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Article ; Online: Reasons for Receiving or Not Receiving Bivalent COVID-19 Booster Vaccinations Among Adults - United States, November 1-December 10, 2022.

Sinclair, Alyssa H / Taylor, Morgan K / Weitz, Joshua S / Beckett, Stephen J / Samanez-Larkin, Gregory R

MMWR. Morbidity and mortality weekly report

2023 Volume 72, Issue 3, Page(s) 73–75

Abstract: Bivalent COVID-19 booster vaccines, developed to protect against both ancestral and Omicron BA.4/BA.5 variants, are recommended to increase protection against SARS-CoV-2 infection and severe disease* (1,2). However, relatively few eligible U.S. adults ... ...

Abstract	Bivalent COVID-19 booster vaccines, developed to protect against both ancestral and Omicron BA.4/BA.5 variants, are recommended to increase protection against SARS-CoV-2 infection and severe disease* (1,2). However, relatively few eligible U.S. adults have received a bivalent booster dose (3), and reasons for low coverage are unclear. An opt-in Internet survey of 1,200 COVID-19-vaccinated U.S. adults was conducted to assess reasons for receiving or not receiving a bivalent booster dose. Participants could select multiple reasons from a list of suggested reasons to report why they had or had not received a bivalent booster dose. The most common reasons cited for not receiving the bivalent booster dose were lack of awareness of eligibility for vaccination (23.2%) or of vaccine availability (19.3%), and perceived immunity against infection (18.9%). After viewing information about eligibility and availability, 67.8% of participants who had not received the bivalent booster dose indicated that they planned to do so; in a follow-up survey 1 month later, 28.6% of these participants reported having received the dose. Among those who had planned to receive the booster dose but had not yet done so, 82.6% still intended to do so. Participants who had still not received the booster dose most commonly reported being too busy to get vaccinated (35.6%). To help increase bivalent booster dose coverage, health care and public health professionals should use evidence-based strategies to convey information about booster vaccination recommendations and waning immunity (4), while also working to increase convenient access.
MeSH term(s)	Humans ; Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Vaccination ; Eligibility Determination ; Health Facilities ; Vaccines, Combined
Chemical Substances	Vaccines, Combined
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7203a5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Diabetic Retinopathy-An Underdiagnosed and Undertreated Inflammatory, Neuro-Vascular Complication of Diabetes.

Sinclair, Stephen H / Schwartz, Stanley S

Frontiers in endocrinology

2019 Volume 10, Page(s) 843

Abstract: Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-threatening condition, is one of the most common diabetes-specific complications. Diabetic retinopathy is now recognized to be an inflammatory, neuro-vascular ... ...

Abstract	Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-threatening condition, is one of the most common diabetes-specific complications. Diabetic retinopathy is now recognized to be an inflammatory, neuro-vascular complication with neuronal injury/dysfunction preceding clinical microvascular damage. Importantly, the same pathophysiologic mechanisms that damage the pancreatic β-cell (e.g., inflammation, epigenetic changes, insulin resistance, fuel excess, and abnormal metabolic environment), also lead to cell and tissue damage causing organ dysfunction, elevating the risk of all complications, including diabetic retinopathy. Viewing diabetic retinopathy within the context whereby diabetes and all its complications arise from common pathophysiologic factors allows for the consideration of a wider array of potential ocular as well as systemic treatments for this common and devastating complication. Moreover, it also raises the importance of the need for methods that will provide more timely detection and prediction of the course in order to address early damage to the neurovascular unit prior to the clinical observation of microangiopathy. Currently, treatment success is limited as it is often initiated far too late and after significant neurodegeneration has occurred. This forward-thinking approach of earlier detection and treatment with a wider array of possible therapies broadens the physician's armamentarium and increases the opportunity for prevention and early treatment of diabetic retinopathy with preservation of good vision, as well the prevention of similar destructive processes occurring among other organs.
Language	English
Publishing date	2019-12-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2019.00843
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Article ; Online: Changes in metabolic profiles of amphipods Allorchestes compressa after acute exposures to copper, pyrene, and their mixtures.

