LIVIVO - Search results -

Search results

Result 1 - 10 of total 14

Search options

Article ; Online: Intracanal microbiome profiles of two apical periodontitis cases in one patient: A comparison with saliva and plaque profiles.

Yamaki, Keiko / Tamahara, Toru / Washio, Jumpei / Sato, Takuichi / Shimizu, Ritsuko / Yamada, Satoru

Clinical and experimental dental research

2024 Volume 10, Issue 2, Page(s) e862

Abstract: Objectives: To determine the characteristics of the endodontic microbiome.: Material and methods: Saliva, plaque, and infected root canal wall dentin of two teeth suffering from apical periodontitis were harvested from a 58-year-old man. Bacterial ... ...

Abstract	Objectives: To determine the characteristics of the endodontic microbiome. Material and methods: Saliva, plaque, and infected root canal wall dentin of two teeth suffering from apical periodontitis were harvested from a 58-year-old man. Bacterial DNA was extracted from each sample, and 16S rRNA gene analysis targeting the V3-V4 region was conducted on the Illumina MiSeq platform using QIIME2. The functional potential of the microbiomes was inferred using PICRUSt2. Results: The four microbiomes were different in structure and membership, yet the nine most abundant metabolic pathways were common among them. The two endodontic microbiomes were more anaerobic, rich in Firmicutes, and scarce in Actinobacteriota and Proteobacteria, compared with saliva and plaque microbiomes. Their profiles were dissimilar despite their clinical and radiographic similarities. Conclusions: The endodontic microbiomes were anaerobic, rich in Firmicutes, scarce in Actinobacteriota and Proteobacteria, and considerably varied within an individual.
MeSH term(s)	Male ; Humans ; Middle Aged ; Saliva ; RNA, Ribosomal, 16S/genetics ; Dental Plaque ; Periapical Periodontitis ; Microbiota/genetics
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2829558-4
ISSN	2057-4347 ; 2057-4347
ISSN (online)	2057-4347
ISSN	2057-4347
DOI	10.1002/cre2.862
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions.

Ochiai, Kyoko / Shima, Hiroki / Tamahara, Toru / Sugie, Nao / Funayama, Ryo / Nakayama, Keiko / Kurosaki, Tomohiro / Igarashi, Kazuhiko

The EMBO journal

2024

Abstract: Transcription factors BACH2 and IRF4 are both essential for antibody class-switch recombination (CSR) in activated B lymphocytes, while they oppositely regulate the differentiation of plasma cells (PCs). Here, we investigated how BACH2 and IRF4 interact ... ...

Abstract	Transcription factors BACH2 and IRF4 are both essential for antibody class-switch recombination (CSR) in activated B lymphocytes, while they oppositely regulate the differentiation of plasma cells (PCs). Here, we investigated how BACH2 and IRF4 interact during CSR and plasma-cell differentiation. We found that BACH2 organizes heterochromatin formation of target gene loci in mouse splenic B cells, including targets of IRF4 activation such as Aicda, an inducer of CSR, and Prdm1, a master plasma-cell regulator. Release of these gene loci from heterochromatin in response to B-cell receptor stimulation was coupled to AKT-mTOR pathway activation. In Bach2-deficient B cells, PC genes' activation depended on IRF4 protein accumulation, without an increase in Irf4 mRNA. Mechanistically, a PU.1-IRF4 heterodimer in activated B cells promoted BACH2 function by inducing gene expression of Bach2 and Pten, a negative regulator of AKT signaling. Elevated AKT activity in Bach2-deficient B cells resulted in IRF4 protein accumulation. Thus, BACH2 and IRF4 mutually modulate the activity of each other, and BACH2 inhibits PC differentiation by both the repression of PC genes and the restriction of IRF4 protein accumulation.
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/s44318-024-00077-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Significance of Bile in the Biliopancreatic Limb on Metabolic Improvement After Duodenal-Jejunal Bypass.

