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Article: Learning motivation and environmental support: how first-generation college students achieve success?

Li, Xiaojing / Liu, Weitong / Hu, Ke

2023 Volume 14, Page(s) 1280783

Abstract: Introduction: With the continuous expansion of higher education worldwide, the academic performance of first-generation college students has become an essential topic in the scope of international educational research. This study examines the impact of ... ...

Abstract	Introduction: With the continuous expansion of higher education worldwide, the academic performance of first-generation college students has become an essential topic in the scope of international educational research. This study examines the impact of learning motivation (i.e., intrinsic and extrinsic motivation) and environmental support (i.e., instructional, relational, and campus support) on the academic outcomes of first-generation college students based on the Cultural Mismatch Theory and Self-Determination Theory from both individual and environmental perspectives. Methods: A two-stage stratified sampling strategy was adopted to guarantee that the samples were representative of the national populations of college students in mainland China. 87418 data were collected from the China College Student Survey (CCSS) 2020, among which 58,864 were first-generation college students. This study primarily employed descriptive statistical analysis and regression analysis methods. Results: Data analysis revealed that intrinsic learning motivation, relational support, campus support, and academic performance of first-generation college students are significantly lower than those of non-first-generation students. However, this study found no significant differences concerning external learning motivation and teaching support. Regression analysis showed that both learning motivation and environmental support positively predicted learning outcomes, with intrinsic learning motivation having the most substantial influence. Moreover, learning motivation and environmental support interact in jointly promoting the student's academic success. Discussion: This study highlighted that the academic development of first-generation college students results from the interplay between individual characteristics and the surrounding environment. Postnatal factors, particularly individual learning motivation, and institutional environment support, play a crucial role in their academic achievements.
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1280783
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Article ; Online: Effects of tetrahedral DNA nanostructures on the treatment of osteoporosis.

Cui, Weitong / Yang, Xiao / Dou, Yikai / Du, Yue / Ma, Xiaohong / Hu, Lei / Lin, Yunfeng

Cell proliferation

2024 , Page(s) e13625

Abstract: Osteoporosis (OP) is a common disease characterized by bone loss and bone tissue microstructure degradation. Drug treatment is a common clinical treatment that aims to increase bone mass and bone density. Tetrahedral DNA nanostructures (TDNs) are three- ... ...

Abstract	Osteoporosis (OP) is a common disease characterized by bone loss and bone tissue microstructure degradation. Drug treatment is a common clinical treatment that aims to increase bone mass and bone density. Tetrahedral DNA nanostructures (TDNs) are three-dimensional tetrahedral frames formed by folding four single-stranded DNA molecules, which have good biological safety and can promote bone regeneration. In this study, a mouse model of OP was established by ovariectomy (OVX) and TDN was injected into the tail vein for 8 weeks. We found that ovariectomized mice could simulate some physiological changes in OP. After treatment with TDNs, some of this destruction in mice was significantly improved, including an increase in the bone volume fraction (BV/TV) and bone trabecular number (Tb. N), decrease in bone separation (Tb. SP), reduction in the damage to the mouse cartilage layer, reduction in osteoclast lacunae in bone trabecula, and reduction in the damage to the bone dense part. We also found that the expression of ALP, β-Catenin, Runx2, Osterix, and bone morphogenetic protein (BMP)2 significantly decreased in OVX mice but increased after TDN treatment. Therefore, this study suggests that TDNs may regulate the Wnt/β-Catenin and BMP signalling pathways to improve the levels of some specific markers of osteogenic differentiation, such as Runx2, ALP, and Osterix, to promote osteogenesis, thus showing a therapeutic effect on OP mice.
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/cpr.13625
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Article ; Online: Pain management with transdermal drug administration: A review.

Hu, Weitong / Bian, Qiong / Zhou, Yanjun / Gao, Jianqing

International journal of pharmaceutics

2022 Volume 618, Page(s) 121696

Abstract: Pain management is an urgent issue to solve with complex mechanisms. Localized acute pain requires rapid and accurate delivery of drugs with less distribution in the blood circulation while chronic pain requires controlled release of drugs with long drug ...

