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  1. Article ; Online: Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy.

    Leone, Robert D / Powell, Jonathan D

    Cancer immunology research

    2021  Volume 9, Issue 3, Page(s) 255–260

    Abstract: The success of immune-checkpoint blockade and chimeric antigen receptor (CAR) T cell therapies has established the remarkable capacity of the immune system to fight cancer. Over the past several years, it has become clear that immune cell responses to ... ...

    Abstract The success of immune-checkpoint blockade and chimeric antigen receptor (CAR) T cell therapies has established the remarkable capacity of the immune system to fight cancer. Over the past several years, it has become clear that immune cell responses to cancer are critically dependent upon metabolic programs that are specific to both immune cell type and function. Metabolic features of cancer cells and the tumor microenvironment impose constraints on immune cell metabolism that can favor immunosuppressive phenotypes and block antitumor responses. Advances in both preclinical and clinical studies have demonstrated that metabolic interventions can dramatically enhance the efficacy of immune-based therapies for cancer. As such, understanding the metabolic requirements of immune cells in the tumor microenvironment, as well as the limitations imposed therein, can have significant benefits for informing both current practice and future research in cancer immunotherapy.
    MeSH term(s) Animals ; Antimetabolites, Antineoplastic/pharmacology ; Antimetabolites, Antineoplastic/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy/methods ; Disease Models, Animal ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy, Adoptive/methods ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Oxidative Phosphorylation/drug effects ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Treatment Outcome ; Tumor Escape ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/immunology ; Warburg Effect, Oncologic/drug effects
    Chemical Substances Antimetabolites, Antineoplastic ; Immune Checkpoint Inhibitors ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2732489-8
    ISSN 2326-6074 ; 2326-6066
    ISSN (online) 2326-6074
    ISSN 2326-6066
    DOI 10.1158/2326-6066.CIR-20-0791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7022: Show issues Location:
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  2. Article ; Online: Rethinking the adenosine-A

    Helms, Rachel S / Powell, Jonathan D

    Current opinion in pharmacology

    2020  Volume 53, Page(s) 77–83

    Abstract: Adenosine signaling through ... ...

    Abstract Adenosine signaling through A
    MeSH term(s) Adenosine/immunology ; Animals ; Homeostasis ; Humans ; Immunotherapy ; Neoplasms/immunology ; Neoplasms/therapy ; Receptor, Adenosine A2A/immunology
    Chemical Substances Receptor, Adenosine A2A ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2020-08-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2020.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5608: Show issues Location:
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  3. Article ; Online: Sporadic extranodal Rosai-Dorfman-Destombes disease treated with tocilizumab.

    Gonzales, Manuel R / White, Jason C / Mangum, D Spencer / Powell, Jonathan L

    Pediatric blood & cancer

    2022  Volume 69, Issue 12, Page(s) e29754

    MeSH term(s) Humans ; Histiocytosis, Sinus/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances tocilizumab (I031V2H011) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29754
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    Zs.A 1131: Show issues Location:
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  4. Article ; Online: Metabolism of immune cells in cancer.

    Leone, Robert D / Powell, Jonathan D

    Nature reviews. Cancer

    2020  Volume 20, Issue 9, Page(s) 516–531

    Abstract: Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer. Cellular metabolism has emerged as a critical determinant of the viability and function of both cancer ... ...

    Abstract Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer. Cellular metabolism has emerged as a critical determinant of the viability and function of both cancer cells and immune cells. In order to sustain prodigious anabolic needs, tumours employ a specialized metabolism that differs from untransformed somatic cells. This metabolism leads to a tumour microenvironment that is commonly acidic, hypoxic and/or depleted of critical nutrients required by immune cells. In this context, tumour metabolism itself is a checkpoint that can limit immune-mediated tumour destruction. Because our understanding of immune cell metabolism and cancer metabolism has grown significantly in the past decade, we are on the cusp of being able to unravel the interaction of cancer cell metabolism and immune metabolism in therapeutically meaningful ways. Although there are metabolic processes that are seemingly fundamental to both cancer and responding immune cells, metabolic heterogeneity and plasticity may serve to distinguish the two. As such, understanding the differential metabolic requirements of the diverse cells that comprise an immune response to cancer offers an opportunity to selectively regulate immune cell function. Such a nuanced evaluation of cancer and immune metabolism can uncover metabolic vulnerabilities and therapeutic windows upon which to intervene for enhanced immunotherapy.
    MeSH term(s) Animals ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immunotherapy ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Tumor Microenvironment
    Language English
    Publishing date 2020-07-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-020-0273-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5563: Show issues Location:
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    Zs.MG 24: Show issues

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  5. Article ; Online: Inhibition of the Adenosine Pathway to Potentiate Cancer Immunotherapy: Potential for Combinatorial Approaches.

