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  1. Article ; Online: Compartmentalized response of the human epidermis to staphylococci.

    Cichy, Joanna

    The British journal of dermatology

    2023  Volume 188, Issue 3, Page(s) 314

    MeSH term(s) Humans ; Staphylococcus ; Staphylococcus aureus ; Epidermis ; Skin ; Keratinocytes ; Staphylococcal Infections
    Language English
    Publishing date 2023-01-18
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljac125
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  2. Article ; Online: Physical activity and sedentary behaviors in Polish children and adolescents.

    Górna, Sara / Pazdro-Zastawny, Katarzyna / Basiak-Rasała, Alicja / Krajewska, Joanna / Kolator, Mateusz / Cichy, Ireneusz / Rokita, Andrzej / Zatoński, Tomasz

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2023  Volume 31, Issue 2, Page(s) 162–163

    MeSH term(s) Child ; Humans ; Adolescent ; Sedentary Behavior ; Poland ; Exercise ; Obesity
    Language English
    Publishing date 2023-11-07
    Publishing country France
    Document type Letter
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/j.arcped.2023.07.009
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    Zs.A 3942: Show issues Location:
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  3. Article ; Online: Antimicrobial Properties of a Peptide Derived from the Male Fertility Factor kl2 Protein of

    Bilska, Bernadetta / Godlewska, Urszula / Damulewicz, Milena / Murzyn, Krzysztof / Kwitniewski, Mateusz / Cichy, Joanna / Pyza, Elżbieta

    Current issues in molecular biology

    2022  Volume 44, Issue 3, Page(s) 1169–1181

    Abstract: Antimicrobial peptides (AMPs) are important components of innate immunity. Here, we report the antimicrobial properties of a peptide derived from the Male fertility factor kl2 (MFF-kl2) protein ... ...

    Abstract Antimicrobial peptides (AMPs) are important components of innate immunity. Here, we report the antimicrobial properties of a peptide derived from the Male fertility factor kl2 (MFF-kl2) protein of
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb44030076
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  4. Article: Chemerin-Derived Peptide Val

    Zegar, Aneta / Godlewska, Urszula / Kozłowska-Chmielewska, Dorota / Majewski, Pawel / Zabel, Brian A / Cichy, Joanna

    Frontiers in microbiology

    2021  Volume 12, Page(s) 742610

    Abstract: Chemerin-derived peptide ... ...

    Abstract Chemerin-derived peptide Val
    Language English
    Publishing date 2021-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.742610
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  5. Article: The role of chemerin and its antibacterial derivatives in maintaining epithelial barrier function

    Godlewska, Urszula / Zegar, Aneta / Cichy, Joanna

    Postepy biochemii

    2020  Volume 66, Issue 2, Page(s) 151–159

    Abstract: The epithelial tissues have continuous contact with external environment, including pathogenic microorganisms. Endogenous antimicrobial proteins and peptides produced by epithelial cells play a key role in controlling microbial burden and composition, ... ...

    Title translation Rola chemeryny i jej antybakteryjnych pochodnych w utrzymaniu funkcji barierowych nabłonka.
    Abstract The epithelial tissues have continuous contact with external environment, including pathogenic microorganisms. Endogenous antimicrobial proteins and peptides produced by epithelial cells play a key role in controlling microbial burden and composition, either directly, or by engaging immune cells. These include active derivatives of multifunctional protein chemerin, which is equipped with both antimicrobial and chemotactic function. Given an increasing number of infections caused by antibiotic-insensitive microorganisms, such as methicillin- resistant S. aureus (MRSA), it is important to fully understand how these epithelia-associated microorganisms are controlled at barrier sites, including skin and oral cavity. Chemerin-derived synthetic peptide 4 (p4) covering central Val66-Pro85 chemerin sequence exhibits broad range of antimicrobial activity against skin- and oral cavity- associated bacteria, including MRSA strains, suggesting its therapeutic potential for bacteria-mediated barrier organs pathologies. In this article we present the overview of protective functions of chemerin and chemerin-derived peptides in the epithelial tissues.
    MeSH term(s) Anti-Bacterial Agents/metabolism ; Bacteria/metabolism ; Chemokines/metabolism ; Drug Resistance, Bacterial ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; Humans ; Methicillin-Resistant Staphylococcus aureus/metabolism
    Chemical Substances Anti-Bacterial Agents ; Chemokines ; RARRES2 protein, human
    Language Polish
    Publishing date 2020-06-27
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 414019-9
    ISSN 0032-5422
    ISSN 0032-5422
    DOI 10.18388/pb.2020_323
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  6. Article ; Online: Secretory leukocyte protease inhibitor modulates FcεRI-dependent but not Mrgprb2-dependent mastocyte function in psoriasis.

