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Article ; Online: Aging with spinal cord injury: A narrative review of consequences and challenges.

Guízar-Sahagún, Gabriel / Grijalva, Israel / Franco-Bourland, Rebecca E / Madrazo, Ignacio

2023 Volume 90, Page(s) 102020

Abstract: Given the increase in life expectancy, aging with a pre-existing spinal cord injury (SCI) is becoming more common. This condition is challenging as compromised health status and functional independence can worsen. We aimed to provide an updated overview ... ...

Abstract	Given the increase in life expectancy, aging with a pre-existing spinal cord injury (SCI) is becoming more common. This condition is challenging as compromised health status and functional independence can worsen. We aimed to provide an updated overview of the consequences of aging with SCI, highlighting the main challenges facing this population in a narrative review of the current literature we retrieved from the PubMed database from 2000 to 2022 on any aspect related to aging in persons with SCI. Here we address adverse circumstances that increase disability and hinder an active lifestyle, such as progressive physical deterioration, secondary health conditions, limitations in personal activity, changes in family and social support structures, aging of caregivers, and depletion of economic resources. Favorable changes are also observed, including psychosocial adjustments that improve quality of life. Additionally, various interventions are discussed to promote well-being, health, and social participation. Due to the relevance of this issue, people with SCI and all those who take care of them must have up-to-date information to carry out the necessary measures to promote healthy aging in a more inclusive social environment.
MeSH term(s)	Humans ; Quality of Life ; Spinal Cord Injuries/psychology ; Aging ; Health Status ; Disabled Persons/psychology
Language	English
Publishing date	2023-07-23
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2023.102020
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Article: Early treatment with dapsone after spinal cord injury in rats decreases the inflammatory response and promotes long-term functional recovery.

Calderón-Estrella, Francisco / Franco-Bourland, Rebecca E / Rios, Camilo / de Jesús-Nicolás, Diana / Pineda, Benjamín / Méndez-Armenta, Marisela / Mata-Bermúdez, Alfonso / Diaz-Ruiz, Araceli

Heliyon

2023 Volume 9, Issue 4, Page(s) e14687

Abstract: Failure of therapeutic strategies for the management and recovery from traumatic spinal cord injury (SCI) is a serious concern. Dapsone (DDS) has been reported as a neuroprotective drug after SCI, although the phase after SC damage (acute or chronic) of ... ...

Abstract	Failure of therapeutic strategies for the management and recovery from traumatic spinal cord injury (SCI) is a serious concern. Dapsone (DDS) has been reported as a neuroprotective drug after SCI, although the phase after SC damage (acute or chronic) of its major impact on functional recovery has yet to be defined. Here, we evaluated DDS acute-phase anti-inflammatory effects and their impact on early functional recovery, one week after moderate SCI, and late functional recovery, 7 weeks thereafter. Female Wistar rats were randomly assigned to each of five experimental groups: sham group; four groups of rats with SCI, treated with DDS (0, 12.5, 25.0, and 37.5 mg/kg ip), starting 3 h after injury. Plasma levels of GRO/KC, and the number of neutrophils and macrophages in cell suspensions from tissue taken at the site of injury were measured as inflammation biomarkers. Hindlimb motor function of injured rats given DDS 12.5 and 25.0 mg/kg daily for 8 weeks was evaluated on the BBB open-field ordinal scale. Six hours after injury all DDS doses decreased GRO/KC plasma levels; 24 h after injury, neutrophil numbers decreased with DDS doses of 25.0 and 37.5 mg/kg; macrophage numbers decreased only at the 37.5 mg/kg dose. In the acute phase, functional recovery was dose-dependent. Final recovery scores were 57.5 and 106.2% above the DDS-vehicle treated control group, respectively. In conclusion, the acute phase dose-dependent anti-inflammatory effects of DDS impacted early motor function recovery affecting final recovery at the end of the study.
Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14687
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Article ; Online: Detection and expression of SapS, a class C nonspecific acid phosphatase with O-phospho-Ltyrosine- phosphatase activity, in Staphylococcus aureus isolates from patients with chronic osteomyelitis

