has successfully demonstrated to predict impending damage to the recurrent laryngeal nerve, by detecting changes in electromyographic recordings. Despite the apparent benefits associated with continuous intraoperative neuromonitoring, its safety is still a debate. The aim of this study was to investigate the electrophysiological impact of continuous intraoperative neuromonitoring on the vagus nerve.
    Methods: In this prospective study, the amplitude of the electromyographic wave of the vagus nerve-recurrent laryngeal nerve axis was measured both proximally and distally to the stimulation electrode placed upon the vagus nerve. Electromyographic signal amplitudes were collected at three distinct events during the operation: during the dissection of the vagus nerve, before application of the continuous stimulation electrode onto the vagus nerve and after its removal.
    Results: In total, 169 vagus nerves were analysed, among 108 included patients undergoing continuous intraoperative neuromonitoring-enhanced endocrine neck surgeries. Electrode application resulted in a significant overall decrease in measured proximo-distal amplitudes of -10.94 µV (95 per cent c.i. -17.06 to -4.82 µV) (P < 0.005), corresponding to a mean(s.d.) decrease of -1.4(5.4) per cent. Before the removal of the electrode, the measured proximo-distal difference in amplitudes was -18.58 µV (95 per cent c.i. -28.31 to -8.86 µV) (P < 0.005), corresponding to a mean(s.d.) decrease of -2.50(9.59) per cent. Seven nerves suffered a loss of amplitude greater than 20 per cent of the baseline measurement.
    Conclusion: In addition to supporting claims that continuous intraoperative neuromonitoring exposes the vagus nerve to injury, this study shows a mild electrophysiological impact of continuous intraoperative neuromonitoring electrode placement on the vagus nerve-recurrent laryngeal nerve axis. However, the small observed differences are negligible and were not associated with a clinically relevant outcome, making continuous intraoperative neuromonitoring a safe adjunct in selected thyroid surgeries.
    MeSH term(s) Humans ; Thyroid Gland ; Prospective Studies ; Thyroidectomy/adverse effects ; Thyroidectomy/methods ; Vagus Nerve/physiology ; Recurrent Laryngeal Nerve/physiology
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: On the Parameterised Complexity of Induced Multipartite Graph Parameters

    Mann, Ryan L. / Mathieson, Luke / Greenhill, Catherine

    2020  

    Abstract: ... We prove that this problem is W[1]-hard. Next, we consider a variant of this problem, where we must decide ... multipartite graph parameter $p$ and a given graph $G$, and for natural numbers $k\geq2$ and $\ell$ ... we must decide whether the maximum value of $p$ over all induced $k$-partite subgraphs of $G$ is at most $\ell$ ...

    Abstract We introduce a family of graph parameters, called induced multipartite graph parameters, and study their computational complexity. First, we consider the following decision problem: an instance is an induced multipartite graph parameter $p$ and a given graph $G$, and for natural numbers $k\geq2$ and $\ell$, we must decide whether the maximum value of $p$ over all induced $k$-partite subgraphs of $G$ is at most $\ell$. We prove that this problem is W[1]-hard. Next, we consider a variant of this problem, where we must decide whether the given graph $G$ contains a sufficiently large induced $k$-partite subgraph $H$ such that $p(H)\leq\ell$. We show that for certain parameters this problem is para-NP-hard, while for others it is fixed-parameter tractable.

    Comment: 8 pages, 0 figures
    Keywords Computer Science - Computational Complexity ; Computer Science - Discrete Mathematics ; Computer Science - Data Structures and Algorithms ; Mathematics - Combinatorics
    Subject code 004
    Publishing date 2020-04-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: What has the immune system got against the glomerular podocyte?

    Mathieson, P W

    Clinical and experimental immunology

    2003  Volume 134, Issue 1, Page(s) 1–5

    MeSH term(s) Complement System Proteins/physiology ; Epithelial Cells/immunology ; Epithelial Cells/ultrastructure ; Glomerulonephritis/immunology ; Glomerulonephritis/pathology ; Glucocorticoids/therapeutic use ; Humans ; Immune System/physiology ; Immune System Diseases/drug therapy ; Immune System Diseases/immunology ; Immune System Diseases/pathology ; Kidney Glomerulus/physiology ; Kidney Glomerulus/ultrastructure ; Microscopy, Electron, Scanning ; Receptors, Chemokine/metabolism ; Receptors, Cytokine/metabolism
    Chemical Substances Glucocorticoids ; Receptors, Chemokine ; Receptors, Cytokine ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2003-05-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1046/j.1365-2249.2003.02236.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Harmful cyanobacterial aerosolization dynamics in the airshed of a eutrophic estuary.

