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  1. Article: Alcohol consumption and prostate cancer: a mini review.

    Rizos, Ch / Papassava, M / Golias, Ch / Charalabopoulos, K

    Experimental oncology

    2010  Volume 32, Issue 2, Page(s) 66–70

    Abstract: Prostate cancer has become a major public health problem worldwide although the etiology of prostate cancer remains largely unknown. Dietary factors, dietary supplements, and physical activity might be important in the prevention of the disease. In the ... ...

    Abstract Prostate cancer has become a major public health problem worldwide although the etiology of prostate cancer remains largely unknown. Dietary factors, dietary supplements, and physical activity might be important in the prevention of the disease. In the majority of studies published, it was observed that high consumption of meat, alcohol and dairy products has been linked to a greater risk. Specifically, alcohol use, and particularly heavy use, may cause cancers of liver, esophagus, larynx, pharynx and oral cavity, with risks for the aero-digestive cancers. Moderate use among women has been related with increases in breast cancer. Alcohol consumption is a modifiable lifestyle factor that may affect prostate cancer risk. Alcohol alters the hormonal environment and in parallel, containing chemical substances such as flavonoids (red wine), may alter tumor cell growth. In this mini review, the relation between alcohol consumption and prostate cancer risk is analyzed.
    MeSH term(s) Alcohol Drinking/adverse effects ; Humans ; Male ; Prostatic Neoplasms/chemically induced ; Prostatic Neoplasms/epidemiology ; Risk Factors
    Language English
    Publishing date 2010-07
    Publishing country Ukraine
    Document type Journal Article ; Review
    ZDB-ID 2176927-8
    ISSN 1812-9269 ; 0204-3564
    ISSN 1812-9269 ; 0204-3564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Amplification and co-regulators of androgen receptor gene in prostate cancer.

    Golias, Ch / Iliadis, I / Peschos, D / Charalabopoulos, K

    Experimental oncology

    2009  Volume 31, Issue 1, Page(s) 3–8

    Abstract: Prostate cancer is the second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group of steroid hormones that include testosterone and its more active metabolite ... ...

    Abstract Prostate cancer is the second most common malignancy among males after lung cancer. The growth of prostate cancer cells depends on the presence of androgens, a group of steroid hormones that include testosterone and its more active metabolite dihydrotestoste-rone. Most prostate cancers are androgen-dependent and respond to the antiandrogens or androgen-deprivation therapy. However, the progression to an androgen-independent stage occurs frequently. Possible mechanisms that could be involved in the development of hormone resistant prostate cancer causes including androgen receptor (AR) mutations, AR amplification/over expression, interaction between AR and other growth factors, and enhanced signaling in a ligand-independent manner are discussed.
    MeSH term(s) Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mutation ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/immunology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/physiopathology ; Receptors, Androgen/genetics ; Receptors, Androgen/immunology ; Receptors, Androgen/metabolism
    Chemical Substances Receptors, Androgen
    Language English
    Publishing date 2009-03
    Publishing country Ukraine
    Document type Journal Article ; Review
    ZDB-ID 2176927-8
    ISSN 1812-9269 ; 0204-3564
    ISSN 1812-9269 ; 0204-3564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The kinin system--bradykinin: biological effects and clinical implications. Multiple role of the kinin system--bradykinin.

    Golias, Ch / Charalabopoulos, A / Stagikas, D / Charalabopoulos, K / Batistatou, A

    Hippokratia

    2009  Volume 11, Issue 3, Page(s) 124–128

    Abstract: The present review article regarding the kinin system-bradykinin is dealing with the biological effects of the abovementioned entity mediated by specific B1 and B2 receptors as well as with its clinical implications known nowadays. The activation of the ... ...

