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  1. Article ; Online: The invention and development of enflurane, isoflurane, sevoflurane, and desflurane.

    Terrell, Ross C

    Anesthesiology

    2008  Volume 108, Issue 3, Page(s) 531–533

    Abstract: Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in ... ...

    Abstract Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or Cl were the best anesthetics.
    MeSH term(s) Animals ; Chemistry, Pharmaceutical/methods ; Chemistry, Pharmaceutical/trends ; Drug Design ; Enflurane/chemical synthesis ; Humans ; Hydrocarbons, Fluorinated/chemical synthesis ; Isoflurane/analogs & derivatives ; Isoflurane/chemical synthesis ; Methyl Ethers/chemical synthesis
    Chemical Substances Hydrocarbons, Fluorinated ; Methyl Ethers ; sevoflurane (38LVP0K73A) ; Enflurane (91I69L5AY5) ; desflurane (CRS35BZ94Q) ; Isoflurane (CYS9AKD70P)
    Language English
    Publishing date 2008-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0b013e31816499cc
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
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    Zs.MO 199: Show issues

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  2. Article ; Online: Drug design and DNA structural research inspired by the Neidle laboratory: DNA minor groove binding and transcription factor inhibition by thiophene diamidines.

    Ogbonna, Edwin N / Paul, Ananya / Ross Terrell, J / Fang, Ziyuan / Chen, Cen / Poon, Gregory M K / Boykin, David W / Wilson, W David

    Bioorganic & medicinal chemistry

    2022  Volume 68, Page(s) 116861

    Abstract: The understanding of sequence-specific DNA minor groove interactions has recently made major steps forward and as a result, the goal of development of compounds that target the minor groove is an active research area. In an effort to develop biologically ...

    Abstract The understanding of sequence-specific DNA minor groove interactions has recently made major steps forward and as a result, the goal of development of compounds that target the minor groove is an active research area. In an effort to develop biologically active minor groove agents, we are preparing and exploring the DNA interactions of diverse diamidine derivatives with a 5'-GAATTC-3' binding site using a powerful array of methods including, biosensor-SPR methods, and X-ray crystallography. The benzimidazole-thiophene module provides an excellent minor groove recognition component. A central thiophene in a benzimidazole-thiophene-phenyl aromatic system provides essentially optimum curvature for matching the shape of the minor groove. Comparison of that structure to one with the benzimidazole replaced with an indole shows that the two structures are very similar, but have some interesting and important differences in electrostatic potential maps, the DNA minor groove binding structure based on x-ray crystallographic analysis, and inhibition of the major groove binding PU.1 transcription factor complex. The binding K
    MeSH term(s) Benzimidazoles/chemistry ; Binding Sites ; DNA/chemistry ; Drug Design ; Indoles/pharmacology ; Models, Molecular ; Nucleic Acid Conformation ; Pentamidine/chemistry ; Surface Plasmon Resonance ; Thiophenes/chemistry ; Thiophenes/pharmacology ; Transcription Factors
    Chemical Substances Benzimidazoles ; Indoles ; Thiophenes ; Transcription Factors ; Pentamidine (673LC5J4LQ) ; DNA (9007-49-2)
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2022.116861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3815: Show issues Location:
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  3. Article ; Online: Gender disparities in academic rank achievement in neurosurgery: a critical assessment.

    Dossani, Rimal H / Terrell, Danielle / Kosty, Jennifer A / Ross, Robert C / Demand, Audrey / Wild, Elizabeth / Peterson, Racheal / Ngwenya, Laura B / Benzil, Deborah L / Notarianni, Christina

    Journal of neurosurgery

    2019  Volume 133, Issue 6, Page(s) 1922–1927

    Abstract: Objective: The objective of this study was to evaluate whether there are disparities in academic rank and promotion between men and women neurosurgeons.: Methods: The profiles of faculty members from 50 academic neurosurgery programs were reviewed to ...

    Abstract Objective: The objective of this study was to evaluate whether there are disparities in academic rank and promotion between men and women neurosurgeons.
    Methods: The profiles of faculty members from 50 academic neurosurgery programs were reviewed to identify years in practice, number of PubMed-indexed publications, Doctor of Philosophy (PhD) attainment, and academic rank. The number of publications at each academic rank was compared between men and women after controlling for years in practice by using a negative binomial regression model. The relationship between gender and each academic rank was also determined after controlling for clustering at the institutional level, years in practice, and number of publications.
    Results: Of 841 faculty members identified, 761 (90%) were men (p = 0.0001). Women represented 12% of the assistant and associate professors but only 4% of the full professors. Men and women did not differ in terms of the percentage holding a PhD, years in practice, or number of publications at any academic rank. After controlling for years in practice and clustering at the facility level, the authors found that men were twice as likely as women to be named full professor (OR 2.2, 95% CI 1.09-4.44, p = 0.03). However, when institution, years in practice, PhD attainment, h-index, and number of publications were considered, men and women were equally likely to attain full professorship (OR 0.9, 95% CI 0.42-1.93).
    Conclusions: Data analysis of the top neurosurgery programs suggests that although there are fewer women than men holding positions in academic neurosurgery, faculty rank attainment does not seem to be influenced by gender.
    Language English
    Publishing date 2019-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2019.8.JNS191219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Structural studies of antitumor compounds that target the RING domain of MDM2.

