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Article ; Online: Readmissions After Surgical Aortic Valve Replacement: Influence of Prosthesis Type.

Sylvester, Christopher B / Ryan, Christopher T / Frankel, William C / Zea-Vera, Rodrigo / Zhang, Qianzi / Wall, Matthew J / Moon, Marc R / Coselli, Joseph S / Rosengart, Todd K / Chatterjee, Subhasis / Ghanta, Ravi K

The Journal of surgical research

2023 Volume 287, Page(s) 124–133

Abstract: ... anticoagulation with mechanical valves (M-AVR) against structural valve degeneration in bioprosthetic valves (B ... estimated with Kaplan-Meier (KM) analysis.: Results: Patients (n = 109,744) who underwent AVR (90,574 B-AVR and 19,170 M ... AVR) were included. B-AVR patients were older (median 68 versus 57 y; P < 0.001) and had more ...

Abstract	Introduction: Prosthesis choice during aortic valve replacement (AVR) weighs lifelong anticoagulation with mechanical valves (M-AVR) against structural valve degeneration in bioprosthetic valves (B-AVR). Methods: The Nationwide Readmissions Database was queried to identify patients who underwent isolated surgical AVR between January 1, 2016 and December 31, 2018, stratifying by prothesis type. Propensity score matching was used to compare risk-adjusted outcomes. Readmission at 1 y was estimated with Kaplan-Meier (KM) analysis. Results: Patients (n = 109,744) who underwent AVR (90,574 B-AVR and 19,170 M-AVR) were included. B-AVR patients were older (median 68 versus 57 y; P < 0.001) and had more comorbidities (mean Elixhauser score: 11.8 versus 10.7; P < 0.001) compared to M-AVR patients. After matching (n = 36,951), there was no difference in age (58 versus 57 y; P = 0.6) and Elixhauser score (11.0 versus 10.8; P = 0.3). B-AVR patients had similar in-hospital mortality (2.3% versus 2.3%; P = 0.9) and cost (mean: $50,958 versus $51,200; P = 0.4) compared with M-AVR patients. However, B-AVR patients had shorter length of stay (8.3 versus 8.7 d; P < 0.001) and fewer readmissions at 30 d (10.3% versus 12.6%; P < 0.001) and 90 d (14.8% versus 17.8%; P < 0.001), and 1 y (P < 0.001, KM analysis). Patients undergoing B-AVR were less likely to be readmitted for bleeding or coagulopathy (5.7% versus 9.9%; P < 0.001) and effusions (9.1% versus 11.9%; P < 0.001). Conclusions: B-AVR patients had similar early outcomes compared to M-AVR patients, but lower rates of readmission. Bleeding, coagulopathy, and effusions are drivers of excess readmissions in M-AVR patients. Readmission reduction strategies targeting bleeding and improved anticoagulation management are warranted in the first year following AVR.
MeSH term(s)	Humans ; Aortic Valve/surgery ; Patient Readmission ; Heart Valve Prosthesis Implantation/adverse effects ; Treatment Outcome ; Bioprosthesis ; Anticoagulants/therapeutic use ; Retrospective Studies ; Prosthesis Design
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80170-7
ISSN	1095-8673 ; 0022-4804
ISSN (online)	1095-8673
ISSN	0022-4804
DOI	10.1016/j.jss.2023.01.007
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Article ; Online: Coronary artery bypass grafting at safety-net versus non-safety-net hospitals.

Frankel, William C / Sylvester, Christopher B / Asokan, Sainath / Ryan, Christopher T / Zea-Vera, Rodrigo / Zhang, Qianzi / Wall, Matthew J / Markan, Sandeep / Coselli, Joseph S / Rosengart, Todd K / Chatterjee, Subhasis / Ghanta, Ravi K

JTCVS open

2023 Volume 13, Page(s) 136–149

Abstract: Objectives: Safety-net hospitals (SNHs) provide essential services to predominantly underserved patients regardless of their ability to pay. We hypothesized that patients who underwent coronary artery bypass grafting (CABG) would have inferior observed ... ...