    Abstract The present review article regarding the kinin system-bradykinin is dealing with the biological effects of the abovementioned entity mediated by specific B1 and B2 receptors as well as with its clinical implications known nowadays. The activation of the kinin system-bradykinin is particularly important in blood pressure regulation and in inflammatory reactions, through bradykinin ability to elevate vascular permeability and to cause vasodilatation in some arteries and veins. Recent data on bradykinin formation and release, synergy with ligands, receptors for bradykinin as well as on bradykinin participation in the mitogenesis process, are given in detail. Therapeutic potentials and future applications in many clinical situations including respiratory allergic reactions, septic shock, hypertension and its treatment, hypotensive transfusion reactions, heart diseases, pancreatitis, hereditary and acquired angioedema, Alzheimer disease and liver cirrhosis with ascites, are discussed in brief. Its role as a neuromediator, regulator of several vascular and renal functions, and its participation in signaling pathways, is also discussed in some detail.
    Language English
    Publishing date 2009-07-02
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2491943-3
    ISSN 1790-8019 ; 1108-4189
    ISSN (online) 1790-8019
    ISSN 1108-4189
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  4. Article: Genetic models of human cancer as a multistep process. Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia.

    Karakosta, A / Golias, Ch / Charalabopoulos, A / Peschos, D / Batistatou, A / Charalabopoulos, K

    Journal of experimental & clinical cancer research : CR

    2005  Volume 24, Issue 4, Page(s) 505–514

    Abstract: Tumour formations arise as a consequence of alterations in the control of cell proliferation as well as with disorders in interactions between cells and their environment that result in invasion and metastasis. Recent advances in understanding the ... ...

    Abstract Tumour formations arise as a consequence of alterations in the control of cell proliferation as well as with disorders in interactions between cells and their environment that result in invasion and metastasis. Recent advances in understanding the genetic basis of malignant diseases have been dominated by research in colorectal cancer. Genetic alterations of several proto-oncogenes and tumor-suppressor genes (e.g. APC/MCC, RAS, DCC, p53 mutations and/or allelic losses, hyperexpression of c-MYC and RB genes), as well as other genomic alterations, appear at characteristic stages of tumor development and are observed in most neoplasms. Generally, the normal cell has multiple independent mechanisms that regulate its growth and differentiation potential, and several separate events would, therefore, be needed to override these control mechanisms, as well as induce the other aspects of the transformed phenotype, like metastasis. These signals may be either positive or negative, and the acquisition of tumorigenicity results from genetic changes that affect these control points following a multistep mode. Statistics of the frequency of cancer incidence with age in humans indicate that for the genesis of e.g. lung carcinoma, five or six steps are required. Other types of cancers, such as leukemias and sarcomas, probably require quite a different number of rate-limiting changes. One of the best characterized tumours to provide a genetic model is colorectal tumorigenesis. Mutations implicated in breast cancer tumorigenicity are also studied and used as a genetic model in the literature worldwide. Finally, activation of c-abl in chronic myelogenous leukaemia (CML) and acute lymphoblastic leukaemia could also be presented as an example, which provides probably the strongest evidence for the role of proto-oncogenes in human malignancy process.
    MeSH term(s) Breast Neoplasms/genetics ; Cell Transformation, Neoplastic/genetics ; Colorectal Neoplasms/genetics ; Female ; Genes, Tumor Suppressor ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Models, Genetic ; Mutation ; Oncogenes/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics
    Language English
    Publishing date 2005-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 803138-1
    ISSN 0392-9078
    ISSN 0392-9078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Cell proliferation and cell cycle control: a mini review.

    Golias, C H / Charalabopoulos, A / Charalabopoulos, K

    International journal of clinical practice

    2004  Volume 58, Issue 12, Page(s) 1134–1141

    Abstract: Tumourigenesis is the result of cell cycle disorganisation, leading to an uncontrolled cellular proliferation. Specific cellular processes-mechanisms that control cell cycle progression and checkpoint traversation through the intermitotic phases are ... ...

