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Article: Carlos II: del hechizo a su patología génito-urinaria.

García-Escudero López, Angel / Arruza Echevarría, A / Padilla Nieva, J / Puig Giró, R

2009 Volume 62, Issue 3, Page(s) 179–185

Abstract: Objectives: We attempt to unravel the complex condition of the last king of the Hapsburg dynasty in Spain, Charles II, called The Bewitched, in whom a genitourinary disorder was preponderant, preventing him from fulfilling one of the objectives of the ... ...

Title translation	Charles II: From spell to genitourinary pathology.
Abstract	Objectives: We attempt to unravel the complex condition of the last king of the Hapsburg dynasty in Spain, Charles II, called The Bewitched, in whom a genitourinary disorder was preponderant, preventing him from fulfilling one of the objectives of the monarchial institution, engendering a heir, and causing a series of complications that led to his death. Methods: We review the works describing the life of the King, with special emphasis on his bloodline, the doubts about his sex at birth, his pathological processes, the repercussion among European Courts, but above all on his marriages and the inability to engender an heir. We also emphasize the thought of 17th century Spanish society which led to the belief that he was bewitched. The nickname he passed into history with. Results: It was deduced that he could have presented posterior hypospadias which, together with monorchism and atrophic testicle, led to the belief that he presented an intersexual state with ambiguous genitals. The physical phenotype leans more towards true hermaphro-ditism and above all a XX male, rather than the more often attributed Klinefelter's syndrome. This is probably also associated with a fragile X syndrome. Very possibly congenital monorenal, death was due to chronic kidney failure caused by glomerulopathy or interstitial nephro-pathy as a consequence of renal lithiasis plus recurrent infections of the urinary tract. Conclusions: As a result of a reiterated endogamic matrimonial policy, the Hapsburg dynasty died out in Spain in 1700, represented by Charles II, a pluripatho-logical king who can only be freed from speculation by chromosomal and genetic studies of his remains buried in El Escorial monastery.
MeSH term(s)	Famous Persons ; History, 17th Century ; Humans ; Male ; Male Urogenital Diseases/history ; Spain
Language	Spanish
Publishing date	2009-08-01
Publishing country	Spain
Document type	Biography ; Historical Article ; Journal Article ; Portrait
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
DOI	10.4321/s0004-06142009000300002
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Article: Prostatectomía radical asistida por robot Da Vinci: un año de experiencia en el Hospital Clínico San Carlos.

Moreno Sierra, Jesús / Núñez Mora, Carlos / Galante Romo, Ma Isabel / Prieto Nogal, Sara / López García Asenjo, José / Silmi Moyano, Angel

Archivos espanoles de urologia

2008 Volume 61, Issue 3, Page(s) 385–396

Abstract: Objectives: Hospital Clínico San Carlos in Madrid is the first Spanish public centre using ...

Title translation	Da Vinci robot assisted radical prostatectomy: one year experience at the Hospital Clínico San Carlos.
Abstract	Objectives: Hospital Clínico San Carlos in Madrid is the first Spanish public centre using the latest surgical technology: the Da Vinci robot. First operation was carried out in our department in October 9th 2006. Since then, numerous changes have happened which enabled us to overcome difficulties, to complete the learning curve. Methods: Between October 9th 2006 and November 30th 2007 we performed 30 radical prostatectomies with the Da Vinci robot. Mean patient age was 63 years (47-70 years) with an ASA (American society of anesthesia) risk below III in all cases, a Gleason score between 2 and 8 and a PSA < or = 15 (3.5-15). Mean prostatic volume measured by transrectal ultrasound was 36 cc (16-90 cc). Results/conclusions: Six trocars and a 15 mm Hg pneumoperitoneum were employed. Mean operative room occupation time was 5.9 hours (4-14 hours). Two cases were converted to open surgery and one to laparoscopy. No major intraoperative complications have happened. In the immediate post-operative period, 2 patients presented plexopathy and arthralgia, 1 infection at the site of one trocar, and 2 haematomas at the site of trocar insertion. Sixteen patients required transfusion (mean 1 red blood cells unit (0-4)). Bladder catheter was retrieved between 5th and 21st post-operative days (mean 11 days). Regarding continence: 10 patients were completely continent or present mild incontinence (0-1 pad) and 5 had moderate incontinence (2-5 pads). Three patients preserve sexual potency, the rest show different grades of dysfunction.
MeSH term(s)	Aged ; Hospitals, Public ; Humans ; Male ; Middle Aged ; Prostatectomy/methods ; Robotics/instrumentation ; Robotics/methods ; Spain ; Time Factors
Language	Spanish
Publishing date	2008-06-20
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
DOI	10.4321/s0004-06142008000300005
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Book: El balneario real de Carlos III en Trillo (1777-1943)

