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  1. Article ; Online: The looming pandemic of COVID-19: What therapeutic options do we have now?

    Afsar, Nasir Ali

    Journal of the Chinese Medical Association : JCMA

    2020  Volume 83, Issue 5, Page(s) 508–509

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Disease Outbreaks ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000000310
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  3. Article ; Online: The looming pandemic of COVID-19 ; What therapeutic options do we have now?

    Afsar, Nasir Ali

    Journal of the Chinese Medical Association

    2020  Volume 83, Issue 5, Page(s) 508–509

    Keywords General Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/jcma.0000000000000310
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 2699: Show issues Location:
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  4. Article: 25-Hydroxyvitamin-D deficiency in chronic kidney disease stages III, IV, and V in South Asian population: a retrospective cohort.

    Abdul Razzaque, Muhammad Raheel / Tebha, Sameer Saleem / Tukruna, Alaa / Arif, Aabiya / Kogut, Lucas Marian / Afsar, Nasir Ali / Shabbir, Dania / Zaidi, Zain Ali

    SAGE open medicine

    2023  Volume 11, Page(s) 20503121221148613

    Abstract: Objective: Vitamin D deficiency in Chronic Kidney Disease is a known fact, but the data regarding the prevalence and extent of vitamin D deficiency in different stages of Chronic Kidney Disease is scarce. This leads to a delay in addressing this issue. ... ...

    Abstract Objective: Vitamin D deficiency in Chronic Kidney Disease is a known fact, but the data regarding the prevalence and extent of vitamin D deficiency in different stages of Chronic Kidney Disease is scarce. This leads to a delay in addressing this issue. We conducted this study to assess vitamin-D deficiency in different stages of Chronic Kidney Disease to improve the evidence available to Physicians and Nephrologists which can help them better address this common finding in Chronic Kidney Disease.
    Methods: This retrospective study from a tertiary care hospital in Karachi, Pakistan, included adult Chronic Kidney Disease patients who had their serum 25 Hydroxy vitamin D levels done. The patients were classified according to stages of Chronic Kidney Disease using Estimated Glomerular Filtration Rate values. Appropriate statistical tests were performed to find a correlation between the severity of vitamin D deficiency in different stages of Chronic Kidney Disease with a statistically significant
    Results: In total, 148 patients were included in the study. All patients had serum 25 Hydroxy vitamin D levels less than 30 ng/ml. The severity of vitamin D deficiency was observed to increase progressively from stage 3A Chronic Kidney Disease through stage 5. Vitamin D levels in Chronic Kidney Disease stage 3 were significantly greater than in Chronic Kidney Disease stages 4 and 5 (
    Conclusion: All Chronic Kidney Disease patients in our study either had vitamin D insufficiency or deficiency. In addition, we observed a significant decrease in vitamin D levels from Chronic Kidney Disease stage 3 to stage 5. Greater serum phosphate levels were detected in stage 5 compared to stages 3A and 3B.
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2735399-0
    ISSN 2050-3121
    ISSN 2050-3121
    DOI 10.1177/20503121221148613
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  5. Article ; Online: Lung resistance-related protein (LRP) predicts favorable therapeutic outcome in Acute Myeloid Leukemia.

    Kulsoom, Bibi / Shamsi, Tahir Sultan / Afsar, Nasir Ali

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 378

    Abstract: There is conflicting evidence that MDR1, MRP2 and LRP expression is responsible for chemotherapy resistance. We conducted this study to explore their role in AML therapy outcomes. Bone marrow and peripheral blood samples of 90 AML patients, receiving ... ...

