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  1. Article ; Online: Career pathways, part 11.

    Hoxhaj, Gerta / Reznik, Ed

    Nature metabolism

    2023  Volume 5, Issue 5, Page(s) 716–719

    MeSH term(s) Career Mobility ; Career Choice
    Language English
    Publishing date 2023-05-04
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-023-00788-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival.

    Kim, Dohun / Hoxhaj, Gerta

    Molecular cell

    2022  Volume 82, Issue 9, Page(s) 1613–1615

    Abstract: Jouandin et al. (2022) show that lysosomal-derived cysteine serves as a signal to promote the tricarboxylic acid (TCA) cycle and suppress TORC1 signaling for Drosophila to endure starvation periods. ...

    Abstract Jouandin et al. (2022) show that lysosomal-derived cysteine serves as a signal to promote the tricarboxylic acid (TCA) cycle and suppress TORC1 signaling for Drosophila to endure starvation periods.
    MeSH term(s) Adaptation, Psychological ; Animals ; Cysteine ; Drosophila ; Drosophila Proteins/genetics ; Mechanistic Target of Rapamycin Complex 1/genetics ; Starvation
    Chemical Substances Drosophila Proteins ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Coping with starvation: Cysteine keeps mTORC1 suppressed to ensure survival

    Kim, Dohun / Hoxhaj, Gerta

    Molecular cell. 2022 May 05, v. 82, no. 9

    2022  

    Abstract: Jouandin et al. (2022) show that lysosomal-derived cysteine serves as a signal to promote the tricarboxylic acid (TCA) cycle and suppress TORC1 signaling for Drosophila to endure starvation periods. ...

    Abstract Jouandin et al. (2022) show that lysosomal-derived cysteine serves as a signal to promote the tricarboxylic acid (TCA) cycle and suppress TORC1 signaling for Drosophila to endure starvation periods.
    Keywords Drosophila ; cysteine ; starvation
    Language English
    Dates of publication 2022-0505
    Size p. 1613-1615.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2022.04.018
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2005/501: Show issues

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  4. Article ; Online: A spoonful of DHAP keeps mTORC1 running on sugars.

    Hoxhaj, Gerta / Locasale, Jason W / Ben-Sahra, Issam

    Nature metabolism

    2020  Volume 2, Issue 9, Page(s) 801–802

    Language English
    Publishing date 2020-07-27
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-020-0246-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: New Insights into Oncogenic Transformation: Elevating Antioxidant and Nucleotide Levels Does the Trick.

    Kesavan, Rushendhiran / Rion, Halie / Hoxhaj, Gerta

    Trends in cancer

    2021  Volume 7, Issue 3, Page(s) 177–179

    Abstract: The molecular elements that govern cellular transformation and tumorigenic competence remain poorly understood. Metabolic reprogramming has emerged as a hallmark of malignant transformation. Recently in Cell Metabolism, Zhang et al. showed that an ... ...

    Abstract The molecular elements that govern cellular transformation and tumorigenic competence remain poorly understood. Metabolic reprogramming has emerged as a hallmark of malignant transformation. Recently in Cell Metabolism, Zhang et al. showed that an increase of cellular antioxidant capacity and nucleotide availability is sufficient to induce oncogenic transformation and tumorigenesis.
    MeSH term(s) Antioxidants ; Carcinogenesis ; Cell Transformation, Neoplastic ; Humans ; Nucleotides
    Chemical Substances Antioxidants ; Nucleotides
    Language English
    Publishing date 2021-01-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2021.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Publisher's Note: ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

    Hoxhaj, Gerta / Najafov, Ayaz / Toth, Rachel / Campbell, David G / Prescott, Alan R / MacKintosh, Carol

    Journal of cell science

    2022  Volume 135, Issue 6

    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.259936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1200: Show issues Location:
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    Zs.MG 14: Show issues

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  7. Article ; Online: The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.

    Hoxhaj, Gerta / Manning, Brendan D

    Nature reviews. Cancer

    2019  Volume 20, Issue 2, Page(s) 74–88

    Abstract: The altered metabolic programme of cancer cells facilitates their cell-autonomous proliferation and survival. In normal cells, signal transduction pathways control core cellular functions, including metabolism, to couple the signals from exogenous growth ...