García López, Aurelio

un libro para conocer su historia

(Tierra de Guadalajara / Guías ; 81)

2011

Author's details	Aurelio García López
Series title	Tierra de Guadalajara / Guías ; 81
MeSH term(s)	Health Resorts/history ; Balneology/history ; Mineral Waters/therapeutic use ; History, 18th Century ; History, 19th Century ; History, 20th Century
Keywords	Spain
Language	Spanish
Size	261 p. :, ill. ;, 21 cm.
Publisher	AACHE ediciones
Publishing place	Guadalajara
Document type	Book
ISBN	9788492886623 ; 8492886625
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: The socio-discursive phenomenon of legitimisation in the coverage of the campaigns of Carlos Gaviria and Alvaro Uribe during the 2006 presidential elections

Raúl Enrique García López / María Juliana Quintero Vélez

Folios, Vol 0, Iss

2013 Volume 38

Abstract: ... newspaper El Tiempo represented the campaigns of the candidates Alvaro Uribe and Carlos Gaviria in the 2006 ... In contrast, the newspaper made the figure of Carlos Gaviria invisible and represented his project as contrary ...

Abstract	DOI: http://dx.doi.org/10.17227/01234870.38folios61.74 This article examines how the daily newspaper El Tiempo represented the campaigns of the candidates Alvaro Uribe and Carlos Gaviria in the 2006 Colombian presidential election. In particular, this study analyses strategies such as the socio-discursive phenomenon of legitimisation, proposed by Pardo (2007), which manifests itself in the newspaper’s representation of the candidates and their campaigns during the week before the election. By means of a comparative analysis of the linguistic processes of authorisation, evaluation and mitigation, and their correlation with three concepts in political science such as charismatic authority (Weber, 1983), Bonapartism (Moncayo, 2004) and legitimacy (Lipset, 1981), conclusions are reached regarding the stance adopted by the newspaper in terms of the two candidates. It is concluded that El Tiempo favoured Uribe’s campaign because of the charismatic representation of his political figure and the legitimisation of his political project. In contrast, the newspaper made the figure of Carlos Gaviria invisible and represented his project as contrary to the interests of the majority of the country.
Keywords	History of scholarship and learning. The humanities ; AZ20-999
Subject code	940
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	Universidad Pedagógica Nacional
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: El Fenómeno sociodiscursivo de legitimación en el cubrimiento de las campañas de Carlos Gaviria y Álvaro Uribe durante las elecciones presidenciales del año 2006

Raúl Enrique García López / María Juliana Quintero Vélez

Folios, Iss 38, Pp 61-

2013 Volume 74

Abstract: ... El Tiempo de las campañas de los candidatos Álvaro Uribe y Carlos Gaviria en la elección presidencial del año 2006 ... invisibilizó la figura de Carlos Gaviria y representó su proyecto como opuesto a los intereses de la mayoría ...