    Abstract There is conflicting evidence that MDR1, MRP2 and LRP expression is responsible for chemotherapy resistance. We conducted this study to explore their role in AML therapy outcomes. Bone marrow and peripheral blood samples of 90 AML patients, receiving chemotherapy, were analyzed by real time PCR. Gene expression was calculated by the 2
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B/biosynthesis ; Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Bone Marrow/metabolism ; Bone Marrow/pathology ; Cytarabine/administration & dosage ; Daunorubicin/administration & dosage ; Drug Resistance, Neoplasm ; Female ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/metabolism ; Leukemia, Promyelocytic, Acute/mortality ; Male ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Vault Ribonucleoprotein Particles/biosynthesis ; ATP-Binding Cassette Sub-Family B Member 4
    Chemical Substances ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; Neoplasm Proteins ; Vault Ribonucleoprotein Particles ; major vault protein ; Cytarabine (04079A1RDZ) ; Daunorubicin (ZS7284E0ZP)
    Language English
    Publishing date 2019-01-23
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-36780-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Learning clinical skills through audiovisual aids embedded in electronic-PBL sessions in undergraduate medical curriculum: perception and performance.

    Arain, Shoukat Ali / Afsar, Nasir Ali / Rohra, Dileep Kumar / Zafar, Muhammad

    Advances in physiology education

    2019  Volume 43, Issue 3, Page(s) 378–382

    Abstract: Learning clinical skills in a large group of undergraduate medical students is challenging. Innovative technology-based modalities are being evaluated to complement limited hospital rotations. We determined the effectiveness of clinical skills-related ... ...

    Abstract Learning clinical skills in a large group of undergraduate medical students is challenging. Innovative technology-based modalities are being evaluated to complement limited hospital rotations. We determined the effectiveness of clinical skills-related audiovisual (AV) aids embedded in electronic-problem-based learning (PBL) sessions, in terms of students' feedback and formative Objective Structured Clinical Examinations (OSCE) grades. This mixed-method study was conducted during the Cardiovascular System module in
    MeSH term(s) Audiovisual Aids ; Clinical Competence/standards ; Curriculum/standards ; Education, Medical, Undergraduate/methods ; Female ; Humans ; Male ; Problem-Based Learning/methods ; Students, Medical/psychology
    Language English
    Publishing date 2019-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024917-5
    ISSN 1522-1229 ; 1043-4046
    ISSN (online) 1522-1229
    ISSN 1043-4046
    DOI 10.1152/advan.00075.2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article: Gene expression of

    Kulsoom, Bibi / Shamsi, Tahir Sultan / Afsar, Nasir Ali

    Cancer management and research

    2018  Volume 10, Page(s) 5573–5589

    Abstract: Purpose: Acute myeloid leukemia patients are commonly treated with cytarabine (Ara-C) and anthracyclines but the sustained remission rate is not very promising. We explored the role of drug-metabolizing enzymes and transporters in the therapeutic ... ...

    Abstract Purpose: Acute myeloid leukemia patients are commonly treated with cytarabine (Ara-C) and anthracyclines but the sustained remission rate is not very promising. We explored the role of drug-metabolizing enzymes and transporters in the therapeutic response.
    Patients and methods: Bone marrow and peripheral blood samples of 90 newly diagnosed acute myeloid leukemia patients treated with standard 3+7 regimen were analyzed through real-time PCR for expression of human equilibrative nucleoside transporter 1, deoxycytidine kinase, cytidine deaminase (
    Results: High
    Conclusion: High expression of
    Language English
    Publishing date 2018-11-09
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S181299
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  8. Article ; Online: 25-Hydroxyvitamin-D deficiency in chronic kidney disease stages III, IV, and V in South Asian population

    Muhammad Raheel Abdul Razzaque / Sameer Saleem Tebha / Alaa Tukruna / Aabiya Arif / Lucas Marian Kogut / Nasir Ali Afsar / Dania Shabbir / Zain Ali Zaidi

    SAGE Open Medicine, Vol

    a retrospective cohort

    2023  Volume 11

    Abstract: Objective: Vitamin D deficiency in Chronic Kidney Disease is a known fact, but the data regarding the prevalence and extent of vitamin D deficiency in different stages of Chronic Kidney Disease is scarce. This leads to a delay in addressing this issue. ... ...