Abstract	Objectives: Safety-net hospitals (SNHs) provide essential services to predominantly underserved patients regardless of their ability to pay. We hypothesized that patients who underwent coronary artery bypass grafting (CABG) would have inferior observed outcomes at SNHs compared with non-SNHs but that matched cohorts would have comparable outcomes. Methods: We queried the Nationwide Readmissions Database for patients who underwent isolated CABG from 2016 to 2018. We ranked hospitals by the percentage of all admissions in which the patient was uninsured or insured with Medicaid; hospitals in the top quartile were designated as SNHs. We used propensity-score matching to mitigate the effect of confounding factors and compare outcomes between SNHs and non-SNHs. Results: A total of 525,179 patients underwent CABG, including 96,133 (18.3%) at SNHs, who had a greater burden of baseline comorbidities (median Elixhauser score 8 vs 7; Conclusions: After matching, early outcomes after CABG were comparable at SNHs and non-SNHs. Improved discharge resources could reduce length of stay and curtail cost, improving the value of CABG at SNHs.
Language	English
Publishing date	2023-01-23
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-2736
ISSN (online)	2666-2736
DOI	10.1016/j.xjon.2023.01.008
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Article ; Online: Predictors of nonpulmonary vein triggers for atrial fibrillation: A clinical risk score.

Thind, Munveer / Oraii, Alireza / Chaumont, Corentin / Arceluz, Martín R / Sekigawa, Masahiro / Yogasundaram, Haran / Sugrue, Alan / Mirwais, Maiwand / AlSalem, Ahmed B / Zado, Erica S / Guandalini, Gustavo S / Markman, Timothy M / Deo, Rajat / Schaller, Robert D / Dixit, Sanjay / Epstein, Andrew E / Supple, Gregory E / Tschabrunn, Cory M / Santangeli, Pasquale /

Callans, David J / Hyman, Matthew C / Nazarian, Saman / Frankel, David S / Marchlinski, Francis E

Heart rhythm

2024

Abstract: Background: Targeting non-pulmonary vein triggers (NPVTs) after pulmonary vein isolation may reduce atrial fibrillation (AF) recurrence. Isoproterenol infusion and cardioversion of spontaneous or induced AF can provoke NPVTs but typically require ... ...

Abstract	Background: Targeting non-pulmonary vein triggers (NPVTs) after pulmonary vein isolation may reduce atrial fibrillation (AF) recurrence. Isoproterenol infusion and cardioversion of spontaneous or induced AF can provoke NPVTs but typically require vasopressor support and increased procedural time. Objective: The purpose of this study was to identify risk factors for the presence of NPVTs and create a risk score to identify higher-risk subgroups. Methods: Using the AF ablation registry at the Hospital of the University of Pennsylvania, we included consecutive patients who underwent AF ablation between January 2021 and December 2022. We excluded patients who did not receive NPVT provocation testing after failing to demonstrate spontaneous NPVTs. NPVTs were defined as non-pulmonary vein ectopic beats triggering AF or focal atrial tachycardia. We used risk factors associated with NPVTs with P <.1 in multivariable logistic regression model to create a risk score in a randomly split derivation set (80%) and tested its predictive accuracy in the validation set (20%). Results: In 1530 AF ablations included, NPVTs were observed in 235 (15.4%). In the derivation set, female sex (odds ratio [OR] 1.40; 95% confidence interval [CI] 0.96-2.03; P = .080), sinus node dysfunction (OR 1.67; 95% CI 0.98-2.87; P = .060), previous AF ablation (OR 2.50; 95% CI 1.70-3.65; P <.001), and left atrial scar (OR 2.90; 95% CI 1.94-4.36; P <.001) were risk factors associated with NPVTs. The risk score created from these risk factors (PRE Conclusion: A risk score incorporating predictors for NPVTs may allow provocation of triggers to be performed in patients with greatest expected yield.
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2024.01.048
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Zs.A 6278: Show issues

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Article ; Online: The Association of Human Cytomegalovirus Infection and Colorectal Cancer: A Clinical Analysis.

Nagel, Brittany / Frankel, Lexi / Ardeljan, Amalia / Cardeiro, Matthew / Rashid, Selena / Takabe, Kazuaki / Rashid, Omar M

World journal of oncology

2023 Volume 14, Issue 2, Page(s) 119–124

Abstract: Background: Human cytomegalovirus (HCMV) commonly infects humans and establishes lifelong infection. It causes disease and increased mortality rates in patients with immunosuppression. HCMV gene products are found to be present in multiple human ... ...