    Plaas, Haley E / Paerl, Ryan W / Baumann, Karsten / Karl, Colleen / Popendorf, Kimberly J / Barnard, Malcolm A / Chang, Naomi Y / Curtis, Nathaniel P / Huang, Hwa / Mathieson, Olivia L / Sanchez, Joel / Maizel, Daniela J / Bartenfelder, Amy N / Braddy, Jeremy S / Hall, Nathan S / Rossignol, Karen L / Sloup, Randolph / Paerl, Hans W

    The Science of the total environment

    2022  Volume 852, Page(s) 158383

    Abstract: In addition to obvious negative effects on water quality in eutrophic aquatic ecosystems, recent work suggests that cyanobacterial harmful algal blooms (CHABs) also impact air quality via emissions carrying cyanobacterial cells and cyanotoxins. However, ... ...

    Abstract In addition to obvious negative effects on water quality in eutrophic aquatic ecosystems, recent work suggests that cyanobacterial harmful algal blooms (CHABs) also impact air quality via emissions carrying cyanobacterial cells and cyanotoxins. However, the environmental controls on CHAB-derived aerosol and its potential public health impacts remain largely unknown. Accordingly, the aims of this study were to 1) investigate the occurrence of microcystins (MC) and putatively toxic cyanobacterial communities in particulate matter ≤ 2.5 μm in diameter (PM
    MeSH term(s) Microcystins/analysis ; Estuaries ; Lakes/microbiology ; Ecosystem ; Cyanobacteria ; Harmful Algal Bloom ; Particulate Matter/analysis
    Chemical Substances Microcystins ; Particulate Matter
    Language English
    Publishing date 2022-09-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.158383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cyclosporin: nephro-protective as well as nephrotoxic?

    Mathieson, P W

    Clinical and experimental immunology

    2000  Volume 121, Issue 2, Page(s) 179–180

    MeSH term(s) Animals ; Cell Adhesion Molecules/biosynthesis ; Cell Adhesion Molecules/genetics ; Cyclosporine/adverse effects ; Cyclosporine/pharmacology ; Cyclosporine/therapeutic use ; Disease Models, Animal ; Fibrosis ; Gene Expression Regulation/drug effects ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Kidney/drug effects ; Kidney/pathology ; Kidney Diseases/chemically induced ; Kidney Transplantation/immunology ; Rats ; Serum Sickness/drug therapy ; Serum Sickness/metabolism ; Tacrolimus/adverse effects ; Tacrolimus/therapeutic use ; Transforming Growth Factor beta/physiology
    Chemical Substances Cell Adhesion Molecules ; Immunosuppressive Agents ; Transforming Growth Factor beta ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2000-08
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1046/j.1365-2249.2000.01289.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nuclear Charge Radius of ^{26m}Al and Its Implication for V_{ud} in the Quark Mixing Matrix.

    Plattner, P / Wood, E / Al Ayoubi, L / Beliuskina, O / Bissell, M L / Blaum, K / Campbell, P / Cheal, B / de Groote, R P / Devlin, C S / Eronen, T / Filippin, L / Garcia Ruiz, R F / Ge, Z / Geldhof, S / Gins, W / Godefroid, M / Heylen, H / Hukkanen, M /
    Imgram, P / Jaries, A / Jokinen, A / Kanellakopoulos, A / Kankainen, A / Kaufmann, S / König, K / Koszorús, Á / Kujanpää, S / Lechner, S / Malbrunot-Ettenauer, S / Müller, P / Mathieson, R / Moore, I / Nörtershäuser, W / Nesterenko, D / Neugart, R / Neyens, G / Ortiz-Cortes, A / Penttilä, H / Pohjalainen, I / Raggio, A / Reponen, M / Rinta-Antila, S / Rodríguez, L V / Romero, J / Sánchez, R / Sommer, F / Stryjczyk, M / Virtanen, V / Xie, L / Xu, Z Y / Yang, X F / Yordanov, D T

    Physical review letters

    2023  Volume 131, Issue 22, Page(s) 222502

    Abstract: ... The measured isotope shift to ^{27}Al in the 3s^{2}3p ^{2}P_{3/2}^{○}→3s^{2}4s ^{2}S_{1/2} atomic transition ...