    Kwiecinska, Patrycja / Kwitniewski, Mateusz / Kwiecien, Kamila / Morytko, Agnieszka / Majewski, Pawel / Pocalun, Natalia / Pastuszczak, Maciej / Migaczewski, Marcin / Cichy, Joanna / Grygier, Beata

    International immunopharmacology

    2023  Volume 122, Page(s) 110631

    Abstract: Psoriasis, which involves mast cells, is a chronic inflammatory skin disorder whose pathophysiology is still not fully understood. We investigated the role of secretory leukocyte protease inhibitor (SLPI), a potential inhibitor of mastocyte serine ... ...

    Abstract Psoriasis, which involves mast cells, is a chronic inflammatory skin disorder whose pathophysiology is still not fully understood. We investigated the role of secretory leukocyte protease inhibitor (SLPI), a potential inhibitor of mastocyte serine proteases, on mast cell-dependent processes of relevance to the skin barrier defense in psoriasis. Here, we demonstrate that the dermal mast cells of patients with psoriasis express SLPI but not those of healthy donors. Moreover, SLPI transcripts were found to be markedly upregulated in murine mast cells by mediators derived from psoriasis skin explant cultures. Using mast cells from SLPI-deficient mice and their SLPI
    MeSH term(s) Animals ; Mice ; Secretory Leukocyte Peptidase Inhibitor/genetics ; Secretory Leukocyte Peptidase Inhibitor/metabolism ; Mast Cells/metabolism ; Proteinase Inhibitory Proteins, Secretory/metabolism ; Psoriasis/metabolism ; Skin
    Chemical Substances Secretory Leukocyte Peptidase Inhibitor ; Proteinase Inhibitory Proteins, Secretory
    Language English
    Publishing date 2023-07-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110631
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    Zs.A 5408: Show issues Location:
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  7. Article ; Online: Gut Microbiota Diversity in HIV-Infected Patients on Successful Antiretroviral Treatment is Linked to Sexual Preferences but not CD4 Nadir.

    Jabłonowska, Elżbieta / Strzelczyk, Joanna / Piekarska, Anna / Wójcik-Cichy, Kamila

    Archivum immunologiae et therapiae experimentalis

    2021  Volume 69, Issue 1, Page(s) 14

    Abstract: The effects of HIV infection and antiretroviral therapy (ART) on the gut microbiome are poorly understood and the literature data are inconsistent. The aim of this study was to assess the alpha and beta diversity of the fecal microbiota in HIV-infected ... ...

    Abstract The effects of HIV infection and antiretroviral therapy (ART) on the gut microbiome are poorly understood and the literature data are inconsistent. The aim of this study was to assess the alpha and beta diversity of the fecal microbiota in HIV-infected patients on successful antiretroviral therapy with regard to sexual preferences and CD4 nadir. Thirty-six HIV-infected ART-treated patients with HIV viremia below 20 copies/ml and CD4 > 500 cells/μl were divided into two subgroups based on CD4 nadir. The composition of the intestinal microbiota was assessed by 16SrRNA sequencing (MiSeq Illumina). The alpha and beta diversity were analyzed according to CD4 nadir count and sexual preference. Several alpha diversity indexes were significantly higher in the MSM group than in heterosexual patients. The alpha diversity did not differ significantly between patients with CD4 nadir > 500 cells/μl and CD4 nadir < 200 cells/μl. Beta diversity was also associated with sexual preference. A significant difference in Weighted Unifrac was observed between all MSM and all non-MSM participants (p = 0.001). The MSM group was more diverse and demonstrated greater distances in Weighted Unifrac than the non-MSM group. The relative abundance of the Prevotella enterotype was higher in the MSM than the non-MSM group. Sexual preferences demonstrated a stronger influence on alpha and beta diversity in HIV-infected patients following successful antiretroviral treatment than HIV infection itself. The observed lack of association between CD4 nadir and alpha and beta diversity may be caused by the restoration of the faecal microbiota following antiretroviral treatment.
    MeSH term(s) Adult ; Anti-Retroviral Agents/administration & dosage ; CD4 Lymphocyte Count ; Case-Control Studies ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/immunology ; HIV/immunology ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/virology ; Humans ; Immunity, Mucosal ; Male ; Middle Aged ; Sexual Behavior/physiology ; Sexual and Gender Minorities ; Treatment Outcome
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2021-05-13
    Publishing country Switzerland
    Document type Journal Article ; Observational Study
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.1007/s00005-021-00616-7
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    Zs.A 393: Show issues Location:
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  8. Article ; Online: Alternative splicing is not a key source of chemerin isoforms diversity.