    Abstract The altered metabolic programme of cancer cells facilitates their cell-autonomous proliferation and survival. In normal cells, signal transduction pathways control core cellular functions, including metabolism, to couple the signals from exogenous growth factors, cytokines or hormones to adaptive changes in cell physiology. The ubiquitous, growth factor-regulated phosphoinositide 3-kinase (PI3K)-AKT signalling network has diverse downstream effects on cellular metabolism, through either direct regulation of nutrient transporters and metabolic enzymes or the control of transcription factors that regulate the expression of key components of metabolic pathways. Aberrant activation of this signalling network is one of the most frequent events in human cancer and serves to disconnect the control of cell growth, survival and metabolism from exogenous growth stimuli. Here we discuss our current understanding of the molecular events controlling cellular metabolism downstream of PI3K and AKT and of how these events couple two major hallmarks of cancer: growth factor independence through oncogenic signalling and metabolic reprogramming to support cell survival and proliferation.
    MeSH term(s) Animals ; Disease Susceptibility ; Energy Metabolism ; Gene Expression Regulation, Neoplastic ; Glucose/metabolism ; Humans ; Neoplasms/etiology ; Neoplasms/metabolism ; Neoplasms/pathology ; Oncogene Proteins/metabolism ; Oxidation-Reduction ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
    Chemical Substances Oncogene Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-11-04
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-019-0216-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5563: Show issues Location:
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    Zs.MG 24: Show issues

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  8. Book: PCR GURU

    Najafov, Ayaz / Hoxhaj, Gerta

    an ultimate benchtop reference for molecular biologists

    2017  

    Author's details Ayaz Najafov, Gerta Hoxhaj
    MeSH term(s) Polymerase Chain Reaction/methods ; Molecular Biology
    Language English
    Size xv, 89 pages :, illustrations
    Document type Book
    ISBN 9780128042311 ; 0128042311
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article ; Online: Itaconate-producing neutrophils regulate local and systemic inflammation following trauma.

    Crossley, Janna L / Ostashevskaya-Gohstand, Sonya / Comazzetto, Stefano / Hook, Jessica S / Guo, Lei / Vishlaghi, Neda / Juan, Conan / Xu, Lin / Horswill, Alexander R / Hoxhaj, Gerta / Moreland, Jessica G / Tower, Robert J / Levi, Benjamin

    JCI insight

    2023  Volume 8, Issue 20

    Abstract: Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that undergo ... ...

    Abstract Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that undergo normal and aberrant repair were evaluated by metabolic profiling to determine its impact on healing outcomes. Metabolomics revealed an increasing abundance of the immunomodulatory metabolite itaconate within the injury site. Subsequent single-cell RNA-Seq and molecular and metabolomic validation identified a highly mature neutrophil subtype, not macrophages, as the primary producers of itaconate following trauma. These mature itaconate-producing neutrophils were highly inflammatory, producing cytokines that promote local injury fibrosis before cycling back to the bone marrow. In the bone marrow, itaconate was shown to alter hematopoiesis, skewing progenitor cells down myeloid lineages, thereby regulating systemic inflammation. Therapeutically, exogenous itaconate was found to reduce injury-site inflammation, promoting tenogenic differentiation and impairing aberrant vascularization with disease-ameliorating effects. These results present an intriguing role for cycling neutrophils as a sensor of inflammation induced by injury - potentially regulating immune cell production in the bone marrow through delivery of endogenously produced itaconate - and demonstrate a therapeutic potential for exogenous itaconate following tendon injury.
    MeSH term(s) Humans ; Neutrophils/metabolism ; Succinates/pharmacology ; Succinates/metabolism ; Succinates/therapeutic use ; Macrophages/metabolism ; Inflammation/metabolism
    Chemical Substances itaconic acid (Q4516562YH) ; Succinates
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.169208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

    Janna L. Crossley / Sonya Ostashevskaya-Gohstand / Stefano Comazzetto / Jessica S. Hook / Lei Guo / Neda Vishlaghi / Conan Juan / Lin Xu / Alexander R. Horswill / Gerta Hoxhaj / Jessica G. Moreland / Robert J. Tower / Benjamin Levi

    JCI Insight, Vol 8, Iss

    2023  Volume 20

    Abstract: Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that undergo ... ...

    Abstract Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that undergo normal and aberrant repair were evaluated by metabolic profiling to determine its impact on healing outcomes. Metabolomics revealed an increasing abundance of the immunomodulatory metabolite itaconate within the injury site. Subsequent single-cell RNA-Seq and molecular and metabolomic validation identified a highly mature neutrophil subtype, not macrophages, as the primary producers of itaconate following trauma. These mature itaconate-producing neutrophils were highly inflammatory, producing cytokines that promote local injury fibrosis before cycling back to the bone marrow. In the bone marrow, itaconate was shown to alter hematopoiesis, skewing progenitor cells down myeloid lineages, thereby regulating systemic inflammation. Therapeutically, exogenous itaconate was found to reduce injury-site inflammation, promoting tenogenic differentiation and impairing aberrant vascularization with disease-ameliorating effects. These results present an intriguing role for cycling neutrophils as a sensor of inflammation induced by injury — potentially regulating immune cell production in the bone marrow through delivery of endogenously produced itaconate — and demonstrate a therapeutic potential for exogenous itaconate following tendon injury
    Keywords Immunology ; Inflammation ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher American Society for Clinical investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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