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Article ; Online: Evaluation of the immune checkpoint factors in idiopathic membranous nephropathy

Motavalli, Roza / Hosseini, Maryam / Soltani-Zangbar, Mohammad Sadegh / Karimi, Abbas / Sadeghi, Mohammadreza / Dolati, Sanam / Yousefi, Mehdi / Etemadi, Jalal

Molecular and Cellular Probes. 2023 June, v. 69 p.101914-

2023

Abstract: Idiopathic membranous nephropathy (IMN), a single-organ autoimmune disease, is recognized by autoantibodies to podocyte proteins and identified as the most frequent cause of nephrotic syndrome in adults. T cells are important contributors in autoimmunity ...

Abstract	Idiopathic membranous nephropathy (IMN), a single-organ autoimmune disease, is recognized by autoantibodies to podocyte proteins and identified as the most frequent cause of nephrotic syndrome in adults. T cells are important contributors in autoimmunity since they promote B-cell development, antibody production, direct inflammation, and organ tissue cytotoxicity. This study investigated the inhibitory immune checkpoint (ICP) receptors expressed on T lymphocytes and other immune cells. Thus, PBMCs from IMN patients were obtained before treatment, and the levels of ICPs such as programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), lymphocyte activation gene-3 (LAG-3), and T cell immunoglobulin-3 (TIM-3) were examined at both gene and protein expression using real time PCR and Western blot tests respectively. The results illustrated that gene expression levels of ICPs reduced significantly in comparison to the control which were verified by related fold changes of protein expression sequentially. Our study revealed that CTLA-4, PD-1, TIM-3, and LAG-3 expression is impaired in IMN patients before treatment which could be a potential target for therapy.
Keywords	B-lymphocytes ; T-lymphocytes ; Western blotting ; antibody formation ; autoantibodies ; autoimmune diseases ; autoimmunity ; cytotoxicity ; gene expression ; genes ; inflammation ; lymphocyte proliferation ; nephrotic syndrome ; programmed cell death ; protein synthesis ; quantitative polymerase chain reaction ; therapeutics ; Nephropathy ; Immune checkpoint ; CTLA-4 ; PD-1 ; TIM-3 ; LAG-3
Language	English
Dates of publication	2023-06
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	639082-1
ISSN	1096-1194 ; 0890-8508
ISSN (online)	1096-1194
ISSN	0890-8508
DOI	10.1016/j.mcp.2023.101914
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Potential contribution of the immune system to the emergence of renal diseases.

Ghassabi, Ali / Motavalli, Roza / Iranzad, Rahim / Pourakbari, Ramin / Etemadi, Jalal / Dolati, Sanam / Yousefi, Mehdi

Immunology letters

2022 Volume 248, Page(s) 1–6

Abstract: Several parts are possessed by kidneys in fundamental physiological functions, which include the regulation of blood pressure, production of blood cells, homeostasis of water, salt, and calcium, and the balance of acids and bases. Thus, several ... ...

Abstract	Several parts are possessed by kidneys in fundamental physiological functions, which include the regulation of blood pressure, production of blood cells, homeostasis of water, salt, and calcium, and the balance of acids and bases. Thus, several pathologies could cause, or be caused by, renal dysfunction. Chronic kidney failure, or chronic kidney disease, is described as the time when kidneys lose their function gradually. Excess fluids and wastes are filtered from the blood and excreted to urine by kidneys. However, in case of advanced stages of chronic kidney failures, deleterious levels of wastes, electrolytes, and fluids could be observed in the body. The activation of immune system, as well as inflammation, are factors with paramount significance in the development of chronic and acute renal failure. Two main branches, including innate and adaptive immunity, compose the immune system. As the first responder, the innate immunity responds nonspecifically to invading pathogens. However, the adaptive immunity provides efficient recognition and response to particular pathogens, and enjoys a memory which is useful in second exposure to a pathogen. Different functions, the mediation of which takes place through cytokines, immune cell subsets, and protein cascades, are performed by these two immune responses. This review is aimed at focusing on data which have linked adaptive immunity, particularly T-cells and inflammatory mechanisms, to the development of renal failure.
MeSH term(s)	Acute Kidney Injury/etiology ; Adaptive Immunity ; Humans ; Immunity, Innate ; Inflammation/pathology ; Kidney ; T-Lymphocytes
Language	English
Publishing date	2022-06-06
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	445150-8
ISSN	1879-0542 ; 0165-2478
ISSN (online)	1879-0542
ISSN	0165-2478
DOI	10.1016/j.imlet.2022.06.003
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Article ; Online: Glucocorticoid Receptor Polymorphisms and Avascular Osteonecrosis After Kidney Transplantation.