Abstract	Background: Human cytomegalovirus (HCMV) commonly infects humans and establishes lifelong infection. It causes disease and increased mortality rates in patients with immunosuppression. HCMV gene products are found to be present in multiple human malignancies and target cellular functions involved in tumor development; additionally, a tumor-cytoreductive role of CMV has also been observed. The purpose of this study was to evaluate the correlation between CMV infection and the incidence of colorectal cancer (CRC). Methods: The data were provided by a national database that is compliant with Health Insurance Portability and Accountability Act (HIPAA). Using International Classification of Disease (ICD)-10 and ICD-9 diagnostic codes, the data were filtered to evaluate patients infected with HCMV versus patients never infected with HCMV. Patient data from 2010 to 2019 were assessed. Access to the database was granted by Holy Cross Health, Fort Lauderdale for the purpose of academic research. Standard statistical methods were used. Results: Between January 2010 and December 2019, the query was analyzed and resulted in 14,235 patients after matching in the infected and control groups. The groups were matched by age range, sex, Charlson Comorbidity Index (CCI) score, and treatment. The incidence of CRC was 1.159% (165 patients) in the HCMV group and 2.845% (405 patients) in the control group. The difference after matching was statistically significant by a P-value < 2.2 × 10 Conclusions: The study shows a statistically significant correlation between CMV infection and a reduced incidence of CRC. Further evaluation is recommended to assess the potential of CMV in reducing CRC incidence.
Language	English
Publishing date	2023-03-24
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2548989-6
ISSN	1920-454X ; 1920-454X
ISSN (online)	1920-454X
ISSN	1920-454X
DOI	10.14740/wjon1565
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Article ; Online: Readmission After Bioprosthetic vs Mechanical Mitral Valve Replacement in the United States.

Sylvester, Christopher B / Ryan, Christopher T / Frankel, William C / Asokan, Sainath / Zea-Vera, Rodrigo / Zhang, Qianzi / Wall, Matthew J / Coselli, Joseph S / Rosengart, Todd K / Chatterjee, Subhasis / Ghanta, Ravi K

The Annals of thoracic surgery

2022 Volume 117, Issue 1, Page(s) 113–118

Abstract: Background: Choosing between a bioprosthetic and a mechanical mitral valve is an important decision for both patients and surgeons. We compared patient outcomes and readmission rates after bioprosthetic mitral valve replacement (Bio-MVR) vs mechanical ... ...

Abstract	Background: Choosing between a bioprosthetic and a mechanical mitral valve is an important decision for both patients and surgeons. We compared patient outcomes and readmission rates after bioprosthetic mitral valve replacement (Bio-MVR) vs mechanical mitral valve replacement (Mech-MVR). Methods: The Nationwide Readmissions Database was queried to identify 31 474 patients who underwent isolated MVR (22 998 Bio-MVR, 8476 Mech-MVR) between January 1, 2016, and December 31, 2018. Propensity score matching by age, sex, elective status, and comorbidities was used to compare outcomes between matched cohorts by prosthesis type. Freedom from readmission within the first calendar year was estimated by Kaplan-Meier analysis and compared between matched cohorts. Results: Bio-MVR patients were older (median age, 69 vs 57 years; P < .001) and had more comorbidities (median Elixhauser score, 14 vs 11; P < .001) compared with Mech-MVR patients. After propensity score matching (n = 15 549), Bio-MVR patients had similar operative mortality (3.5% vs 3.4%; P = .97) and costs ($50 958 vs $49 782; P = .16) but shorter lengths of stay (8 vs 9 days; P < .001) and fewer 30-day (16.0% vs 18.1%; P = .04) and 90-day (23.8% vs 26.8%; P = .01) readmissions compared with Mech-MVR patients. The difference in readmissions persisted at 1 year (P = .045). Readmission for bleeding or coagulopathy complications was less common with Bio-MVR (5.7% vs 10.1%; P < .001). Conclusions: Readmission was more common after Mech-MVR than after Bio-MVR. Identifying and closely observing patients at high risk for bleeding complications may bridge the readmissions gap between Bio-MVR and Mech-MVR.
MeSH term(s)	Humans ; United States/epidemiology ; Aged ; Mitral Valve/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Patient Readmission ; Treatment Outcome ; Heart Valve Prosthesis ; Retrospective Studies
Language	English
Publishing date	2022-07-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2022.05.064
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Zs.A 252: Show issues

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Article ; Online: Determinants of murein hydrolase targeting to cross-wall of Staphylococcus aureus peptidoglycan.

