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Book: Kompetenzorientiertes Manual zur Behandlung von Störungen der sozialen Interaktion

Schilbach, Leonhard / Bartholomäus, Marie / Böhm, Juliane / Buchholz, Felicitas / Parpart, Hella / Albantakis, Laura / Thaler, Hanna

2022

Author's details	Leonhard Schilbach, Marie Bartholomäus, Juliane Böhm, Felicitas Buchholz, Hella Parpart, Laura Albantakis, Hanna Thaler
Keywords	Interaktion ; Psychische Störung ; Psychotherapie
Subject	Behandlung ; Psychologische Behandlung ; Seelische Störung ; Mental disorder ; Psychische Krankheit ; Seelische Krankheit ; Psychiatrische Krankheit ; Psychische Erkrankung ; Psychische Störungen ; Interaktionsprozess ; Interaktives Verhalten ; Interpersonelle Interaktion ; Personale Interaktion ; Soziale Beziehung ; Soziale Interaktion ; Interaktionen
Language	German
Size	XII, 158 Seiten, Illustrationen, 27 cm x 21 cm, 477 g
Edition	1. Auflage
Publisher	Elsevier
Publishing place	München
Publishing country	Germany
Document type	Book
Note	Mit Freischalt-Code zu Online-Inhalten ; "+ Plus im Web" - Titelumschlag
HBZ-ID	HT021322041
ISBN	978-3-437-22621-2 ; 3-437-22621-5 ; 9783437063602 ; 343706360X
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Treatment Effects in Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale-Reply.

Kent, David M / Saver, Jeffrey L / Thaler, David E

JAMA

2022 Volume 327, Issue 14, Page(s) 1403

MeSH term(s)	Cardiac Catheterization ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/surgery ; Humans ; Randomized Controlled Trials as Topic ; Risk Factors ; Secondary Prevention ; Septal Occluder Device ; Stroke/therapy ; Treatment Outcome
Language	English
Publishing date	2022-04-12
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2022.2661
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Article ; Online: Correction to: Disruption of joint arthroplasty services in Europe during the COVID-19 pandemic: an online survey within the European Hip Society (EHS) and the European Knee Associates (EKA).

Thaler, M / Khosravi, Ismail / Hirschmann, M T / Kort, N P / Zagra, L / Epinette, J A / Liebensteiner, M C

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

2023 Volume 31, Issue 12, Page(s) 6125

Language	English
Publishing date	2023-10-23
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1159064-6
ISSN	1433-7347 ; 0942-2056
ISSN (online)	1433-7347
ISSN	0942-2056
DOI	10.1007/s00167-023-07636-0
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Article: Functional Precision Medicine Successfully Guides Therapeutic Regimen of 'Cancer of Unknown Primary' Later Classified as Triple-Negative Breast Cancer: A Case Report.

Ruhe, Larissa / Heibl, Sonja / Czompo, Manfred / Haybaeck, Johannes / Loskutov, Jürgen / Regenbrecht, Manuela Johanna / Thaler, Josef / Wedeken, Lena / Alexander Regenbrecht, Christian René

Case reports in oncology

2024 Volume 17, Issue 1, Page(s) 490–496

Abstract: Introduction: Controlled randomized trials, molecular analytics, and guideline recommendations have so far been irreplaceable tools to ensure appropriate treatment and decision-making for physicians and patients. Individual patient models are ... ...

Abstract	Introduction: Controlled randomized trials, molecular analytics, and guideline recommendations have so far been irreplaceable tools to ensure appropriate treatment and decision-making for physicians and patients. Individual patient models are increasingly complementing these methods, particularly in the case of advanced cancers, rare cancers, and cancers of unknown primary (CUP), as in these cases comprehensive clinical evidence is unavailable, often resulting in poor treatment success, even after stratification. Case presentation: Here we report a 53-year-old patient with CUP with axillary lymph node metastases for whom patient-derived 3D (PD3D Conclusion: We conclude that pre-therapeutic drug sensitivity screening with PD3D tumor models can be essential in guiding and enabling an effective personalized treatment for patients with hard-to-treat cancers, like CUP or TNBC.
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000538137
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Article: Detection of Cellular Senescence Reveals the Existence of Senescent Tumor Cells within Invasive Breast Carcinomas and Related Metastases.