    Terrell, James Ross / Tang, Sijia / Faniyi, Oluwafoyinsola Omobodunde / Jeong, In Ho / Yin, Jun / Nijampatnam, Bhavitavya / Velu, Sadanandan E / Wang, Wei / Zhang, Ruiwen / Luo, Ming

    publication RETRACTED

    Protein science : a publication of the Protein Society

    2021  Volume 31, Issue 8, Page(s) e4367

    Abstract: ... at the sidechain of Tyr489 at the C-terminus of MDM2 RING domain. The C-terminus of MDM2 RING domain, especially ...

    Abstract Mouse double minute 2 homolog (MDM2) is an E3 ubiquitin-protein ligase that is involved in the transfer of ubiquitin to p53 and other protein substrates. The expression of MDM2 is elevated in cancer cells and inhibitors of MDM2 showed potent anticancer activities. Many inhibitors target the p53 binding domain of MDM2. However, inhibitors such as Inulanolide A and MA242 are found to bind the RING domain of MDM2 to block ubiquitin transfer. In this report, crystal structures of MDM2 RING domain in complex with Inulanolide A and MA242 were solved. These inhibitors primarily bind in a hydrophobic site centered at the sidechain of Tyr489 at the C-terminus of MDM2 RING domain. The C-terminus of MDM2 RING domain, especially residue Tyr489, is required for ubiquitin discharge induced by MDM2. The binding of these inhibitors at Tyr489 may interrupt interactions between the MDM2 RING domain and the E2-Ubiquitin complex to inhibit ubiquitin transfer, regardless of what the substrate is. Our results suggest a new mechanism of inhibition of MDM2 E3 activity for a broad spectrum of substrates.
    MeSH term(s) Animals ; Mice ; Protein Binding ; Protein Structure, Tertiary ; Proto-Oncogene Proteins c-mdm2/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Ubiquitin/chemistry ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; Ubiquitin ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3407: Show issues Location:
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    Zs.MO 1: Show issues

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  5. Article: Pathology, physiologic parameters, tissue contaminants, and tissue thiamine in morbid and healthy central Florida adult American alligators (Alligator mississippiensis).

    Honeyfield, Dale C / Ross, J Perran / Carbonneau, Dwayne A / Terrell, Scott P / Woodward, Allan R / Schoeb, Trenton R / Perceval, H Franklin / Hinterkopf, Joy P

    Journal of wildlife diseases

    2008  Volume 44, Issue 2, Page(s) 280–294

    Abstract: An investigation of adult alligator (Alligator mississippiensis) mortalities in Lake Griffin, central Florida, was conducted from 1998-2004. Alligator mortality was highest in the months of April and May and annual death count peaked in 2000. Bacterial ... ...

    Abstract An investigation of adult alligator (Alligator mississippiensis) mortalities in Lake Griffin, central Florida, was conducted from 1998-2004. Alligator mortality was highest in the months of April and May and annual death count peaked in 2000. Bacterial pathogens, heavy metals, and pesticides were not linked with the mortalities. Blood chemistry did not point to any clinical diagnosis, although differences between impaired and normal animals were noted. Captured alligators with signs of neurologic impairment displayed unresponsive and uncoordinated behavior. Three of 21 impaired Lake Griffin alligators were found to have neural lesions characteristic of thiamine deficiency in the telencephalon, particularly the dorsal ventricular ridge. In some cases, lesions were found in the thalamus, and parts of the midbrain. Liver and muscle tissue concentrations of thiamine (vitamin B(1)) were lowest in impaired Lake Griffin alligators when compared to unimpaired alligators or to alligators from Lake Woodruff. The consumption of thiaminase-positive gizzard shad (Dorosoma cepedianum) is thought to have been the cause of the low tissue thiamine and resulting mortalities.
    MeSH term(s) Alligators and Crocodiles/metabolism ; Animals ; Cause of Death ; Female ; Florida ; Hydrolases/administration & dosage ; Hydrolases/metabolism ; Male ; Mortality ; Nervous System/pathology ; Neurologic Examination/veterinary ; Seasons ; Thiamine/metabolism ; Thiamine/therapeutic use ; Thiamine Deficiency/mortality ; Thiamine Deficiency/pathology ; Thiamine Deficiency/veterinary
    Chemical Substances Hydrolases (EC 3.-) ; thiaminase II (EC 3.5.99.2) ; Thiamine (X66NSO3N35)
    Language English
    Publishing date 2008-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 410709-3
    ISSN 1943-3700 ; 0090-3558
    ISSN (online) 1943-3700
    ISSN 0090-3558
    DOI 10.7589/0090-3558-44.2.280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1441: Show issues Location:
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