Abstract	El presente artículo examina la representación mediática hecha por el diario El Tiempo de las campañas de los candidatos Álvaro Uribe y Carlos Gaviria en la elección presidencial del año 2006 en Colombia. En particular, este estudio analiza las formas como el fenómeno sociodiscursivo de legitimación, tal como la propone Pardo (2007), se manifestó en la representación que el diario hizo de los candidatos y sus campañas durante la semana previa a la elección. Mediante un análisis comparativo de los procesos lingüísticos de autorización y evaluación y mitigación, y su correlación con tres conceptos de la ciencia política tales como la dominación carismática (Weber, 1983), el bonapartismo (Moncayo, 2004) y la legitimidad (Lipset, 1981) se llega a conclusiones en cuanto al posicionamiento del diario en relación a las dos candidaturas. Se concluye que El Tiempo favoreció la campaña uribista mediante la representación carismática de su figura política y la legitimación de su proyecto político. De manera opuesta, el diario invisibilizó la figura de Carlos Gaviria y representó su proyecto como opuesto a los intereses de la mayoría del país.
Keywords	legitimidad ; elecciones ; prensa escrita ; Análisis Crítico del Discurso [ ACD ] ; History of scholarship and learning. The humanities ; AZ20-999
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	Universidad Pedagógica Nacional
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Meta-analysis: Real-world effectiveness and safety of ustekinumab in patients with ulcerative colitis.

Taxonera, Carlos / Olivares, David / López-García, Olga N / Alba, Cristina

Alimentary pharmacology & therapeutics

2023 Volume 57, Issue 6, Page(s) 610–619

Abstract: Background: Evidence on real-world outcomes of ustekinumab for ulcerative colitis (UC) patients is needed.: Aims: To summarise evidence on the real-world outcomes of ustekinumab for UC and conduct a meta-analysis of effectiveness and safety data.: ... ...

Abstract	Background: Evidence on real-world outcomes of ustekinumab for ulcerative colitis (UC) patients is needed. Aims: To summarise evidence on the real-world outcomes of ustekinumab for UC and conduct a meta-analysis of effectiveness and safety data. Methods: A systematic search was conducted through September 2022 in electronic databases for observational studies evaluating ustekinumab for UC. A random-effects meta-analysis model was used to calculate the pooled effect sizes (percentages or incidence rates [IRs]) of effectiveness and safety outcomes. Results: In all, 19 studies were included with 3786 patients. More than 92% of patients were previously treated with any biologic, 61.1% with both anti-TNF and vedolizumab and 16.4% with any biologic and tofacitinib. Clinical remission was achieved in 45.4% at week 8 (95% CI: 30.1%-60.6%), 43.8% (38.4%-49.2%) at weeks 12-16, 44.6% (35.9%-53.3%) at month 6, and 50.6% (36.3%-64.8%) at month 12. Response was achieved in 61.2%, 59.4%, 65.2% and 76.8% at weeks 8, 12-16, month 6 and 12, respectively. CS-free remission was achieved in 18.7%, 36.8%, 34.5% and 39% at weeks 8, 12-16, month 6 and 12, respectively. Overall, 58.2% of patients had endoscopic improvement at month 12. Almost 30% of the patients needed dose escalation, which was effective in 40% of these patients. The IRs of colectomy, adverse events (AEs), serious AEs and serious infections were 4.8, 7.9, 0.8 and 0.3 per 100 patient-years, respectively. Conclusions: This meta-analysis confirms the effectiveness and safety of ustekinumab in a highly treatment-refractory population of UC patients.
MeSH term(s)	Humans ; Colitis, Ulcerative/drug therapy ; Ustekinumab/therapeutic use ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Colectomy ; Biological Products/therapeutic use ; Treatment Outcome ; Remission Induction
Chemical Substances	Ustekinumab (FU77B4U5Z0) ; Tumor Necrosis Factor Inhibitors ; Biological Products
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.17386
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Article ; Online: Análisis morfológico de los estados inmaduro y adulto de Parlatoria oleae (Colvée) (Hemiptera, Diaspididae) y su desarrollo poblacional en relación con grados días acumulados en manzanos Malus sylvestris Mill. en San Carlos, Mendoza, Argentina.

