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Article ; Online: Oncogenic K-Ras

Ito, Mai / Tanuma, Nobuhiro / Kotani, Yui / Murai, Kokoro / Kondo, Ayumi / Sumiyoshi, Mami / Shima, Hiroshi / Matsuda, Satoshi / Watanabe, Toshio

FEBS open bio

2024 Volume 14, Issue 4, Page(s) 545–554

Abstract: ... the role(s) of Ppp6c in cell proliferation remains controversial. It is unclear how oncogenic K-Ras ... to shed light on how oncogenic K-Ras modulates tumor cell growth. Contrary to our expectations, loss ... of oncogenic Ras-expressing mouse embryonic fibroblasts (MEFs). These findings show that oncogenic K-Ras ...

Abstract	Protein phosphatase 6 is a Ser/Thr protein phosphatase and its catalytic subunit is Ppp6c. Ppp6c is thought to be indispensable for proper growth of normal cells. On the other hand, loss of Ppp6c accelerates growth of oncogenic Ras-expressing cells. Although it has been studied in multiple contexts, the role(s) of Ppp6c in cell proliferation remains controversial. It is unclear how oncogenic K-Ras overcomes cell proliferation failure induced by Ppp6c deficiency; therefore, in this study, we attempted to shed light on how oncogenic K-Ras modulates tumor cell growth. Contrary to our expectations, loss of Ppp6c decreased proliferation, anchorage-independent growth in soft agar, and tumor formation of oncogenic Ras-expressing mouse embryonic fibroblasts (MEFs). These findings show that oncogenic K-Ras
MeSH term(s)	Animals ; Mice ; Cell Proliferation/genetics ; Fibroblasts/metabolism ; Phosphoprotein Phosphatases/genetics ; Phosphoprotein Phosphatases/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism
Chemical Substances	Phosphoprotein Phosphatases (EC 3.1.3.16) ; protein phosphatase 6 (EC 3.1.3.16) ; Hras protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13775
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Article: Severe Early-Onset Vitamin K Deficiency Bleeding in a Neonate Born to a Mother with Crohn's Disease in Clinical Remission: A Case Report.

Ikenaga, Chiho / Uchi, Ryosuke / Ishida, Fumihiko / Hirata, Michisato / Iwama, Kazuhiro / Ina, Shinichiro / Tatsuno, Yuko / Kemmotsu, Takahiro / Shibasaki, Jun / Ito, Shuichi

AJP reports

2024 Volume 14, Issue 1, Page(s) e1–e6

Abstract: Vitamin K deficiency bleeding (VKDB) in neonates is a significant disorder that causes skin ... of warfarin and anticoagulants, and maternal vitamin K deficiency. We report the case of a neonate with early ... Her blood tests at delivery showed an elevated prothrombin induced by vitamin K deficiency or antagonist II (PIVKA ...

Abstract	Vitamin K deficiency bleeding (VKDB) in neonates is a significant disorder that causes skin, gastrointestinal, and intracranial hemorrhaging. Early-onset VKDB occurs within 24 hours of birth, and its prognosis is poor due to severe hemorrhage. The causes of early-onset VKDB include maternal intake of warfarin and anticoagulants, and maternal vitamin K deficiency. We report the case of a neonate with early-onset VKDB born to a mother with Crohn's disease. The neonate developed severe cerebellar hemorrhage on the day of birth and subsequent noncommunicating hydrocephalus requiring a ventriculoperitoneal shunt. The mother had a 14-year history of Crohn's disease and short bowel owing to intestinal resection. She was in complete remission during pregnancy according to the Crohn's Disease Activity Index. Endoscopic examination performed shortly before pregnancy revealed inflammatory findings in the residual small intestine. Her blood tests at delivery showed an elevated prothrombin induced by vitamin K deficiency or antagonist II (PIVKA-II) level of 26,900 mAU/mL. A definitive protocol to prevent early-onset VKDB in mothers with Crohn's disease complicated by a short bowel is lacking. Administering vitamin K to mothers with elevated PIVKA-II levels before delivery may help prevent early-onset VKDB.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2628074-7
ISSN	2157-7005 ; 2157-6998
ISSN (online)	2157-7005
ISSN	2157-6998
DOI	10.1055/a-2219-5024
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Article ; Online: K-Ras

Lee, You-Soub / Lee, Ja-Yeol / Song, Soo-Hyun / Kim, Da-Mi / Lee, Jung-Won / Chi, Xin-Zi / Ito, Yoshiaki / Bae, Suk-Chul

Molecules and cells

2020 Volume 43, Issue 10, Page(s) 889–897

Abstract: K-RAS ...

