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Article ; Online: When solid recovered fuel (SRF) production and consumption maximize environmental benefits? A life cycle assessment.

Ferronato, Navarro / Giaquinta, Chiara / Conti, Fabio / Torretta, Vincenzo

2024 Volume 178, Page(s) 199–209

Abstract: Solid recovered fuel (SRF) from non-recyclable waste obtained from source separation and mechanical treatments can replace carbon coke in cement plants, contributing to the carbon neutrality. A life cycle assessment (LCA) of the SRF production from non- ... ...

Abstract	Solid recovered fuel (SRF) from non-recyclable waste obtained from source separation and mechanical treatments can replace carbon coke in cement plants, contributing to the carbon neutrality. A life cycle assessment (LCA) of the SRF production from non-recyclable and selected waste was conducted in an Italian mechanical treatment plant to estimate the potential environmental impacts per ton of SRF produced. The analysis would contribute to evaluate the benefits that can be obtained due to coke substitution in best- and worst-case scenarios. The avoided impacts achieved were assessed, together with an evaluation of the variables that can affect the environmental benefits: SRF biogenic carbon content (in percentage of paper and cardboard); transportation distances travelled from the treatment plant to the cement kiln; the renewable energy used in the mechanical facility. On average, about 35.6 kgCO
MeSH term(s)	Animals ; Refuse Disposal ; Coke/analysis ; Renewable Energy ; Carbon ; Life Cycle Stages ; Solid Waste/analysis ; Waste Management
Chemical Substances	Coke ; Carbon (7440-44-0) ; Solid Waste
Language	English
Publishing date	2024-02-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2024.02.029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Programmes to manage food selectivity in individuals with autism spectrum disorder.

Breda, Chiara / Santero, Sara / Conti, Maria Vittoria / Cena, Hellas

Nutrition research reviews

2024 , Page(s) 1–14

Abstract: Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders characterised by impaired social communication and restricted interests/repetitive behaviours. In this regard, sensory processing difficulties and delayed oral motor skills ...

Abstract	Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders characterised by impaired social communication and restricted interests/repetitive behaviours. In this regard, sensory processing difficulties and delayed oral motor skills often predispose individuals with ASD to food selectivity (FS). It is usually associated with repetitive eating patterns that can lead to multiple malnutrition conditions. The objective of this narrative review is to present an overview about the existing nutritional interventions aiming at promoting a healthy eating pattern and addressing food selectivity among individuals with ASD. Regarding the interventions targeting nutrition education, the majority of the analysed studies failed to demonstrate their effectiveness. On the other hand, many educational interventions involving taste or cooking sessions, as well as behavioural interventions for FS, demonstrated effective results. Moreover, multidisciplinary in tailoring such programmes, including psychology speech therapy and nutritional skills, is acknowledged as a key approach.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1003534-5
ISSN	1475-2700 ; 0954-4224
ISSN (online)	1475-2700
ISSN	0954-4224
DOI	10.1017/S0954422424000052
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Article ; Online: Integrating network pharmacology: The next-generation approach in ocular drug discovery.

Lazzara, Francesca / Conti, Federica / Giuffrida, Erika / Eandi, Chiara Maria / Drago, Filippo / Platania, Chiara Bianca Maria / Bucolo, Claudio

Current opinion in pharmacology

2024 Volume 74, Page(s) 102425

Abstract: With the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can ... ...

Abstract	With the spread of the "omics" sciences, the approaches of systems biology can be considered as new paradigms of pharmacological research for discovery of novel targets and/or treatments for complex multifactorial diseases. Data from omics sciences can be used for the design of biologic networks, that in turn can be quantitatively analyzed to identify new pharmacological targets. In this review, we will introduce the concept of network pharmacology, particularly the application of this innovative approach in the field of ocular pharmacology, with a focus on retinal diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma.
MeSH term(s)	Humans ; Network Pharmacology ; Eye ; Diabetic Retinopathy/drug therapy ; Retinal Diseases ; Drug Discovery
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2037057-X
ISSN	1471-4973 ; 1471-4892
ISSN (online)	1471-4973
ISSN	1471-4892
DOI	10.1016/j.coph.2023.102425
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Article ; Online: Understanding Intrinsic Warhead Reactivity and Cysteine Druggability in Covalent Drug Discovery

Chiara Borsari / Alexandra Ioana Corfu / Paola Conti

CHIMIA, Vol 77, Iss

2023 Volume 5

Keywords	Covalent inhibitors ; Druggable cysteines ; Intrinsic reactivity ; Rational Design ; Warhead ; Chemistry ; QD1-999
Language	German
Publishing date	2023-05-01T00:00:00Z
Publisher	Swiss Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Keep Your Friends Close, and Your Enemies Closer

Tacchi, Jack / Boldrini, Chiara / Passarella, Andrea / Conti, Marco

Structural Properties of Negative Relationships on Twitter

2024

Abstract: The Ego Network Model (ENM) is a model for the structural organisation of relationships, rooted in evolutionary anthropology, that is found ubiquitously in social contexts. It takes the perspective of a single user (Ego) and organises their contacts ( ... ...