Cotarelo, Cristina L / Schad, Arno / Schmidt, Marcus / Hönig, Arnd / Sleeman, Jonathan P / Thaler, Sonja

Cancers

2023 Volume 15, Issue 6

Abstract: Oncogene-induced senescence is thought to constitute a barrier to carcinogenesis by arresting cells at risk of malignant transformation. However, numerous findings suggest that senescent cells may conversely promote tumor growth and metastatic ... ...

Abstract	Oncogene-induced senescence is thought to constitute a barrier to carcinogenesis by arresting cells at risk of malignant transformation. However, numerous findings suggest that senescent cells may conversely promote tumor growth and metastatic progression, for example, through the senescence-associated secretory phenotype (SASP) they produce. Here, we investigated the degree to which senescent tumor cells exist within untreated human primary breast carcinomas and whether the presence of senescent cancer cells in primary tumors is recapitulated in their matched lymph node metastases. For the detection of senescence, we used SA-β-galactosidase (SA-β-gal) staining and other senescence markers such as Ki67, p21, p53, and p16. In patients with invasive luminal A and B breast carcinomas, we found broad similarities in the appearance of cancer cells between primary tumors and their corresponding metastases. Analysis of lymph nodes from patients with other breast cancer subtypes also revealed senescent tumor cells within metastatic lesions. Collectively, our findings show that senescent tumor cells exist within primary breast carcinomas and metastatic lesions. These results suggest a potential role for senescent breast tumor cells during metastatic progression and raise the question as to whether the targeting of senescent tumor cells with anti-senescent drugs might represent a novel avenue for improved treatment of breast and other cancers.
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061860
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Article ; Online: Multisensory perception and decision-making with a new sensory skill.

Negen, James / Bird, Laura-Ashleigh / Slater, Heather / Thaler, Lore / Nardini, Marko

Journal of experimental psychology. Human perception and performance

2023 Volume 49, Issue 5, Page(s) 600–622

Abstract: It is clear that people can learn a new sensory skill-a new way of mapping sensory inputs onto world states. It remains unclear how flexibly a new sensory skill can become embedded in multisensory perception and decision-making. To address this, we ... ...

Abstract	It is clear that people can learn a new sensory skill-a new way of mapping sensory inputs onto world states. It remains unclear how flexibly a new sensory skill can become embedded in multisensory perception and decision-making. To address this, we trained typically sighted participants (N = 12) to use a new echo-like auditory cue to distance in a virtual world, together with a noisy visual cue. Using model-based analyses, we tested for key markers of efficient multisensory perception and decision-making with the new skill. We found that 12 of 14 participants learned to judge distance using the novel auditory cue. Their use of this new sensory skill showed three key features: (a) It enhanced the speed of timed decisions; (b) it largely resisted interference from a simultaneous digit span task; and (c) it integrated with vision in a Bayes-like manner to improve precision. We also show some limits following this relatively short training: Precision benefits were lower than the Bayes-optimal prediction, and there was no forced fusion of signals. We conclude that people already embed new sensory skills in flexible multisensory perception and decision-making after a short training period. A key application of these insights is to the development of sensory augmentation systems that can enhance human perceptual abilities in novel ways. The limitations we reveal (sub-optimality, lack of fusion) provide a foundation for further investigations of the limits of these abilities and their brain basis. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Visual Perception ; Bayes Theorem ; Learning ; Auditory Perception ; Photic Stimulation
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	189734-2
ISSN	1939-1277 ; 0096-1523
ISSN (online)	1939-1277
ISSN	0096-1523
DOI	10.1037/xhp0001114
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Article ; Online: Clinical practice of continuous rhythm monitoring after embolic stroke of undetermined source.

von Falkenhausen, Aenne Solvejg / Wischmann, Johannes / Keidel, Linus M / Kellnar, Antonia M / Thaler, Raffael / Lackermair, Korbinian / Estner, Heidi L / Höglinger, Günter / Massberg, Steffen / Kääb, Stefan / Kellert, Lars / Sinner, Moritz F

PloS one

2024 Volume 19, Issue 4, Page(s) e0302404

Abstract: Aims: Embolic stroke of undetermined source (ESUS) accounts for up to 20% of ischemic strokes annually. Undetected atrial fibrillation (AF) is one important potential underlying cause. For AF, oral anticoagulation has evolved as the most preferable ... ...

