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  1. Article: Prothesenversorgung: "Nehmt euch Zeit für die Kinder!" Interview mit Benjamin Born

    Born, Benjamin

    Orthopädie-Technik

    2021  Volume 72, Issue 5, Page(s) 16

    Language German
    Document type Article
    ZDB-ID 207441-2
    ISSN 0340-5591
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 887: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Mild Cardiotoxicity and Continued Trastuzumab Treatment in the Context of HER2-Positive Breast Cancer.

    de la Brassinne Bonardeaux, Orianne / Born, Benjamin / Moonen, Marie / Lancellotti, Patrizio

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: Breast cancer is the leading cause of cancer death in women worldwide. Trastuzumab, the main HER2-targeted treatment, faces limitations due to potential cardiotoxicity. The management of patients with mild cardiotoxicity on trastuzumab remains uncertain, ...

    Abstract Breast cancer is the leading cause of cancer death in women worldwide. Trastuzumab, the main HER2-targeted treatment, faces limitations due to potential cardiotoxicity. The management of patients with mild cardiotoxicity on trastuzumab remains uncertain, resulting in treatment discontinuation and negative oncological outcomes. This retrospective study analyzed 23 patients who experienced decreased left ventricular function during trastuzumab treatment. During the 18-month follow-up period, two patients (9%) had severe declines in function, leading to treatment cessation, and one patient (4%) developed heart failure symptoms. However, 21 patients showed mild, reversible myocardial dysfunction without significant differences in final ventricular function compared to a control group (58.4% vs. 61.7%, respectively;
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How artificial intelligence can help us 'Choose Wisely'.

    Mehta, Nishila / Born, Karen / Fine, Benjamin

    Bioelectronic medicine

    2021  Volume 7, Issue 1, Page(s) 5

    Abstract: The overuse of low value medical tests and treatments drives costs and patient harm. Efforts to address overuse, such as Choosing Wisely campaigns, typically rely on passive implementation strategies- a form of low reliability system change. Embedding ... ...

    Abstract The overuse of low value medical tests and treatments drives costs and patient harm. Efforts to address overuse, such as Choosing Wisely campaigns, typically rely on passive implementation strategies- a form of low reliability system change. Embedding guidelines into clinical decision support (CDS) software is a higher leverage approach to provide ordering suggestions through an interface embedded within the clinical workflow. Growth in computing power is increasingly enabling artificial intelligence (AI) to augment such decision making tools. This article offers a roadmap of opportunities for AI-enabled CDS to reduce overuse, which are presented according to a patient's journey of care.
    Language English
    Publishing date 2021-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929561-0
    ISSN 2332-8886 ; 2332-8886
    ISSN (online) 2332-8886
    ISSN 2332-8886
    DOI 10.1186/s42234-021-00066-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Silver carboxylate-TiO

    Allu, Sai / Whitaker, Colin / Stone, Benjamin / Vishwanath, Neel / Clippert, Drew / Jouffroy, Elia / Antoci, Valentin / Born, Christopher / Garcia, Dioscaris R

    OTA international : the open access journal of orthopaedic trauma

    2024  Volume 7, Issue 2 Suppl, Page(s) e299

    Abstract: Introduction: With the rise in antibiotic resistance, new methodologies are needed to combat musculoskeletal infections. Silver is an antimicrobial that can be synthesized in different forms, but its pharmacokinetics are difficult to control. This study ...

    Abstract Introduction: With the rise in antibiotic resistance, new methodologies are needed to combat musculoskeletal infections. Silver is an antimicrobial that can be synthesized in different forms, but its pharmacokinetics are difficult to control. This study details the antibacterial efficacy and cellular cytotoxicity of a formulation consisting of silver carboxylate (AgCar) released through a titanium dioxide/polydimethylsiloxane matrix with a predictable release profile on
    Methods: Through an Institutional Animal Care and Use Committee and IRB-approved protocol, AgCar was applied to live Yucatan porcine skin and histologically analyzed for skin penetration. Graphite Furnace Atomic Absorption Spectroscopy (GFAAS) was used to measure elution of AgCar. Dose-response curves were generated through optical density to assess potency. Finally, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to quantify the cellular cytotoxicity of the novel formulation. The results were subject to statistical analysis using analysis of variance and post hoc Tukey tests.
    Results: The silver carboxylate coating demonstrated deep penetration into the epithelium at the level of the deep pilosebaceous glands in animal models. GFAAS testing demonstrated the extended elution profile of silver carboxylate over 96 hours, while 100% silver with no titanium dioxide-polydimethylsiloxane matrix fully eluted within 48 hours. 10x silver carboxylate demonstrated superior antimicrobial activity to antibiotics and other silver formulations and showed minimal cytotoxicity compared with other silver formulations.
    Discussion/clinical relevance: Current antimicrobial therapies in wound care and surgical antisepsis, such as chlorhexidine gluconate, have pitfalls including poor skin penetration and short duration of efficacy. The broad antimicrobial activity, extended elution, and deep skin penetration of this AgCar formulation show great promise for surgical site infection and wound care treatment. Novel technology to fight the growing threat of microbial resistance should be at the forefront of orthopaedic surgical site infection prevention and treatment.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2167
    ISSN (online) 2574-2167
    DOI 10.1097/OI9.0000000000000299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Location, Location, Location: Long-run Trends in Housing Markets and Regional Economic Development

