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  1. Article ; Online: The kidney in COVID-19: protagonist or figurant?

    Staico, Maria F / Zaffanello, Marco / DI Pietro, Giulia / Fanos, Vassilios / Marcialis, Maria A

    Panminerva medica

    2020  Volume 65, Issue 1, Page(s) 65–75

    Abstract: The etiology of injury in COVID-19 patients is diverse and multifactorial. Autopsy and biopsy studies reveal, alongside podocyte and tubular cell anomalies, the presence of virion within the cells. Evidence suggests that, in addition to the direct ... ...

    Abstract The etiology of injury in COVID-19 patients is diverse and multifactorial. Autopsy and biopsy studies reveal, alongside podocyte and tubular cell anomalies, the presence of virion within the cells. Evidence suggests that, in addition to the direct cytopathic effect of SARS-CoV-2 on the glomeruli and renal tubules, there is also the indirect effect of cell-mediated immunity, the cytokines storm and the cross-talk between organs with possible systemic effects of the disease. These mechanisms are interconnected and have profound therapeutic implications involving extracorporeal removal of inflammatory cytokines. Dialysis patients, and children, in particular, should be classified as "at high risk" of contracting the disease. Infections are one of the most frequent causes of death in children with chronic renal failure who undergo dialysis. The reasons for this particular susceptibility are to be found in the compromised immune system, secondary to chronic malnutrition, immunosuppressive therapy, and uremia, frequent contact with healthcare personnel and other patients attending the dialysis unit and in need of the presence of other family members during treatment.
    MeSH term(s) Child ; Humans ; COVID-19/pathology ; SARS-CoV-2 ; Kidney/pathology ; Renal Dialysis ; Cytokines
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123572-2
    ISSN 1827-1898 ; 0031-0808
    ISSN (online) 1827-1898
    ISSN 0031-0808
    DOI 10.23736/S0031-0808.20.03965-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Randomized Angiographic and Intravascular Ultrasound Comparison of Dual-Antiplatelet Therapy vs Triple-Antiplatelet Therapy to Reduce Neointimal Tissue Proliferation in Diabetic Patients.

    Zuliani Mauro, Maria Fernanda / Mangione, J Armando / Costa, J Ribamar / Costa, Ricardo / Piva E Mattos, Luiz Alberto / Staico, Rodolfo / Feres, Fausto / Siqueira, Dimytri / Sousa, Amanda / Abizaid, Alexandre

    The Journal of invasive cardiology

    2017  Volume 29, Issue 3, Page(s) 76–81

    Abstract: Background: Previous studies have suggested a benefit of cilostazol in addition to standard dual-antiplatelet therapy (DAPT), reducing in-stent late luminal loss and restenosis after percutaneous coronary intervention (PCI) with bare-metal and drug- ... ...

    Abstract Background: Previous studies have suggested a benefit of cilostazol in addition to standard dual-antiplatelet therapy (DAPT), reducing in-stent late luminal loss and restenosis after percutaneous coronary intervention (PCI) with bare-metal and drug-eluting stent (DES) implantation. However, there is a paucity of intravascular ultrasound (IVUS) assessment of neointimal tissue hyperplasia (NIH) after triple-antiplatelet therapy (TAPT), especially in diabetic patients treated with DES.
    Methods: This prospective, placebo-controlled trial was conducted in diabetic patients randomized (1:1) to receive either standard DAPT (aspirin and clopidogrel) vs TAPT with cilostazol for a minimum of 12 months after PCI with Endeavor zotarolimus-eluting stent (E-ZES). The primary endpoint was the 9-month comparison of percentage of NIH in both groups. Additionally, we compared in-stent late lumen loss, binary restenosis, major adverse cardiac event (MACE; cardiac death, non-fatal myocardial infarction, and restenosis) rates, and the incidence of vascular/bleeding complications.
    Results: In total, 133 diabetic patients were enrolled (cilostazol cohort = 65 patients) with 56.4% male and mean age of 60.8 years. Overall, the two cohorts were comparable in terms of baseline clinical and angiographic characteristics, except for the reference vessel diameter, which was smaller among patients randomized to cilostazol (2.48 ± 0.46 mm vs 2.69 ± 0.48 mm; P=.01). At 9 months, there was a non-significant trend toward less percentage of NIH obstruction in the TAPT cohort (33.2 ± 8.29% vs 35.1 ± 8.45%; P=.07). However, this finding did not impact angiographic late-lumen loss (0.60 ± 0.46 mm cilostazol group vs 0.64 ± 0.48 mm control group; P=.30) and binary restenosis (9.8% vs 6.8%; P=.99). MACE rate also did not significantly differ between the cohorts (13.8% cilostazol group vs 8.8% control group; P=.81). Of note, the addition of a third antiplatelet agent did not increase vascular and bleeding complications.
    Conclusion: In diabetic patients treated with E-ZES, TAPT with cilostazol did not add any significant benefit in terms of NIH suppression or MACE reduction.
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1154372-3
    ISSN 1557-2501 ; 1042-3931
    ISSN (online) 1557-2501
    ISSN 1042-3931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 31: Show issues

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  3. Article ; Online: [No title information]

    Feres, Fausto / Costa, Ricardo A / Siqueira, Dimytri / Costa, J Ribamar / Chamié, Daniel / Staico, Rodolfo / Chaves, Áurea J / Abizaid, Alexandre / Marin-Neto, José Antônio / Rassi, Anis / Botelho, Roberto / Alves, Cláudia Maria Rodrigues / Saad, Jamil Abdalla / Mangione, José A / Lemos, Pedro A / Quadros, Alexandre S / Queiroga, Marcelo A Cartaxo / Cantarelli, Marcelo J C / Figueira, Hélio Roque

    Arquivos brasileiros de cardiologia

    2017  Volume 109, Issue 1 Suppl 1, Page(s) 1–81

    Title translation DIRETRIZ DA SOCIEDADE BRASILEIRA DE CARDIOLOGIA E DA SOCIEDADE BRASILEIRA DE HEMODINÂMICA E CARDIOLOGIA INTERVENCIONISTA SOBRE INTERVENÇÃO CORONÁRIA PERCUTÂNEA.
    Language Portuguese
    Publishing date 2017-06
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.5935/abc.20170111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 548: Show issues Location:
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