Abstract	The Ego Network Model (ENM) is a model for the structural organisation of relationships, rooted in evolutionary anthropology, that is found ubiquitously in social contexts. It takes the perspective of a single user (Ego) and organises their contacts (Alters) into a series of (typically 5) concentric circles of decreasing intimacy and increasing size. Alters are sorted based on their tie strength to the Ego, however, this is difficult to measure directly. Traditionally, the interaction frequency has been used as a proxy but this misses the qualitative aspects of connections, such as signs (i.e. polarity), which have been shown to provide extremely useful information. However, the sign of an online social relationship is usually an implicit piece of information, which needs to be estimated by interaction data from Online Social Networks (OSNs), making sign prediction in OSNs a research challenge in and of itself. This work aims to bring the ENM into the signed networks domain by investigating the interplay of signed connections with the ENM. This paper delivers 2 main contributions. Firstly, a new and data-efficient method of signing relationships between individuals using sentiment analysis and, secondly, we provide an in-depth look at the properties of Signed Ego Networks (SENs), using 9 Twitter datasets of various categories of users. We find that negative connections are generally over-represented in the active part of the Ego Networks, suggesting that Twitter greatly over-emphasises negative relationships with respect to "offline" social networks. Further, users who use social networks for professional reasons have an even greater share of negative connections.
Keywords	Computer Science - Social and Information Networks
Subject code	300
Publishing date	2024-01-29
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design of Na

Conti, Debora Maria / Urru, Claudia / Bruni, Giovanna / Galinetto, Pietro / Albini, Benedetta / Milanese, Chiara / Pisani, Silvia / Berbenni, Vittorio / Capsoni, Doretta

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 8

Abstract: The NASICON-structured ... ...

Abstract	The NASICON-structured Na
Language	English
Publishing date	2024-04-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29081885
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Article ; Online: Cognitive alterations and brain functional changes following chemotherapy treatment in breast cancer patients: A systematic review on resting-state fMRI studies.

Conti, Lorenzo / Pizzoli, Silvia Francesca Maria / Marzorati, Chiara / Grasso, Roberto / Petralia, Giuseppe / Pravettoni, Gabriella

Applied neuropsychology. Adult

2024 , Page(s) 1–16

Abstract: Cognitive dysfunctions and functional brain modifications are among the side effects reported by breast cancer patients that persist beyond the chemotherapy. This paper aims at synthesizing the evidence on cognitive and functional brain changes and their ...

Abstract	Cognitive dysfunctions and functional brain modifications are among the side effects reported by breast cancer patients that persist beyond the chemotherapy. This paper aims at synthesizing the evidence on cognitive and functional brain changes and their associations in breast cancer patients treated with chemotherapy. A systematic literature search was performed using PubMed, Ovid MEDLINE, Scopus, and Embase up to July 2022. Eligible studies evaluated adult women with breast cancer treated with systemic chemotherapy, that performed cognitive assessment and resting-state functional MRI. Methodological quality was assessed. Sixteen studies were included, with a total of 1054 female participants. All studies reported alterations mainly concerned the fronto-parieto-temporal system and specifically involved the disruption of the DMN. Consistent with these findings, BCPs showed changes in cognitive performance reporting dysfunctions in executive ability, memory, and attention. However, not all the studies found a significant association between functional brain alterations and cognitive dysfunction. Some limitations including lack of sample homogeneity and different methodological approaches were reported. This work highlighted the presence of cognitive dysfunctions and functional brain alteration in breast cancer patients treated with chemotherapy. This allows a greater awareness of the side effects, promoting better clinical management. However, further research is needed to investigate the cause-effect relationship between cognitive and functional alterations.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2673736-X
ISSN	2327-9109 ; 2327-9095
ISSN (online)	2327-9109
ISSN	2327-9095
DOI	10.1080/23279095.2024.2303362
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Article ; Online: Synchrotron radiation X-ray diffraction computed tomography (XRDCT): a new tool in cultural heritage and stone conservation for 3D non-destructive probing and phase analysis of inorganic re-treatments.

Possenti, Elena / Marinoni, Nicoletta / Conti, Claudia / Realini, Marco / Vaughan, Gavin B M / Colombo, Chiara

The Analyst

2024 Volume 149, Issue 7, Page(s) 2059–2072

Abstract: The issue of preserving carbonatic stones of cultural heritage (CH) restored in the past that have undergone new decay phenomena is strongly emerging and conservation science has not yet found a reliable solution. In this paper, we propose the ... ...