Shen, Hao / Nzabanita, Damien / Sinclair, Georgia M / Vu, Hung / Grist, Stephen / Nugegoda, Dayanthi / Long, Sara M

Environmental toxicology and pharmacology

2023 Volume 99, Page(s) 104120

Abstract: ... of copper and pyrene, and their mixtures, for 24 and 48 h. Changes in polar metabolites were assessed using ... metabolites had changed following exposures to mixtures. Furthermore, changes were mainly observed after 24 h ... but had seemingly returned to control levels after 48 h. Multiple types of metabolites were affected ...

Abstract	Amphipods are ideal indicators for biomonitoring and ecotoxicological studies of environmental contaminants because they are extensively distributed in aquatic environments, are easy to collect and are important in nutrient cycling. Marine amphipods (Allorchestes compressa) were exposed to two concentrations of copper and pyrene, and their mixtures, for 24 and 48 h. Changes in polar metabolites were assessed using Gas Chromatography Mass Spectrometry (GC-MS)-based untargeted metabolomics. Generally, limited metabolite changes were observed for copper and pyrene single exposures (eight and two significant metabolites, respectively), while 28 metabolites had changed following exposures to mixtures. Furthermore, changes were mainly observed after 24 h but had seemingly returned to control levels after 48 h. Multiple types of metabolites were affected including amino acids, Tricarboxylic acid (TCA) cycle intermediates, sugars, fatty acids, and hormones. This study highlights the sensitivity of metabolomics in assessing the impacts of low concentrations of chemicals compared to traditional ecotoxicological endpoints.
MeSH term(s)	Animals ; Copper/toxicity ; Amphipoda/metabolism ; Pyrenes/toxicity ; Pyrenes/metabolism ; Metabolomics/methods ; Metabolome
Chemical Substances	Copper (789U1901C5) ; pyrene (9E0T7WFW93) ; Pyrenes
Language	English
Publishing date	2023-04-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2023.104120
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Article: Scenario-Based Messages on Social Media Motivate COVID-19 Information Seeking.

Sinclair, Alyssa H / Taylor, Morgan K / Davidson, Audra / Weitz, Joshua S / Beckett, Stephen J / Samanez-Larkin, Gregory R

Journal of applied research in memory and cognition

2023 Volume 13, Issue 1, Page(s) 124–135

Abstract: Communicating information about health risks empowers individuals to make informed decisions. To identify effective communication strategies, we manipulated the specificity, self-relevance, and emotional framing of messages designed to motivate ... ...

Abstract	Communicating information about health risks empowers individuals to make informed decisions. To identify effective communication strategies, we manipulated the specificity, self-relevance, and emotional framing of messages designed to motivate information seeking about COVID-19 exposure risk. In Study 1 (N=221,829), we conducted a large-scale social media field study. Using Facebook advertisements, we targeted users by age and political attitudes. Episodic specificity drove engagement: Advertisements that contextualized risk in specific scenarios produced the highest click-through rates, across all demographic groups. In Study 2, we replicated and extended our findings in an online experiment (N=4,233). Message specificity (but not self-relevance or emotional valence) drove interest in learning about COVID-19 risks. Across both studies, we found that older adults and liberals were more interested in learning about COVID-19 risks. However, message specificity increased engagement across demographic groups. Overall, evoking specific scenarios motivated information seeking about COVID-19, facilitating risk communication to a broad audience.
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2653816-7
ISSN	2211-3681
ISSN	2211-3681
DOI	10.1037/mac0000114
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Article ; Online: Alternative Splicing of Differentiated Myeloid Cell Transcripts after Infection by

Dumler, J Stephen / Sinclair, Sara H / Shetty, Amol C

Frontiers in cellular and infection microbiology

2018 Volume 8, Page(s) 14

Abstract: Eukaryotic proteome diversity exceeds that encoded within individual genes, and results in part from alternative splicing events of pre-messenger RNA. The diversity of these splicing events can shape the outcome in development and differentiation of ... ...