Martínez-Canseco, Carlos / Franco-Bourland, Rebecca E / González-Huerta, Norma / Paredes-Espinosa, Marco Antonio / Giono-Cerezo, Silvia / Sánchez-Chapul, Laura / Paniagua-Pérez, Rogelio / Valdez-Mijares, René / Hernández-Flores, Cecilia

Biomedica : revista del Instituto Nacional de Salud

2023 Volume 43, Issue 2, Page(s) 200–212

Abstract: Introduction: The identity of Staphylococcus aureus virulence factors involved in chronic osteomyelitis remains unresolved. SapS is a class C non-specific acid phosphatase and a well-known virulence factor that has been identified in S. aureus strain ... ...

Title translation	Detección y expresión de SapS, una fosfatasa ácida no específica de clase C con actividad de fosfatasa O-fosfotirosina, en aislamientos de Staphylococcus aureus de pacientes con osteomielitis crónica
Abstract	Introduction: The identity of Staphylococcus aureus virulence factors involved in chronic osteomyelitis remains unresolved. SapS is a class C non-specific acid phosphatase and a well-known virulence factor that has been identified in S. aureus strain 154 but in protein extracts from rotting vegetables. Objective: To identify the SapS gene and characterize the activity of SapS from S. aureus strains: 12 isolates from bone infected samples of patients treated for chronic osteomyelitis and 49 from a database with in silico analysis of complete bacterial genomes. Materials and methods: The SapS gene was isolated and sequenced from 12 S. aureus clinical isolates and two reference strains; 49 S. aureus strains and 11 coagulase-negative staphylococci were tested using in silico PCR. Culture media semi-purified protein extracts from the clinical strains were assayed for phosphatase activity with p-nitro-phenylphosphate, O-phospho-L-tyrosine, O-phospho-L-serine, and OphosphoL-threonine in conjunction with various phosphatase inhibitors. Results: SapS was detected in the clinical and in-silico S. aureus strains, but not in the in silico coagulase-negative staphylococci strains. Sec-type I lipoprotein-type N-terminal signal peptide sequences; secreted proteins, and aspartate bipartite catalytic domains coding sequences were found in the SapS nucleotide and amino acid sequence analysis. SapS dephosphorylated with p-nitro-phenyl-phosphate and ophosphoLtyrosine were selectively resistant to tartrate and fluoride, but sensitive to vanadate and molybdate. Conclusion: SapS gene was found in the genome of the clinical isolates and the in silico Staphylococcus aureus strains. SapS shares biochemical similarities with known virulent bacterial, such as protein tyrosine phosphatases, suggesting it may be a virulence factor in chronic osteomyelitis.
MeSH term(s)	Humans ; Staphylococcus aureus/genetics ; Acid Phosphatase/genetics ; Coagulase ; Staphylococcal Infections ; Staphylococcus
Chemical Substances	Acid Phosphatase (EC 3.1.3.2) ; Coagulase
Language	Spanish
Publishing date	2023-06-30
Publishing country	Colombia
Document type	Journal Article
ZDB-ID	2059952-3
ISSN	2590-7379 ; 2590-7379
ISSN (online)	2590-7379
ISSN	2590-7379
DOI	10.7705/biomedica.6604
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Article ; Online: Can psychopathy be prevented? Clinical, neuroimaging, and genetic data: an exploratory study.

Ostrosky, Feggy / Decety, Jean / Lozano, Azucena / Lujan, Angélica / Perez, Martha / Munguia, Ana / Castañeda, Dianela / Diaz, Karla / Lara, Rafael / Sacristan, Emilio / Bobes, Maria A / Borja, Karina / Camarena, Beatriz / Hernández-Muñoz, Sandra / Álvarez, Aurora / Franco-Bourland, Rebecca E

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

2023 , Page(s) 1–21

Abstract: The aim of the study was to explore the relationship among brain functional activations elicited by an emotional paradigm, clinical scores (PTSD, anxiety, and depression), psychopathic traits, and genetic characteristics (5-HTTLPR) in a group of severely ...