Abstract	Pain management is an urgent issue to solve with complex mechanisms. Localized acute pain requires rapid and accurate delivery of drugs with less distribution in the blood circulation while chronic pain requires controlled release of drugs with long drug retention time. The transdermal route, a promising way with high patient compliance was known for painless delivery, long drug retention time, stable blood concentration, easily controlled dosage and release rate as well as the fewer side effects. This review presents transdermal route for pain management according to the different sites of action which drugs aim to reach, and illustrates different analgesic mechanisms, dosage forms, transdermal enhancements and clinical applications. In addition, the review concludes the difference of pain types and presents the future aims of pain management, thereby providing a reference for researches focusing on percutaneous analgesia.
MeSH term(s)	Administration, Cutaneous ; Analgesics ; Analgesics, Opioid ; Humans ; Pain/chemically induced ; Pain/drug therapy ; Pain Management ; Pharmaceutical Preparations
Chemical Substances	Analgesics ; Analgesics, Opioid ; Pharmaceutical Preparations
Language	English
Publishing date	2022-03-23
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2022.121696
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Article ; Online: Curcumin-loaded pH-sensitive carboxymethyl chitosan nanoparticles for the treatment of liver cancer.

Yang, Xinyu / Meng, Dongdong / Jiang, Ning / Wang, Chaoxing / Zhang, Jinbo / Hu, Yanqiu / Lun, Jiaming / Jia, Rui / Zhang, Xueyun / Sun, Weitong

Journal of biomaterials science. Polymer edition

2024 Volume 35, Issue 5, Page(s) 628–656

Abstract: In this study, the pH-responsive API-CMCS-SA (ACS) polymeric nanoparticles (NPs) based on 1-(3-amino-propyl) imidazole (API), stearic acid (SA), and carboxymethyl chitosan (CMCS) were fabricated for the effective transport of curcumin (CUR) in liver ... ...

Abstract	In this study, the pH-responsive API-CMCS-SA (ACS) polymeric nanoparticles (NPs) based on 1-(3-amino-propyl) imidazole (API), stearic acid (SA), and carboxymethyl chitosan (CMCS) were fabricated for the effective transport of curcumin (CUR) in liver cancer. CUR-ACS-NPs with various degrees of substitution (DS) were employed to prepare through ultrasonic dispersion method. The effect of different DS on NPs formation was discussed. The obtained CUR-ACS-NPs (DS
MeSH term(s)	Humans ; Curcumin/chemistry ; Chitosan/chemistry ; Drug Carriers/chemistry ; Nanoparticles/chemistry ; Liver Neoplasms/drug therapy ; Hydrogen-Ion Concentration ; Particle Size
Chemical Substances	Curcumin (IT942ZTH98) ; Chitosan (9012-76-4) ; Drug Carriers
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1014190-x
ISSN	1568-5624 ; 1568-5616 ; 0920-5063
ISSN (online)	1568-5624 ; 1568-5616
ISSN	0920-5063
DOI	10.1080/09205063.2024.2304949
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Article ; Online: Cerium oxide boosted CoFe-N codoped carbon nanotubes with abundant oxygen-vacancies toward efficient oxygen reduction and methanol oxidation reaction.

Huang, Zhiye / Li, Woyuan / Jiang, Junjie / Zhou, Weitong / Zhang, Mingmei / Mao, Ruiji / Wang, Zhuokai / Xie, Jimin / Hu, Zonggui

Journal of colloid and interface science

2023 Volume 654, Issue Pt A, Page(s) 164–173

Abstract: In this study, we designed a novel strategy that utilizes N-doped carbon nanotubes as the chemical bond supporter to stabilize ultrafine CoFe alloy and introduces secondary ... ...