Kawana, Tomomi / Imoto, Hirofumi / Tanaka, Naoki / Tsuchiya, Takahiro / Yamamura, Akihiro / Saijo, Fumito / Maekawa, Masamitsu / Tamahara, Toru / Shimizu, Ritsuko / Nakagawa, Kei / Ohnuma, Shinobu / Kamei, Takashi / Unno, Michiaki

Obesity surgery

2024 Volume 34, Issue 5, Page(s) 1665–1673

Abstract: Introduction: Duodenal-jejunal bypass (DJB) is an experimental procedure in metabolic surgery that does not have a restrictive component. Changes in bile acid (BA) dynamics and intestinal microbiota are possibly related to metabolic improvement after ... ...

Abstract	Introduction: Duodenal-jejunal bypass (DJB) is an experimental procedure in metabolic surgery that does not have a restrictive component. Changes in bile acid (BA) dynamics and intestinal microbiota are possibly related to metabolic improvement after DJB. Our previous studies involving obese diabetic rats showed the crucial role of the biliopancreatic limb (BPL) in metabolic improvement after DJB caused by BA reabsorption. We established a new DJB procedure to prevent bile from flowing into the BPL and aimed to elucidate the importance of bile in the BPL after DJB. Methods: Otsuka Long-Evans Tokushima Fatty rats with diabetes were divided into three groups: two DJB groups and a sham group (n = 11). Duodenal-jejunal anastomosis was performed proximal to the papilla of Vater in the DJB group (n = 11). However, the DJB-D group (n = 11) underwent a new procedure with duodenal-jejunal anastomosis distal to the papilla of Vater for preventing bile flow into the BPL. Results: Glucose metabolism improved and weight gain was suppressed in the DJB group, but not in the DJB-D and sham groups. Serum BA level and conjugated BA concentration were elevated in the DJB group. The gut microbiota was altered only in the DJB group; the abundance of Firmicutes and Bacteroidetes decreased and that of Actinobacteria increased. However, the DJB-D group exhibited no apparent change in the gut microbiota, similar to the sham group. Conclusion: BAs are essential in the BPL for metabolic improvement after DJB; they can improve the gut microbiota in these processes.
MeSH term(s)	Rats ; Animals ; Bile ; Diabetes Mellitus, Experimental/surgery ; Diabetes Mellitus, Type 2/surgery ; Diabetes Mellitus, Type 2/metabolism ; Obesity, Morbid/surgery ; Jejunum/surgery ; Jejunum/metabolism ; Duodenum/surgery ; Duodenum/metabolism ; Bile Acids and Salts/metabolism ; Blood Glucose/metabolism ; Gastric Bypass/methods
Chemical Substances	Bile Acids and Salts ; Blood Glucose
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-024-07176-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3381: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: [Extensive analysis of protein phosphorylation: An example of transcription factor Bach2].

Shima, Hiroki / Ando, Ryo / Tamahara, Toru / Igarashi, Kazuhiko

Seikagaku. The Journal of Japanese Biochemical Society

2016 Volume 88, Issue 1, Page(s) 31–35

MeSH term(s)	Animals ; B-Lymphocytes/metabolism ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Gene Regulatory Networks ; Host Cell Factor C1 ; Humans ; Phosphorylation ; Signal Transduction
Chemical Substances	Basic-Leucine Zipper Transcription Factors ; Host Cell Factor C1
Language	Japanese
Publishing date	2016-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	282319-6
ISSN	0037-1017
ISSN	0037-1017
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 592: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dental care using an oral appliance to support hematopoietic stem cell transplantation for NK/T cell lymphoma, nasal type, with palatal perforation.

Suenaga, Hanako / Iikubo, Masahiro / Tamahara, Toru / Dodo, Mina / Peck, Chris / Koseki, Takeyoshi / Harigae, Hideo / Sasaki, Keiichi

Journal of prosthodontic research

2021 Volume 66, Issue 2, Page(s) 353–356

Abstract: Patient: A 33-year-old man diagnosed with extranodal natural killer cell/T-cell lymphoma, nasal type (ENKTCL-NT) inducing palatal perforation was referred to the perioperative oral care support center of Tohoku University Hospital for dental care to ... ...

