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Article ; Online: Study on tissue distribution, metabolite profiling, and excretion of [

Ma, Ziyan / Tang, Minghai / Chen, Lijuan

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115984

Abstract: Flonoltinib Maleate (FM) is a dual-target inhibitor that selectively suppresses Janus kinase 2/FMS-like tyrosine kinase 3 (JAK2/FLT3), which is currently in phase I/IIa clinical trial in China for the treatment of myeloproliferative neoplasms (MPNs). In ... ...

Abstract	Flonoltinib Maleate (FM) is a dual-target inhibitor that selectively suppresses Janus kinase 2/FMS-like tyrosine kinase 3 (JAK2/FLT3), which is currently in phase I/IIa clinical trial in China for the treatment of myeloproliferative neoplasms (MPNs). In this research, we used [
MeSH term(s)	Rats ; Animals ; Dogs ; Rats, Sprague-Dawley ; Tissue Distribution ; Bile/metabolism ; Feces/chemistry ; Maleates/analysis ; Maleates/metabolism ; Chromatography, High Pressure Liquid/methods ; Administration, Oral
Chemical Substances	Maleates
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115984
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Article ; Online: Geniposide Attenuates Oxygen-glucose Deprivation/Recovery-induced Retinal Ganglion Cell Injury via Akt/Nrf-2 Signaling Pathway.

Hu, Minghai / Chen, Dekun / Wu, Xiuyu / Ren, Guo-Feng

Current medicinal chemistry

2024

Abstract: Background: Glaucoma is an eye disease. Its pathological process involves retinal ischemia-reperfusion (I/R), which causes irreversible blindness in patients. Geniposide (Gen), a bioactive iridoid glycoside extracted from the fruit of gardenia, exhibits ...

Abstract	Background: Glaucoma is an eye disease. Its pathological process involves retinal ischemia-reperfusion (I/R), which causes irreversible blindness in patients. Geniposide (Gen), a bioactive iridoid glycoside extracted from the fruit of gardenia, exhibits many biological effects, such as anti-oxidative stress, anti-inflammation, anti-apoptosis, anti-endoplasmic reticulum stress, and anti-thrombotic effects. However, its therapeutic potential for the retinal I/R injury remains unclear. This study investigated the protective effect of Gen against I/R injury by inhibiting abnormal reactive oxygen species (ROS) and retinal neuron apoptosis. Methods: We used oxygen-glucose deprivation/reoxygenation (OGD/R) to induce R28 cells to mimic the pathological process of I/R in glaucoma. We conducted CCK-8 analysis and TUNEL staining to examine cell proliferation and apoptosis in glaucoma. Western blotting was used to assay the expressions of apoptosis and Akt/Nrf-2 pathway-related proteins. Results: The production of ROS was detected by using the corresponding kit. Cell viability decreased, whereas TUNEL staining-positive cells and ROS production increased after the OGD/R injury. The contents of cleaved caspase-3 and Bax/Bcl-2 increased after the OGD/R injury. Treatment with 200 μM of Gen effectively improved the cell viability and suppressed cell apoptosis and ROS production. In addition, Gen could significantly promote the activation of the Akt/Nrf-2 signaling pathway in R28 cells, which was blocked by the inhibition of Akt/Nrf-2. We in vivo verified the neuroprotective effect of Gen by establishing an acute high intraocular pressure (aHIOP) model and obtained similar results to those of the in vitro experimental results. Conclusion: Hence, it can be suggested that Gen provides neuroprotection against the OGD/R-induced injury of R28 cells by activating the Akt/Nrf-2 signaling pathway, which is beneficial for the clinical treatment of glaucoma.
Language	English
Publishing date	2024-04-19
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673272406231212054710
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Article ; Online: Comparative Study of Octavinyl Oligomeric Sesquisiloxane Nanomaterial-Modified Asphalt Using Molecular Dynamics Method.

Feng, Lei / Zhao, Peng / Chen, Tongdan / Jing, Minghai

Polymers

2022 Volume 14, Issue 21

Abstract: This paper mainly studies the compatibility and properties of octavinyl oligomeric silsesquioxane nanomaterial (nano-OvPOSS)-modified asphalt, in comparison with those of traditional zinc oxide nanomaterial (nano-ZnO) and silica nanomaterial (nano- ... ...

Abstract	This paper mainly studies the compatibility and properties of octavinyl oligomeric silsesquioxane nanomaterial (nano-OvPOSS)-modified asphalt, in comparison with those of traditional zinc oxide nanomaterial (nano-ZnO) and silica nanomaterial (nano-SiO
Language	English
Publishing date	2022-10-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14214577
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Article ; Online: Design and synthesis of highly selective Janus kinase 3 covalent inhibitors for the treatment of rheumatoid arthritis.