Frankel, Matthew B / Schneewind, Olaf

The Journal of biological chemistry

2012 Volume 287, Issue 13, Page(s) 10460–10471

Abstract: Cells of eukaryotic or prokaryotic origin express proteins with LysM domains that associate with the cell wall envelope of bacteria. The molecular properties that enable LysM domains to interact with microbial cell walls are not yet established. ... ...

Abstract	Cells of eukaryotic or prokaryotic origin express proteins with LysM domains that associate with the cell wall envelope of bacteria. The molecular properties that enable LysM domains to interact with microbial cell walls are not yet established. Staphylococcus aureus, a spherical microbe, secretes two murein hydrolases with LysM domains, Sle1 and LytN. We show here that the LysM domains of Sle1 and LytN direct murein hydrolases to the staphylococcal envelope in the vicinity of the cross-wall, the mid-cell compartment for peptidoglycan synthesis. LysM domains associate with the repeating disaccharide β-N-acetylmuramic acid, (1→4)-β-N-acetylglucosamine of staphylococcal peptidoglycan. Modification of N-acetylmuramic acid with wall teichoic acid, a ribitol-phosphate polymer tethered to murein linkage units, prevents the LysM domain from binding to peptidoglycan. The localization of LytN and Sle1 to the cross-wall is abolished in staphylococcal tagO mutants, which are defective for wall teichoic acid synthesis. We propose a model whereby the LysM domain ensures septal localization of LytN and Sle1 followed by processive cleavage of peptidoglycan, thereby exposing new LysM binding sites in the cross-wall and separating bacterial cells.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Wall/genetics ; Cell Wall/metabolism ; Mutation ; N-Acetylmuramoyl-L-alanine Amidase/genetics ; N-Acetylmuramoyl-L-alanine Amidase/metabolism ; Peptidoglycan/genetics ; Peptidoglycan/metabolism ; Protein Structure, Tertiary ; Staphylococcus aureus/enzymology ; Staphylococcus aureus/genetics
Chemical Substances	Bacterial Proteins ; Peptidoglycan ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28)
Language	English
Publishing date	2012-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M111.336404
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Article ; Online: Evaluation of organized atrial arrhythmias after cryptogenic stroke.

Pothineni, Naga Venkata K / Batnyam, Uyanga / Schwennesen, Hannah / Tierney, Ann / Messé, Steven R / Cucchiara, Brett / Mendelson, Todd B / Luebbert, Jeffrey J / Yang, Wei / Kumareswaran, Ramanan / Hyman, Matthew C / Lin, David / Dixit, Sanjay / Epstein, Andrew E / Arkles, Jeffrey S / Nazarian, Saman / Schaller, Robert D / Supple, Gregory E / Callans, David /

Yaeger, Amaryah / Frankel, David S / Santangeli, Pasquale / Kasner, Scott E / Marchlinski, Francis E / Deo, Rajat

Heart rhythm O2

2023 Volume 5, Issue 1, Page(s) 34–40

Abstract: Background: Long-term rhythm monitoring to detect atrial fibrillation (AF) following a cryptogenic stroke (CS) is well established. However, the burden of organized atrial arrhythmias in this population is not well defined.: Objective: The purpose of ...