Abstract	In this study, we designed a novel strategy that utilizes N-doped carbon nanotubes as the chemical bond supporter to stabilize ultrafine CoFe alloy and introduces secondary CeO
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.10.040
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Article ; Online: Boosting activity on copper functionalized biomass graphene by coupling nanocrystalline Nb

Zhang, Mingmei / Huang, Zhiye / Jiang, Junjie / Zhou, Weitong / Li, Woyuan / Xie, Jimin / Hu, Zonggui / Wang, Zhonghua / Yan, Zaoxue

Journal of colloid and interface science

2023 Volume 652, Issue Pt A, Page(s) 1–11

Abstract: A novel and hierarchical porous but cross-linked copper-doped biomass graphene (Cu@HPBG) combined with ... ...

Abstract	A novel and hierarchical porous but cross-linked copper-doped biomass graphene (Cu@HPBG) combined with Nb
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.08.010
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Book ; Online: Relax Image-Specific Prompt Requirement in SAM

Hu, Jian / Lin, Jiayi / Cai, Weitong / Gong, Shaogang

A Single Generic Prompt for Segmenting Camouflaged Objects

2023

Abstract: Camouflaged object detection (COD) approaches heavily rely on pixel-level annotated datasets. Weakly-supervised COD (WSCOD) approaches use sparse annotations like scribbles or points to reduce annotation effort, but this can lead to decreased accuracy. ... ...

Abstract	Camouflaged object detection (COD) approaches heavily rely on pixel-level annotated datasets. Weakly-supervised COD (WSCOD) approaches use sparse annotations like scribbles or points to reduce annotation effort, but this can lead to decreased accuracy. The Segment Anything Model (SAM) shows remarkable segmentation ability with sparse prompts like points. However, manual prompt is not always feasible, as it may not be accessible in real-world application. Additionally, it only provides localization information instead of semantic one, which can intrinsically cause ambiguity in interpreting the targets. In this work, we aim to eliminate the need for manual prompt. The key idea is to employ Cross-modal Chains of Thought Prompting (CCTP) to reason visual prompts using the semantic information given by a generic text prompt. To that end, we introduce a test-time adaptation per-instance mechanism called Generalizable SAM (GenSAM) to automatically enerate and optimize visual prompts the generic task prompt for WSCOD. In particular, CCTP maps a single generic text prompt onto image-specific consensus foreground and background heatmaps using vision-language models, acquiring reliable visual prompts. Moreover, to test-time adapt the visual prompts, we further propose Progressive Mask Generation (PMG) to iteratively reweight the input image, guiding the model to focus on the targets in a coarse-to-fine manner. Crucially, all network parameters are fixed, avoiding the need for additional training. Experiments demonstrate the superiority of GenSAM. Experiments on three benchmarks demonstrate that GenSAM outperforms point supervision approaches and achieves comparable results to scribble supervision ones, solely relying on general task descriptions as prompts. our codes is in: https://lwpyh.github.io/GenSAM/. Comment: Accepted by AAAI2024
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2023-12-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Strain Characterization of

Wang, Shujie / Zhang, Defu / Jiang, Chenggang / He, Haijuan / Cui, Chenchen / Duan, Weitong / Hu, Shouping / Wang, Jun / Cai, Xuehui

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 2

Abstract: Streptococcus ... ...

Abstract	Streptococcus suis
Language	English
Publishing date	2021-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10020213
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Article ; Online: The left adrenal vein: An important direction for right adrenal venous sampling.

Xiong, Hongliang / Du, Li / Yang, Jiao / Hu, WeiTong / Huang, JiaBing / Li, YunDe / Chen, Xi / Dong, YiFei

Journal of clinical hypertension (Greenwich, Conn.)

2023 Volume 25, Issue 12, Page(s) 1145–1150

Abstract: This study aimed to evaluate the guiding role of left adrenal vein (LAV) for right adrenal venous sampling (AVS). A total of 347 patients who were diagnosed with primary aldosteronism (PA) and underwent successful AVS procedures from January 2020 to July ...