    Dohmen, Martin [Verfasser] / Schularick, Moritz [Akademischer Betreuer] / Born, Benjamin [Gutachter]

    2022  

    Author's details Martin Dohmen ; Gutachter: Benjamin Born ; Betreuer: Moritz Schularick
    Keywords Wirtschaft ; Economics
    Subject code sg330
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: The lockdown effect: A counterfactual for Sweden.

    Born, Benjamin / Dietrich, Alexander M / Müller, Gernot J

    PloS one

    2021  Volume 16, Issue 4, Page(s) e0249732

    Abstract: While most countries imposed a lockdown in response to the first wave of COVID-19 infections, Sweden did not. To quantify the lockdown effect, we approximate a counterfactual lockdown scenario for Sweden through the outcome in a synthetic control unit. ... ...

    Abstract While most countries imposed a lockdown in response to the first wave of COVID-19 infections, Sweden did not. To quantify the lockdown effect, we approximate a counterfactual lockdown scenario for Sweden through the outcome in a synthetic control unit. We find, first, that a 9-week lockdown in the first half of 2020 would have reduced infections and deaths by about 75% and 38%, respectively. Second, the lockdown effect starts to materialize with a delay of 3-4 weeks only. Third, the actual adjustment of mobility patterns in Sweden suggests there has been substantial voluntary social restraint, although the adjustment was less strong than under the lockdown scenario. Lastly, we find that a lockdown would not have caused much additional output loss.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Female ; Humans ; Male ; Models, Biological ; Quarantine ; SARS-CoV-2 ; Sweden/epidemiology
    Language English
    Publishing date 2021-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0249732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The lockdown effect

    Benjamin Born / Alexander M Dietrich / Gernot J Müller

    PLoS ONE, Vol 16, Iss 4, p e

    A counterfactual for Sweden.

    2021  Volume 0249732

    Abstract: While most countries imposed a lockdown in response to the first wave of COVID-19 infections, Sweden did not. To quantify the lockdown effect, we approximate a counterfactual lockdown scenario for Sweden through the outcome in a synthetic control unit. ... ...

    Abstract While most countries imposed a lockdown in response to the first wave of COVID-19 infections, Sweden did not. To quantify the lockdown effect, we approximate a counterfactual lockdown scenario for Sweden through the outcome in a synthetic control unit. We find, first, that a 9-week lockdown in the first half of 2020 would have reduced infections and deaths by about 75% and 38%, respectively. Second, the lockdown effect starts to materialize with a delay of 3-4 weeks only. Third, the actual adjustment of mobility patterns in Sweden suggests there has been substantial voluntary social restraint, although the adjustment was less strong than under the lockdown scenario. Lastly, we find that a lockdown would not have caused much additional output loss.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Mild Cardiotoxicity and Continued Trastuzumab Treatment in the Context of HER2-Positive Breast Cancer

    Orianne de la Brassinne Bonardeaux / Benjamin Born / Marie Moonen / Patrizio Lancellotti

    Journal of Clinical Medicine, Vol 12, Iss 21, p

    2023  Volume 6708

    Abstract: Breast cancer is the leading cause of cancer death in women worldwide. Trastuzumab, the main HER2-targeted treatment, faces limitations due to potential cardiotoxicity. The management of patients with mild cardiotoxicity on trastuzumab remains uncertain, ...

    Abstract Breast cancer is the leading cause of cancer death in women worldwide. Trastuzumab, the main HER2-targeted treatment, faces limitations due to potential cardiotoxicity. The management of patients with mild cardiotoxicity on trastuzumab remains uncertain, resulting in treatment discontinuation and negative oncological outcomes. This retrospective study analyzed 23 patients who experienced decreased left ventricular function during trastuzumab treatment. During the 18-month follow-up period, two patients (9%) had severe declines in function, leading to treatment cessation, and one patient (4%) developed heart failure symptoms. However, 21 patients showed mild, reversible myocardial dysfunction without significant differences in final ventricular function compared to a control group (58.4% vs. 61.7%, respectively; p = 0.059). The declines in function were most pronounced at nine months but improved at twelve and eighteen months. Various echocardiographic parameters changed significantly over time. As predictors of severe cardiotoxicity, we identified the following: LVEF before initial chemotherapy ( p = 0.022), as well as baseline LVEF before treatment with trastuzumab ( p = 0.007); initial left ventricular end systolic volume ( p = 0.027); and the initial global longitudinal strain ( p = 0.021) and initial velocity time integral in the left ventricular outflow track ( p = 0.027). In conclusion, the continuation of trastuzumab should be considered for most patients with mild cardiotoxicity, with close cardiac monitoring and cardioprotective measures. However, identifying the patients at risk of developing severe cardiotoxicity is necessary. According to our data, the initial LVEF and GLS levels appear to be reliable predictors.
    Keywords trastuzumab cardiotoxicity ; cardiomyopathy ; HER2-positive breast cancer ; echocardiography ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Serum Adiponectin and Leptin Among Ghanaian Migrants in Amsterdam and Their Compatriots in Rural and Urban Ghana: The RODAM Study.