Abstract	Patient: A 33-year-old man diagnosed with extranodal natural killer cell/T-cell lymphoma, nasal type (ENKTCL-NT) inducing palatal perforation was referred to the perioperative oral care support center of Tohoku University Hospital for dental care to support cancer treatment including chemotherapy and hematopoietic stem cell transplantation (HSCT). Dental review during chemotherapy revealed mucositis suspected to be caused by mucosal trauma from altered jaw function (chewing and speech) due to palatal perforation. Although the patient was already in the cleanroom, an oral appliance as well as conservative care as recommended in oral management guidelines for HSCT were used to prevent worsening of oral mucositis at subsequent HSCT including High-dose chemotherapy and total body irradiation. After HSCT, a prosthodontist fitted a palatal obturator made by a dental technician and an oral surgeon reviewed the necrotic bone and removed the sequestra according to the changes in the palate. This approach involving a multidisciplinary team including a hematologist improved the impaired oral function and minimized oral complications. Discussion: ENKTCL-NT and its treatment have a significant impact on patients' oral status. Hence, it is important to provide customized dental care based on previously endorsed guidelines according to the type of disease, treatment requirements, and oral and systemic status. Conclusion: This report indicated the importance of dental care with a customized plan before, during, and after HSCT for ENKTCL-NT with multidisciplinary supportive care for cancer patients to improve the impaired oral function and to minimize oral complications.
MeSH term(s)	Adult ; Dental Care ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphoma, Extranodal NK-T-Cell/diagnosis ; Lymphoma, Extranodal NK-T-Cell/pathology ; Lymphoma, Extranodal NK-T-Cell/therapy ; Male ; Palate/pathology
Language	English
Publishing date	2021-07-15
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2470657-7
ISSN	2212-4632 ; 1883-1958
ISSN (online)	2212-4632
ISSN	1883-1958
DOI	10.2186/jpr.JPR_D_20_00270
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Design of the spacer for brachytherapy using

Suenaga, Hanako / Tamahara, Toru / Dodo, Mina / Murakami, Toshimitsu / Sasaki, Satoshi / Ito, Kengo / Jingu, Keiichi / Koseki, Takeyoshi / Sasaki, Keiichi

Journal of prosthodontic research

2018 Volume 62, Issue 4, Page(s) 518–521

Abstract: Patients: Seventy-one and 73 years-old males visited a perioperative oral care support center to receive perioperative oral management during tongue cancer (T: Discussion: Tongue impression made the spacers as small as possible by thickening just ... ...

Abstract	Patients: Seventy-one and 73 years-old males visited a perioperative oral care support center to receive perioperative oral management during tongue cancer (T Discussion: Tongue impression made the spacers as small as possible by thickening just around the cancer lesions so that the patients could wear them comfortably, while keeping adequate distance between the radiation sources and peripheral normal tissues. Breakable hard materials were avoided so that the patients were able to utilize the spacers safely without accidentally swallowing a broken fragment. Additionally, considering the upward movement of the tongue in a sleeping posture, the upper spacers were also prepared to protect the maxillae. Computer simulation revealed that the design of our spacers had enough effect on a reduction in radiation to prevent osteoradionecrosis in the maxilla as well as mandibular body. Conclusions: This report demonstrated the importance of the spacers created with consideration of patients' wearing condition to improve their QOL during brachytherapy.
MeSH term(s)	Aged ; Brachytherapy/adverse effects ; Brachytherapy/instrumentation ; Carcinoma/radiotherapy ; Equipment Design ; Gold Radioisotopes/administration & dosage ; Gold Radioisotopes/adverse effects ; Humans ; Male ; Mandible ; Maxilla ; Movement ; Osteoradionecrosis/etiology ; Osteoradionecrosis/prevention & control ; Perioperative Care ; Quality of Life ; Radiation Protection/instrumentation ; Radiopharmaceuticals/administration & dosage ; Radiopharmaceuticals/adverse effects ; Stomatitis/etiology ; Stomatitis/prevention & control ; Tongue/physiology ; Tongue Neoplasms/radiotherapy ; Wearable Electronic Devices
Chemical Substances	Gold Radioisotopes ; Radiopharmaceuticals
Language	English
Publishing date	2018-08-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2470657-7
ISSN	2212-4632 ; 1883-1958
ISSN (online)	2212-4632
ISSN	1883-1958
DOI	10.1016/j.jpor.2018.07.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3907: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project.