Abstract	Eukaryotic proteome diversity exceeds that encoded within individual genes, and results in part from alternative splicing events of pre-messenger RNA. The diversity of these splicing events can shape the outcome in development and differentiation of normal tissues, and is important in pathogenic circumstances such as cancer and some heritable conditions. A role for alternative splicing of eukaryotic genes in response to viral and intracellular bacterial infections has only recently been recognized, and plays an important role in providing fitness for microbial survival, while potentially enhancing pathogenicity.
MeSH term(s)	Alternative Splicing ; Anaplasma phagocytophilum/physiology ; Cell Differentiation/genetics ; Computational Biology/methods ; Ehrlichiosis/genetics ; Ehrlichiosis/metabolism ; Ehrlichiosis/microbiology ; Gene Expression Profiling ; Gene Ontology ; HL-60 Cells ; Humans ; Myeloid Cells/cytology ; Myeloid Cells/metabolism ; Spliceosomes/metabolism ; Transcriptional Activation ; Transcriptome
Language	English
Publishing date	2018-02-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2018.00014
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Communicating COVID-19 exposure risk with an interactive website counteracts risk misestimation.

Sinclair, Alyssa H / Taylor, Morgan K / Brandel-Tanis, Freyja / Davidson, Audra / Chande, Aroon T / Rishishwar, Lavanya / Andris, Clio / Adcock, R Alison / Weitz, Joshua S / Samanez-Larkin, Gregory R / Beckett, Stephen J

PloS one

2023 Volume 18, Issue 10, Page(s) e0290708

Abstract: During the COVID-19 pandemic, individuals depended on risk information to make decisions about everyday behaviors and public policy. Here, we assessed whether an interactive website influenced individuals' risk tolerance to support public health goals. ... ...

Abstract	During the COVID-19 pandemic, individuals depended on risk information to make decisions about everyday behaviors and public policy. Here, we assessed whether an interactive website influenced individuals' risk tolerance to support public health goals. We collected data from 11,169 unique users who engaged with the online COVID-19 Event Risk Tool (https://covid19risk.biosci.gatech.edu/) between 9/22/21 and 1/22/22. The website featured interactive elements, including a dynamic risk map, survey questions, and a risk quiz with accuracy feedback. After learning about the risk of COVID-19 exposure, participants reported being less willing to participate in events that could spread COVID-19, especially for high-risk large events. We also uncovered a bias in risk estimation: Participants tended to overestimate the risk of small events but underestimate the risk of large events. Importantly, even participants who voluntarily sought information about COVID risks tended to misestimate exposure risk, demonstrating the need for intervention. Participants from liberal-leaning counties were more likely to use the website tools and more responsive to feedback about risk misestimation, indicating that political partisanship influences how individuals seek and engage with COVID-19 information. Lastly, we explored temporal dynamics and found that user engagement and risk estimation fluctuated over the course of the Omicron variant outbreak. Overall, we report an effective large-scale method for communicating viral exposure risk; our findings are relevant to broader research on risk communication, epidemiological modeling, and risky decision-making.
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Pandemics/prevention & control ; Communication
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0290708
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Slowed Progression of Age-Related Geographic Atrophy Following Subthreshold Laser.

Luttrull, Jeffrey K / Sinclair, Stephen H / Elmann, Solly / Chang, David B / Kent, David

Clinical ophthalmology (Auckland, N.Z.)

2020 Volume 14, Page(s) 2983–2993

Abstract: Purpose: To determine the effect of panmacular low-intensity/high-density subthreshold diode micropulse laser (SDM) on age-related geographic atrophy (ARGA) progression.: Methods: The retinal images of all eyes with ARGA in a previously reported ... ...