    Kusi-Mensah, Yaw A / Hayfron-Benjamin, Charles / Chetty, Sean / van der Linden, Eva L / Meeks, Karlijn Ac / Beune, Erik / Anokye-Danso, Frederick / Ahima, Rexford S / van den Born, Bert-Jan / Agyemang, Charles

    Clinical medicine insights. Endocrinology and diabetes

    2023  Volume 16, Page(s) 11795514231218592

    Abstract: Background: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified.!# ...

    Abstract Background: The rapidly rising cardiometabolic disease (CMD) burden in urbanizing sub-Saharan African populations and among sub-Saharan African migrants in Europe likely affects serum adiponectin and leptin levels, but this has not yet been quantified.
    Objectives: To compare the serum levels of adiponectin and leptin among migrant, and non-migrant (urban and rural) populations of Ghanaian descent.
    Methods: Cross-sectional analysis of serum leptin and adiponectin in the multi-centre Research on Obesity and Diabetes among African Migrants (RODAM) study. Logistic-regression models were used to examine the association between these adipocyte-derived hormones after stratification (sex, geographic area) and adjustments for potential confounders.
    Results: A total of 2518 Ghanaians were included. Rural participants had the highest serum adiponectin and lowest leptin levels compared to Amsterdam and urban Ghanaians (
    Conclusion: Urbanization is associated with serum adiponectin and leptin levels after adjusting for confounding covariates in sub-Saharan Africans. These findings serve as a backdrop for further research on the role adipokines play in CMD epidemiology among Africans.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2628990-8
    ISSN 1179-5514
    ISSN 1179-5514
    DOI 10.1177/11795514231218592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Macrovascular and renal microvascular complications in West Africans with intermediate hyperglycemia living in West Africa and Europe: The RODAM study.

    Bannerman-Williams, Emmanuel / Hayfron-Benjamin, Charles F / Atiase, Yacoba / Bahendeka, Silver / Meeks, Karlijn / Klipstein-Grobusch, Kerstin / Addo, Juliet / Mockenhaupt, Frank / Schulze, Matthias B / Beune, Erik / van den Born, Bert-Jan / Agyemang, Charles

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e19334

    Abstract: Background: Metabolic conditions, including intermediate hyperglycemia (IH), affect migrants to a greater extent than the populations of origin. Evidence suggests that IH increases the risk of vascular complications, but it is unclear whether the ... ...

    Abstract Background: Metabolic conditions, including intermediate hyperglycemia (IH), affect migrants to a greater extent than the populations of origin. Evidence suggests that IH increases the risk of vascular complications, but it is unclear whether the differences in IH between the non-migrant and migrant populations translate to differences in vascular complications between the two populations. We compared the prevalence of macrovascular and renal microvascular complications among West Africans with IH living in West Africa and their migrant compatriots in Europe.
    Methods: Data from the multicenter Research on Obesity and Diabetes among African Migrants(RODAM) study were analyzed. Ghanaians with IH(524 non-migrant and 1439 migrants) were included. Logistic regression analyses were used to determine the associations between migrant status and macrovascular [coronary artery disease(CAD) and peripheral artery disease(PAD)] and renal microvascular[nephropathy] complications with adjustment for age, sex, socioeconomic status, smoking, systolic blood pressure, BMI, total cholesterol, HbA1c, C-reactive protein, and serum uric acid.
    Findings: The prevalence of microvascular/macrovascular complications was higher in non-migrants than in migrants(nephropathy 15.3vs.9.7%; PAD 3.1%vs.1.3%; and CAD 15.8% vs. 5.0%). The differences persisted in the fully adjusted model: nephropathy [odds ratio, 2.12; 95% CI(1.46-3.08); PAD, 4.44(1.87-10.51); CAD 2.35(1.64-3.37)]. Non-migrant females had higher odds of nephropathy[2.14(1.34-3.43)], PAD[7.47(2.38-23.40)] and CAD [2.10(1.34-3.27)] compared to migrant females. Non-migrant males had higher odds of nephropathy[2.54(1.30-4.97)] and CAD[2.85(1.48-5.50)], but not PAD[1.81(0.32-10.29)],than their migrant peers.
    Interpretation: Macrovascular and renal microvascular complications were more prevalent in non-migrants than in migrant West Africans with IH. Further studies are needed to identify factors that increase the risk to aid preventive/treatment strategies.
    Language English
    Publishing date 2023-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e19334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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