Abstract	The aim of the study was to explore the relationship among brain functional activations elicited by an emotional paradigm, clinical scores (PTSD, anxiety, and depression), psychopathic traits, and genetic characteristics (5-HTTLPR) in a group of severely maltreated children compared to a healthy control group before and after the implementation of a Trauma Focused-Cognitive Behavioral Therapy. The final sample consisted of an experimental group of 14 maltreated children (mean age = 8.77 years old,
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1262599-1
ISSN	1744-4136 ; 0929-7049
ISSN (online)	1744-4136
ISSN	0929-7049
DOI	10.1080/09297049.2023.2277396
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Article ; Online: Early treatment with dapsone after spinal cord injury in rats decreases the inflammatory response and promotes long-term functional recovery

Calderón-Estrella, Francisco / Franco-Bourland, Rebecca E. / Rios, Camilo / de Jesús-Nicolás, Diana / Pineda, Benjamín / Méndez-Armenta, Marisela / Mata-Bermúdez, Alfonso / Diaz-Ruiz, Araceli

Heliyon. 2023 Mar. 20, p.e14687-

2023

Abstract	Failure of therapeutic strategies for the management and recovery from traumatic spinal cord injury (SCI) is a serious concern. Dapsone (DDS) has been reported as a neuroprotective drug after SCI, although the phase after SC damage (acute or chronic) of its major impact on functional recovery has yet to be defined. Here, we evaluated DDS acute-phase anti-inflammatory effects and their impact on early functional recovery, one week after moderate SCI, and late functional recovery, 7 weeks thereafter. Female Wistar rats were randomly assigned to each of five experimental groups: sham group; four groups of rats with SCI, treated with DDS (0, 12.5, 25.0, and 37.5 mg/kg ip), starting 3 h after injury. Plasma levels of GRO/KC, and the number of neutrophils and macrophages in cell suspensions from tissue taken at the site of injury were measured as inflammation biomarkers. Hindlimb motor function of injured rats given DDS 12.5 and 25.0 mg/kg daily for 8 weeks was evaluated on the BBB open-field ordinal scale. Six hours after injury all DDS doses decreased GRO/KC plasma levels; 24 h after injury, neutrophil numbers decreased with DDS doses of 25.0 and 37.5 mg/kg; macrophage numbers decreased only at the 37.5 mg/kg dose. In the acute phase, functional recovery was dose-dependent. Final recovery scores were 57.5 and 106.2% above the DDS-vehicle treated control group, respectively. In conclusion, the acute phase dose-dependent anti-inflammatory effects of DDS impacted early motor function recovery affecting final recovery at the end of the study.
Keywords	animal injuries ; biomarkers ; dapsone ; dose response ; females ; hindlimbs ; inflammation ; macrophages ; neutrophils ; therapeutics ; Spinal cord injury ; Inflammatory response ; Interleukin-8 ; Motor function recovery
Language	English
Dates of publication	2023-0320
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14687
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Early treatment with dapsone after spinal cord injury in rats decreases the inflammatory response and promotes long-term functional recovery

Francisco Calderón-Estrella / Rebecca E. Franco-Bourland / Camilo Rios / Diana de Jesús-Nicolás / Benjamín Pineda / Marisela Méndez-Armenta / Alfonso Mata-Bermúdez / Araceli Diaz-Ruiz

Heliyon, Vol 9, Iss 4, Pp e14687- (2023)