Lanati, S.J. / López García, G.P

Horticultura Argentina, Vol 30, Iss 72, Pp 27-

2011 Volume 36

Abstract: Studies were carried in Red delicious apple grove in Mendoza during two seasons: 2007-2008 and 2008-2009 with objective of analyze morphologically stages of development of Parlatoria oleae (Colvée) and explain the population development (number of ... ...

Abstract	Studies were carried in Red delicious apple grove in Mendoza during two seasons: 2007-2008 and 2008-2009 with objective of analyze morphologically stages of development of Parlatoria oleae (Colvée) and explain the population development (number of generations) related to accumulated degree days. Were sampled five plant from which were obtained five outbreaks and five fruits, were counted in the laboratory individuals under stereo microscope, separating the different stages of development: eggs (h), first nymphal stage (N1), second nymphal stage (N2), female (H), prepupa and pupa (P). With the data obtained were elaborated population curves that represented the annual generations of the specie. Through direct observation and stereo microscope with micrometric lens was made analysis descriptive and morphological, the simple sine formula belonging at the program of calculus of degree days of the California University used to obtain the integral termic of the species. The scale presented two annuals generations with maximum first instar nymphs (N1) in spring (October, 240-270 °D) and summer (February, 1490-1505 °D). In winter only were found females fertilized. The constant termic generational obtained of data, considering a lower threshold temperature of 10 °C and maximum of 32 °C, was estimated at 825-870 °D in 115-103 days accumulated in the first generation and 1,300 °D in 260 days for the second generation considering the winter passage. --- Se realizaron estudios en monte de manzanos Red delicious ubicado en Mendoza durante dos temporadas: 2007-2008 y 2008-2009 con objetivo de analizar morfológicamente los estados de desarrollo de Parlatoria oleae (Colvée) y describir el desarrollo poblacional (número de generaciones) relacionado con grados días acumulados. Se muestrearon cinco plantas de las que se obtuvieron cinco brotes y cinco frutos; en laboratorio se contabilizaron los individuos bajo microscopio estereoscópico, separando los distintos estados de desarrollo: huevos (h), primer estadio ninfal (N1), segundo estadio ninfal (N2), hembras (H), prepupas y pupas (P). Con los datos obtenidos se elaboraron curvas poblacionales que representaron las generaciones anuales de la especie. Mediante observación directa y lupa binocular con lente micrométrico se efectuó el análisis descriptivo y morfológico. La fórmula de seno simple perteneciente al programa de cálculo de grados días de la Universidad de California se utilizó para la obtención de la integral térmica de la especie. El diaspídido presentó dos generaciones anuales con máximos de ninfas de primer estadio (N1) en primavera (octubre, 240-270 °D) y en verano (febrero, 1490-1505 °D). En invierno se encontraron solo hembras fecundadas. La constante térmica generacional obtenida de datos a campo, considerando una temperatura umbral inferior de 10 °C y máxima de 32 °C, se estimó en 825-870 °D acumulados en 115-103 días en la primera generación y 1.300 °D en 260 días para la segunda generación considerando el pasaje invernal.
Keywords	Parlatoria apple ; Annuals generations ; Population ; Temperatures ; Morphological description / Palabras claves: Parlatoria del manzano ; Generaciones anuales ; Población ; Temperaturas ; Descripción morfológica. ; Plant culture ; SB1-1110 ; Agriculture ; S ; DOAJ:Plant Sciences ; DOAJ:Agriculture and Food Sciences
Language	Spanish
Publishing date	2011-01-01T00:00:00Z
Publisher	Asociación Argentina de Horticultura (ASAHO)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Top-down specific preparatory activations for selective attention and perceptual expectations.

Peñalver, José M G / López-García, David / González-García, Carlos / Aguado-López, Blanca / Górriz, Juan M / Ruz, María

NeuroImage

2023 Volume 271, Page(s) 119960

Abstract: Proactive cognition brain models are mainstream nowadays. Within these, preparation is understood as an endogenous, top-down function that takes place prior to the actual perception of a stimulus and improves subsequent behavior. Neuroimaging has shown ... ...