    Abstract Tumourigenesis is the result of cell cycle disorganisation, leading to an uncontrolled cellular proliferation. Specific cellular processes-mechanisms that control cell cycle progression and checkpoint traversation through the intermitotic phases are deregulated. Normally, these events are highly conserved due to the existence of conservatory mechanisms and molecules such as cell cycle genes and their products: cyclins, cyclin dependent kinases (Cdks), Cdk inhibitors (CKI) and extra cellular factors (i.e. growth factors). Revolutionary techniques using laser cytometry and commercial software are available to quantify and evaluate cell cycle processes and cellular growth. S-phase fraction measurements, including ploidy values, using histograms and estimation of indices such as the mitotic index and tumour-doubling time indices, provide adequate information to the clinician to evaluate tumour aggressiveness, prognosis and the strategies for radiotherapy and chemotherapy in experimental researches.
    MeSH term(s) Cell Cycle/genetics ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Cyclin-Dependent Kinases/metabolism ; Cyclins/metabolism ; Flow Cytometry ; Immunohistochemistry ; Mitosis/genetics ; Neoplasms/pathology ; Pyrimidines/metabolism
    Chemical Substances Cyclins ; Pyrimidines ; Cyclin-Dependent Kinases (EC 2.7.11.22)
    Language English
    Publishing date 2004-12-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1386246-7
    ISSN 1742-1241 ; 1368-5031
    ISSN (online) 1742-1241
    ISSN 1368-5031
    DOI 10.1111/j.1742-1241.2004.00284.x
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  6. Article: Molecular profiling and genomic microarrays in prostate cancer.

    Golias, Ch / Charalabopoulos, A / Stagikas, D / Giannakopoulos, X / Peschos, D / Batistatou, A / Sofikitis, N / Charalabopoulos, K

    Experimental oncology

    2007  Volume 29, Issue 2, Page(s) 82–84

    Abstract: In the present review article a global approach regarding the usefulness of genomic microarrays in prostate cancer management, is attempted. Cancer is a multistep process of mutations in key regulatory genes and epigenetic alterations that result in loss ...

    Abstract In the present review article a global approach regarding the usefulness of genomic microarrays in prostate cancer management, is attempted. Cancer is a multistep process of mutations in key regulatory genes and epigenetic alterations that result in loss of balanced gene expression. A complete knowledge of the interaction between the genetic variability of the neoformation (tumor profiling) and the genetic variability of the host (inherited genome profiling), will be able to determine the better strategy against the cancer and the less toxicity for the patient. Alterations in the sequence of the hormone binding domain of the androgen receptor as well as mutations in some genes, determine radioresistance and resistance or sensitivity to some chemotherapeutic drugs. New therapies using monoclonal antibodies directed against specific extracellular binding domains of some receptors are based on molecular alterations observed in tumors.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Gene Expression Profiling ; Genome, Human ; Humans ; Male ; Molecular Biology/methods ; Mutation ; Oligonucleotide Array Sequence Analysis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Receptors, Androgen/chemistry ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism
    Chemical Substances Antibodies, Monoclonal ; Receptors, Androgen
    Language English
    Publishing date 2007-06
    Publishing country Ukraine
    Document type Journal Article ; Review
    ZDB-ID 2176927-8
    ISSN 1812-9269 ; 0204-3564
    ISSN 1812-9269 ; 0204-3564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Giant simple renal cyst complicated with hypertension.

    Giannakopoulos, X / Charalabopoulos, K / Charalabopoulos, A / Golias, C H / Peschos, D / Sofikitis, N

    International journal of clinical practice. Supplement

    2005  , Issue 147, Page(s) 69–71

    Abstract: Solitary renal cysts are a common and usually asymptomatic occurrence in older patients. They may be associated with hypertension or abdominal disturbances, as they can be responsible for compression of surrounding tissues and distortion of renal vessels. ...

    Abstract Solitary renal cysts are a common and usually asymptomatic occurrence in older patients. They may be associated with hypertension or abdominal disturbances, as they can be responsible for compression of surrounding tissues and distortion of renal vessels. This report presents an interesting case of a hypertensive patient with a solitary renal cyst of a marked size. Owing to the high risk of performing a surgical procedure in such a patient, a distinct therapeutic solution was opted for. Successful management of this case was achieved by a combination of percutaneous fluid aspiration and injection of alcohol and Vibramycin inside the cystic cavity. Percutaneous fluid evacuation combined with the administration of a sclerosing agent is suggested as a safe and effective alternative for cyst decompression and blood pressure normalisation.
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Hypertension/etiology ; Kidney Diseases, Cystic/complications ; Kidney Diseases, Cystic/diagnostic imaging ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2005-03-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1368-504X
    ISSN 1368-504X
    DOI 10.1111/j.1368-504x.2005.00396.x
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