Yao, Hualiang / Zhang, Jie / Zheng, Qisheng / Zeng, Xianxia / Huang, Huaizheng / Ling, Zhen / Tang, Minghai / Chen, Zhiquan / Wang, Wenchu / He, Linhong

Archiv der Pharmazie

2024 , Page(s) e2300753

Abstract: Selective inhibition of Janus kinase 3 (JAK3) is a promising strategy for the treatment of autoimmune diseases. Based on the discovery of a hydrophobic pocket unutilized between the lead compound RB1 and the JAK3 protein, a series of covalent JAK3 ... ...

Abstract	Selective inhibition of Janus kinase 3 (JAK3) is a promising strategy for the treatment of autoimmune diseases. Based on the discovery of a hydrophobic pocket unutilized between the lead compound RB1 and the JAK3 protein, a series of covalent JAK3 inhibitors were prepared by introducing various aromatic fragments to RB1. Among them, J1b (JAK3 IC
Language	English
Publishing date	2024-03-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202300753
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Article ; Online: Study on the Influence of Nano-OvPOSS on the Compatibility, Molecular Structure, and Properties of SBS Modified Asphalt by Molecular Dynamics Simulation.

Feng, Lei / Zhao, Peng / Chen, Tongdan / Jing, Minghai

Polymers

2022 Volume 14, Issue 19

Abstract: The present research is carried out to inspect the influence of nano-OvPOSS (octavinyl oligomeric silsesquioxane) with different particle sizes on styrene-butadiene-styrene (SBS) modified asphalt through the method of molecular dynamics simulation. This ... ...

Abstract	The present research is carried out to inspect the influence of nano-OvPOSS (octavinyl oligomeric silsesquioxane) with different particle sizes on styrene-butadiene-styrene (SBS) modified asphalt through the method of molecular dynamics simulation. This nanomaterial is investigated for the first time to be used in asphalt modification. With the construction of modified asphalt simulation models and the analysis of their mixing energy, radius of gyration (R
Language	English
Publishing date	2022-10-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14194121
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Article ; Online: Construction and applications of SARS-CoV-2 pseudoviruses: a mini review.

Chen, Minghai / Zhang, Xian-En

International journal of biological sciences

2021 Volume 17, Issue 6, Page(s) 1574–1580

Abstract: The ongoing coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to global public health and social stability. There is an urgent need for understanding the nature and ... ...

Abstract	The ongoing coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to global public health and social stability. There is an urgent need for understanding the nature and infection mechanism of the virus. Owing to its high infectivity and pathogenicity and lack of effective treatments, live SARS-CoV-2 has to be handled in biosafety level 3 laboratories, which has impeded research into SARS-CoV-2 and the development of vaccines and therapeutics. Pseudotyped viruses that lack certain gene sequences of the virulent virus are safer and can be investigated in biosafety level 2 laboratories, providing a useful virological tool for the study of SARS-CoV-2. In this review, we will discuss the construction of SARS-CoV-2 pseudoviruses based on different packaging systems, current applications, limitations, and further explorations.
MeSH term(s)	Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/virology ; Humans ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Viral Genome Packaging
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Language	English
Publishing date	2021-04-10
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.59184
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Article ; Online: Comparative Study of Octavinyl Oligomeric Sesquisiloxane Nanomaterial-Modified Asphalt Using Molecular Dynamics Method

Lei Feng / Peng Zhao / Tongdan Chen / Minghai Jing

Polymers, Vol 14, Iss 4577, p

2022 Volume 4577

Abstract	This paper mainly studies the compatibility and properties of octavinyl oligomeric silsesquioxane nanomaterial (nano-OvPOSS)-modified asphalt, in comparison with those of traditional zinc oxide nanomaterial (nano-ZnO) and silica nanomaterial (nano-SiO 2 ), through the method of molecular dynamics simulation. Nano-OvPOSS, an organic–inorganic nano-hybrid material, is studied for the first time in the application of asphalt modification. By studying different sizes and types of nanomaterials, this paper elucidates the superiority of nano-OvPOSS as an asphalt modifier owing to the unique microstructure of eight organic groups of its inorganic framework. According to the results, nano-OvPOSS does not aggregate in the modified asphalt system and displays the best compatibility with asphalt when compared with nano-SiO 2 and nano-ZnO. Moreover, nano-OvPOSS exhibits the most favorable compatibility with resinous oil out of the four asphalt components. The size of nano-OvPOSS determines its compatibility with asphalt. The smaller the particle size of nano-OvPOSS, the better its compatibility with asphalt. Therefore, out of all the four sizes of nano-OvPOSS (4.4 Å, 7 Å, 10 Å, and 20 Å) adopted in this study, the 4.4 Å nano-OvPOSS exhibits the best compatibility with asphalt. Additionally, compared with nano-SiO 2 and nano-ZnO, nano-OvPOSS is capable of attracting more asphalt molecules around it so that it reduces the largest amount of ratio of free volume (RFV) of matrix asphalt, which can be reduced by 9.4%. Besides these characteristics, the addition of nano-OvPOSS into the matrix asphalt contributes to higher heat capacity, bulk modulus, and shear modulus of the asphalt system, which were increased by 14.3%, 74.7%, and 80.2%, respectively, thereby guaranteeing a more desirable temperature stability and deformation resistance in the asphalt system. Accordingly, nano-OvPOSS can be employed as a viable asphalt modifier to ensure a well-rounded performance of modified asphalt.
Keywords	nano-OvPOSS ; nano-ZnO ; nano-SiO 2 ; compatibility ; modified asphalt ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synergistic effect of polyvinyl chloride and coal ash on thermal separation of heavy metals from MSWI fly ash through molten salt process.