Abstract	Proactive cognition brain models are mainstream nowadays. Within these, preparation is understood as an endogenous, top-down function that takes place prior to the actual perception of a stimulus and improves subsequent behavior. Neuroimaging has shown the existence of such preparatory activity separately in different cognitive domains, however no research to date has sought to uncover their potential similarities and differences. Two of these, often confounded in the literature, are Selective Attention (information relevance) and Perceptual Expectation (information probability). We used EEG to characterize the mechanisms that pre-activate specific contents in Attention and Expectation. In different blocks, participants were cued to the relevance or to the probability of target categories, faces vs. names, in a gender discrimination task. Multivariate Pattern (MVPA) and Representational Similarity Analyses (RSA) during the preparation window showed that both manipulations led to a significant, ramping-up prediction of the relevant or expected target category. However, classifiers trained with data from one condition did not generalize to the other, indicating the existence of unique anticipatory neural patterns. In addition, a Canonical Template Tracking procedure showed that there was stronger anticipatory perceptual reinstatement for relevance than for expectation blocks. Overall, the results indicate that preparation during attention and expectation acts through distinguishable neural mechanisms. These findings have important implications for current models of brain functioning, as they are a first step towards characterizing and dissociating the neural mechanisms involved in top-down anticipatory processing.
MeSH term(s)	Humans ; Motivation ; Brain Mapping ; Attention/physiology ; Cognition ; Cues
Language	English
Publishing date	2023-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2023.119960
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Article ; Online: Tolerance of Chromosomal Instability in Cancer: Mechanisms and Therapeutic Opportunities.

Gronroos, Eva / López-García, Carlos

Cancer research

2018 Volume 78, Issue 23, Page(s) 6529–6535

Abstract: Chromosomal instability (CIN) is the result of ongoing changes in the number (aneuploidy) and structure of chromosomes. CIN is induced by chromosome missegregation in mitosis and leads to karyotypic diversity within the cancer cell population, thereby ... ...

Abstract	Chromosomal instability (CIN) is the result of ongoing changes in the number (aneuploidy) and structure of chromosomes. CIN is induced by chromosome missegregation in mitosis and leads to karyotypic diversity within the cancer cell population, thereby adding to intratumor heterogeneity. Regardless of the overall pro-oncogenic function of CIN, its onset is typically detrimental for cell fitness and thus tumors must develop CIN-tolerance mechanisms in order to propagate. There is overwhelming genetic and functional evidence linking mutations in the tumor suppressor
MeSH term(s)	Adaptation, Biological/genetics ; Animals ; Biomarkers ; Chromosomal Instability ; Chromosome Segregation ; Gene Dosage ; Humans ; Karyotype ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Proteostasis ; Signal Transduction ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Biomarkers ; TP53 protein, human ; Tumor Suppressor Protein p53
Language	English
Publishing date	2018-11-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-18-1958
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Article ; Online: Influence of Teaching Styles on the Learning Academic Confidence of Teachers in Training.

Granero-Gallegos, Antonio / Escaravajal, Juan Carlos / López-García, Ginés David / Baños, Raúl

Journal of Intelligence

2022 Volume 10, Issue 3

Abstract: The objective of this research was to analyze the mediation of academic engagement and the satisfaction of basic needs between teaching styles and academic confidence amongst teachers during initial training. The research design was observational, ... ...

Abstract	The objective of this research was to analyze the mediation of academic engagement and the satisfaction of basic needs between teaching styles and academic confidence amongst teachers during initial training. The research design was observational, descriptive, cross-sectional, and non-randomized. In total, 920 university students in initial teacher training participated (61.85% women) (
Language	English
Publishing date	2022-09-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721035-2
ISSN	2079-3200 ; 2079-3200
ISSN (online)	2079-3200
ISSN	2079-3200
DOI	10.3390/jintelligence10030071
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