2023

Abstract	Failure of therapeutic strategies for the management and recovery from traumatic spinal cord injury (SCI) is a serious concern. Dapsone (DDS) has been reported as a neuroprotective drug after SCI, although the phase after SC damage (acute or chronic) of its major impact on functional recovery has yet to be defined. Here, we evaluated DDS acute-phase anti-inflammatory effects and their impact on early functional recovery, one week after moderate SCI, and late functional recovery, 7 weeks thereafter. Female Wistar rats were randomly assigned to each of five experimental groups: sham group; four groups of rats with SCI, treated with DDS (0, 12.5, 25.0, and 37.5 mg/kg ip), starting 3 h after injury. Plasma levels of GRO/KC, and the number of neutrophils and macrophages in cell suspensions from tissue taken at the site of injury were measured as inflammation biomarkers. Hindlimb motor function of injured rats given DDS 12.5 and 25.0 mg/kg daily for 8 weeks was evaluated on the BBB open-field ordinal scale. Six hours after injury all DDS doses decreased GRO/KC plasma levels; 24 h after injury, neutrophil numbers decreased with DDS doses of 25.0 and 37.5 mg/kg; macrophage numbers decreased only at the 37.5 mg/kg dose. In the acute phase, functional recovery was dose-dependent. Final recovery scores were 57.5 and 106.2% above the DDS-vehicle treated control group, respectively. In conclusion, the acute phase dose-dependent anti-inflammatory effects of DDS impacted early motor function recovery affecting final recovery at the end of the study.
Keywords	Spinal cord injury ; Dapsone ; Inflammatory response ; Interleukin-8 ; Motor function recovery ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Detection and expression of SapS, a class C nonspecific acid phosphatase with O-phospho-Ltyrosine- phosphatase activity, in Staphylococcus aureus isolates from patients with chronic osteomyelitis

Carlos Martínez-Canseco / Rebecca E. Franco-Bourland / Norma González-Huerta / Marco Antonio Paredes-Espinosa / Silvia Giono-Cerezo / Laura Sánchez-Chapul / Rogelio Paniagua-Pérez / René Valdez-Mijares / Cecilia Hernández-Flores

Biomédica: revista del Instituto Nacional de Salud, Vol 43, Iss 2, Pp 200-

2023 Volume 212

Abstract: Introduction. The identity of Staphylococcus aureus virulence factors involved in chronic osteomyelitis remains unresolved. SapS is a class C non-specific acid phosphatase and a well-known virulence factor that has been identified in S. aureus strain 154 ...

Abstract	Introduction. The identity of Staphylococcus aureus virulence factors involved in chronic osteomyelitis remains unresolved. SapS is a class C non-specific acid phosphatase and a well-known virulence factor that has been identified in S. aureus strain 154 but in protein extracts from rotting vegetables. Objective. To identify the SapS gene and characterize the activity of SapS from S. aureus strains: 12 isolates from bone infected samples of patients treated for chronic osteomyelitis and 49 from a database with in silico analysis of complete bacterial genomes. Materials and methods. The SapS gene was isolated and sequenced from 12 S. aureus clinical isolates and two reference strains; 49 S. aureus strains and 11 coagulase-negative staphylococci were tested using in silico PCR. Culture media semi-purified protein extracts from the clinical strains were assayed for phosphatase activity with p-nitro-phenylphosphate, O-phospho-L-tyrosine, O-phospho-L-serine, and OphosphoL-threonine in conjunction with various phosphatase inhibitors. Results. SapS was detected in the clinical and in-silico S. aureus strains, but not in the in silico coagulase-negative staphylococci strains. Sec-type I lipoprotein-type N-terminal signal peptide sequences; secreted proteins, and aspartate bipartite catalytic domains coding sequences were found in the SapS nucleotide and amino acid sequence analysis. SapS dephosphorylated with p-nitro-phenyl-phosphate and ophosphoLtyrosine were selectively resistant to tartrate and fluoride, but sensitive to vanadate and molybdate. Conclusion. SapS gene was found in the genome of the clinical isolates and the in silico Staphylococcus aureus strains. SapS shares biochemical similarities with known virulent bacterial, such as protein tyrosine phosphatases, suggesting it may be a virulence factor in chronic osteomyelitis.
Keywords	staphylococcus aureus ; virulence factors ; osteomyelitis ; Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Instituto Nacional de Salud
Document type	Article ; Online
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Article: The liver is the key organ for the development of metabolic syndrome.