Saito, Sakae / Aoki, Yuichi / Tamahara, Toru / Goto, Maki / Matsui, Hiroyuki / Kawashima, Junko / Danjoh, Inaho / Hozawa, Atsushi / Kuriyama, Shinichi / Suzuki, Yoichi / Fuse, Nobuo / Kure, Shigeo / Yamashita, Riu / Tanabe, Osamu / Minegishi, Naoko / Kinoshita, Kengo / Tsuboi, Akito / Shimizu, Ritsuko / Yamamoto, Masayuki

Frontiers in cellular and infection microbiology

2021 Volume 10, Page(s) 604596

Abstract: A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by ... ...

Abstract	A baseline oral microbiome study of the Tohoku Medical Megabank Organization (TMM) was planned to characterize the profile of the oral microbiome in the Japanese population. The study also aimed to clarify risk factors for multifactorial diseases by integrated analysis of the oral microbiome and host genome/omics information. From 2013 to 2016, we collected three types of oral biospecimens, saliva, supragingival plaque, and tongue swab, from a total of 25,101 participants who had a dental examination in TMM. In this study, we used two independent cohorts; the Community-Based Cohort and Birth and Three-Generation Cohort as discovery and validation cohorts, respectively, and we selected participants examined by a single dentist. We found through the 16S ribosomal RNA gene sequencing analysis of 834 participants of the Community-Based Cohort Study that there are differences in the microbial composition and community structure between saliva and plaque. The species diversities in both saliva and plaque were increased in correlation with the severity of periodontal disease. These results were nicely reproduced in the analysis of 455 participants of the Birth and Three-Generation Cohort Study. In addition, strong positive and negative associations of microbial taxa in both plaque and saliva with periodontitis-associated biofilm formation were detected by co-occurrence network analysis. The classes
MeSH term(s)	Cohort Studies ; Humans ; Microbiota ; Prospective Studies ; RNA, Ribosomal, 16S/genetics ; Saliva
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2021-01-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2020.604596
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation

Tamahara, Toru / Ochiai, Kyoko / Muto, Akihiko / Kato, Yukinari / Sax, Nicolas / Matsumoto, Mitsuyo / Koseki, Takeyoshi / Igarashi, Kazuhiko

Molecular and Cellular Biology. 2017 Dec. 1, v. 37, no. 24 p.e00418-17-

2017

Abstract: The transcription factor Bach2 regulates both acquired and innate immunity at multiple steps, including antibody class switching and regulatory T cell development in activated B and T cells, respectively. However, little is known about the molecular ... ...

Abstract	The transcription factor Bach2 regulates both acquired and innate immunity at multiple steps, including antibody class switching and regulatory T cell development in activated B and T cells, respectively. However, little is known about the molecular mechanisms of Bach2 regulation in response to signaling of cytokines and antigen. We show here that mammalian target of rapamycin (mTOR) controls Bach2 along B cell differentiation with two distinct mechanisms in pre-B cells. First, mTOR complex 1 (mTORC1) inhibited accumulation of Bach2 protein in nuclei and reduced its stability. Second, mTOR complex 2 (mTORC2) inhibited FoxO1 to reduce Bach2 mRNA expression. Using expression profiling and chromatin immunoprecipitation assay, the Ccnd3 gene, encoding cyclin D3, was identified as a new direct target of Bach2. A proper cell cycle was lost at pre-B and mature B cell stages in Bach2-deficient mice. Furthermore, AZD8055, an mTOR inhibitor, increased class switch recombination in wild-type mature B cells but not in Bach2-deficient cells. These results suggest that the mTOR-Bach2 cascade regulates proper cell cycle arrest in B cells as well as immunoglobulin gene rearrangement.
Keywords	B-lymphocytes ; T-lymphocytes ; antibodies ; antigens ; cell cycle checkpoints ; cell differentiation ; chromatin immunoprecipitation ; cyclins ; cytokines ; gene expression ; gene rearrangement ; immunoglobulin genes ; innate immunity ; mammals ; rapamycin ; transcription factors ; B cells ; cell cycle ; immunoglobulin gene rearrangement ; mTOR ; transcription factor
Language	English
Dates of publication	2017-1201
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00418-17
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1666: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Progress report of the Tohoku Medical Megabank Community-Based Cohort Study: Study profile of the repeated center-based survey during second period in Miyagi Prefecture.

