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  1. Article: Colostrum and Lactoferrin Protect against Side Effects of Therapy with Antibiotics, Anti-inflammatory Drugs and Steroids, and Psychophysical Stress: A Comprehensive Review.

    Artym, Jolanta / Zimecki, Michał

    Biomedicines

    2023  Volume 11, Issue 4

    Abstract: In this article, we review the benefits of applying bovine colostrum (BC) and lactoferrin (LF) in animal models and clinical trials that include corticosteroid application and psychic stress, treatment with non-steroid anti-inflammatory drugs (NSAIDs) ... ...

    Abstract In this article, we review the benefits of applying bovine colostrum (BC) and lactoferrin (LF) in animal models and clinical trials that include corticosteroid application and psychic stress, treatment with non-steroid anti-inflammatory drugs (NSAIDs) and antibiotics. A majority of the reported investigations were performed with native bovine or recombinant human LF, applied alone or in combination with probiotics, as nutraceutics and diet supplements. Apart from reducing adverse side effects of the applied therapeutics, BC and LF augmented their efficacy and improved the wellness of patients. In conclusion, LF and complete native colostrum, preferably administered with probiotic bacteria, are highly recommended for inclusion in therapeutic protocols in NSAIDs and corticosteroid anti-inflammatory, as well as antibiotic, therapies. These colostrum-based products can also be of value for individuals subjected to prolonged psychophysical stress (mediated by endogenous corticosteroids), especially at high ambient temperatures (soldiers and emergency services), as well as physically active people and training athletes. They are also recommended for patients during recovery from trauma and surgery, which are always associated with severe psychophysical stress.
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11041015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Colostrum Proteins in Protection against Therapy-Induced Injuries in Cancer Chemo- and Radiotherapy: A Comprehensive Review.

    Artym, Jolanta / Zimecki, Michał

    Biomedicines

    2023  Volume 11, Issue 1

    Abstract: In this article, we review the benefits of application of colostrum and colostrum-derived proteins in animal models and clinical trials that include chemotherapy with antimetabolic drugs, radiotherapy and surgical interventions. A majority of the ... ...

    Abstract In this article, we review the benefits of application of colostrum and colostrum-derived proteins in animal models and clinical trials that include chemotherapy with antimetabolic drugs, radiotherapy and surgical interventions. A majority of the reported investigations was performed with bovine colostrum (BC) and native bovine or recombinant human lactoferrin (LF), applied alone, in nutraceutics or in combination with probiotics. Apart from reducing side effects of the applied therapeutics, radiation and surgical procedures, BC and LF augmented their efficacy and improved the wellness of patients. In conclusion, colostrum and colostrum proteins, preferably administered with probiotic bacteria, are highly recommended for inclusion to therapeutic protocols in cancer chemo- and radiotherapy as well as during the surgical treatment of cancer patients.
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11010114
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  3. Article ; Online: Potential impact of obligatory use of opioids in invasive procedures on interpretation of experimental data

    Michał Zimecki

    Postępy Higieny i Medycyny Doświadczalnej, Vol 72, Pp 52-

    2018  Volume 57

    Abstract: Application of opioids as an analgesic drug is a common practice in the prevention of pain in patients and experimental animals in highly invasive procedures. Very recently, new legal regulations were implemented that broaden the application of ... ...

    Abstract Application of opioids as an analgesic drug is a common practice in the prevention of pain in patients and experimental animals in highly invasive procedures. Very recently, new legal regulations were implemented that broaden the application of analgesics in procedures where pain relievers have not been previously obligatory. However, in light of hitherto studies, the application of opioids has adverse effects on the condition of animals in experiments. Harmful effects of opioids include: lower intake of water and food, weight loss, increased mortality, susceptibility to infection by experimental pathogens and chemicals inducing pathological changes. The above listed actions, induced by opioids, may significantly affect interpretation of experimental data. The aim of this article is to review selected studies in animal models, mainly on the application of morphine and buprenorphine, including the mechanism of opioid action. Alternative methods of analgesia, involving other types of pain relievers, such as non-steroid anti-inflammatory drugs, are also described. Since opioids significantly affect the values of investigated parameters, some experimental procedures should be probably modified in order to lower the detrimental effects of this class of pain relievers. In consequence, new protocols would probably consider the application of lower doses of compounds or pathogens required for the induction of defined, experimentally induced disease states. A wider application of analgesics, of a different mechanism of action than opioids, would also be an alternative.
    Keywords opioids ; morphine ; buprenorphine ; experimental protocols ; ethics committee ; Medicine ; R
    Subject code 630
    Language English
    Publishing date 2018-02-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Antimicrobial and Prebiotic Activity of Lactoferrin in the Female Reproductive Tract: A Comprehensive Review.