    Thompson, Elizabeth A / Powell, Jonathan D

    Annual review of medicine

    2020  Volume 72, Page(s) 331–348

    Abstract: Cancer immunotherapy has revolutionized the way that we think about treating cancer. Although checkpoint blockade therapy, including anti-PD-1/PD-L1 and anti-CTLA-4, has shown remarkable success, the responses are limited to only a subset of patients. ... ...

    Abstract Cancer immunotherapy has revolutionized the way that we think about treating cancer. Although checkpoint blockade therapy, including anti-PD-1/PD-L1 and anti-CTLA-4, has shown remarkable success, the responses are limited to only a subset of patients. This discrepancy highlights the many overlapping avenues for immune evasion or suppression that can be employed by a tumor. One such mechanism of immunosuppression is adenosinergic signaling within the tumor microenvironment. We provide an overview of the current status of clinical trials targeting the adenosine pathway, including CD73, CD39, and adenosine receptors. Additionally, we highlight several avenues that may be explored to further potentiate responses in the clinic by combining adenosine-targeting agents to target multiple arms of the pathway or by using conventional immunotherapy agents.
    MeSH term(s) Adenosine/antagonists & inhibitors ; Adenosine/metabolism ; Humans ; Immunotherapy/methods ; Neoplasms/therapy
    Chemical Substances Adenosine (K72T3FS567)
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207930-6
    ISSN 1545-326X ; 0066-4219
    ISSN (online) 1545-326X
    ISSN 0066-4219
    DOI 10.1146/annurev-med-060619-023155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.321: Show issues Location:
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  6. Article ; Online: Analysis of Substance Use Disorder Treatment Admissions in the US by Sex and Race and Ethnicity Before and During the COVID-19 Pandemic.

    Cantor, Jonathan H / Whaley, Christopher M / Stein, Bradley D / Powell, David

    JAMA network open

    2022  Volume 5, Issue 9, Page(s) e2232795

    MeSH term(s) COVID-19 ; Ethnicity ; Humans ; Pandemics ; SARS-CoV-2 ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.32795
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Geospatially clustered low COVID-19 vaccine rates among adolescents in socially vulnerable US counties

    Sophie R. Alphonso / Marcus R. Andrews / Seann D. Regan / Alyssa Shishkov / Jonathan H. Cantor / Tiffany M. Powell-Wiley / Kosuke Tamura

    Preventive Medicine Reports, Vol 37, Iss , Pp 102545- (2024)

    1481  

    Abstract: COVID-19 vaccinations are widely available across the United States (U.S.), yet little is known about the spatial clustering of COVID-19 vaccinations. This study aimed to test for geospatial clustering of COVID-19 vaccine rates among adolescents aged 12– ... ...

    Abstract COVID-19 vaccinations are widely available across the United States (U.S.), yet little is known about the spatial clustering of COVID-19 vaccinations. This study aimed to test for geospatial clustering of COVID-19 vaccine rates among adolescents aged 12–17 across the U.S. counties and to compare these clustering patterns by sociodemographic characteristics.County-level data on COVID-19 vaccinations and sociodemographic characteristics were obtained from the COVID-19 Community Profile Report up to April 14, 2022. A total of 3,108 counties were included in the analysis. Global Moran’s I statistic and Anselin Local Moran’s analysis were used, and clustering patterns were compared to sociodemographic variables using t-tests. Counties with low COVID-19 vaccinated clusters were more likely, when compared to unclustered counties, to have higher numbers of individuals in poverty and uninsured individuals, and higher values of Social Vulnerability Index (SVI) and COVID-19 Community Vulnerability Index (CCVI). While high COVID-19 vaccinated clusters, compared to neighboring counties, had lower numbers of Black population, individuals in poverty, and uninsured individuals, and lower values of SVI and CCVI, but a higher number of Hispanic population. This study emphasizes the importance of addressing systemic barriers, such as poverty and lack of health insurance, which were found to be associated with low COVID-19 vaccination coverage.
    Keywords COVID-19 ; Spatial analysis ; Vaccine coverage ; Adolescents ; Disparities ; Geospatial clustering ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Peeking under the Hood of Naive T Cells.