Abstract	Background: Long-term rhythm monitoring to detect atrial fibrillation (AF) following a cryptogenic stroke (CS) is well established. However, the burden of organized atrial arrhythmias in this population is not well defined. Objective: The purpose of this study was to assess the incidence and risk factors for organized atrial arrhythmias in patients with CS. Methods: We evaluated all patients with CS who received an insertable cardiac monitor (ICM) between October 2014 and April 2020. All ICM transmissions categorized as AF, tachycardia, or bradycardia were reviewed. We evaluated the time to detection of organized AF and the combination of either organized atrial arrhythmia or AF. Results: A total of 195 CS patients with ICMs were included (51% men; mean age 66 ± 12 years; mean CHA Conclusion: Organized atrial arrhythmias lasting ≥30 seconds are detected in nearly one-fourth of CS patients. Two-thirds of these patients did not have AF. Further studies are required to evaluate the impact of organized atrial arrhythmias on recurrent stroke risk.
Language	English
Publishing date	2023-12-02
Publishing country	United States
Document type	Journal Article
ISSN	2666-5018
ISSN (online)	2666-5018
DOI	10.1016/j.hroo.2023.11.016
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Article ; Online: SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein Secretion.

Chan, Yvonne G Y / Frankel, Matthew B / Missiakas, Dominique / Schneewind, Olaf

Journal of bacteriology

2016 Volume 198, Issue 7, Page(s) 1123–1136

Abstract: Unlabelled: The envelope of Staphylococcus aureus is comprised of peptidoglycan and its attached secondary polymers, teichoic acid, capsular polysaccharide, and protein. Peptidoglycan synthesis involves polymerization of lipid II precursors into glycan ... ...

Abstract	Unlabelled: The envelope of Staphylococcus aureus is comprised of peptidoglycan and its attached secondary polymers, teichoic acid, capsular polysaccharide, and protein. Peptidoglycan synthesis involves polymerization of lipid II precursors into glycan strands that are cross-linked at wall peptides. It is not clear whether peptidoglycan structure is principally determined during polymerization or whether processive enzymes affect cell wall structure and function, for example, by generating conduits for protein secretion. We show here that S. aureus lacking SagB, a membrane-associated N-acetylglucosaminidase, displays growth and cell-morphological defects caused by the exaggerated length of peptidoglycan strands. SagB cleaves polymerized glycan strands to their physiological length and modulates antibiotic resistance in methicillin-resistant S. aureus (MRSA). Deletion of sagB perturbs protein trafficking into and across the envelope, conferring defects in cell wall anchoring and secretion, as well as aberrant excretion of cytoplasmic proteins. Importance: Staphylococcus aureus is thought to secrete proteins across the plasma membrane via the Sec pathway; however, protein transport across the cell wall envelope has heretofore not been studied. We report that S. aureus sagB mutants generate elongated peptidoglycan strands and display defects in protein secretion as well as aberrant excretion of cytoplasmic proteins. These results suggest that the thick peptidoglycan layer of staphylococci presents a barrier for protein secretion and that SagB appears to extend the Sec pathway across the cell wall envelope.
MeSH term(s)	Amino Acid Sequence ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Drug Resistance, Bacterial ; Gene Expression Regulation, Bacterial/physiology ; Hexosaminidases/genetics ; Hexosaminidases/metabolism ; Molecular Sequence Data ; Mutation ; Polysaccharides/chemistry ; Polysaccharides/metabolism ; Staphylococcus aureus/enzymology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/metabolism
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Polysaccharides ; Hexosaminidases (EC 3.2.1.-)
Language	English
Publishing date	2016-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2968-3
ISSN	1098-5530 ; 0021-9193
ISSN (online)	1098-5530
ISSN	0021-9193
DOI	10.1128/JB.00983-15
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Article ; Online: Association Between Body Mass Index and Functional Outcomes in Patients With Intracerebral Hemorrhage.

Becerril-Gaitan, Andrea / Ding, Dale / Ironside, Natasha / Southerland, Andrew M / Worrall, Bradford B / Testai, Fernando D / Flaherty, Matthew L / Elkind, Mitchell S / Koch, Sebastian / Sung, Gene / Kittner, Steven J / Mayson, Douglas J / Gonzales, Nicole / McCauley, Jacob L / Malkoff, Marc / Hall, Christiana E / Frankel, Michael R / James, Michael L / Anderson, Christopher D /

Aronowski, Jaroslaw / Savitz, Sean I / Woo, Daniel / Chen, Ching-Jen

Neurology

2023 Volume 102, Issue 2, Page(s) e208014

Abstract: Background and objectives: Evidence of the so-called "obesity paradox," which refers to the protective effect and survival benefit of obesity in patients with spontaneous intracerebral hemorrhage (ICH), remains controversial. This study aims to ... ...