Abstract	Purpose: To determine the effect of panmacular low-intensity/high-density subthreshold diode micropulse laser (SDM) on age-related geographic atrophy (ARGA) progression. Methods: The retinal images of all eyes with ARGA in a previously reported database, consisting of all eyes with dry age-related macular degeneration (AMD) active in a vitreoretinal practice electronic medical record (EMR), were identified and analyzed to determine the velocity of radial linear ARGA progression during observation and after panmacular SDM. Results: Sixty-seven eyes of 49 patients with ARGA, mean age of 86 years were identified as having follow-up both before and after initiation of SDM treatment. All were included in the study. These eyes were followed a mean 910 days (2.5 years) prior to SDM treatment and a mean 805 days (2.2 years) after. Measurement masked to treatment vs observation found the radius of ARGA lesions progressed 1 to 540 µm per year (mean 137µm, SD 107) prior to treatment (controls); and -44 to 303 µm per year (mean 73µm, SD 59) after initiation of periodic panmacular SDM laser. Thus, the velocity of radial linear progression decreased 47% per year following panmacular SDM (p<0.0001). There were no adverse treatment effects. Conclusion: In cohort of eyes with high-risk dry AMD, panmacular SDM slowed linear radial ARGA progression velocity 47% per year (p<0.0001) without adverse treatment effects. Validated, these findings would constitute an important advance in the prevention of age-related visual loss and a benchmark for future therapies.
Language	English
Publishing date	2020-10-01
Publishing country	New Zealand
Document type	Journal Article
ISSN	1177-5467
ISSN	1177-5467
DOI	10.2147/OPTH.S268322
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Article ; Online: Communicating COVID-19 exposure risk with an interactive website counteracts risk misestimation.

Alyssa H Sinclair / Morgan K Taylor / Freyja Brandel-Tanis / Audra Davidson / Aroon T Chande / Lavanya Rishishwar / Clio Andris / R Alison Adcock / Joshua S Weitz / Gregory R Samanez-Larkin / Stephen J Beckett

PLoS ONE, Vol 18, Iss 10, p e

2023 Volume 0290708

Abstract	During the COVID-19 pandemic, individuals depended on risk information to make decisions about everyday behaviors and public policy. Here, we assessed whether an interactive website influenced individuals' risk tolerance to support public health goals. We collected data from 11,169 unique users who engaged with the online COVID-19 Event Risk Tool (https://covid19risk.biosci.gatech.edu/) between 9/22/21 and 1/22/22. The website featured interactive elements, including a dynamic risk map, survey questions, and a risk quiz with accuracy feedback. After learning about the risk of COVID-19 exposure, participants reported being less willing to participate in events that could spread COVID-19, especially for high-risk large events. We also uncovered a bias in risk estimation: Participants tended to overestimate the risk of small events but underestimate the risk of large events. Importantly, even participants who voluntarily sought information about COVID risks tended to misestimate exposure risk, demonstrating the need for intervention. Participants from liberal-leaning counties were more likely to use the website tools and more responsive to feedback about risk misestimation, indicating that political partisanship influences how individuals seek and engage with COVID-19 information. Lastly, we explored temporal dynamics and found that user engagement and risk estimation fluctuated over the course of the Omicron variant outbreak. Overall, we report an effective large-scale method for communicating viral exposure risk; our findings are relevant to broader research on risk communication, epidemiological modeling, and risky decision-making.
Keywords	Medicine ; R ; Science ; Q
Subject code	332
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Safety of transfoveal subthreshold diode micropulse laser for fovea-involving diabetic macular edema in eyes with good visual acuity.

Luttrull, Jeffrey K / Sinclair, Stephen H

Retina (Philadelphia, Pa.)

2014 Volume 34, Issue 10, Page(s) 2010–2020

Abstract: Purpose: To determine the safety of transfoveal subthreshold diode micropulse laser for fovea-involving diabetic macular edema.: Methods: The records of all patients treated with transfoveal subthreshold diode micropulse laser for fovea-involving ... ...

