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  1. Book: Mediator

    Conaway, Joan Weliky

    a multifunctional regulator of RNA polymerase II transcription

    (NCI Center for Cancer Research eminent lecture series)

    2015  

    Abstract: CIT): NCI Center for Cancer Research Eminent Lecture Series Joan Conaway is an Investigator ... Her laboratory, which she co-directs with her husband Ronald Conaway, studies molecular mechanisms responsible ...

    Author's details Joan Conaway
    Series title NCI Center for Cancer Research eminent lecture series
    Abstract (CIT): NCI Center for Cancer Research Eminent Lecture Series Joan Conaway is an Investigator at the Stowers Institute for Medical Research in Kansas City, Missouri, USA. She received her undergraduate training at Bryn Mawr College, where she majored in Chemistry and Biology, and a PhD in Cell Biology from the Stanford University School of Medicine, where she worked in the laboratory of Dr. Roger Kornberg. Her laboratory, which she co-directs with her husband Ronald Conaway, studies molecular mechanisms responsible for the regulation of RNA polymerase II transcription in mammalian cells, with a focus on the interplay between transcriptional coregulators and the transcription initiation and elongation machinery.
    MeSH term(s) Mediator Complex Subunit 1
    Language English
    Size 1 online resource (1 streaming video file (1 hr., 7 min.)) :, color, sound.
    Document type Book
    Note Closed-captioned. ; Access restricted to HHS only.
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Article: The Mediator complex and transcription elongation.

    Conaway, Ronald C / Conaway, Joan Weliky

    Biochimica et biophysica acta

    2012  Volume 1829, Issue 1, Page(s) 69–75

    Abstract: Background: Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies ... ...

    Abstract Background: Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies have brought to light an expanded role for Mediator at post-initiation stages of transcription.
    Scope of review: We provide a brief description of the structure of Mediator and its function in the regulation of Pol II transcription initiation, and we summarize recent findings implicating Mediator in the regulation of various stages of Pol II transcription elongation.
    Major conclusions: Emerging evidence is revealing new roles for Mediator in nearly all stages of Pol II transcription, including initiation, promoter escape, elongation, pre-mRNA processing, and termination.
    General significance: Mediator plays a central role in the regulation of gene expression by impacting nearly all stages of mRNA synthesis. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
    MeSH term(s) Animals ; Humans ; Mediator Complex/chemistry ; Mediator Complex/genetics ; Mediator Complex/metabolism ; Mediator Complex/physiology ; Models, Biological ; RNA Polymerase II/chemistry ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA Polymerase II/physiology ; Structure-Activity Relationship ; Transcription Elongation, Genetic/physiology
    Chemical Substances Mediator Complex ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2012-09-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagrm.2012.08.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Origins and activity of the Mediator complex.

    Conaway, Ronald C / Conaway, Joan Weliky

    Seminars in cell & developmental biology

    2011  Volume 22, Issue 7, Page(s) 729–734

    Abstract: The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. ... ...

    Abstract The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription.
    MeSH term(s) Animals ; Evolution, Molecular ; Gene Expression Regulation ; Humans ; Mediator Complex/chemistry ; Mediator Complex/genetics ; Mediator Complex/metabolism ; Plant Physiological Phenomena ; Promoter Regions, Genetic ; Protein Biosynthesis ; RNA Polymerase II/biosynthesis ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription, Genetic
    Chemical Substances Mediator Complex ; Saccharomyces cerevisiae Proteins ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2011-07-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2011.07.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Function and regulation of the Mediator complex.

    Conaway, Ronald C / Conaway, Joan Weliky

    Current opinion in genetics & development

    2011  Volume 21, Issue 2, Page(s) 225–230

    Abstract: Over the past few years, advances in biochemical and genetic studies of the structure and function of the Mediator complex have shed new light on its subunit architecture and its mechanism of action in transcription by RNA polymerase II (pol II). The ... ...

    Abstract Over the past few years, advances in biochemical and genetic studies of the structure and function of the Mediator complex have shed new light on its subunit architecture and its mechanism of action in transcription by RNA polymerase II (pol II). The development of improved methods for reconstitution of recombinant Mediator subassemblies is enabling more in-depth analyses of basic features of the mechanisms by which Mediator interacts with and controls the activity of pol II and the general initiation factors. The discovery and characterization of multiple, functionally distinct forms of Mediator characterized by the presence or absence of the Cdk8 kinase module have led to new insights into how Mediator functions in both Pol II transcription activation and repression. Finally, progress in studies of the mechanisms by which the transcriptional activation domains (ADs) of DNA binding transcription factors target Mediator have brought to light unexpected complexities in the way Mediator participates in signal transduction.
    MeSH term(s) Animals ; Humans ; Mediator Complex/metabolism ; Protein Binding ; RNA Polymerase II/metabolism ; Signal Transduction ; Transcriptional Activation
    Chemical Substances Mediator Complex ; RNA Polymerase II (EC 2.7.7.-)
    Language English
    Publishing date 2011-02-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2011.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Mediator comes out from the shadows.