Abstract	Background and objectives: Evidence of the so-called "obesity paradox," which refers to the protective effect and survival benefit of obesity in patients with spontaneous intracerebral hemorrhage (ICH), remains controversial. This study aims to determine the association between body mass index (BMI) and functional outcomes in patients with ICH and whether it is modified by race/ethnicity. Methods: Included individuals were derived from the Ethnic/Racial Variations of Intracerebral Hemorrhage study, which prospectively recruited 1,000 non-Hispanic White, 1,000 non-Hispanic Black, and 1,000 Hispanic patients with spontaneous ICH. Only patients with available BMI were included. The primary outcome was 90-day mortality. Secondary outcomes were mortality at discharge, modified Rankin Scale (mRS), Barthel Index, and self-reported health status measures at 90 days. Associations between BMI and ICH outcomes were assessed using univariable and multivariable logistic, ordinal, and linear regression models, as appropriate. Sensitivity analyses after excluding frail patients and by patient race/ethnicity were performed. Results: A total of 2,841 patients with ICH were included. The median age was 60 years (interquartile range 51-73). Most patients were overweight (n = 943; 33.2%) or obese (n = 1,032; 36.3%). After adjusting for covariates, 90-day mortality was significantly lower among overweight and obese patients than their normal weight counterparts (adjusted odds ratio [aOR] = 0.71 [0.52-0.98] and aOR = 0.70 [0.50-0.97], respectively). Compared with patients with BMI <25 kg/m Conclusion: We demonstrated that a higher BMI is associated with decreased mortality, improved functional outcomes, and better self-reported health status at 90 days, thus supporting the paradoxical role of obesity in patients with ICH. The beneficial effect of high BMI does not seem to be modified by race/ethnicity or sex, whereas age may play a significant role in patient functional outcomes.
MeSH term(s)	Humans ; Middle Aged ; Body Mass Index ; Overweight ; Ethnicity ; Obesity/complications ; Cerebral Hemorrhage/complications
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000208014
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Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Development of the Abbott RealTime ZIKA assay for the qualitative detection of Zika virus RNA from serum, plasma, urine, and whole blood specimens using the m2000 system

Frankel, Matthew B / Kinnari Pandya / Jeffrey Gersch / Sarah Siddiqui / George J. Schneider

Journal of virological methods. 2017,

2017

Abstract: Zika virus is an arthropod-borne flavivirus that has rapidly developed into a world-wide concern. Discovered in 1947, the virus was relatively obscure until an outbreak occurred in 2007 in the Yap islands and spread eventually to the Americas in 2015. ... ...

Abstract	Zika virus is an arthropod-borne flavivirus that has rapidly developed into a world-wide concern. Discovered in 1947, the virus was relatively obscure until an outbreak occurred in 2007 in the Yap islands and spread eventually to the Americas in 2015. Only 20% of patients infected with Zika virus develop symptoms. However, there can be serious consequences of infection including birth defects in developing fetuses and links to Guillain-BarrÃ© syndrome. The swift rise in infections has necessitated the development of diagnostic tests for both the detection of viral RNA and the presence of virus-specific antibodies. Abbott has developed a dual target RT-PCR assay for the detection of Zika virus RNA within serum, plasma, whole blood, and urine using the automated m2000 system for sample extraction to result reporting. The Abbott RealTime ZIKA assay has a limit of detection of 30 copies per mL in serum, 40 copies per mL in plasma and urine, and 120 copies per mL in whole blood and demonstrates high specificity against challenges from closely related infectious agents.
Keywords	RNA ; Zika virus ; antibodies ; blood serum ; congenital abnormalities ; detection limit ; diagnostic techniques ; fetus ; islands ; pathogens ; patients ; reverse transcriptase polymerase chain reaction ; urine ; viruses ; North America ; South America ; Yap
Language	English
Size	p. .
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2017.05.002
Database	NAL-Catalogue (AGRICOLA)

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Inter-library loan at ZB MED

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

Order via subito

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In stock of ZB MED Cologne/Königswinter

Order via subito