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  1. Book: Apoptosis in cancer pathogenesis and anti-cancer therapy

    Gregory, Christopher D.

    new perspectives and opportunities

    (Advances in experimental medicine and biology ; 930)

    2016  

    Author's details Christopher D. Gregory editor
    Series title Advances in experimental medicine and biology ; 930
    Collection
    Keywords cell death ; inflammation ; macrophages ; oncogenes ; phagocytes ; tumors
    Language English
    Size XVII, 247 Seiten, Illustrationen, Diagramme, 23.5 cm x 15.5 cm, 0 g
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019112462
    ISBN 978-3-319-39404-6 ; 3-319-39404-5 ; 9783319394060 ; 3319394061
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  2. Book ; Online ; E-Book: Apoptosis in cancer pathogenesis and anti-cancer therapy

    Gregory, Christopher D.

    new perspectives and opportunities

    (Advances in experimental medicine and biology ; 930)

    2016  

    Author's details Christopher D. Gregory editor
    Series title Advances in experimental medicine and biology ; 930
    Collection
    Keywords cell death ; inflammation ; macrophages ; oncogenes ; phagocytes ; tumors
    Language English
    Size 1 Online-Ressource (xviii, 247 Seiten)
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019077713
    ISBN 978-3-319-39406-0 ; 9783319394046 ; 3-319-39406-1 ; 3319394045
    DOI 10.1007/978-3-319-39406-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  3. Article ; Online: Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis.

    Gregory, Christopher D

    Immunological reviews

    2023  Volume 319, Issue 1, Page(s) 100–127

    Abstract: Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved regulated cell death program and a profoundly important homeostatic mechanism ... ...

    Abstract Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved regulated cell death program and a profoundly important homeostatic mechanism that is common (alongside tumor cell proliferation) in actively growing cancers, as well as in tumors responding to cytotoxic anti-cancer therapies. Although well known for its cell-autonomous tumor-suppressive qualities, apoptosis harbors pro-oncogenic properties which are deployed through non-cell-autonomous mechanisms and which generally remain poorly defined. Here, the roles of apoptosis in tumor biology are reviewed, with particular focus on the secreted and fragmentation products of apoptotic tumor cells and their effects on tumor-associated macrophages, key supportive cells in the aberrant homeostasis of the tumor microenvironment. Historical aspects of cell loss in tumor growth kinetics are considered and the impact (and potential impact) on tumor growth of apoptotic-cell clearance (efferocytosis) as well as released soluble and extracellular vesicle-associated factors are discussed from the perspectives of inflammation, tissue repair, and regeneration programs. An "apoptosis-centric" view is proposed in which dying tumor cells provide an important platform for intricate intercellular communication networks in growing cancers. The perspective has implications for future research and for improving cancer diagnosis and therapy.
    MeSH term(s) Humans ; Macrophages/metabolism ; Tumor Microenvironment ; Apoptosis ; Phagocytosis ; Neoplasms/metabolism ; Homeostasis
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: The Immunomodulatory Properties of Extracellular Vesicles from Pathogens, Immune Cells and Non-Immune Cells

    Poon, Ivan K. H. / Gregory, Christopher D. / Kaparakis-Liaskos, Maria

    2019  

    Keywords Medicine ; Immunology ; apoptotic cells ; Apoptotic bodies ; bacterial membrane vesicles ; Exosomes ; extracellular vesicles ; immunomodulatory ; Microvesicles ; outer membrane vesicles ; Parasites ; tumour cells
    Size 1 electronic resource (141 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231385
    ISBN 9782889457540 ; 2889457540
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis

    Gregory, Christopher D.

    Immunological Reviews. 2023 Oct., v. 319, no. 1 p.100-127

    2023  

    Abstract: Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved regulated cell death program and a profoundly important homeostatic mechanism ... ...

    Abstract Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved regulated cell death program and a profoundly important homeostatic mechanism that is common (alongside tumor cell proliferation) in actively growing cancers, as well as in tumors responding to cytotoxic anti‐cancer therapies. Although well known for its cell‐autonomous tumor‐suppressive qualities, apoptosis harbors pro‐oncogenic properties which are deployed through non‐cell‐autonomous mechanisms and which generally remain poorly defined. Here, the roles of apoptosis in tumor biology are reviewed, with particular focus on the secreted and fragmentation products of apoptotic tumor cells and their effects on tumor‐associated macrophages, key supportive cells in the aberrant homeostasis of the tumor microenvironment. Historical aspects of cell loss in tumor growth kinetics are considered and the impact (and potential impact) on tumor growth of apoptotic‐cell clearance (efferocytosis) as well as released soluble and extracellular vesicle‐associated factors are discussed from the perspectives of inflammation, tissue repair, and regeneration programs. An “apoptosis‐centric” view is proposed in which dying tumor cells provide an important platform for intricate intercellular communication networks in growing cancers. The perspective has implications for future research and for improving cancer diagnosis and therapy.
    Keywords apoptosis ; cell communication ; cell proliferation ; cytotoxicity ; growth models ; homeostasis ; inflammation ; macrophages ; neoplasm cells ; neoplasms ; therapeutics ; tissue repair
    Language English
    Dates of publication 2023-10
    Size p. 100-127.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13259
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Extracellular vesicles arising from apoptosis: forms, functions, and applications.

    Gregory, Christopher D / Rimmer, Michael P

    The Journal of pathology

    2023  Volume 260, Issue 5, Page(s) 592–608

    Abstract: Extracellular vesicles (EVs) are lipid bilayer-enclosed subcellular bodies produced by most, if not all cells. Research over the last two decades has recognised the importance of EVs in intercellular communication and horizontal transfer of biological ... ...

    Abstract Extracellular vesicles (EVs) are lipid bilayer-enclosed subcellular bodies produced by most, if not all cells. Research over the last two decades has recognised the importance of EVs in intercellular communication and horizontal transfer of biological material. EVs range in diameter from tens of nanometres up to several micrometres and are able to transfer a spectrum of biologically active cargoes - from whole organelles, through macromolecules including nucleic acids and proteins, to metabolites and small molecules - from their cells of origin to recipient cells, which may consequently become physiologically or pathologically altered. Based on their modes of biogenesis, the most renowned EV classes are (1) microvesicles, (2) exosomes (both produced by healthy cells), and (3) EVs from cells undergoing regulated death by apoptosis (ApoEVs). Microvesicles bud directly from the plasma membrane, while exosomes are derived from endosomal compartments. Current knowledge of the formation and functional properties of ApoEVs lags behind that of microvesicles and exosomes, but burgeoning evidence indicates that ApoEVs carry manifold cargoes, including mitochondria, ribosomes, DNA, RNAs, and proteins, and perform diverse functions in health and disease. Here we review this evidence, which demonstrates substantial diversity in the luminal and surface membrane cargoes of ApoEVs, permitted by their very broad size range (from around 50 nm to >5 μm; the larger often termed apoptotic bodies), strongly suggests their origins through both microvesicle- and exosome-like biogenesis pathways, and indicates routes through which they interact with recipient cells. We discuss the capacity of ApoEVs to recycle cargoes and modulate inflammatory, immunological, and cell fate programmes in normal physiology and in pathological scenarios such as cancer and atherosclerosis. Finally, we provide a perspective on clinical applications of ApoEVs in diagnostics and therapeutics. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
    MeSH term(s) Humans ; Extracellular Vesicles/metabolism ; Exosomes/metabolism ; Cell-Derived Microparticles/metabolism ; Neoplasms/metabolism ; Apoptosis
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nicotinic and muscarinic acetylcholine receptor antagonism dose-dependently decreases sign- but not goal-tracking behavior in male rats.

    Gheidi, Ali / Fitzpatrick, Christopher J / Gregory, Jordan D / Morrow, Jonathan D

    Psychopharmacology

    2023  Volume 240, Issue 4, Page(s) 871–880

    Abstract: Rationale: Acetylcholinergic antagonists have shown some promise in reducing addiction-related behaviors in both preclinical and clinical studies. However, the psychological mechanisms by which these drugs are able to affect addictive behavior remain ... ...

    Abstract Rationale: Acetylcholinergic antagonists have shown some promise in reducing addiction-related behaviors in both preclinical and clinical studies. However, the psychological mechanisms by which these drugs are able to affect addictive behavior remain unclear. A particular key process for the development of addiction is the attribution of incentive salience to reward-related cues, which can be specifically measured in animals using a Pavlovian conditioned approach procedure. When confronted with a lever that predicts food delivery, some rats engage with the lever directly (i.e., they sign track), indicating attribution of incentive-motivational properties to the lever itself. In contrast, others treat the lever as a predictive cue and approach the location of impending food delivery (i.e., they goal track), without treating the lever itself as a reward.
    Objectives: We tested whether systemic antagonism of the either nicotinic or muscarinic acetylcholine receptors would selectively affect sign- or goal-tracking behavior, indicating a selective effect on incentive salience attribution.
    Methods: A total of 98 male Sprague Dawley rats were either given the muscarinic antagonist scopolamine (100, 50, or 10 µg/kg i.p.) or the nicotinic antagonist mecamylamine (0.3, 1.0, or 3 mg/kg i.p.) before being trained on a Pavlovian conditioned approach procedure.
    Results: Scopolamine dose-dependently decreased sign tracking behavior and increased goal-tracking behavior. Mecamylamine reduced sign-tracking but did not affect goal-tracking behavior.
    Conclusions: Antagonism of either muscarinic or nicotinic acetylcholine receptors can reduce incentive sign-tracking behavior in male rats. This effect appears to be specifically due to a reduction in incentive salience attribution since goal-tracking either increased or was not affected by these manipulations.
    MeSH term(s) Rats ; Animals ; Male ; Motivation ; Rats, Sprague-Dawley ; Nicotine/pharmacology ; Mecamylamine/pharmacology ; Reward ; Scopolamine Derivatives/pharmacology ; Cues
    Chemical Substances Nicotine (6M3C89ZY6R) ; Mecamylamine (6EE945D3OK) ; Scopolamine Derivatives
    Language English
    Publishing date 2023-02-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-023-06328-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Acute Intentional Deformation of Open Tibial Fractures for Complex Soft Tissue Closure in the Pediatric Patient.

    Halsey, Jordan N / Iobst, Christopher A / Pearson, Gregory D

    Eplasty

    2022  Volume 22, Page(s) e35

    Abstract: Background. ...

    Abstract Background.
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2412803-X
    ISSN 1937-5719
    ISSN 1937-5719
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  9. Article: Comparison of online to face-to-face instruction for anatomy review in a third-year clinical course.

    Faydenko, Jocelyn / Grieve, Thomas / Madigan, Dana / Pocius, Judith D / Olsen, Christopher / Cramer, Gregory D

    The Journal of chiropractic education

    2024  

    Abstract: Objective: This project compared student learning and satisfaction of an anatomy review delivered by a face-to-face lecture (F2FL) and an online learning module (OLM) for third-year doctor of chiropractic students.: Methods: This cohort study ... ...

    Abstract Objective: This project compared student learning and satisfaction of an anatomy review delivered by a face-to-face lecture (F2FL) and an online learning module (OLM) for third-year doctor of chiropractic students.
    Methods: This cohort study compared student learning and satisfaction of a pediatric spinal anatomy review delivered via F2FL (cohort 1, n = 23) and OLM (cohort 2, n = 18) in 2 successive 2019 (pre-COVID) course offerings. Previously validated pre- and post-tests were given. Students completed a survey assessing delivery, comfort with online learning and online learning technology, and preference of F2FL vs OLM of review material. Pre- and post-test results were assessed using repeated-measures analysis of variance.
    Results: Testing results showed an improvement with both groups (F2FL 53.7%, p < .001 vs OLM 51.8%, p < .001), with no significant difference between the F2FL and OLM groups (p = .53; p = .82). The survey showed: 83.3% of OLM students felt the online method was effective, and 88.9% of the OLM students would prefer online reviews or have no preference between online or face-to-face; meanwhile, 80% of the F2FL group thought the lecture engaging/effective, whereas 60% of the F2FL group would have preferred to have the material presented online.
    Conclusion: The OLM was found to be as effective as the F2FL for the content assessed. The majority of students would prefer the online method for future anatomy review content presented in the course. This strategy could be applied to provide review materials in other clinical courses, allowing material to be developed and given by content experts while freeing valuable in-class time.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2261817-X
    ISSN 1042-5055
    ISSN 1042-5055
    DOI 10.7899/JCE-23-10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Molecular insights into orphan G protein-coupled receptors relevant to schizophrenia.

    Lu, Yao / Hatzipantelis, Cassandra J / Langmead, Christopher J / Stewart, Gregory D

    British journal of pharmacology

    2023  

    Abstract: ... with therapeutics based on 70-year old science. All currently approved therapeutics primarily target the dopamine D ...

    Abstract Schizophrenia remains a sizable socio-economic burden that continues to be treated with therapeutics based on 70-year old science. All currently approved therapeutics primarily target the dopamine D
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16221
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