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  1. Book ; Online: What's New in Endocrinology?

    Holly, Jeff M. P. / LeRoith, Derek

    2020  

    Keywords Medicine ; Endocrinology ; obesity ; reproduction ; stress ; cancer ; aging
    Size 1 electronic resource (163 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230130
    ISBN 9782889633920 ; 2889633926
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Prevention of Type 2 diabetes

    LeRoith, Derek

    from science to therapy

    2012  

    Author's details Derek LeRoith ed
    Keywords Non-insulin-dependent diabetes--Prevention ; Non-insulin-dependent diabetes--Diagnosis
    Subject code 616.462405
    Language English
    Size XIII, 259 S. : Ill., graph. Darst., Kt., 24 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017252388
    ISBN 978-1-4614-3313-2 ; 1-4614-3313-4 ; 9781461433149 ; 1461433142
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Insulin like growth factors and cancer

    LeRoith, Derek

    from basic biology to therapeutics

    (Cancer drug discovery and development)

    2011  

    Title variant Insulin-like growth factors and cancer
    Author's details Derek LeRoith ed
    Series title Cancer drug discovery and development
    Keywords Receptors, Somatomedin ; Somatomedins
    Language English
    Size XII, 284 S. : Ill., 24 cm
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017001939
    ISBN 978-1-461-40597-9 ; 1-461-40597-1 ; 9781461405986 ; 146140598X
    Database Catalogue ZB MED Medicine, Health

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  4. Article: Hallmarks of cancer: The insulin-like growth factors perspective.

    Werner, Haim / LeRoith, Derek

    Frontiers in oncology

    2022  Volume 12, Page(s) 1055589

    Abstract: The identification of a series of attributes ... ...

    Abstract The identification of a series of attributes or
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1055589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Obesity

    LeRoith, Derek / Karnieli, Eddy

    (Medical clinics of North America ; 95,5)

    2011  

    Author's details guest ed. Derek LeRoith ; Eddy Karnieli
    Series title Medical clinics of North America ; 95,5
    Collection
    Language English
    Size XV S., S. 855 - 1040 : Ill., graph. Darst.
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT016988933
    ISBN 978-1-4557-2369-0 ; 1-4557-2369-X
    Database Catalogue ZB MED Medicine, Health

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  6. Article: A MESSAGE FROM THE EDITOR-IN-CHIEF.

    LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2020  Volume 26, Issue 1, Page(s) 5

    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/1934-2403-26.1.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Management of Type 2 Diabetes Mellitus in the Very Elderly: One Practice's Experience.

    Grajower, Martin M / LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2023  Volume 29, Issue 7, Page(s) 560–565

    Abstract: Objective: Type 2 diabetes mellitus (T2DM) affects 25% of adults over age 65. Nevertheless, few clinical trials include patients over age 75.: Methods: This case series reports retrospective data on a cohort of 85 patients aged 80 and over (mean 88.1, ...

    Abstract Objective: Type 2 diabetes mellitus (T2DM) affects 25% of adults over age 65. Nevertheless, few clinical trials include patients over age 75.
    Methods: This case series reports retrospective data on a cohort of 85 patients aged 80 and over (mean 88.1, range 80-104) with T2DM, managed by a single endocrinologist. The practice's computerized data base was searched for all patients 80 years of age and older with a diagnosis of T2DM.
    Results: The major observations were the significant decrease in the use of agents associated with hypoglycemia (sulfonylureas and insulin), and the beneficial and well-tolerated use of glucagon like peptide-1 receptor analogues (GLP-1 RA). The mean A1c in the entire cohort dropped from 7.6% to 6.6% over a mean of 9 months. Nearly one-half of the cohort were treated with GLP1-RA, reflecting studies demonstrating the safety and efficacy of this class of drugs in less elderly patients. At presentation, 75% were on sulfonylurea and/or insulin; this number was reduced to 27%. Furthermore, none of the patients required short-acting (bolus) insulin to achieve the individualized A1c target.
    Conclusion: Patients with T2DM aged 80 and over respond well to GLP1-RA drugs, drastically reducing the need for agents associated with hypoglycemia. The important question, which will require larger and prospective studies, is whether the lowering of A1c, as shown in this paper, and the use of GLP-1 RA specifically, are associated with improved morbidity and mortality in the very elderly.
    MeSH term(s) Adult ; Aged ; Humans ; Aged, 80 and over ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Hypoglycemic Agents/therapeutic use ; Glycated Hemoglobin ; Retrospective Studies ; Prospective Studies ; Insulin/therapeutic use ; Hypoglycemia/chemically induced ; Hypoglycemia/epidemiology ; Hypoglycemia/prevention & control ; Sulfonylurea Compounds/therapeutic use ; Glucagon-Like Peptide-1 Receptor ; Insulin, Regular, Human/therapeutic use ; Glucagon-Like Peptide 1/therapeutic use
    Chemical Substances Hypoglycemic Agents ; Glycated Hemoglobin ; Insulin ; Sulfonylurea Compounds ; Glucagon-Like Peptide-1 Receptor ; Insulin, Regular, Human ; Glucagon-Like Peptide 1 (89750-14-1)
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2023.03.271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Management and prevention of glucose dysregulation

    LeRoith, Derek

    (Clinical cornerstone ; 8, Suppl. 7)

    2007  

    Author's details guest ed. Derek LeRoith
    Series title Clinical cornerstone ; 8, Suppl. 7
    Collection
    Language English
    Size S48 S. : graph. Darst.
    Publisher Excerpta Medica
    Publishing place Bridgewater, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015309979
    Database Catalogue ZB MED Medicine, Health

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  9. Book ; Online: Hot topics of debate on Turner syndrome: growth, puberty, cardiovascular risks, fertility and psychosocial development

    Uçar, Ahmet / Sze Choong Wong, Jarod / Darendeliler, Feyza / Holly, Jeff M. P. / LeRoith, Derek

    2019  

    Keywords Medicine ; Endocrinology ; Turner Syndrome ; Natriuretic Peptides ; Growth Hormone ; cardiovascular risk ; short stature ; Autoimmunity ; Puberty ; Fertility ; psychosocial ; cognitive
    Size 1 electronic resource (94 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230816
    ISBN 9782889632107 ; 2889632105
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article: A Message from the Editor-in-Chief.

    LeRoith, Derek

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2019  Volume 25, Issue 1, Page(s) 5

    MeSH term(s) Periodicals as Topic
    Language English
    Publishing date 2019-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.4158/1934-2403-25.1.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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