    Xu, Wei / Powell, Jonathan D

    Cell metabolism

    2018  Volume 28, Issue 6, Page(s) 801–802

    Abstract: Signaling and transcriptional regulation of metabolic reprogramming upon T cell activation has been studied intensively. In this issue of Cell Metabolism, Ricciardi et al. (2018) show that translational regulation of key metabolic enzymes GLUT1 and ACC1 ... ...

    Abstract Signaling and transcriptional regulation of metabolic reprogramming upon T cell activation has been studied intensively. In this issue of Cell Metabolism, Ricciardi et al. (2018) show that translational regulation of key metabolic enzymes GLUT1 and ACC1 plays a novel role in human naive CD4 T cell activation and subset differentiation.
    MeSH term(s) CD4-Positive T-Lymphocytes/immunology ; Cell Differentiation ; Cell Division ; Humans ; Lymphocyte Activation ; Signal Transduction
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2018.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6169: Show issues Location:
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  9. Article ; Online: Improving Adherence to Evidence-based Practice for Uncomplicated UTI in a Pediatric Emergency Department.

    Kline, Jaclyn N / Powell, Lauren N / Albert, Jonathan D / Bishara, Amy C / Heffren, Joshua C / Badolato, Gia M / Berkowitz, Deena D

    Pediatric quality & safety

    2023  Volume 8, Issue 3, Page(s) e654

    Abstract: Introduction: Uncomplicated urinary tract infections (uUTIs) are among the more common pediatric bacterial infections. Despite their prevalence, significant variability exists in the treatment duration and antibiotic selection for uUTI. Our first aim ... ...

    Abstract Introduction: Uncomplicated urinary tract infections (uUTIs) are among the more common pediatric bacterial infections. Despite their prevalence, significant variability exists in the treatment duration and antibiotic selection for uUTI. Our first aim was to improve adherence to a three-day course of antibiotic treatment for uUTI in children over 24 months old. Our second aim was to increase the selection of cephalexin in this population.
    Methods: We conducted a single-center quality improvement study from March 2021 to March 2022. One thousand four hundred thirty-five patients were included across our baseline and intervention periods. We created an order set with embedded discharge prescriptions and followed this with education and provider feedback. The outcome measures for this study were percent of children receiving 3 days of antibiotic treatment and percent of children prescribed cephalexin. In addition, we tracked order set use as a process measure, and 7-day emergency department revisit as a balancing measure.
    Results: Rates of 3-day prescriptions for uUTI demonstrated special cause variation with an increase from 3% to 44%. Prescription rates of cephalexin for uUTI demonstrated special cause variation with an increase from 49% to 74%. The process measure of order set use improved from 0% to 49% after implementation. No change occurred in 7-day emergency department revisits.
    Conclusion: We demonstrated improved use of shorter course therapy for uUTI with a first-generation cephalosporin throughout this project without adverse events. We leveraged an order set with embedded discharge prescriptions to achieve our goals.
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article
    ISSN 2472-0054
    ISSN (online) 2472-0054
    DOI 10.1097/pq9.0000000000000654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Immune dysregulation as a driver of idiopathic pulmonary fibrosis.

    Shenderov, Kevin / Collins, Samuel L / Powell, Jonathan D / Horton, Maureen R

    The Journal of clinical investigation

    2021  Volume 131, Issue 2

    Abstract: Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide, reducing their quality of life and leading to death from respiratory failure within years of diagnosis. Treatment options remain limited, with only two FDA-approved ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) affects hundreds of thousands of people worldwide, reducing their quality of life and leading to death from respiratory failure within years of diagnosis. Treatment options remain limited, with only two FDA-approved drugs available in the United States, neither of which reverse the lung damage caused by the disease or prolong the life of individuals with IPF. The only cure for IPF is lung transplantation. In this review, we discuss recent major advances in our understanding of the role of the immune system in IPF that have revealed immune dysregulation as a critical driver of disease pathophysiology. We also highlight ways in which an improved understanding of the immune system's role in IPF may enable the development of targeted immunomodulatory therapies that successfully halt or potentially even reverse lung fibrosis.
    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/immunology ; Idiopathic Pulmonary Fibrosis/therapy ; Immunologic Factors/therapeutic use ; Lung/immunology ; Lung Transplantation ; United States
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI143226
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