Franco-Bourland, Rebecca E / Méndez-Sánchez, Nahum

Annals of hepatology

2011 Volume 10, Issue 2, Page(s) 216–217

MeSH term(s)	Animals ; Humans ; Liver/metabolism ; Liver/physiopathology ; Liver Diseases/complications ; Liver Diseases/metabolism ; Liver Diseases/physiopathology ; Metabolic Syndrome/etiology ; Metabolic Syndrome/metabolism ; Metabolic Syndrome/physiopathology
Language	English
Publishing date	2011-04-13
Publishing country	Mexico
Document type	Editorial
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
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Article ; Online: The liver is the key organ for the development of metabolic syndrome

Rebecca E. Franco-Bourland / Nahum Méndez-Sánchez

Annals of Hepatology, Vol 10, Iss 2, Pp 216-

2011 Volume 217

Keywords	Specialties of internal medicine ; RC581-951
Language	English
Publishing date	2011-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Temporal changes of spinal subarachnoid space patency after graded spinal cord injury in rats.

Franco-Bourland, Rebecca E / Reyes-Alva, Horacio J / Quintana-Armenta, Alejandra / Martinez-Cruz, Angelina / Madrazo, Ignacio / Guizar-Sahagun, Gabriel

Injury

2015 Volume 46, Issue 4, Page(s) 634–637

Abstract: Introduction: Disturbances in spinal subarachnoid space (SSAS) patency after SCI have been reported as an incidental finding, but there is a lack of information on its in vivo extent and time course. For substances and cells carried in the cerebrospinal ...

Abstract	Introduction: Disturbances in spinal subarachnoid space (SSAS) patency after SCI have been reported as an incidental finding, but there is a lack of information on its in vivo extent and time course. For substances and cells carried in the cerebrospinal fluid (CSF) to reach damaged neural tissue and promote reparative processes, CSF must be able to flow freely in SASS. Objective: To characterise the extent and time course of SSAS patency disruption in vivo in a rat model after graded SCI. Materials and methods: Anaesthetised rats were subjected to mild or severe cord contusion at T9. Estimation of SSAS patency was carried out at 1h and 1, 3, 7, 15, 30 and 90 days postinjury, as well as in naïve rats, by quantifying the passage of superparamagnetic beads injected into the CSF at the cisterna magna and recovered at spinal level L2. CSF volume recovery was measured simultaneously. Data were analysed by the two-way ANOVA test. Results: Estimation of SSAS patency revealed nearly complete blockage early after contusion that was unevenly restored entering the chronic stages. Volume of CSF recovered was also significantly decreased early after injury compared to naïve rats, but was fully restored by 1 month postinjury. Overall, although modestly different from each other, changes in both parameters were more pronounced after severe rather than mild injuries for each time point examined. Conclusions: SCI alters SSAS patency. Its extent is a function primarily of time elapsed after lesion and secondly of injury severity. It is reasonable to expect that disturbances in SASS patency might alter CSF dynamics and impair self-reparative mechanisms and intrathecal therapeutics, making SSAS patency blockage a key target for SCI management.
MeSH term(s)	Animals ; Blood-Nerve Barrier/pathology ; Cerebrospinal Fluid Pressure/physiology ; Contusions ; Disease Models, Animal ; Female ; Rats ; Rats, Long-Evans ; Recovery of Function ; Spinal Cord/pathology ; Spinal Cord Injuries/pathology ; Subarachnoid Space/pathology
Language	English
Publishing date	2015-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2015.01.007
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