Abstract	K-RAS
MeSH term(s)	Adenocarcinoma of Lung/chemically induced ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/pathology ; Animals ; Core Binding Factor Alpha 3 Subunit/genetics ; Core Binding Factor Alpha 3 Subunit/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/chemically induced ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mutation ; Neoplasms, Experimental/chemically induced ; Neoplasms, Experimental/genetics ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Urethane/adverse effects
Chemical Substances	Core Binding Factor Alpha 3 Subunit ; Runx3 protein, mouse ; Trp53 protein, mouse ; Tumor Suppressor Protein p53 ; Urethane (3IN71E75Z5) ; Hras protein, mouse (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1148964-9
ISSN	0219-1032 ; 1016-8478
ISSN (online)	0219-1032
ISSN	1016-8478
DOI	10.14348/molcells.2020.0182
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Article ; Online: Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K.

Sato, Shun / Yamamoto, Kana / Ito, Moeno / Nishino, Katsutoshi / Otsuka, Takanao / Irie, Kazuhiro / Nagao, Masaya

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 10

Abstract: Background: Cathepsin K, which is involved in bone resorption, is a good target for treating ... Cathepsin K inhibitors were isolated from the methanol extract of : Results: Two types of cathepsin K ...

Abstract	Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have been attracting attention for use in new medicines. Methods: Cathepsin K inhibitors were isolated from the methanol extract of Results: Two types of cathepsin K inhibitors were identified in the methanol extract of Conclusions: Different allosteric inhibitors that bind to different sites in combination, as shown in this study, may be useful for designing new allosteric inhibitory drugs with high specificity and few side effects.
MeSH term(s)	Humans ; Cathepsin K/metabolism ; Allosteric Site ; Kinetics ; Methanol ; Bone Resorption ; Cathepsins/metabolism
Chemical Substances	Cathepsin K (EC 3.4.22.38) ; Methanol (Y4S76JWI15) ; Cathepsins (EC 3.4.-)
Language	English
Publishing date	2023-05-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28104197
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Article ; Online: A non-canonical vitamin K cycle is a potent ferroptosis suppressor.

Mishima, Eikan / Ito, Junya / Wu, Zijun / Nakamura, Toshitaka / Wahida, Adam / Doll, Sebastian / Tonnus, Wulf / Nepachalovich, Palina / Eggenhofer, Elke / Aldrovandi, Maceler / Henkelmann, Bernhard / Yamada, Ken-Ichi / Wanninger, Jonas / Zilka, Omkar / Sato, Emiko / Feederle, Regina / Hass, Daniela / Maida, Adriano / Mourão, André Santos Dias /

Linkermann, Andreas / Geissler, Edward K / Nakagawa, Kiyotaka / Abe, Takaaki / Fedorova, Maria / Proneth, Bettina / Pratt, Derek A / Conrad, Marcus

Nature

2022 Volume 608, Issue 7924, Page(s) 778–783

Abstract: Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid ... ...

Abstract	Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation
MeSH term(s)	Antidotes/pharmacology ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Carbon-Carbon Ligases/metabolism ; Coenzymes/metabolism ; Ferroptosis/drug effects ; Hydroquinones/metabolism ; Hydroquinones/pharmacology ; Lipid Peroxidation/drug effects ; Oxidation-Reduction ; S100 Calcium-Binding Protein A4/metabolism ; Vitamin K/metabolism ; Vitamin K/pharmacology ; Warfarin/adverse effects
Chemical Substances	Antidotes ; Antioxidants ; Coenzymes ; Hydroquinones ; S100 Calcium-Binding Protein A4 ; Vitamin K (12001-79-5) ; Warfarin (5Q7ZVV76EI) ; Carbon-Carbon Ligases (EC 6.4.-) ; glutamyl carboxylase (EC 6.4.-) ; hydroquinone (XV74C1N1AE)
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05022-3
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Article ; Online: Cardiomyopathy Does Not Exacerbate the Severity of Pneumonia Caused by a SARS-CoV-2 Delta Variant in the J2N-k Hamster Model.