    Artym, Jolanta / Zimecki, Michał

    Biomedicines

    2021  Volume 9, Issue 12

    Abstract: Women's intimate health depends on several factors, such as age, diet, coexisting metabolic disorders, hormonal equilibrium, sexual activity, drug intake, contraception, surgery, and personal hygiene. These factors may affect the homeostasis of the ... ...

    Abstract Women's intimate health depends on several factors, such as age, diet, coexisting metabolic disorders, hormonal equilibrium, sexual activity, drug intake, contraception, surgery, and personal hygiene. These factors may affect the homeostasis of the internal environment of the genital tract: the vulva, vagina and cervix. This equilibrium is dependent on strict and complex mutual interactions between epithelial cells, immunocompetent cells and microorganisms residing in this environment. The microbiota of the genital tract in healthy women is dominated by several species of symbiotic bacteria of the
    Language English
    Publishing date 2021-12-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9121940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of Modifications on the Immunosuppressive Properties of Cyclolinopeptide A and Its Analogs in Animal Experimental Models.

    Zimecki, Michał / Kaczmarek, Krzysztof

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 9

    Abstract: The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed. The modifications included ... ...

    Abstract The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed. The modifications included truncation of the peptide chain, replacement of amino acid residues with proteinogenic or non-proteinogenic ones, modifications of peptide bond, and others. The studies revealed changes in the immunosuppressive potency of these analogs investigated in a number of in vitro and in vivo experimental models, predominantly in rodents, as well as differences in their postulated mechanism of action. The modified peptides were compared with cyclosporine A and parent CLA. Some of the synthesized and investigated peptides show potential therapeutic usefulness.
    MeSH term(s) Amino Acid Sequence/genetics ; Animals ; Bedding and Linens ; Immunosuppressive Agents/chemistry ; Immunosuppressive Agents/pharmacology ; Models, Animal ; Peptides/chemistry ; Peptides/genetics ; Peptides/pharmacology ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/genetics ; Peptides, Cyclic/pharmacology ; Seeds/chemistry ; Structure-Activity Relationship
    Chemical Substances Immunosuppressive Agents ; Peptides ; Peptides, Cyclic ; cyclolinopeptide A
    Language English
    Publishing date 2021-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26092538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article: Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation.

    Burster, Timo / Mustafa, Zhadyra / Myrzakhmetova, Dinara / Zhanapiya, Anuar / Zimecki, Michal

    Frontiers in chemistry

    2021  Volume 9, Page(s) 784003

    Abstract: During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, ...

    Abstract During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing.
    Language English
    Publishing date 2021-11-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2021.784003
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  7. Article ; Online: Effects of Modifications on the Immunosuppressive Properties of Cyclolinopeptide A and Its Analogs in Animal Experimental Models

    Michał Zimecki / Krzysztof Kaczmarek

    Molecules, Vol 26, Iss 2538, p

    2021  Volume 2538

    Abstract: The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed. The modifications included ... ...