Abstract	Aims: Embolic stroke of undetermined source (ESUS) accounts for up to 20% of ischemic strokes annually. Undetected atrial fibrillation (AF) is one important potential underlying cause. For AF, oral anticoagulation has evolved as the most preferable means of secondary stroke prevention. To detect unrecognized paroxysmal AF, long-term ECG monitoring is required, and implantable cardiac monitors (ICM) appear most suitable. Yet, ICMs are particularly costly, implantation is invasive, and remote monitoring places a personnel burden on health care providers. Here, we use data from a large cohort of ESUS patients to systematically analyze the effort of ICM remote monitoring for AF diagnosis and the strain on health care providers. Methods and results: From a prospective, single-center, observational ESUS registry, we analyzed all ICM-equipped patients post-ESUS (n = 172) between January 1st, 2018, and December 31st, 2019. Through January 2nd, 2023, 48 patients (27.9%) were diagnosed with AF by ICM remote monitoring. During follow-up, a total of 29,180 remote monitoring episodes were transmitted, of which 17,742 were alarms for AF. A systematic estimation of workload revealed that on average, 20.3 trained physician workhours are required to diagnose one patient with AF. Conclusion: ICM remote monitoring is useful to diagnose AF in cohort of post-ESUS patients. However, the number of ICM alarms is high, even in a cohort at known high risk of AF and in whom AF detection is therapeutically consequential. Improved automated event classification, clear recommendations for ICM interrogation after AF diagnosis, and a careful patient selection for ICM monitoring are warranted.
MeSH term(s)	Humans ; Embolic Stroke/complications ; Prospective Studies ; Risk Factors ; Atrial Fibrillation/complications ; Stroke
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302404
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Article ; Online: Human Echolocators Have Better Localization Off Axis.

Thaler, Lore / Norman, L J / De Vos, H P J C / Kish, D / Antoniou, M / Baker, C J / Hornikx, M C J

Psychological science

2022 Volume 33, Issue 7, Page(s) 1143–1153

Abstract: Here, we report novel empirical results from a psychophysical experiment in which we tested the echolocation abilities of nine blind adult human experts in click-based echolocation. We found that they had better acuity in localizing a target and used ... ...

Abstract	Here, we report novel empirical results from a psychophysical experiment in which we tested the echolocation abilities of nine blind adult human experts in click-based echolocation. We found that they had better acuity in localizing a target and used lower intensity emissions (i.e., mouth clicks) when a target was placed 45° off to the side compared with when it was placed at 0° (straight ahead). We provide a possible explanation of the behavioral result in terms of binaural-intensity signals, which appear to change more rapidly around 45°. The finding that echolocators have better echo-localization off axis is surprising, because for human source localization (i.e., regular spatial hearing), it is well known that performance is best when targets are straight ahead (0°) and decreases as targets move farther to the side. This may suggest that human echolocation and source hearing rely on different acoustic cues and that human spatial hearing has more facets than previously thought.
MeSH term(s)	Adult ; Animals ; Cues ; Echolocation ; Hearing ; Humans ; Mouth ; Sound Localization
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2022256-7
ISSN	1467-9280 ; 0956-7976
ISSN (online)	1467-9280
ISSN	0956-7976
DOI	10.1177/09567976211068070
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Article ; Online: R-Propranolol Has Broad-Spectrum Anti-Coronavirus Activity and Suppresses Factors Involved in Pathogenic Angiogenesis.

Thaler, Melissa / Salgado-Benvindo, Clarisse / Leijs, Anouk / Tas, Ali / Ninaber, Dennis K / Arbiser, Jack L / Snijder, Eric J / van Hemert, Martijn J

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: The SARS-CoV-2 pandemic highlighted the need for broad-spectrum antivirals to increase our preparedness. Patients often require treatment by the time that blocking virus replication is less effective. Therefore, therapy should not only aim to inhibit the ...