Etemadi, Jalal / Jafari Nakhjavani, Mohammad Reza / Sepehri, Saber / Motavalli, Roza / Hejazian, Seyed Sina / Hejazain, Seyyedeh Mina / Abediazar, Sima / Zununi Vahed, Sepideh

Iranian journal of kidney diseases

2023 Volume 1, Issue 2, Page(s) 86–91

Abstract: Introduction: Glucocorticoids (GCs) are commonly prescribed as immunosuppressive agents after kidney transplantation and their most common non-traumatic adverse effect is Avascular Necrosis (AVN) of the femoral head. In this regard, this study aimed to ... ...

Abstract	Introduction: Glucocorticoids (GCs) are commonly prescribed as immunosuppressive agents after kidney transplantation and their most common non-traumatic adverse effect is Avascular Necrosis (AVN) of the femoral head. In this regard, this study aimed to evaluate the glucocorticoid receptor (GR) polymorphisms among kidney transplant recipients and their potential role as a risk factor for the incidence of AVN. Methods: In this study, 99 renal transplant recipients were evaluated for the correlations of GR polymorphisms including N363S (rs6195), BclI (rs41423247), ER22/23EK (rs6189/rs6190), and A3669G (rs6198) with AVN after renal transplantation. Results: Results showed that none of the renal-transplanted patients neither with GC hypersensitive polymorphisms (N363S and BclI) nor with GC-resistant polymorphisms (A3669G and ER22/23EK) developed AVN (P > .05). In addition, the medications of the renal recipients with AVN were significantly different from the nonAVN patients (P < .001). Conclusion: The study results indicate that the GR polymorphisms have no critical roles in the susceptibility to AVN after renal transplantation. However, further studies to confirm the results are recommended. DOI: 10.52547/ijkd.7221.
MeSH term(s)	Humans ; Receptors, Glucocorticoid/genetics ; Kidney Transplantation/adverse effects ; Polymorphism, Genetic ; Glucocorticoids/adverse effects ; Osteonecrosis/genetics ; Osteonecrosis/drug therapy
Chemical Substances	Receptors, Glucocorticoid ; Glucocorticoids
Language	English
Publishing date	2023-04-15
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2388271-2
ISSN	1735-8604 ; 1735-8582
ISSN (online)	1735-8604
ISSN	1735-8582
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The association of Treg and Th17 cells development factors and anti-TPO autoantibodies in patients with recurrent pregnancy loss.

Niafar, Mitra / Samaie, Vajihe / Soltani-Zangbar, Mohammad Sadegh / Motavalli, Roza / Dolati, Sanam / Danaii, Shahla / Mehdizadeh, Amir / Yousefi, Mehdi

BMC research notes

2023 Volume 16, Issue 1, Page(s) 302

Abstract: Objectives: Thyroid autoimmunity is considered as the most prevalent autoimmune condition in women in fertility age. There are different clinical evidences indicating the association between thyroid autoimmunity and increased risk of RPL. This study ... ...

Abstract	Objectives: Thyroid autoimmunity is considered as the most prevalent autoimmune condition in women in fertility age. There are different clinical evidences indicating the association between thyroid autoimmunity and increased risk of RPL. This study aimed to analyze the association of Tregs and Th17 cells development factors and anti-thyroid peroxidase (anti-TPO) antibodies in RPL patients. Healthy controls (n = 36), TPO + controls (n = 25) and TPO + RPL (n = 32) participated in this study. After blood sampling, the frequency of Th17 and Tregs was evaluated using flow cytometry. Real-time PCR and ELISA was used to assess the status of Tregs and Th17 related transcription factors and cytokines in mRNA and protein level, respectively. Results: TPO + RPL group showed a higher Th17 frequency compared to healthy controls and TPO + controls groups (p = 0.0002 and p = 0.04, respectively). Additionally, mRNA expression levels of RORγT and IL-17 were significantly higher in TPO + RPL compared to healthy controls and TPO + controls groups. In contrast, Foxp3 and TGFβ expression was lower in TPO + RPL. ELISA findings also indicated a significantly higher IL-17 and lower TGFβ secretion in TPO + RPL compared to healthy controls and TPO + controls. Thyroid autoimmunity should intensely be controlled specially in patients with RPL history.
MeSH term(s)	Pregnancy ; Humans ; Female ; T-Lymphocytes, Regulatory ; Interleukin-17 ; Peroxidase ; Th17 Cells ; Autoantibodies ; Peroxidases ; Transforming Growth Factor beta ; Abortion, Habitual ; RNA, Messenger
Chemical Substances	Interleukin-17 ; Peroxidase (EC 1.11.1.7) ; Autoantibodies ; Peroxidases (EC 1.11.1.-) ; Transforming Growth Factor beta ; RNA, Messenger
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-023-06579-6
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Article ; Online: Evaluation of the immune checkpoint factors in idiopathic membranous nephropathy.