Iwatsuki-Horimoto, Kiyoko / Ito, Mutsumi / Okuda-Hamabata, Moe / Takagi, Hisayoshi / Imai, Masaki / Kawaoka, Yoshihiro

Viruses

2023 Volume 15, Issue 12

Abstract: ... causes more severe disease with cardiomyopathy in a J2N-k animal model. Here, we investigated ... the sensitivity of J2N-k hamsters, as a cardiomyopathy animal model, to a delta strain of SARS-CoV-2 compared ... to J2N-n control animals. We found that J2N-k hamsters were less susceptible to this delta strain ...

Abstract	Cardiovascular disease is one of many risk factors that have been linked to increased severity or mortality in coronavirus disease 2019 (COVID-19) patients; however, the exact role of SARS-CoV-2 in the pathogenesis of cardiac inflammatory injury has not been established. A previous study reported that SARS-CoV-2 causes more severe disease with cardiomyopathy in a J2N-k animal model. Here, we investigated the sensitivity of J2N-k hamsters, as a cardiomyopathy animal model, to a delta strain of SARS-CoV-2 compared to J2N-n control animals. We found that J2N-k hamsters were less susceptible to this delta strain than J2N-n animals, and we found no evidence that cardiomyopathy is a risk factor in this animal model. Since the previous study reported that SARS-CoV-2 causes more severe disease with cardiomyopathy in the same animal model, further analysis of the relationship between cardiomyopathy and SARS-CoV-2 infection is needed.
MeSH term(s)	Humans ; Cricetinae ; Animals ; SARS-CoV-2 ; COVID-19/complications ; Cardiomyopathies/etiology ; Disease Models, Animal ; Mesocricetus
Language	English
Publishing date	2023-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15122280
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Article ; Online: Measurement of CP Violation in B^{0}→K_{S}^{0}π^{0} Decays at Belle II.

Adachi, I / Adamczyk, K / Aggarwal, L / Ahmed, H / Aihara, H / Akopov, N / Aloisio, A / Anh Ky, N / Asner, D M / Atmacan, H / Aushev, T / Aushev, V / Aversano, M / Babu, V / Bae, H / Bahinipati, S / Bambade, P / Banerjee, Sw / Barrett, M /