    Abstract The consequences of manipulations in structure and amino acid composition of native cyclolinopeptide A (CLA) from linen seeds, and its linear precursor on their biological activities and mechanisms of action, are reviewed. The modifications included truncation of the peptide chain, replacement of amino acid residues with proteinogenic or non-proteinogenic ones, modifications of peptide bond, and others. The studies revealed changes in the immunosuppressive potency of these analogs investigated in a number of in vitro and in vivo experimental models, predominantly in rodents, as well as differences in their postulated mechanism of action. The modified peptides were compared with cyclosporine A and parent CLA. Some of the synthesized and investigated peptides show potential therapeutic usefulness.
    Keywords cyclolinopeptide A (CLA) ; cyclosporine A ; immunosuppression ; PGE2 ; edge-to-face ; cis -peptide bond ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  8. Article ; Online: Antiviral Activity of a Cyclic Pro-Pro-

    Zaczyńska, Ewa / Kaczmarek, Krzysztof / Zabrocki, Janusz / Artym, Jolanta / Zimecki, Michał

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 11

    Abstract: The core of Cyclolinopeptide A (CLA, cyclo(LIILVPPFF)), responsible for its high immunosuppressive activity, contains a Pro-Pro-Phe-Phe sequence. A newly synthesized cyclic tetrapeptide, cyclo(Pro-Pro- ...

    Abstract The core of Cyclolinopeptide A (CLA, cyclo(LIILVPPFF)), responsible for its high immunosuppressive activity, contains a Pro-Pro-Phe-Phe sequence. A newly synthesized cyclic tetrapeptide, cyclo(Pro-Pro-
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Dipeptides ; Herpesvirus 1, Human ; Immunosuppressive Agents/pharmacology ; Mice ; Peptides ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/pharmacology
    Chemical Substances Antiviral Agents ; Dipeptides ; Immunosuppressive Agents ; Peptides ; Peptides, Cyclic ; prolyl-proline
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27113552
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article: Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review.

    Artym, Jolanta / Zimecki, Michał / Kruzel, Marian L

    Biomedicines

    2021  Volume 9, Issue 8

    Abstract: Pregnancy is a physiological state that demands higher level of nutrients, including vitamins and minerals, for the growth and maintenance of the fetus. Iron deficiency is a part of most common diet deficiencies in pregnancy and has high clinical ... ...

    Abstract Pregnancy is a physiological state that demands higher level of nutrients, including vitamins and minerals, for the growth and maintenance of the fetus. Iron deficiency is a part of most common diet deficiencies in pregnancy and has high clinical significance leading to the development of syderopenic anemia and its consequences for mother and child, such as higher risk of perinatal death, susceptibility to infection, intra-uteral growth inhibition, prematurity and low birth weight. Hence, iron supplementation is recommended for pregnant women; however dietary intake of iron from most commercially available formulas is often insufficient due to iron-poor bioavailability, or have undesired side-effects in the gastrointestinal tract, resulting in a discouraging and distrustful attitude to such treatment. The results of numerous studies indicate that diet supplementation with lactoferrin (LTF), an iron-binding protein, may be advantageous in prophylaxis and treatment of iron deficiency anemia. LTF, administered orally, normalizes iron homeostasis, not only by facilitating iron absorption, but also by inhibiting inflammatory processes responsible for anemia of chronic diseases, characterized by a functional iron deficit for physiological processes. LTF also protects against infections and inflammatory complications, caused by diagnostic surgical interventions in pregnant women. Beneficial, multidirectional actions of LTF during pregnancy encompass, in addition, inhibition of oxidative stress, normalization of intestine and genital tract microbiota and carbohydrate-lipid metabolism, protection of intestine barrier function, promotion of wound healing, as well as hypotensive, analgesic and antistress actions. Bovine lactoferrin (BLTF) is readily available on the nutritional market and generally recognized as safe (GRAS) for use in human diet.
    Language English
    Publishing date 2021-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9080898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Journal Impact Factor and Self-Citations.

    Górski, Andrzej / Zimecki, Michał / Krotkiewski, Hubert

    Archivum immunologiae et therapiae experimentalis

    2021  Volume 69, Issue 1, Page(s) 21

    MeSH term(s) Bibliometrics ; Humans ; Journal Impact Factor ; Publishing
    Language English
    Publishing date 2021-08-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 282209-x
    ISSN 1661-4917 ; 0004-069X
    ISSN (online) 1661-4917
    ISSN 0004-069X
    DOI 10.1007/s00005-021-00621-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 393: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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