Abstract	Purpose: To determine the safety of transfoveal subthreshold diode micropulse laser for fovea-involving diabetic macular edema. Methods: The records of all patients treated with transfoveal subthreshold diode micropulse laser for fovea-involving diabetic macular edema in two retina clinics were reviewed. The eligibility included fovea-involving diabetic macular edema by spectral domain optical coherence tomography and pretreatment visual acuity of 20/40 or better. Results: Thirty-nine eyes of 27 patients aged 50 years to 87 years (mean, 69 years) were included. Postoperative follow-up ranged from 3 months to 36 months (mean, 11 months). Fourteen patients were insulin dependent, and 19 had nonproliferative retinopathy. The preoperative visual acuity was 20/20 (10 eyes), 20/25 (10 eyes), 20/30 (8 eyes), and 20/40 (11 eyes). No eye had evidence of laser-induced macular damage by any imaging means postoperatively. There were no adverse treatment effects. Logarithm of the minimum angle of resolution visual acuity was improved on average of 0.03 units at 4 months to 7 months of follow-up (P = 0.0449, paired t-test) and otherwise stable. The central foveal thickness was improved at 4 months to 7 months (P = 0.05, paired t-test) and 8 months to 12 months, postoperatively (P = 0.04, mixed model accounting). Maximum macular thickness was improved at 4 months to 7 months postoperatively (P = 0.01, paired t-test and mixed model accounting). Conclusion: In a small retrospective series, transfoveal subthreshold diode micropulse laser was safe and effective for the treatment of fovea-involving diabetic macular edema in eyes with good preoperative visual acuity that were not the candidates for conventional photocoagulation or intravitreal injection. Further study is warranted.
MeSH term(s)	Aged ; Aged, 80 and over ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 2/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/physiopathology ; Diabetic Retinopathy/radiotherapy ; Female ; Follow-Up Studies ; Fovea Centralis ; Humans ; Lasers, Semiconductor/therapeutic use ; Low-Level Light Therapy ; Macular Edema/diagnosis ; Macular Edema/physiopathology ; Macular Edema/radiotherapy ; Male ; Middle Aged ; Retrospective Studies ; Sensory Thresholds ; Tomography, Optical Coherence ; Visual Acuity/physiology
Language	English
Publishing date	2014-10
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000000177
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1724: Show issues

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Article ; Online: Low incidence of choroidal neovascularization following subthreshold diode micropulse laser (SDM) in high-risk AMD.

Luttrull, Jeffrey K / Sinclair, Stephen H / Elmann, Solly / Glaser, Bert M

PloS one

2018 Volume 13, Issue 8, Page(s) e0202097

Abstract: Purpose: To determine the incidence of new choroidal neovascularization (CNV) in eyes with dry age-related macular degeneration (AMD) following subthreshold diode micropulse laser (SDM).: Method: In an observational retrospective cohort study, the ... ...

Abstract	Purpose: To determine the incidence of new choroidal neovascularization (CNV) in eyes with dry age-related macular degeneration (AMD) following subthreshold diode micropulse laser (SDM). Method: In an observational retrospective cohort study, the records of all patients active in the electronic medical records database were reviewed to identify eyes with dry AMD treated with SDM. Identified eyes were classified by simplified AREDS categories, and analyzed for the primary endpoint of new CNV after treatment. Results: The EMR revealed SDM was offered to 373/392 (95%) patients with dry AMD and elected by 363/373 (97%) between 2008-2017. Follow up was available for 354/363 patients (547 eyes, 98%) (range 6-108 mos., avg. 22). CNV risk factors included age (median 84 years, 67% > 80); reticular pseudodrusen (214 eyes, 39%); AREDS category (78% category 3 and 4); and fellow eye CNV (128 eyes, 23%). New CNV developed in 9/547 eyes (1.6%, annualized rate 0.87%). Visual acuity was unchanged. There were no adverse treatment effects. Summary: In a review of a large group of eyes with exceptionally high-risk AMD, SDM was followed by a very low incidence of new CNV. If confirmed by further study, SDM would offer a new and highly effective treatment to reduce the risk of vision loss from AMD.
MeSH term(s)	Aged ; Aged, 80 and over ; Choroidal Neovascularization/epidemiology ; Choroidal Neovascularization/etiology ; Comorbidity ; Female ; Follow-Up Studies ; Humans ; Incidence ; Kaplan-Meier Estimate ; Laser Therapy/adverse effects ; Laser Therapy/methods ; Macular Degeneration/complications ; Macular Degeneration/epidemiology ; Macular Degeneration/therapy ; Male ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2018-08-23
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0202097
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