Baudot, J / Bauer, M / Baur, A / Beaubien, A / Becker, J / Behera, P K / Bennett, J V / Bertacchi, V / Bertemes, M / Bertholet, E / Bessner, M / Bettarini, S / Bhuyan, B / Bianchi, F / Bilka, T / Biswas, D / Bodrov, D / Bondar, A / Borah, J / Bozek, A / Bračko, M / Branchini, P / Briere, R A / Browder, T E / Budano, A / Bussino, S / Campajola, M / Cao, L / Casarosa, G / Cecchi, C / Cerasoli, J / Chang, P / Cheaib, R / Cheema, P / Chekelian, V / Chen, C / Cheon, B G / Chilikin, K / Chirapatpimol, K / Cho, H-E / Cho, K / Cho, S-J / Choi, S-K / Choudhury, S / Cochran, J / Corona, L / Cremaldi, L M / Das, S / Dattola, F / De La Cruz-Burelo, E / De La Motte, S A / de Marino, G / De Nuccio, M / De Pietro, G / de Sangro, R / Destefanis, M / De Yta-Hernandez, A / Dhamija, R / Di Canto, A / Di Capua, F / Dingfelder, J / Doležal, Z / Domínguez Jiménez, I / Dong, T V / Dorigo, M / Dort, K / Dreyer, S / Dubey, S / Dujany, G / Ecker, P / Eliachevitch, M / Feichtinger, P / Ferber, T / Ferlewicz, D / Fillinger, T / Finck, C / Finocchiaro, G / Fodor, A / Forti, F / Fulsom, B G / Gabrielli, A / Ganiev, E / Garcia-Hernandez, M / Garg, R / Garmash, A / Gaudino, G / Gaur, V / Gaz, A / Gellrich, A / Ghosh, D / Giakoustidis, G / Giordano, R / Giri, A / Glazov, A / Gobbo, B / Godang, R / Goldenzweig, P / Gradl, W / Grammatico, T / Granderath, S / Graziani, E / Greenwald, D / Gruberová, Z / Gu, T / Guan, Y / Gudkova, K / Halder, S / Han, Y / Hara, K / Hara, T / Hayasaka, K / Hayashii, H / Hazra, S / Hearty, C / Hedges, M T / Heredia de la Cruz, I / Hernández Villanueva, M / Hershenhorn, A / Higuchi, T / Hill, E C / Hoek, M / Hohmann, M / Hsu, C-L / Humair, T / Iijima, T / Inami, K / Ipsita, N / Ishikawa, A / Ito, S / Itoh, R / Iwasaki, M / Jackson, P / Jacobs, W W / Jang, E-J / Ji, Q P / Jia, S / Jin, Y / Johnson, A / Joo, K K / Junkerkalefeld, H / Kaleta, M / Kaliyar, A B / Kandra, J / Kang, K H / Kang, S / Kar, S / Karyan, G / Kawasaki, T / Keil, F / Ketter, C / Kiesling, C / Kim, C-H / Kim, D Y / Kim, K-H / Kim, Y-K / Kindo, H / Kodyš, P / Koga, T / Kohani, S / Kojima, K / Korobov, A / Korpar, S / Kovalenko, E / Kowalewski, R / Kraetzschmar, T M G / Križan, P / Krokovny, P / Kuhr, T / Kumar, J / Kumar, M / Kumara, K / Kunigo, T / Kuzmin, A / Kwon, Y-J / Lacaprara, S / Lai, Y-T / Lam, T / Lange, J S / Laurenza, M / Leboucher, R / Le Diberder, F R / Leitl, P / Levit, D / Li, C / Li, L K / Libby, J / Liu, Q Y / Liu, Z Q / Liventsev, D / Longo, S / Lueck, T / Luo, T / Lyu, C / Ma, Y / Maggiora, M / Maharana, S P / Maiti, R / Maity, S / Mancinelli, G / Manfredi, R / Manoni, E / Mantovano, M / Marcantonio, D / Marcello, S / Marinas, C / Martel, L / Martellini, C / Martinov, T / Massaccesi, L / Masuda, M / Matsuda, T / Matsuoka, K / Matvienko, D / Maurya, S K / McKenna, J A / Mehta, R / Meier, F / Merola, M / Metzner, F / Milesi, M / Miller, C / Mirra, M / Miyabayashi, K / Mizuk, R / Mohanty, G B / Molina-Gonzalez, N / Mondal, S / Moneta, S / Moser, H-G / Mrvar, M / Mussa, R / Nakamura, I / Nakazawa, Y / Narimani Charan, A / Naruki, M / Natochii, A / Nayak, L / Nayak, M / Nazaryan, G / Nisar, N K / Nishida, S / Ono, H / Onuki, Y / Oskin, P / Pakhlov, P / Pakhlova, G / Paladino, A / Paoloni, E / Pardi, S / Parham, K / Park, H / Park, S-H / Passeri, A / Patra, S / Paul, S / Pedlar, T K / Peschke, R / Pestotnik, R / Pham, F / Piccolo, M / Piilonen, L E / Podesta-Lerma, P L M / Podobnik, T / Pokharel, S / Praz, C / Prell, S / Prencipe, E / Prim, M T / Purwar, H / Rad, N / Rados, P / Raeuber, G / Raiz, S / Reif, M / Reiter, S / Remnev, M / Ripp-Baudot, I / Rizzo, G / Robertson, S H / Roehrken, M / Roney, J M / Rostomyan, A / Rout, N / Russo, G / Sahoo, D / Sandilya, S / Sangal, A / Santelj, L / Sato, Y / Savinov, V / Scavino, B / Schmitt, C / Schwanda, C / Schwartz, A J / Seino, Y / Selce, A / Senyo, K / Serrano, J / Sevior, M E / Sfienti, C / Shan, W / Sharma, C / Shi, X D / Shillington, T / Shiu, J-G / Shtol, D / Sibidanov, A / Simon, F / Singh, J B / Skorupa, J / Sobie, R J / Sobotzik, M / Soffer, A / Sokolov, A / Solovieva, E / Spataro, S / Spruck, B / Starič, M / Stavroulakis, P / Stefkova, S / Stottler, Z S / Stroili, R / Sumihama, M / Sumisawa, K / Sutcliffe, W / Svidras, H / Takahashi, M / Takizawa, M / Tamponi, U / Tanaka, S / Tanida, K / Tenchini, F / Thaller, A / Tittel, O / Tiwary, R / Tonelli, D / Torassa, E / Trabelsi, K / Tsaklidis, I / Uchida, M / Ueda, I / Uglov, T / Unger, K / Unno, Y / Uno, K / Uno, S / Urquijo, P / Ushiroda, Y / Vahsen, S E / van Tonder, R / Varner, G S / Varvell, K E / Vinokurova, A / Vismaya, V S / Vitale, L / Wach, B / Wakai, M / Wakeling, H M / Wallner, S / Wang, E / Wang, M-Z / Wang, Z / Warburton, A / Watanabe, M / Watanuki, S / Welsch, M / Wessel, C / Won, E / Xu, X P / Yabsley, B D / Yamada, S / Yan, W / Yang, S B / Yin, J H / Yoshihara, K / Yuan, C Z / Yusa, Y / Zani, L / Zhang, Y / Zhilich, V / Zhou, Q D / Zhukova, V I