Motavalli, Roza / Hosseini, Maryam / Soltani-Zangbar, Mohammad Sadegh / Karimi, Abbas / Sadeghi, Mohammadreza / Dolati, Sanam / Yousefi, Mehdi / Etemadi, Jalal

Molecular and cellular probes

2023 Volume 69, Page(s) 101914

Abstract	Idiopathic membranous nephropathy (IMN), a single-organ autoimmune disease, is recognized by autoantibodies to podocyte proteins and identified as the most frequent cause of nephrotic syndrome in adults. T cells are important contributors in autoimmunity since they promote B-cell development, antibody production, direct inflammation, and organ tissue cytotoxicity. This study investigated the inhibitory immune checkpoint (ICP) receptors expressed on T lymphocytes and other immune cells. Thus, PBMCs from IMN patients were obtained before treatment, and the levels of ICPs such as programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), lymphocyte activation gene-3 (LAG-3), and T cell immunoglobulin-3 (TIM-3) were examined at both gene and protein expression using real time PCR and Western blot tests respectively. The results illustrated that gene expression levels of ICPs reduced significantly in comparison to the control which were verified by related fold changes of protein expression sequentially. Our study revealed that CTLA-4, PD-1, TIM-3, and LAG-3 expression is impaired in IMN patients before treatment which could be a potential target for therapy.
MeSH term(s)	Adult ; Humans ; Programmed Cell Death 1 Receptor/genetics ; Programmed Cell Death 1 Receptor/metabolism ; Hepatitis A Virus Cellular Receptor 2/genetics ; Hepatitis A Virus Cellular Receptor 2/metabolism ; Glomerulonephritis, Membranous/genetics ; Glomerulonephritis, Membranous/metabolism ; T-Lymphocytes/metabolism
Chemical Substances	Programmed Cell Death 1 Receptor ; Hepatitis A Virus Cellular Receptor 2
Language	English
Publishing date	2023-04-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639082-1
ISSN	1096-1194 ; 0890-8508
ISSN (online)	1096-1194
ISSN	0890-8508
DOI	10.1016/j.mcp.2023.101914
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2230: Show issues

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Article ; Online: Evaluation of T helper17 as skeletal homeostasis factor in peripheral blood mononuclear cells and T helper cells of end-stage renal disease cases with impaired parathyroid hormone.

Motavalli, Roza / Soltani-Zangbar, Mohammad Sadegh / Fereydoonzadeh, Khadijeh / Hajivalili, Mahsa / Ahmadian Heris, Javad / Kahroba, Houman / Niknafs, Bahram / Motavalli Khiavi, Farhad / Dolati, Sanam / Sadeghi, Mohammadreza / Yousefi, Mehdi / Etemadi, Jalal

Molecular biology reports

2023 Volume 50, Issue 5, Page(s) 4097–4104

Abstract: Background: Chronic renal failure is mainly connected with high and low parathyroid hormone (PTH) levels and immunological impairments. The present study aimed to evaluate T helper 17 (Th17) cells as a crucial modulator of the immune system and skeletal ...