    Abstract Collinear laser spectroscopy was performed on the isomer of the aluminium isotope ^{26m}Al. The measured isotope shift to ^{27}Al in the 3s^{2}3p ^{2}P_{3/2}^{○}→3s^{2}4s ^{2}S_{1/2} atomic transition enabled the first experimental determination of the nuclear charge radius of ^{26m}Al, resulting in R_{c}=3.130(15)  fm. This differs by 4.5 standard deviations from the extrapolated value used to calculate the isospin-symmetry breaking corrections in the superallowed β decay of ^{26m}Al. Its corrected Ft value, important for the estimation of V_{ud} in the Cabibbo-Kobayashi-Maskawa matrix, is thus shifted by 1 standard deviation to 3071.4(1.0) s.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.222502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: What proportion of patients with chronic noncancer pain are prescribed an opioid medicine? Systematic review and meta-regression of observational studies.

    Mathieson, S / Wertheimer, G / Maher, C G / Christine Lin, C-W / McLachlan, A J / Buchbinder, R / Pearson, S-A / Underwood, M

    Journal of internal medicine

    2020  Volume 287, Issue 5, Page(s) 458–474

    Abstract: ... prescribing in recent years) (P = 0.014) and not geographic region (P = 0.056). Opioid prescribing ...

    Abstract Guidelines now discourage opioid analgesics for chronic noncancer pain because the benefits frequently do not outweigh the harms. We aimed to determine the proportion of patients with chronic noncancer pain who are prescribed an opioid, the types prescribed and factors associated with prescribing. Database searches were conducted from inception to 29 October 2018 without language restrictions. We included observational studies of adults with chronic noncancer pain measuring opioid prescribing. Opioids were categorized as weak (e.g. codeine) or strong (e.g. oxycodone). Study quality was assessed using a risk of bias tool designed for observational studies measuring prevalence. Individual study results were pooled using a random-effects model. Meta-regression investigated study-level factors associated with prescribing (e.g. sampling year, geographic region as per World Health Organization). The overall evidence quality was assessed using Grading of Recommendations Assessment, Development and Evaluation criteria. Of the 42 studies (5,059,098 participants) identified, the majority (n = 28) were from the United States of America. Eleven studies were at low risk of bias. The pooled estimate of the proportion of patients with chronic noncancer pain prescribed opioids was 30.7% (95% CI 28.7% to 32.7%, n = 42 studies, moderate-quality evidence). Strong opioids were more frequently prescribed than weak (18.4% (95% CI 16.0-21.0%, n = 15 studies, low-quality evidence), versus 8.5% (95% CI 7.2-9.9%, n = 15 studies, low-quality evidence)). Meta-regression determined that opioid prescribing was associated with year of sampling (more prescribing in recent years) (P = 0.014) and not geographic region (P = 0.056). Opioid prescribing for patients with chronic noncancer pain is common and has increased over time.
    MeSH term(s) Analgesics/therapeutic use ; Analgesics, Opioid/therapeutic use ; Chronic Pain/drug therapy ; Drug Therapy/statistics & numerical data ; Humans ; Observational Studies as Topic ; Pain Management/statistics & numerical data
    Chemical Substances Analgesics ; Analgesics, Opioid
    Language English
    Publishing date 2020-02-25
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Is complement a target for therapy in renal disease?

    Mathieson, P W

    Kidney international

    1998  Volume 54, Issue 5, Page(s) 1429–1436

    Abstract: Complement deposition in the injured kidney is common, especially in glomerulonephritis. The precise role of the complement system in the mediation of tissue injury in the kidney has been defined in recent years, and this has assumed extra importance ... ...