Physical review letters

2023 Volume 131, Issue 11, Page(s) 111803

Abstract: We report a measurement of the CP-violating parameters C and S in B^{0}→K_{S}^{0}π^{0} decays ...

Abstract	We report a measurement of the CP-violating parameters C and S in B^{0}→K_{S}^{0}π^{0} decays at Belle II using a sample of 387×10^{6} BB[over ¯] events recorded in e^{+}e^{-} collisions at a center-of-mass energy corresponding to the ϒ(4S) resonance. These parameters are determined by fitting the proper decay-time distribution of a sample of 415 signal events. We obtain C=-0.04_{-0.15}^{+0.14}±0.05 and S=0.75_{-0.23}^{+0.20}±0.04, where the first uncertainties are statistical and the second are systematic.
Language	English
Publishing date	2023-09-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.111803
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Article ; Online: Castration Induces Down-Regulation of A-Type K

Ohya, Susumu / Ito, Katsunori / Hatano, Noriyuki / Ohno, Akitoshi / Muraki, Katsuhiko / Imaizumi, Yuji

International journal of molecular sciences

2019 Volume 20, Issue 17

Abstract: A-type K ...

Abstract	A-type K
MeSH term(s)	Animals ; Blotting, Western ; Castration/adverse effects ; Down-Regulation ; Electrophysiology ; Kv Channel-Interacting Proteins/genetics ; Kv Channel-Interacting Proteins/metabolism ; Male ; Methyltestosterone/pharmacology ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Rats ; Rats, Wistar ; Testosterone/metabolism ; Vas Deferens/drug effects ; Vas Deferens/metabolism
Chemical Substances	Kv Channel-Interacting Proteins ; Testosterone (3XMK78S47O) ; Methyltestosterone (V9EFU16ZIF)
Language	English
Publishing date	2019-08-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20174073
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Article ; Online: Co-expression of nuclear heterogeneous nuclear ribonucleic protein K and estrogen receptor α in endometrial cancer.