Abstract	Background: Chronic renal failure is mainly connected with high and low parathyroid hormone (PTH) levels and immunological impairments. The present study aimed to evaluate T helper 17 (Th17) cells as a crucial modulator of the immune system and skeletal homeostasis in hemodialysis patients with impaired intact PTH (iPTH). Methods: In this research, blood samples were taken from ESRD patients with high (> 300 pg/mL), normal (150-300 pg/mL), and low (< 150 pg/mL) serum intact parathyroid hormone (iPTH( levels (n = 30 in each group). The frequency of Th17 (CD4 Results: The number of Th17 cells remarkably increased in subjects with high iPTH against low and normal iPTH. Also, RORɣt and STAT3 levels were significantly higher in high iPTH ESRD patients than in other groups in the expression of mRNA and protein levels. These findings are confirmed by evaluating the IL-17 and IL-23 in the supernatant of cultured PBMCs and isolated Th cells. Conclusion: Our findings indicated that increased serum PTH levels in hemodialysis cases may be involved in increasing the differentiation of CD4 + cells to Th17 cells in PBMC.
MeSH term(s)	Humans ; Parathyroid Hormone/metabolism ; Leukocytes, Mononuclear ; Kidney Failure, Chronic ; Renal Dialysis ; Cytokines/metabolism ; Th17 Cells/metabolism
Chemical Substances	Parathyroid Hormone ; Cytokines
Language	English
Publishing date	2023-03-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08306-7
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Article ; Online: The association of Treg and Th17 cells development factors and anti-TPO autoantibodies in patients with recurrent pregnancy loss

Mitra Niafar / Vajihe Samaie / Mohammad Sadegh Soltani-Zangbar / Roza Motavalli / Sanam Dolati / Shahla Danaii / Amir Mehdizadeh / Mehdi Yousefi

BMC Research Notes, Vol 16, Iss 1, Pp 1-

2023 Volume 7

Abstract: Abstract Objectives Thyroid autoimmunity is considered as the most prevalent autoimmune condition in women in fertility age. There are different clinical evidences indicating the association between thyroid autoimmunity and increased risk of RPL. This ... ...

Abstract	Abstract Objectives Thyroid autoimmunity is considered as the most prevalent autoimmune condition in women in fertility age. There are different clinical evidences indicating the association between thyroid autoimmunity and increased risk of RPL. This study aimed to analyze the association of Tregs and Th17 cells development factors and anti–thyroid peroxidase (anti-TPO) antibodies in RPL patients. Healthy controls (n = 36), TPO + controls (n = 25) and TPO + RPL (n = 32) participated in this study. After blood sampling, the frequency of Th17 and Tregs was evaluated using flow cytometry. Real-time PCR and ELISA was used to assess the status of Tregs and Th17 related transcription factors and cytokines in mRNA and protein level, respectively. Results TPO + RPL group showed a higher Th17 frequency compared to healthy controls and TPO + controls groups (p = 0.0002 and p = 0.04, respectively). Additionally, mRNA expression levels of RORγT and IL-17 were significantly higher in TPO + RPL compared to healthy controls and TPO + controls groups. In contrast, Foxp3 and TGFβ expression was lower in TPO + RPL. ELISA findings also indicated a significantly higher IL-17 and lower TGFβ secretion in TPO + RPL compared to healthy controls and TPO + controls. Thyroid autoimmunity should intensely be controlled specially in patients with RPL history.
Keywords	Thyroid autoimmunity ; Interleukin-17 ; TGFβ ; Pregnancy loss ; Th17 ; Tregs ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluation of the immune checkpoint factors in idiopathic membranous nephropathy

Roza Motavalli / Maryam Hosseini / Mohammad Sadegh Soltani-Zangbar / Abbas Karimi / Mohammadreza Sadeghi / Sanam Dolati / Mehdi Yousefi / Jalal Etemadi

Molecular and Cellular Probes, Vol 69, Iss , Pp 101914- (2023)

2023

Abstract	Idiopathic membranous nephropathy (IMN), a single-organ autoimmune disease, is recognized by autoantibodies to podocyte proteins and identified as the most frequent cause of nephrotic syndrome in adults. T cells are important contributors in autoimmunity since they promote B–cell development, antibody production, direct inflammation, and organ tissue cytotoxicity. This study investigated the inhibitory immune checkpoint (ICP) receptors expressed on T lymphocytes and other immune cells. Thus, PBMCs from IMN patients were obtained before treatment, and the levels of ICPs such as programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), lymphocyte activation gene-3 (LAG-3), and T cell immunoglobulin-3 (TIM-3) were examined at both gene and protein expression using real time PCR and Western blot tests respectively. The results illustrated that gene expression levels of ICPs reduced significantly in comparison to the control which were verified by related fold changes of protein expression sequentially. Our study revealed that CTLA-4, PD-1, TIM-3, and LAG-3 expression is impaired in IMN patients before treatment which could be a potential target for therapy.
Keywords	Nephropathy ; Immune checkpoint ; CTLA-4 ; PD-1 ; TIM-3 ; LAG-3 ; Biology (General) ; QH301-705.5 ; Medicine ; R
Subject code	570 ; 616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Application of Emerging Plant-Derived Nanoparticles as a Novel Approach for Nano-Drug Delivery Systems.