    Kwiecien, Kamila / Majewski, Pawel / Bak, Maciej / Brzoza, Piotr / Godlewska, Urszula / Skulimowska, Izabella / Cichy, Joanna / Kwitniewski, Mateusz

    Molecular biology reports

    2023  Volume 50, Issue 3, Page(s) 2521–2529

    Abstract: Background: Chemerin is a chemoattractant protein with adipokine and antimicrobial properties encoded by the retinoic acid receptor responder 2 (RARRES2) gene. Chemerin bioactivity largely depends on carboxyl-terminal proteolytic processing that ... ...

    Abstract Background: Chemerin is a chemoattractant protein with adipokine and antimicrobial properties encoded by the retinoic acid receptor responder 2 (RARRES2) gene. Chemerin bioactivity largely depends on carboxyl-terminal proteolytic processing that generates chemerin isoforms with different chemotactic, regulatory, and antimicrobial potentials. While these mechanisms are relatively well known, the role of alternative splicing in generating isoform diversity remains obscure.
    Methods and results: Using rapid amplification of cDNA ends (RACE) PCR, we determined RARRES2 transcript variants present in mouse and human tissues and identified novel transcript variant 4 of mouse Rarres2 encoding mChem153K. Moreover, analyses of real-time quantitative PCR (RT-qPCR) and publicly-available next-generation RNA sequencing (RNA-seq) datasets showed that different alternatively spliced variants of mouse Rarres2 are present in mouse tissues and their expression patterns were unaffected by inflammatory and infectious stimuli except brown adipose tissue. However, only one transcript variant of human RARRES2 was present in liver and adipose tissue.
    Conclusion: Our findings indicate a limited role for alternative splicing in generating chemerin isoform diversity under all tested conditions.
    MeSH term(s) Humans ; Animals ; Mice ; Chemokines/genetics ; Chemokines/metabolism ; Alternative Splicing/genetics ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Adipokines/metabolism ; Protein Isoforms/genetics ; Protein Isoforms/metabolism
    Chemical Substances Chemokines ; Intercellular Signaling Peptides and Proteins ; Adipokines ; Protein Isoforms ; chemerin protein, mouse
    Language English
    Publishing date 2023-01-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-08174-7
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  9. Article: Life history strategies of

    Pyrka, Ewa / Kanarek, Gerard / Gabrysiak, Julia / Jeżewski, Witold / Cichy, Anna / Stanicka, Anna / Żbikowska, Elżbieta / Zaleśny, Grzegorz / Hildebrand, Joanna

    International journal for parasitology. Parasites and wildlife

    2022  Volume 18, Page(s) 201–211

    Abstract: ... Species ... ...

    Abstract Species of
    Language English
    Publishing date 2022-06-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2715239-X
    ISSN 2213-2244
    ISSN 2213-2244
    DOI 10.1016/j.ijppaw.2022.06.002
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  10. Article ; Online: Correction to: Ketogenic diet impairs neurological development of neonatal rats and affects biochemical composition of maternal brains: evidence of functional recovery in pups.

    Kosiek, Wojciech / Rauk, Zuzanna / Szulc, Piotr / Cichy, Anna / Rugieł, Marzena / Chwiej, Joanna / Janeczko, Krzysztof / Setkowicz, Zuzanna

    Brain structure & function

    2022  Volume 227, Issue 7, Page(s) 2569

    Language English
    Publishing date 2022-04-29
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-022-02500-2
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