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  1. Article ; Online: A temperature-adjustable

    Huang, Weifeng / Chen, Tao / Luo, Jun / Su, Geer / Wei, Hang

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 31, Page(s) 4242–4245

    Abstract: We introduce an ... ...

    Abstract We introduce an innovative
    Language English
    Publishing date 2024-04-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00220b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Combustion Enhancement of Gel Propellant Containing High Concentration Aluminum Particles Based on Carbon Synergistic Effect.

    Chen, Jiyuan / Zhao, Hui / Li, Weifeng / Liu, Haifeng

    Gels (Basel, Switzerland)

    2024  Volume 10, Issue 2

    Abstract: The addition of aluminum particles to gel propellants can improve combustion performance. However, the agglomeration of aluminum during the combustion process can result in a series of negative effects. In this paper, the aluminum agglomeration ... ...

    Abstract The addition of aluminum particles to gel propellants can improve combustion performance. However, the agglomeration of aluminum during the combustion process can result in a series of negative effects. In this paper, the aluminum agglomeration inhibition method of gel propellant based on carbon synergistic effect is proposed. Carbon particles exhibit excellent combustion properties, and the gaseous product CO
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10020089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine

    Binhao Chen / Weifeng Jin

    Frontiers in Neuroscience, Vol

    2023  Volume 17

    Abstract: This review provides insight into the complex network of signaling pathways and mechanisms involved in stroke pathophysiology. It summarizes the historical progress of stroke-related signaling pathways, identifying potential interactions between them and ...

    Abstract This review provides insight into the complex network of signaling pathways and mechanisms involved in stroke pathophysiology. It summarizes the historical progress of stroke-related signaling pathways, identifying potential interactions between them and emphasizing that stroke is a complex network disease. Of particular interest are the Hippo signaling pathway and ferroptosis signaling pathway, which remain understudied areas of research, and are therefore a focus of the review. The involvement of multiple signaling pathways, including Sonic Hedgehog (SHH), nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE), hypoxia-inducible factor-1α (HIF-1α), PI3K/AKT, JAK/STAT, and AMPK in pathophysiological mechanisms such as oxidative stress and apoptosis, highlights the complexity of stroke. The review also delves into the details of traditional Chinese medicine (TCM) therapies such as Rehmanniae and Astragalus, providing an analysis of the recent status of western medicine in the treatment of stroke and the advantages and disadvantages of TCM and western medicine in stroke treatment. The review proposes that since stroke is a network disease, TCM has the potential and advantages of a multi-target and multi-pathway mechanism of action in the treatment of stroke. Therefore, it is suggested that future research should explore more treasures of TCM and develop new therapies from the perspective of stroke as a network disease.
    Keywords stroke ; crosstalk ; network disease ; traditional Chinese medicine ; pathway ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Subject code 306
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine.

    Chen, Binhao / Jin, Weifeng

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1200061

    Abstract: This review provides insight into the complex network of signaling pathways and mechanisms involved in stroke pathophysiology. It summarizes the historical progress of stroke-related signaling pathways, identifying potential interactions between them and ...

    Abstract This review provides insight into the complex network of signaling pathways and mechanisms involved in stroke pathophysiology. It summarizes the historical progress of stroke-related signaling pathways, identifying potential interactions between them and emphasizing that stroke is a complex network disease. Of particular interest are the Hippo signaling pathway and ferroptosis signaling pathway, which remain understudied areas of research, and are therefore a focus of the review. The involvement of multiple signaling pathways, including Sonic Hedgehog (SHH), nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE), hypoxia-inducible factor-1α (HIF-1α), PI3K/AKT, JAK/STAT, and AMPK in pathophysiological mechanisms such as oxidative stress and apoptosis, highlights the complexity of stroke. The review also delves into the details of traditional Chinese medicine (TCM) therapies such as Rehmanniae and Astragalus, providing an analysis of the recent status of western medicine in the treatment of stroke and the advantages and disadvantages of TCM and western medicine in stroke treatment. The review proposes that since stroke is a network disease, TCM has the potential and advantages of a multi-target and multi-pathway mechanism of action in the treatment of stroke. Therefore, it is suggested that future research should explore more treasures of TCM and develop new therapies from the perspective of stroke as a network disease.
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1200061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of neutrophil extracellular trap-driven gastric cancer heterogeneity and C5AR1 as a therapeutic target.

    Zhao, Jing / Li, Xiangyu / Li, Liming / Chen, Beibei / Xu, Weifeng / He, Yunduan / Chen, Xiaobing

    Acta biochimica et biophysica Sinica

    2024  Volume 56, Issue 4, Page(s) 538–550

    Abstract: Neutrophil extracellular traps (NETs) are implicated in gastric cancer (GC) growth, metastatic dissemination, cancer-associated thrombosis, ...

    Abstract Neutrophil extracellular traps (NETs) are implicated in gastric cancer (GC) growth, metastatic dissemination, cancer-associated thrombosis,
    MeSH term(s) Humans ; Extracellular Traps/metabolism ; Neutrophils ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Phenotype ; Tumor Microenvironment/genetics
    Language English
    Publishing date 2024-02-29
    Publishing country China
    Document type Journal Article
    ZDB-ID 2175256-4
    ISSN 1745-7270 ; 0582-9879 ; 1672-9145
    ISSN (online) 1745-7270
    ISSN 0582-9879 ; 1672-9145
    DOI 10.3724/abbs.2023290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oral abrocitinib in the treatment of granuloma annulare: a case report.

    Liu, Wenyan / Chen, Weifeng / Tian, Xin / Yu, Yihui / Zhu, Junhui / Liang, Jingyao / Zhang, Xibao

    The Journal of dermatological treatment

    2024  Volume 35, Issue 1, Page(s) 2313090

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Granuloma Annulare/drug therapy ; Granuloma Annulare/pathology ; Pyrimidines/therapeutic use ; Sulfonamides/therapeutic use ; Janus Kinase Inhibitors/therapeutic use ; Treatment Outcome
    Chemical Substances abrocitinib (73SM5SF3OR) ; Pyrimidines ; Sulfonamides ; Janus Kinase Inhibitors
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2024.2313090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Development of a UiO-66 Based Waterborne Flame-Retardant Coating for PC/ABS Material.

    Chen, Shaojun / Zeng, Youhan / Bi, Weifeng / Zhuo, Haitao / Zhong, Haiqiang

    Polymers

    2024  Volume 16, Issue 2

    Abstract: The flame-retardancy of polymeric materials has garnered great interest. Most of the flame retardants used in copolymers are functionalized additives, which can deteriorate the intrinsic properties of these materials. As a new type of flame retardant, ... ...

    Abstract The flame-retardancy of polymeric materials has garnered great interest. Most of the flame retardants used in copolymers are functionalized additives, which can deteriorate the intrinsic properties of these materials. As a new type of flame retardant, functionalized metal-organic frameworks (MOFs) can be used in surface coatings of polymers. To reduce the flammability, a mixture of phytic acid, multi-wall carbon nanotubes, zirconium-based MOFs, and UiO-66 was coated on a PC/ABS substrate. The structure of the UiO-66-based flame retardant was established by FT-IR, XRD, XPS, and SEM. The flammable properties of coated PC/ABS materials were assessed by LOI, a vertical combustion test, TGA, CCT, and Raman spectroscopy. The presence of a UiO-66-based coating on the PC/ABS surface resulted in a good flame-retardant performance. Heat release and smoke generation were significantly reduced. Importantly, the structure and mechanical properties of PC/ABS were less impacted by the presence of the flame-retardant coating. Hence, this work presents a new strategy for the development of high-performance PC/ABC materials with both excellent flame-retardancy and good mechanical properties.
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym16020275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Depths of Malignancy: On the Prognosis of Breast Cancer [Response to Letter].

    He, Jing / Tong, Ling / Wu, Ping / Wu, Yibo / Shi, Weifeng / Chen, Ling

    International journal of general medicine

    2023  Volume 16, Page(s) 1807–1808

    Language English
    Publishing date 2023-05-15
    Publishing country New Zealand
    Document type Journal Article ; Comment
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S415713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reversibly Adhesive, Anti-Swelling, and Antibacterial Hydrogels for Tooth-Extraction Wound Healing.

    Li, Siyu / Zhi, Lunhao / Chen, Qin / Zhao, Weifeng / Zhao, Changsheng

    Advanced healthcare materials

    2024  , Page(s) e2400089

    Abstract: Oral wound treatment faces challenges due to the complex oral environment, thus, sealing the wound quickly becomes necessary. Although some materials have achieved adhesion and sterilization, how to effectively solve the contradiction between strong ... ...

    Abstract Oral wound treatment faces challenges due to the complex oral environment, thus, sealing the wound quickly becomes necessary. Although some materials have achieved adhesion and sterilization, how to effectively solve the contradiction between strong adhesion and on-demand removal remains a challenge. Herein, a reversibly adhesive hydrogel is designed by free radical copolymerization of cationic monomer [2-(acryloyloxy) ethyl] trimethylammonium chloride (ATAC), hydrophobic monomer ethylene glycol phenyl ether acrylate (PEA) and N-isopropylacrylamide (NIPAAm). The cationic quaternary ammonium salts provide electrostatic interactions, the hydrophobic groups provide hydrophobic interactions, and the PNIPAAm chain segments provide hydrogen bonding, leading to strong adhesion. Therefore, the hydrogel obtains an adhesion strength of 18.67 KPa to oral mucosa and can seal wounds fast within 10 s. Furthermore, unlike pure PNIPAAm, the hydrogel has a lower critical solution temperature of 40.3 °C due to the contribution of ATAC and PEA, enabling rapid removal with 40 °C water after treatment. In addition, the hydrogel realizes excellent anti-swelling ratio (≈80%) and antibacterial efficiency (over 90%). Animal experiments prove that the hydrogel effectively reduces inflammation infiltration, promotes collagen deposition and vascular regeneration. Thus, hydrogel as a multi-functional dressing has great application prospects in oral wound management.
    Language English
    Publishing date 2024-02-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202400089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6966: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Pyrvinium Pamoate Induces Cell Apoptosis and Autophagy in Colorectal Cancer.

    Zheng, Wenqian / Chen, Kangke / Lv, Yiming / Lao, Weifeng / Zhu, Hongbo

    Anticancer research

    2024  Volume 44, Issue 3, Page(s) 1193–1199

    Abstract: Background/aim: In earlier research, we demonstrated that pyrvinium pamoate (PP) can effectively inhibit the proliferation and migration of colorectal cancer (CRC) cells. In the current study, we further explore the possibility of PP, as a potential ... ...

    Abstract Background/aim: In earlier research, we demonstrated that pyrvinium pamoate (PP) can effectively inhibit the proliferation and migration of colorectal cancer (CRC) cells. In the current study, we further explore the possibility of PP, as a potential therapeutic drug in the treatment of CRC.
    Materials and methods: Hoechst 33258 staining, immunofluorescence, and western blotting were used to further investigate the connection between PP and CRC cell apoptosis and autophagy.
    Results: We found that PP promoted apoptosis and autophagy of CRC cells. At the protein level, the expression of proteins related to the PI3K/mTOR signaling pathway exhibited a negative correlation with the dosage of PP. PP may therefore induce apoptosis and autophagy by inhibiting the PI3K/mTOR signaling pathway.
    Conclusion: Our in vitro experiments demonstrated that PP could inhibit the progression of colorectal cancer cells by inducing apoptosis and autophagy. The detailed mechanism needs further investigation.
    MeSH term(s) Humans ; TOR Serine-Threonine Kinases/metabolism ; Apoptosis ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Autophagy ; Cell Proliferation ; Proto-Oncogene Proteins c-akt/metabolism ; Cell Line, Tumor ; Pyrvinium Compounds
    Chemical Substances pyrvinium (6B9991FLU3) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Pyrvinium Compounds
    Language English
    Publishing date 2024-02-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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