Sarvarian, Parisa / Samadi, Parisa / Gholipour, Elham / Shams Asenjan, Karim / Hojjat-Farsangi, Mohammad / Motavalli, Roza / Motavalli Khiavi, Farhad / Yousefi, Mehdi

Immunological investigations

2021 Volume 51, Issue 4, Page(s) 1039–1059

Abstract: Nanotechnology has enabled the delivery of small molecular drugs packaged in nanosized vesicles to the target tissues. Plant-Derived Nanoparticles (PDNPs) are vesicles with natural origin and unique properties. These nanoparticles have several advantages ...

Abstract	Nanotechnology has enabled the delivery of small molecular drugs packaged in nanosized vesicles to the target tissues. Plant-Derived Nanoparticles (PDNPs) are vesicles with natural origin and unique properties. These nanoparticles have several advantages over synthetic exosomes and liposomes. They provide bioavailability and biodistribution of therapeutic agents when delivered into different tissues. These nanoparticles can be modified according to the specificity of their functions in target tissues. When PDNPs are internalized, they can induce stem cells proliferation, reduce colitis injury, activate intrinsic and extrinsic apoptosis pathways, and inhibit tumor growth and progression. These properties make them potential drug delivery systems in targeting diseased tissues, such as inflammatory regions and different cancers.
MeSH term(s)	Drug Delivery Systems ; Exosomes/metabolism ; Humans ; Nanoparticle Drug Delivery System ; Nanoparticles ; Neoplasms/pathology ; Tissue Distribution
Chemical Substances	Nanoparticle Drug Delivery System
Language	English
Publishing date	2021-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2021.1891094
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Article ; Online: Roles of microRNAs in renal disorders related to primary podocyte dysfunction.

Iranzad, Rahim / Motavalli, Roza / Ghassabi, Ali / Pourakbari, Ramin / Etemadi, Jalal / Yousefi, Mehdi

Life sciences

2021 Volume 277, Page(s) 119463

Abstract: Through the regulation of gene expression, microRNAs (miRNAs) are capable of modulating vital biological processes, such as proliferation, differentiation, and apoptosis. Several mechanisms control the function of miRNAs, including translational ... ...

Abstract	Through the regulation of gene expression, microRNAs (miRNAs) are capable of modulating vital biological processes, such as proliferation, differentiation, and apoptosis. Several mechanisms control the function of miRNAs, including translational inhibition and targeted miRNA degradation. Through utilizing high-throughput screening methods, such as small RNA sequencing and microarray, alterations in miRNA expression of kidneys have recently been observed both in rodent models and humans throughout the development of chronic kidney disease (CKD) and acute kidney injury (AKI). The levels of miRNAs in urine supernatant, sediment, and exosomal fraction could predict novel biomarker candidates in different diseases of kidneys, including IgA nephropathy, lupus nephritis, and diabetic nephropathy. The therapeutic potential of administrating anti-miRNAs and miRNAs has also been reported recently. The present study is aimed at reviewing the state-of-the-art research with regards to miRNAs involved in renal disorders related to primary podocyte dysfunction by laying particular emphasis on Focal Segmental Glomerulosclerosis (FSGS), Minimal Change Disease (MCD) and Membranous Nephropathy (MN).
MeSH term(s)	Apoptosis/genetics ; Biomarkers/metabolism ; Diabetic Nephropathies/metabolism ; Glomerulonephritis, Membranous/metabolism ; Glomerulosclerosis, Focal Segmental/metabolism ; Humans ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Lupus Nephritis/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nephrosis, Lipoid/metabolism ; Podocytes/metabolism ; Podocytes/physiology ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/metabolism
Chemical Substances	Biomarkers ; MicroRNAs
Language	English
Publishing date	2021-04-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119463
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