Abstract	This study aimed to evaluate the guiding role of left adrenal vein (LAV) for right adrenal venous sampling (AVS). A total of 347 patients who were diagnosed with primary aldosteronism (PA) and underwent successful AVS procedures from January 2020 to July 2021 were retrospectively analyzed. According to the different quadrant position of the orifice of right adrenal vein (RAV), the area where the orifice of RAV is located is divided into three areas: A, B, and C and the area A is further subdivided into A1, A2, and A3 areas. By counting the area where the orifice of RAV is located, the guiding role of the LAV on the RAV is determined. Most of the orifice of RAV are located in area A, and the proportions of areas A, B, and C was 96.8%, 1.4%, and 1.7%, respectively. In area A, areas A1, A2, and A3 account for 80.9%, 17.0%, and 2.1%, respectively. High body mass index, female and smaller the angle between the LAV and horizontal line was associated with the closer positional relationship between the LAV on the RAV. These findings suggest that most of the horizontal position of the RAV orifice is close to the horizontal position of the most distal end of the LAV, which indicate that the LAV location can play an important role on the guiding for right AVS. Additionally, body mass index, sex, and the angle of the LAV was largely related to location of the orifice of the RAV.
MeSH term(s)	Humans ; Female ; Retrospective Studies ; Hypertension ; Adrenal Glands/blood supply ; Vena Cava, Inferior ; Body Mass Index ; Hyperaldosteronism/diagnosis ; Aldosterone
Chemical Substances	Aldosterone (4964P6T9RB)
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.14742
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Article ; Online: BcNAC056 Interacts with BcWRKY1 to Regulate Leaf Senescence in Pak Choi.

Yuan, Shuilin / Wang, Yuan / Hu, Die / Zhu, Weitong / Xiao, Dong / Liu, Tongkun / Hou, Xilin / Li, Ying

Plant & cell physiology

2023 Volume 64, Issue 9, Page(s) 1091–1105

Abstract: Senescence is the final stage of leaf development. For leafy vegetables such as pak choi, leaf senescence is adverse to yield due to the harvest period shortening. However, the regulatory mechanisms of leaf senescence are largely unknown in leafy ... ...

Abstract	Senescence is the final stage of leaf development. For leafy vegetables such as pak choi, leaf senescence is adverse to yield due to the harvest period shortening. However, the regulatory mechanisms of leaf senescence are largely unknown in leafy vegetables. Here, we isolated and characterized a NAC gene, BcNAC056, in pak choi [Brassica campestris (syn. Brassica rapa) ssp. chinensis cv. 49caixin]. BcNAC056-GFP was located in the nucleus at the subcellular level, and BcNAC056 was responsive to leaf senescence and different hormones at the transcriptional level. Heterologous overexpression of BcNAC056 in Arabidopsis promoted leaf senescence, accompanied by the increased expression of senescence-associated genes (SAGs), whereas virus-induced gene silencing-based silencing in pak choi delayed leaf senescence. The following transcriptome analysis showed that heterologous overexpression of BcNAC056 enhanced some AtSAG transcripts in Arabidopsis. Electrophoretic mobility shift assay (EMSA) and dual-luciferase (LUC) reporter assay revealed that BcNAC056 activated SAG12 by directly binding to the promoter. In addition, with the LUC reporter and transient overexpression assays, we proposed that BcNAC056-BcWRKY1 interaction promoted the activation of BcSAG12. Taken together, our findings revealed a new regulatory mechanism of leaf senescence in pak choi.
MeSH term(s)	Plant Senescence ; Arabidopsis/genetics ; Brassica/metabolism ; Brassica rapa/genetics ; Brassica rapa/metabolism ; Plant Leaves/metabolism
Language	English
Publishing date	2023-08-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	208907-5
ISSN	1471-9053 ; 0032-0781
ISSN (online)	1471-9053
ISSN	0032-0781
DOI	10.1093/pcp/pcad073
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