Hozawa, Atsushi / Nakaya, Kumi / Nakaya, Naoki / Nakamura, Tomohiro / Kogure, Mana / Hatanaka, Rieko / Chiba, Ippei / Kanno, Ikumi / Sugawara, Junichi / Kodama, Eiichi / Hamanaka, Yohei / Kobayashi, Tomoko / Uruno, Akira / Tsuchiya, Naho / Hirata, Takumi / Narita, Akira / Tsuboi, Akito / Tamahara, Toru / Otsuki, Akihito /

Journal of epidemiology

2024

Abstract: Background: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM ... ...

Abstract	Background: The purpose of this study was to report the basic profile of the Miyagi Prefecture part of a repeated center-based survey during the second period (2nd period survey) of the Tohoku Medical Megabank Community-Based Cohort Study (TMM CommCohort Study), as well as the participants' characteristics based on their participation type in the baseline survey. Methods: The 2nd period survey, conducted from June 2017 to March 2021, included participants of the TMM CommCohort Study (May 2013 to March 2016). In addition to the questionnaire, blood, urine, and physiological function tests were performed during the 2nd period survey. There were three main ways of participation in the baseline survey: Type 1, Type 1 additional, or Type 2 survey. The 2nd period survey was conducted in the same manner as the Type 2 survey, which was based on the community support center (CSC). Results: In Miyagi Prefecture, 29,383 (57.7%) of 50,967 participants participated in the 2nd period survey. The participation rate among individuals who had visited the CSC was approximately 80%. Although some factors differed depending on the participation type in the baseline survey, the 2nd period survey respondents in the Type 1 and Type 2 survey groups at baseline had similar traits. Conclusions: The 2nd period survey of the TMM CommCohort Study provided detailed follow-up information. Following up on the health conditions of the participants will clarify the long-term effects of disasters and contribute to personalized prevention.
Language	English
Publishing date	2024-02-24
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1442118-5
ISSN	1349-9092 ; 0917-5040
ISSN (online)	1349-9092
ISSN	0917-5040
DOI	10.2188/jea.JE20230241
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4931: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation.

Tamahara, Toru / Ochiai, Kyoko / Muto, Akihiko / Kato, Yukinari / Sax, Nicolas / Matsumoto, Mitsuyo / Koseki, Takeyoshi / Igarashi, Kazuhiko

Molecular and cellular biology

2017 Volume 37, Issue 24

Abstract	The transcription factor Bach2 regulates both acquired and innate immunity at multiple steps, including antibody class switching and regulatory T cell development in activated B and T cells, respectively. However, little is known about the molecular mechanisms of Bach2 regulation in response to signaling of cytokines and antigen. We show here that mammalian target of rapamycin (mTOR) controls Bach2 along B cell differentiation with two distinct mechanisms in pre-B cells. First, mTOR complex 1 (mTORC1) inhibited accumulation of Bach2 protein in nuclei and reduced its stability. Second, mTOR complex 2 (mTORC2) inhibited FoxO1 to reduce
MeSH term(s)	Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Basic-Leucine Zipper Transcription Factors/genetics ; Basic-Leucine Zipper Transcription Factors/metabolism ; Cell Cycle/physiology ; Cell Differentiation/physiology ; Cyclin D3/metabolism ; Mice ; Mice, Knockout ; Morpholines/pharmacology ; Recombination, Genetic ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Bach2 protein, mouse ; Basic-Leucine Zipper Transcription Factors ; Ccnd3 protein, mouse ; Cyclin D3 ; Morpholines ; (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol (970JJ37FPW) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; mTOR protein, mouse (EC 2.7.1.1)
Language	English
Publishing date	2017-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00418-17
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1666: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito