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  1. Article ; Online: Magnesium and vitamin D in long COVID syndrome; do they help?

    Wolf, Federica I / Trapani, Valentina

    Magnesium research

    2024  

    Abstract: Since the start of the COVID-19 pandemic, it has become increasingly clear that the disease can have relevant multisystemic and long-term effects, and several studies have attempted to identify key determinants of the disease course. Here we discuss ... ...

    Abstract Since the start of the COVID-19 pandemic, it has become increasingly clear that the disease can have relevant multisystemic and long-term effects, and several studies have attempted to identify key determinants of the disease course. Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with a higher number of clinical manifestations, as compared to patients with normal levels of both nutrients. We highlight the potential synergistic effects of these deficiencies and propose that future studies should explore a causal link with the risk of developing long COVID. Most importantly, randomized clinical trials are needed to determine if magnesium and vitamin D supplementation can improve long COVID symptoms, providing a safe and affordable support therapy to the benefit of patients and society.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036384-1
    ISSN 1952-4021 ; 0953-1424
    ISSN (online) 1952-4021
    ISSN 0953-1424
    DOI 10.1684/mrh.2024.0521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2658: Show issues Location:
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  2. Article ; Online: Glasgow Magnesium Symposium 2022: Wrap up and depart

    Wolf, Federica I / Trapani, Valentina / Touyz, Rhian

    Magnesium research

    2022  Volume 35, Issue 2, Page(s) 71–79

    Title translation Glasgow Magnesium Symposium 2022: Wrap up and depart.
    MeSH term(s) Humans ; Magnesium
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-10-10
    Publishing country England
    Document type Congress
    ZDB-ID 1036384-1
    ISSN 1952-4021 ; 0953-1424
    ISSN (online) 1952-4021
    ISSN 0953-1424
    DOI 10.1684/mrh.2022.0501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The TRPM7 channel kinase: rekindling an old flame or not?

    Trapani, Valentina / Wolf, Federica I

    Cardiovascular research

    2019  Volume 116, Issue 3, Page(s) 476–478

    MeSH term(s) Calcium ; Fibrosis ; Humans ; Inflammation ; Protein-Serine-Threonine Kinases ; TRPM Cation Channels
    Chemical Substances TRPM Cation Channels ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-10-03
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvz229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dysregulation of Mg

    Trapani, Valentina / Wolf, Federica I

    Cell calcium

    2019  Volume 83, Page(s) 102078

    Abstract: Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of ... ...

    Abstract Derangement of magnesium homeostasis underlies the pathophysiology of many diseases, including cancer. Recent advances support the view that aberrant expression of Mg
    MeSH term(s) Animals ; Biomarkers, Tumor/metabolism ; Cell Membrane/metabolism ; Cell Proliferation ; Homeostasis ; Humans ; Neoplasms/metabolism ; Protein Conformation ; Protein Domains/genetics ; Structure-Activity Relationship ; Transient Receptor Potential Channels/metabolism
    Chemical Substances Biomarkers, Tumor ; Transient Receptor Potential Channels
    Language English
    Publishing date 2019-08-31
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2019.102078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Magnesium Intake and Human Health

    Wolf, Federica / Trapani, Valentina

    2018  

    Abstract: ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[Magnesium is universally recognized as an essential nutrient for human life and health. Indeed, ...

    Abstract ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms.[Magnesium is universally recognized as an essential nutrient for human life and health. Indeed, magnesium plays an important physiologic role in every organ of the human body. Disturbances of Mg homeostasis have been implicated in the pathophysiology of several diseases, and Mg supplementation has been evaluated in numerous large-scale clinical trials. The World Health Organization has listed magnesium as among those essential nutrients that are consumed in suboptimal amounts by the general population. In particular, this occurs in Western (Westernized) countries, where a modest to mild Mg2+ deficiency is thought to be common. The consequences of suboptimal Mg intake are largely unknown. A deeper understanding of the link between magnesium intake, its systemic homeostasis, and human pathophysiology is therefore much needed. Here, we have invited the experts to contribute original research or review articles that may help elucidate the pathophysiology of Mg and its underlying molecular mechanisms.]
    Keywords Diseases of the circulatory (Cardiovascular) system
    Size 1 electronic resource (182 p.)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099561
    ISBN 9783038973348 ; 9783038973355 ; 3038973343 ; 3038973351
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online ; Conference proceedings: A guided tour of presentations at the XIV International Magnesium Symposium.

    Rosanoff, Andrea / Wolf, Federica I

    Magnesium research

    2016  Volume 29, Issue 3, Page(s) 55–59

    MeSH term(s) Animals ; Disease ; Humans ; Magnesium/administration & dosage ; Magnesium/analysis ; Magnesium/metabolism ; Magnesium/therapeutic use
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2016-03-01
    Publishing country England
    Document type Congresses
    ZDB-ID 1036384-1
    ISSN 1952-4021 ; 0953-1424
    ISSN (online) 1952-4021
    ISSN 0953-1424
    DOI 10.1684/mrh.2016.0405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mitochondrial magnesium to the rescue.