    Abstract Complement deposition in the injured kidney is common, especially in glomerulonephritis. The precise role of the complement system in the mediation of tissue injury in the kidney has been defined in recent years, and this has assumed extra importance with the recent development of specific forms of therapy directed at the complement pathway. As well as the induction of cell lysis, complement has many subtle effects on cell biology, particularly on endothelial cells. Complement components are produced locally in the kidney. Detailed studies of certain rare forms of nephritis have provided evidence that complement activation can directly cause tissue injury. Appreciation of the importance of complement in hyperacute rejection of xenotransplants has given new impetus to the development of complement inhibitors. A narrative review is provided, with a brief overview of the complement pathway and its regulatory mechanisms, mechanisms of complement-induced tissue injury, local complement production, and the renal consequences of complement dysregulation. Currently available forms of therapy aimed at the complement system are reviewed, and possible future therapeutic strategies are suggested. The complement system plays a direct causal role in tissue injury in certain forms of renal disease. Specific forms of therapy are becoming available that can selectively interrupt complement activation or promote its regulation. Much of the drive for the development of these therapies comes from the field of xenotransplantation, but these forms of therapy should also be tested in various primary renal diseases.
    MeSH term(s) Animals ; Complement Activation ; Complement System Proteins/physiology ; Humans ; Kidney Diseases/immunology ; Kidney Diseases/therapy
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 1998-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1046/j.1523-1755.1998.00129.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The ins and outs of glomerular crescent formation.

    Mathieson, P W

    Clinical and experimental immunology

    1997  Volume 110, Issue 2, Page(s) 155–157

    MeSH term(s) Animals ; Glomerulonephritis/immunology ; Glomerulonephritis/pathology ; Humans ; Kidney Glomerulus/immunology ; Kidney Glomerulus/pathology ; Macrophages/immunology ; Macrophages/pathology
    Language English
    Publishing date 1997-11
    Publishing country England
    Document type Editorial ; Review
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1111/j.1365-2249.1997.tb08311.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib.

    Vigoda, Myles / Mathieson, Chase / Evans, Nathaniel / Hale, Carolyn / Jennings, Jennifer / Lucero, Olivia / Jeng, Sophia / Bottomly, Daniel / Clayburgh, Daniel / Andersen, Peter / Li, Ryan / Petrisor, Daniel / Tyner, Jeffrey W / McWeeney, Shannon / Kulesz-Martin, Molly

    Cancer biology & therapy

    2022  Volume 23, Issue 1, Page(s) 310–318

    Abstract: In this study, we report a differential response of mitogen-activated protein kinase-kinase (MEK) inhibitor trametinib in 20 head and neck squamous cell carcinoma (HNSCC) patients' tumor-derived cell cultures. Relatively sensitive and resistant cases to ... ...

    Abstract In this study, we report a differential response of mitogen-activated protein kinase-kinase (MEK) inhibitor trametinib in 20 head and neck squamous cell carcinoma (HNSCC) patients' tumor-derived cell cultures. Relatively sensitive and resistant cases to trametinib were identified using high throughput metabolic assays and validated in extended dose response studies in vitro. High throughput metabolic assays exploring combination therapies with trametinib were subjected to synergy models and maximal synergistic dose analyses. These yielded several candidates, including axtinib, GDC-0032, GSK-690693, and SGX-523. The combination regimen of trametinib and AXL/MET/VEGFR inhibitor glesatinib showed initial efficacy both in vitro and in vivo (92% reduction in tumor volume). Sensitivity was validated in vivo in a patient-derived xenograft (PDX) model in which trametinib as a single agent effected reduction in tumor volume up to 72%. Reverse Phase Protein Arrays (RPPA) demonstrated differentially expressed proteins and phosphoproteins upon trametinib treatment. Furthermore, resistant cell lines showed a compensatory mechanism via increases in MAPK and non-MAPK pathway proteins that may represent targets for future combination regimens. Intrinsic-targeted options have potential to address paucity of medical treatment options for HNSCC cancer patients, enhance response to extrinsic targeted agents, and/or reduce morbidity as neoadjuvant to surgical treatments.
    MeSH term(s) Head and Neck Neoplasms/drug therapy ; Humans ; Proteomics ; Pyridones ; Pyrimidinones/pharmacology ; Pyrimidinones/therapeutic use ; Squamous Cell Carcinoma of Head and Neck/drug therapy
    Chemical Substances Pyridones ; Pyrimidinones ; trametinib (33E86K87QN)
    Language English
    Publishing date 2022-03-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.1080/15384047.2022.2055420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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