Miki, Yasuhiro / Iwabuchi, Erina / Takagi, Kiyoshi / Suzuki, Takashi / Sasano, Hironobu / Yaegashi, Nobuo / Ito, Kiyoshi

Pathology, research and practice

2022 Volume 231, Page(s) 153795

Abstract: Heterogeneous nuclear ribonucleic protein K (hnRNPK) regulates the expression of various genes ...

Abstract	Heterogeneous nuclear ribonucleic protein K (hnRNPK) regulates the expression of various genes, but has contradictory roles as a tumor promoter and a tumor suppressor. We recently reported that the expression of hnRNPK is negatively associated with malignant behavior of breast cancer where it was induced by estrogen, and bound to estrogen receptor α (ERα) in the nucleus of breast cancer cells. However, the significance of hnRNPK in endometrial cancer, also an estrogen-dependent cancer, remains unclear. In this study, we first examined the localization of hnRNPK and ERα in normal endometrium and endometrial cancer. hnRNPK and ERα immunoreactivity was detected in the nuclei of endometrial glandular and carcinoma cells. In normal endometria, hnRNPK labeling index/immuno-intensity was significantly higher in the proliferative phase than in the secretory phase. In endometrial cancer tissues, hnRNPK labeling index/immuno-intensity was significantly higher in the adjacent non-malignant glandular cells compared to that in carcinoma cells. Immunohistochemistry results for ERα were identical to that of hnRNPK both in normal endometrium and endometrial cancer. In normal and cancerous tissues, the median value of the hnRNPK labeling index was significantly higher in the ERα-high group. Intratumoral estrogen, but not androgen, measured using liquid chromatography-tandem mass spectrometry, was significantly positively correlated with the hnRNPK labeling index in endometrial cancer tissues. Database analysis revealed that the hnRNPK high expression group had a significantly better prognosis for both overall and disease-free survival. These results suggest that hnRNPK interacts with ERα to regulate endometrial changes during the menstrual cycle and suppress the malignant behavior of endometrial cancer.
MeSH term(s)	Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/genetics ; Estrogen Receptor alpha/analysis ; Estrogen Receptor alpha/genetics ; Female ; Gene Expression/genetics ; Gene Expression/physiology ; Heterogeneous-Nuclear Ribonucleoprotein K/analysis ; Heterogeneous-Nuclear Ribonucleoprotein K/genetics ; Humans ; Japan
Chemical Substances	Estrogen Receptor alpha ; Heterogeneous-Nuclear Ribonucleoprotein K ; HNRNPK protein, human (146410-60-8)
Language	English
Publishing date	2022-02-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2022.153795
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Article ; Online: Increased door-to-puncture time during off-duty hours results in poor treatment outcomes for acute ischemic stroke: A subanalysis of the K-NET registry.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

2023 , Page(s) 15910199231205050

Abstract: ... comprised 1571 patients listed in the multicenter stroke registry (K-NET) who had undergone endovascular ...

Abstract	Background: For patients who undergo endovascular treatment for acute ischemic stroke, the total time for treatment may increase during off-duty hours leading to worse outcomes. The present study compared endovascular treatment outcomes for on-duty and off-duty hours and examined factors that could be responsible for the prolonged treatment of patients in a multicenter registry. Methods: The study group comprised 1571 patients listed in the multicenter stroke registry (K-NET) who had undergone endovascular treatment between January 2018 and June 2020. The modified Rankin Scale (mRS), evaluated at 90 days after stroke onset, was utilized as the primary outcome. Patients were divided into on-duty and off-duty patients based on admission time. Multivariate logistic regression analysis was used to identify the independent factors that increased the time from admission to puncture during the off-duty period. Results: The mean mRS score at 90 days after stroke onset was 2.9, similar in both on-duty and off-duty patients, with no significant difference ( Conclusion: Door-to-puncture time >60 min during off-duty hours was associated with poor outcomes related to low NIHSS, high pre-mRS, posterior circulation, and diabetes.
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1354913-3
ISSN	2385-2011 ; 1591-0199 ; 1123-9344
ISSN (online)	2385-2011
ISSN	1591-0199 ; 1123-9344
DOI	10.1177/15910199231205050
Database	MEDical Literature Analysis and Retrieval System OnLINE

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