    Trapani, Valentina / Wolf, Federica I

    Magnesium research

    2015  Volume 28, Issue 2, Page(s) 79–84

    MeSH term(s) Animals ; Cation Transport Proteins/metabolism ; Fungal Proteins/metabolism ; Humans ; Magnesium/metabolism ; Mitochondria/metabolism
    Chemical Substances Cation Transport Proteins ; Fungal Proteins ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036384-1
    ISSN 1952-4021 ; 0953-1424
    ISSN (online) 1952-4021
    ISSN 0953-1424
    DOI 10.1684/mrh.2015.0386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota

    Del Chierico, Federica / Trapani, Valentina / Petito, Valentina / Reddel, Sofia / Pietropaolo, Giuseppe / Graziani, Cristina / Masi, Letizia / Gasbarrini, Antonio / Putignani, Lorenza / Scaldaferri, Franco / Wolf, Federica I.

    Nutrients. 2021 Nov. 23, v. 13, no. 12

    2021  

    Abstract: Nutritional deficiencies are common in inflammatory bowel diseases (IBD). In patients, magnesium (Mg) deficiency is associated with disease severity, while in murine models, dietary Mg supplementation contributes to restoring mucosal function. Since Mg ... ...

    Abstract Nutritional deficiencies are common in inflammatory bowel diseases (IBD). In patients, magnesium (Mg) deficiency is associated with disease severity, while in murine models, dietary Mg supplementation contributes to restoring mucosal function. Since Mg availability modulates key bacterial functions, including growth and virulence, we investigated whether the beneficial effects of Mg supplementation during colitis might be mediated by gut microbiota. The effects of dietary Mg modulation were assessed in a murine model of dextran sodium sulfate (DSS)-induced colitis by monitoring magnesemia, weight, and fecal consistency. Gut microbiota were analyzed by 16S-rRNA based profiling on fecal samples. Mg supplementation improved microbiota richness in colitic mice, increased abundance of Bifidobacterium and reduced Enterobacteriaceae. KEEG pathway analysis predicted an increase in biosynthetic metabolism, DNA repair and translation pathways during Mg supplementation and in the presence of colitis, while low Mg conditions favored catabolic processes. Thus, dietary Mg supplementation increases bacteria involved in intestinal health and metabolic homeostasis, and reduces bacteria involved in inflammation and associated with human diseases, such as IBD. These findings suggest that Mg supplementation may be a safe and cost-effective strategy to ameliorate disease symptoms and restore a beneficial intestinal flora in IBD patients.
    Keywords Bifidobacterium ; DNA repair ; Enterobacteriaceae ; animal models ; biosynthesis ; colitis ; cost effectiveness ; dextran ; disease severity ; homeostasis ; humans ; inflammation ; intestinal microorganisms ; intestines ; magnesium ; mice ; sodium sulfate ; virulence
    Language English
    Dates of publication 2021-1123
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13124188
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Dietary magnesium: the magic mineral that protects from colon cancer?

    Trapani, Valentina / Wolf, Federica I / Scaldaferri, Franco

    Magnesium research

    2015  Volume 28, Issue 3, Page(s) 108–111

    MeSH term(s) Colorectal Neoplasms/epidemiology ; Diet ; Humans ; Magnesium/administration & dosage
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2015-07
    Publishing country England
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1036384-1
    ISSN 1952-4021 ; 0953-1424
    ISSN (online) 1952-4021
    ISSN 0953-1424
    DOI 10.1684/mrh.2015.0390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota.

    Del Chierico, Federica / Trapani, Valentina / Petito, Valentina / Reddel, Sofia / Pietropaolo, Giuseppe / Graziani, Cristina / Masi, Letizia / Gasbarrini, Antonio / Putignani, Lorenza / Scaldaferri, Franco / Wolf, Federica I

    Nutrients

    2021  Volume 13, Issue 12

    Abstract: Nutritional deficiencies are common in inflammatory bowel diseases (IBD). In patients, magnesium (Mg) deficiency is associated with disease severity, while in murine models, dietary Mg supplementation contributes to restoring mucosal function. Since Mg ... ...

    Abstract Nutritional deficiencies are common in inflammatory bowel diseases (IBD). In patients, magnesium (Mg) deficiency is associated with disease severity, while in murine models, dietary Mg supplementation contributes to restoring mucosal function. Since Mg availability modulates key bacterial functions, including growth and virulence, we investigated whether the beneficial effects of Mg supplementation during colitis might be mediated by gut microbiota. The effects of dietary Mg modulation were assessed in a murine model of dextran sodium sulfate (DSS)-induced colitis by monitoring magnesemia, weight, and fecal consistency. Gut microbiota were analyzed by 16S-rRNA based profiling on fecal samples. Mg supplementation improved microbiota richness in colitic mice, increased abundance of
    MeSH term(s) Animals ; Colitis/chemically induced ; Colitis/microbiology ; Colitis/therapy ; Dextran Sulfate ; Disease Models, Animal ; Dysbiosis/microbiology ; Dysbiosis/therapy ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/drug effects ; Magnesium/pharmacology ; Magnesium Deficiency/microbiology ; Magnesium Deficiency/therapy ; Mice ; Mice, Inbred C57BL ; RNA, Ribosomal, 16S
    Chemical Substances RNA, Ribosomal, 16S ; Dextran Sulfate (9042-14-2) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2021-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13124188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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