Abstract	The SARS-CoV-2 pandemic highlighted the need for broad-spectrum antivirals to increase our preparedness. Patients often require treatment by the time that blocking virus replication is less effective. Therefore, therapy should not only aim to inhibit the virus, but also to suppress pathogenic host responses, e.g., leading to microvascular changes and pulmonary damage. Clinical studies have previously linked SARS-CoV-2 infection to pathogenic intussusceptive angiogenesis in the lungs, involving the upregulation of angiogenic factors such as ANGPTL4. The β-blocker propranolol is used to suppress aberrant ANGPTL4 expression in the treatment of hemangiomas. Therefore, we investigated the effect of propranolol on SARS-CoV-2 infection and the expression of ANGPTL4. SARS-CoV-2 upregulated ANGPTL4 in endothelial and other cells, which could be suppressed with R-propranolol. The compound also inhibited the replication of SARS-CoV-2 in Vero-E6 cells and reduced the viral load by up to ~2 logs in various cell lines and primary human airway epithelial cultures. R-propranolol was as effective as S-propranolol but lacks the latter's undesired β-blocker activity. R-propranolol also inhibited SARS-CoV and MERS-CoV. It inhibited a post-entry step of the replication cycle, likely via host factors. The broad-spectrum antiviral effect and suppression of factors involved in pathogenic angiogenesis make R-propranolol an interesting molecule to further explore for the treatment of coronavirus infections.
MeSH term(s)	Animals ; Chlorocebus aethiops ; Humans ; COVID-19 ; Propranolol/pharmacology ; SARS-CoV-2 ; Vero Cells ; Cell Line ; Antiviral Agents/pharmacology ; Virus Replication
Chemical Substances	Propranolol (9Y8NXQ24VQ) ; Antiviral Agents
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054588
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Article ; Online: Evaluation of Classic and Quantitative Imaging Features in the Differentiation of Benign and Atypical Lipomatous Soft Tissue Tumors Using a Standardized Multiparametric MRI Protocol: A Prospective Single-Centre Study in 45 Patients.

Gruber, Leonhard / Kremser, Christian / Zelger, Bettina / Schwabegger, Anton / Josip, Ena / Dammerer, Dietmar / Thaler, Martin / Henninger, Benjamin

Current oncology (Toronto, Ont.)

2023 Volume 30, Issue 3, Page(s) 3315–3328

Abstract: Background: Discrimination between benign and atypical lipomatous tumors (ALT) is important due to potential local complications and recurrence of ALT but can be difficult due to the often-similar imaging appearance. Using a standardized MRI protocol, ... ...

Abstract	Background: Discrimination between benign and atypical lipomatous tumors (ALT) is important due to potential local complications and recurrence of ALT but can be difficult due to the often-similar imaging appearance. Using a standardized MRI protocol, this study aimed to rank established and quantitative MRI features by diagnostic value in the differentiation of benign and atypical lipomatous tumors and to develop a robust scoring system. Methods: Patients with clinical or sonographic suspicion of a lipomatous tumor were prospectively and consecutively enrolled from 2015 to 2019 after ethic review board approval. Histology was confirmed for all ALT and 85% of the benign cases. Twenty-one demographic and morphologic and twenty-three quantitative features were extracted from a standardized MRI protocol (T1/T2-proton-density-weighting, turbo-inversion recovery magnitude, T2* multi-echo gradient-echo imaging, qDIXON-Vibe fat-quantification, T1 relaxometry, T1 mapping, diffusion-weighted and post-contrast sequences). A ranking of these features was generated through a Bayes network analysis with gain-ratio feature evaluation. Results: Forty-five patients were included in the analysis (mean age, 61.2 ± 14.2 years, 27 women [60.0%]). The highest-ranked ALT predictors were septation thickness (gain ratio merit [GRM] 0.623 ± 0.025, Conclusions: Several single MRI features have a substantial diagnostic value in the identification of ALT, yet a multiparametric approach by a simple combination algorithm may support radiologists in the identification of lipomatous tumors in need for further histological assessment.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Multiparametric Magnetic Resonance Imaging ; Prospective Studies ; Bayes Theorem ; Lipoma/diagnostic imaging ; Soft Tissue Neoplasms/diagnostic imaging ; Liposarcoma/diagnosis ; Liposarcoma/pathology
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol30030252
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