Abstract	The issue of preserving carbonatic stones of cultural heritage (CH) restored in the past that have undergone new decay phenomena is strongly emerging and conservation science has not yet found a reliable solution. In this paper, we propose the application of synchrotron radiation X-ray diffraction computed tomography (XRDCT) to explore the effects of using inorganic-mineral products (ammonium oxalate; ammonium phosphate) in sequence as a novel, compatible and effective re-treatment approach to consolidate decayed carbonatic stones already treated with inorganic-mineral treatments. High-quality XRDCT datasets were used to qualitatively/quantitatively investigate and 3D localize the complex mixture of crystalline phases formed after the conservation re-treatments within a porous carbonatic stone substrate. The XRDCT reconstruction images and the structural refinements of XRD patterns with the Rietveld methods showed that the phase composition of reaction products, their volume distribution, and weight fraction vary as a function of the treatment sequence and penetration depth. The high potential of XRDCT allows (i) assessment of peculiar trends of each treatment/treatment sequence; (ii) exploration of the reaction steps of the sequential treatments and (iii) demonstration of the consolidating effect of inorganic re-treatments, non-destructively and at the micron scale. Above all, our study (i) provides new analytical tools to support the conservation choices, (ii) showcases new analytical possibilities for XRDCT in conservation science, including in investigations of CH materials and decay processes, and (iii) opens up new perspectives in analytical chemistry and material characterisation for the non-destructive and non-invasive analysis of reactions within heterogeneous polycrystalline systems.
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an02208k
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Article ; Online: The Application of tDCS to Treat Pain and Psychocognitive Symptoms in Cancer Patients: A Scoping Review.

Capetti, Benedetta / Conti, Lorenzo / Marzorati, Chiara / Grasso, Roberto / Ferrucci, Roberta / Pravettoni, Gabriella

Neural plasticity

2024 Volume 2024, Page(s) 6344925

Abstract: Background: The use of transcranial direct current stimulation (tDCS) to modulate pain, psychological aspects, and cognitive functions has increased in recent years. The present scoping review aims to investigate the use of tDCS in cancer patients and ... ...

Abstract	Background: The use of transcranial direct current stimulation (tDCS) to modulate pain, psychological aspects, and cognitive functions has increased in recent years. The present scoping review aims to investigate the use of tDCS in cancer patients and its significant impact on psychocognitive and pain related symptoms. Methods: From the earliest available date to June 2023, a comprehensive search was conducted in three electronic scientific databases-PubMed, Scopus, and Embase-and other supplementary sources. Ten relevant studies were identified and included, comprising single case studies, randomized controlled trials, pilot studies, and one retrospective study. PRISMA guidelines for scoping reviews were followed. Results: These studies investigated the use of tDCS to improve pain and psychocognitive aspects in patients with various types of cancer, including breast, oral, bladder, lung, pancreatic, head and neck cancer, hepatocellular carcinoma, and meningioma. Overall, the results suggest that tDCS has shown efficacy in relieving pain, reducing anxiety and depression, and improving cognitive function in cancer patients. Conclusion: Due to the limited number and high heterogeneity of the existing literature in this field, more investigation and the establishment of standardized protocols would be required to obtain more conclusive evidence.
MeSH term(s)	Humans ; Transcranial Direct Current Stimulation/methods ; Neoplasms/therapy ; Neoplasms/psychology ; Neoplasms/complications ; Pain Management/methods ; Depression/therapy ; Cognition/physiology ; Pain/psychology ; Anxiety/therapy
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	1454938-4
ISSN	1687-5443 ; 2090-5904 ; 0792-8483
ISSN (online)	1687-5443
ISSN	2090-5904 ; 0792-8483
DOI	10.1155/2024/6344925
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Article: Multi-Inflammatory Syndrome in Children (MIS-C) in 2023: Is It Time to Forget about It?

La Torre, Francesco / Taddio, Andrea / Conti, Chiara / Cattalini, Marco

Children (Basel, Switzerland)

2023 Volume 10, Issue 6

Abstract: Multisystem inflammatory syndrome in children (MIS-C) is defined as a clinically serious condition requiring hospitalization involving fever, multi-system organ dysfunction, and an increase in inflammatory biomarkers. The syndrome was originally ... ...

Abstract	Multisystem inflammatory syndrome in children (MIS-C) is defined as a clinically serious condition requiring hospitalization involving fever, multi-system organ dysfunction, and an increase in inflammatory biomarkers. The syndrome was originally described as a post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which usually causes COVID-19. During the COVID-19 pandemic, not only did the virus undergo mutations but vaccines against SARS-CoV-2 were also developed. Both these conditions led to a decrease in the incidence of MIS-C. This narrative review summarizes the recent updates for MIS-C, particularly regarding the change in incidence, the link between the SARS-CoV-2 vaccine and MIS-C, and new updates of MIS-C treatments.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10060980
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