    Conaway, Ronald C / Conaway, Joan Weliky

    Structure (London, England : 1993)

    2009  Volume 17, Issue 4, Page(s) 485–486

    MeSH term(s) Binding Sites ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Fungal Proteins/ultrastructure ; Gene Expression Regulation, Fungal ; Genes, Fungal ; Models, Molecular ; Protein Binding ; Protein Conformation ; Transcription, Genetic
    Chemical Substances Fungal Proteins
    Language English
    Publishing date 2009-04-15
    Publishing country United States
    Document type Comment ; News ; Research Support, N.I.H., Extramural
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2009.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The INO80 chromatin remodeling complex in transcription, replication and repair.

    Conaway, Ronald C / Conaway, Joan Weliky

    Trends in biochemical sciences

    2009  Volume 34, Issue 2, Page(s) 71–77

    Abstract: The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved ... ...

    Abstract The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.
    MeSH term(s) Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Animals ; Chromatin/metabolism ; Chromatin Assembly and Disassembly/genetics ; DNA Repair ; DNA Replication ; Humans ; Models, Biological ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription, Genetic
    Chemical Substances Chromatin ; INO80 complex, S cerevisiae ; Saccharomyces cerevisiae Proteins ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2009-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2008.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Mediator complex and transcription elongation

    Conaway, Ronald C / Conaway, Joan Weliky

    BBA - Gene Regulatory Mechanisms. 2013 Jan., v. 1829, no. 1

    2013  

    Abstract: BACKGROUND: Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies ... ...

    Abstract BACKGROUND: Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies have brought to light an expanded role for Mediator at post-initiation stages of transcription. SCOPE OF REVIEW: We provide a brief description of the structure of Mediator and its function in the regulation of Pol II transcription initiation, and we summarize recent findings implicating Mediator in the regulation of various stages of Pol II transcription elongation. MAJOR CONCLUSIONS: Emerging evidence is revealing new roles for Mediator in nearly all stages of Pol II transcription, including initiation, promoter escape, elongation, pre-mRNA processing, and termination. GENERAL SIGNIFICANCE: Mediator plays a central role in the regulation of gene expression by impacting nearly all stages of mRNA synthesis. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
    Keywords DNA-directed RNA polymerase ; gene expression regulation ; messenger RNA
    Language English
    Dates of publication 2013-01
    Size p. 69-75.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2918786-2
    ISSN 1876-4320 ; 1874-9399
    ISSN (online) 1876-4320
    ISSN 1874-9399
    DOI 10.1016/j.bbagrm.2012.08.017
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: New clues to actin function in chromatin regulation.

    Gottschalk, Aaron J / Conaway, Ronald C / Conaway, Joan Weliky

    Nature structural & molecular biology

    2008  Volume 15, Issue 5, Page(s) 432–433

    MeSH term(s) Actins/metabolism ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Humans ; Nuclear Proteins/metabolism
    Chemical Substances Actins ; Chromatin ; Nuclear Proteins
    Language English
    Publishing date 2008-05
    Publishing country United States
    Document type Comment ; News
    ZDB-ID 2126708-X
    ISSN 1545-9985 ; 1545-9993
    ISSN (online) 1545-9985
    ISSN 1545-9993
    DOI 10.1038/nsmb0508-432
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article: Origins and activity of the Mediator complex

    Conaway, Ronald C / Conaway, Joan Weliky

    Seminars in cell & developmental biology. 2011 Sept., v. 22, no. 7

    2011  

    Abstract: The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. ... ...

    Abstract The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription.
    Keywords DNA ; DNA-directed RNA polymerase ; Saccharomyces cerevisiae ; transcription (genetics) ; transcription factors ; transcriptional activation ; yeasts
    Language English
    Dates of publication 2011-09
    Size p. 729-734.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2011.07.021
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Function and regulation of the Mediator complex

    Conaway, Ronald C / Conaway, Joan Weliky

    Current Opinion in Genetics & Development. 2011 Apr., v. 21, no. 2

    2011  

    Abstract: Over the past few years, advances in biochemical and genetic studies of the structure and function of the Mediator complex have shed new light on its subunit architecture and its mechanism of action in transcription by RNA polymerase II (pol II). The ... ...

    Abstract Over the past few years, advances in biochemical and genetic studies of the structure and function of the Mediator complex have shed new light on its subunit architecture and its mechanism of action in transcription by RNA polymerase II (pol II). The development of improved methods for reconstitution of recombinant Mediator subassemblies is enabling more in-depth analyses of basic features of the mechanisms by which Mediator interacts with and controls the activity of pol II and the general initiation factors. The discovery and characterization of multiple, functionally distinct forms of Mediator characterized by the presence or absence of the Cdk8 kinase module have led to new insights into how Mediator functions in both Pol II transcription activation and repression. Finally, progress in studies of the mechanisms by which the transcriptional activation domains (ADs) of DNA binding transcription factors target Mediator have brought to light unexpected complexities in the way Mediator participates in signal transduction.
    Keywords DNA ; DNA-directed RNA polymerase ; mechanism of action ; signal transduction ; transcription factors ; transcriptional activation
    Language English
    Dates of publication 2011-04
    Size p. 225-230.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1077312-5
    ISSN 1879-0380 ; 0959-437X
    ISSN (online) 1879-0380
    ISSN 0959-437X
    DOI 10.1016/j.gde.2011.01.013
    Database NAL-Catalogue (AGRICOLA)

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