Jing, Minghai / Zhao, Peng / Chen, Tongdan / Li, Jiangjiang

Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA

2022 Volume 40, Issue 11, Page(s) 1660–1668

Abstract: Municipal solid waste incineration fly ash (FA) contains high contents of salts and high concentrations of heavy metals, which makes FA disposal extremely difficult. However, heavy metal elements could potentially be separated from FA during thermal ... ...

Abstract	Municipal solid waste incineration fly ash (FA) contains high contents of salts and high concentrations of heavy metals, which makes FA disposal extremely difficult. However, heavy metal elements could potentially be separated from FA during thermal treatment process to make it possible to be recycled. This work aims to study the volatilization of heavy metals in FA treated by molten salt method. The influence of polyvinyl chloride (PVC) and coal ash (CA) on volatilization of heavy metals was investigated. Within the scope of this study, the highest heavy metal removal rate can be under the condition: the calcium chloride/sodium chloride weight ratio 1:1, the FA/molten salt weight ratio 1:10, treatment temperature 1000°C for 2 hours in reducing atmosphere. The volatilization rates of lead, zinc, copper, chromium and manganese were 86.20, 67.53, 65.24, 50.07 and 39.45%, respectively. On the basis of molten salt treatment, adding PVC could promote the volatilization of heavy metals. The volatilization rate of lead was 96.71%, and the volatilization rates of chromium and manganese were higher than 60% when the content of PVC was 5 wt%. When adding 10 wt% CA and 1 wt% polyvinyl chloride, the volatilization rate of lead could reach 100%. The experiments and thermodynamic calculations showed that silicon dioxide and aluminium oxide in CA and hydrochloric acid decomposed from PVC could promote the chlorination and volatilization of heavy metals. The volatilized heavy metal chlorides provided the possibility of recovery and utilization of heavy metals in FA.
Language	English
Publishing date	2022-06-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1480483-9
ISSN	1096-3669 ; 1399-3070 ; 0734-242X
ISSN (online)	1096-3669 ; 1399-3070
ISSN	0734-242X
DOI	10.1177/0734242X221105209
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Article ; Online: A target echo simulation method for wideband LFM-PRPC signals based on segmentation processing

Chen, Shihong / Pan, Minghai / Tao, Qingchang

Remote Sensing Letters. 2022 Nov. 02, v. 13, no. 11 p.1090-1099

2022

Abstract: To address the target echo simulation problem for linear frequency-modulated and pseudorandom phase-coded (LFM-PRPC) signals, this letter proposes a target echo reconstruction method based on segmentation processing. We treat the phase mutation points of ...

Abstract	To address the target echo simulation problem for linear frequency-modulated and pseudorandom phase-coded (LFM-PRPC) signals, this letter proposes a target echo reconstruction method based on segmentation processing. We treat the phase mutation points of an LFM-PRPC pulse signal as the basis for segmentation, approximately dividing the time-domain signal into several narrowband, short-term pulse signals, and then calculate the target echo signal corresponding to each pulse. Finally, we reconstruct the full pulse of the wideband target echo signal. This method not only reflects the intrapulse modulation characteristics of a radar signal and the wideband electromagnetic scattering characteristics of the target but also effectively improves the real-time performance of wideband radar target echo signal calculations without reducing the calculation accuracy. Moreover, it is applicable to both uniform and pseudorandom (nonuniform) coded signals. The results prove the reliability and feasibility of the proposed method.
Keywords	clothing ; point mutation ; radar ; reliability ; remote sensing
Language	English
Dates of publication	2022-1102
Size	p. 1090-1099.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	2150-7058
DOI	10.1080/2150704X.2022.2120778
Database	NAL-Catalogue (AGRICOLA)

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Article: In Situ Fabrication of CdS/Cd(OH)

Chen, Ran / Qian, Liping / Xu, Shengyou / Wan, Shunli / Ma, Minghai / Zhang, Lei / Jiang, Runren

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 17

Abstract: Photocatalytic hydrogen production is a promising technology that can generate renewable energy. However, light absorption and fast electron transfer are two main challenges that restrict the practical application of photocatalysis. Moreover, most of the ...

Abstract	Photocatalytic hydrogen production is a promising technology that can generate renewable energy. However, light absorption and fast electron transfer are two main challenges that restrict the practical application of photocatalysis. Moreover, most of the composite photocatalysts that possess better photocatalytic performance are fabricated by various methods, many of which are complicated and in which, the key conditions are hard to control. Herein, we developed a simple method to prepare CdS/Cd(OH)
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13172453
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