    Abstract Objective: Vitamin D deficiency in Chronic Kidney Disease is a known fact, but the data regarding the prevalence and extent of vitamin D deficiency in different stages of Chronic Kidney Disease is scarce. This leads to a delay in addressing this issue. We conducted this study to assess vitamin-D deficiency in different stages of Chronic Kidney Disease to improve the evidence available to Physicians and Nephrologists which can help them better address this common finding in Chronic Kidney Disease. Methods: This retrospective study from a tertiary care hospital in Karachi, Pakistan, included adult Chronic Kidney Disease patients who had their serum 25 Hydroxy vitamin D levels done. The patients were classified according to stages of Chronic Kidney Disease using Estimated Glomerular Filtration Rate values. Appropriate statistical tests were performed to find a correlation between the severity of vitamin D deficiency in different stages of Chronic Kidney Disease with a statistically significant p value of <0.05 and a 95% confidence interval. Results: In total, 148 patients were included in the study. All patients had serum 25 Hydroxy vitamin D levels less than 30 ng/ml. The severity of vitamin D deficiency was observed to increase progressively from stage 3A Chronic Kidney Disease through stage 5. Vitamin D levels in Chronic Kidney Disease stage 3 were significantly greater than in Chronic Kidney Disease stages 4 and 5 ( p value < 0.001), and stage 5 patients had the lowest vitamin D levels in our study. Similar, statistically significant findings were observed for serum phosphate levels, too, with stage 5 Chronic Kidney Disease patients having a greater serum phosphate concentration than stages 3A and 3B ( p value = 0.002, 0.006). Conclusion: All Chronic Kidney Disease patients in our study either had vitamin D insufficiency or deficiency. In addition, we observed a significant decrease in vitamin D levels from Chronic Kidney Disease stage 3 to stage 5. Greater serum phosphate levels were detected in stage 5 ...
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Stress, anxiety, and depression among medical students in a multiethnic setting.

    Kulsoom, Bibi / Afsar, Nasir Ali

    Neuropsychiatric disease and treatment

    2015  Volume 11, Page(s) 1713–1722

    Abstract: Background: Contemporary literature suggests that medical education might adversely affect students' mental health. Alfaisal University in Riyadh, Saudi Arabia is a developing institution; hence, there has been a concern regarding the mental well-being ... ...

    Abstract Background: Contemporary literature suggests that medical education might adversely affect students' mental health. Alfaisal University in Riyadh, Saudi Arabia is a developing institution; hence, there has been a concern regarding the mental well-being of the students.
    Objectives: This study was designed to assess the traits of depression, anxiety, and stress among students in relation to potential underlying reasons.
    Methods: All 575 medical students across the 5 years of study participated by filling out the Depression, Anxiety, and Stress Scale-21 (DASS-21) questionnaire anonymously twice. Firstly, 2-3 weeks before a major examination (pre-examination), and secondly, during regular classes (post-examination). Correlation was sought regarding sex, year of scholarship, attendance of a premedical university preparatory program (UPP), housing, and smoking. Subjective comments from students were also obtained.
    Results: A total of 76.8% and 74.9% of students participated in pre-and post-examination groups, respectively. The majority were the children of expatriate workers in Saudi Arabia, and included Arabs, South Asians, and North Americans. Prevalence of depression, anxiety, and stress was high (43%, 63%, and 41%, respectively) which reduced (to 30%, 47%, and 30%, respectively) to some extent after examinations. Saudis and those who had attended UPP had higher DASS-21 scores. Smoking and female sex predicted higher levels of "baseline" depression, anxiety, or stress. The students perceived the curriculum and schedule to be the primary causes of their high DASS-21 scores.
    Conclusion: The students had high "baseline" traits of depression, anxiety, and stress, and these were higher if an examination was near, especially among Saudis and those who had attended UPP. Smoking and female sex predicted higher levels of "baseline" depression, anxiety, or stress. Students suggested that study burden and a busy schedule were the major reasons for their high DASS-21 scores.
    Language English
    Publishing date 2015-07-16
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S83577
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  10. Article: Homeopathy--much ado about nothing?

    Afsar, Nasir Ali

    JPMA. The Journal of the Pakistan Medical Association

    2007  Volume 57, Issue 5, Page(s) 275

    MeSH term(s) Evidence-Based Medicine ; Homeopathy ; Humans ; Pakistan
    Language English
    Publishing date 2007-05
    Publishing country Pakistan
    Document type Letter
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
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